Rachel M McLoughlin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    Rachel M McLoughlin
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Clin Invest 112:598-607. 2003
  2. ncbi IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection
    Rachel M McLoughlin
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:1323-32. 2008
  3. pmc Characterization of regulatory T cells in urban newborns
    Ngoc P Ly
    Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
    Clin Mol Allergy 7:8. 2009
  4. pmc A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
    Qun Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:2853-63. 2006
  5. pmc CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections
    Rachel M McLoughlin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10408-13. 2006
  6. pmc Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection
    Jerry C Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 78:4176-86. 2010
  7. doi Bacteroides fragilis-stimulated interleukin-10 contains expanding disease
    Ronit Cohen-Poradosu
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 204:363-71. 2011
  8. pmc The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism
    Christopher Weidenmaier
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13227. 2010
  9. pmc Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection
    Kathleen J Zaleski
    Shire Pharmaceuticals, 700 Main Street, Cambridge, MA 02139, USA
    Antimicrob Agents Chemother 50:3856-60. 2006
  10. ncbi Viral IL-6 blocks neutrophil infiltration during acute inflammation
    Ceri A Fielding
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom
    J Immunol 175:4024-9. 2005

Collaborators

  • Kathleen J Zaleski
  • Arthur Tzianabos
  • Suzanne M Hurst
  • Anwen S Williams
  • M Ernst
  • Brendan J Jenkins
  • Ceri A Fielding
  • Jerry C Lee
  • Nicholas Topley
  • Simon A Jones
  • Ronit Cohen-Poradosu
  • Christopher Weidenmaier
  • Ngoc P Ly
  • Dennis L Kasper
  • Chantal S Colmont
  • Qun Wang
  • Peter J Richards
  • Stefan Rose-John
  • Jennifer L Greenwich
  • Andrew Cumming
  • Laura Saward
  • Jean C Lee
  • George G Zhanel
  • Xiaobing Han
  • Begona Ruiz-Perez
  • GEORGE T O'CONNOR
  • William W Cruikshank
  • James E Gern
  • Diane R Gold
  • Cynthia M Visness
  • Paul K Wallace
  • Meri Najdovska
  • Dianne Grail
  • Louise McLeod
  • Brian A Cobb
  • Marie Charrel-Dennis
  • Douglas Golenbock
  • Naoki Yamamoto
  • Sankichi Horiuchi
  • Michael Ehrmann
  • Sandra Grau
  • Mari A Nowell
  • Dean A Harris
  • Marina Kovaleva

Detail Information

Publications15

  1. pmc Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    Rachel M McLoughlin
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Clin Invest 112:598-607. 2003
    ..These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking...
  2. ncbi IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection
    Rachel M McLoughlin
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:1323-32. 2008
    ..aureus pathogenesis by facilitating bacterial survival within the neutrophil. These findings suggest avenues for novel immunomodulatory approaches to control S. aureus infections...
  3. pmc Characterization of regulatory T cells in urban newborns
    Ngoc P Ly
    Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
    Clin Mol Allergy 7:8. 2009
    ..The objective of this study was to compare Treg phenotype and function in cord blood (CB) of newborns to those in peripheral blood (PB) of a subset of participating mothers...
  4. pmc A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
    Qun Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:2853-63. 2006
    ..fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways...
  5. pmc CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections
    Rachel M McLoughlin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10408-13. 2006
    ..aureus infections in controlling local CXC chemokine production, neutrophil recruitment to the site of infection, and subsequent bacterial replication...
  6. pmc Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection
    Jerry C Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 78:4176-86. 2010
    ..We propose a novel role for a HABP as an innate immunomodulator in the treatment of MSSA and MRSA surgical wound infection through enhancement of the local CXC chemokine-driven neutrophil response...
  7. doi Bacteroides fragilis-stimulated interleukin-10 contains expanding disease
    Ronit Cohen-Poradosu
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 204:363-71. 2011
    ..Deaths were due to exuberant proinflammatory responses, not increased bacterial burden. During infection or commensalism, induction of IL-10 by B. fragilis is critical to this microbe's interactions with the immune system...
  8. pmc The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism
    Christopher Weidenmaier
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13227. 2010
    ..An understanding of this novel T cell-dependent host response to staphylococcal abscess formation may lead to the development of new strategies to combat S. aureus skin and soft tissue infections...
  9. pmc Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection
    Kathleen J Zaleski
    Shire Pharmaceuticals, 700 Main Street, Cambridge, MA 02139, USA
    Antimicrob Agents Chemother 50:3856-60. 2006
    ..These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting...
  10. ncbi Viral IL-6 blocks neutrophil infiltration during acute inflammation
    Ceri A Fielding
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom
    J Immunol 175:4024-9. 2005
    ..These data suggest that vIL-6 has the capacity to suppress innate immune responses and thereby influence the outcome of opportunistic infections in HHV8-associated disease...
  11. ncbi Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms
    Rachel M McLoughlin
    Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom
    J Immunol 172:5676-83. 2004
    ..These data confirm that sIL-6R-mediated signaling primarily limits neutrophil influx; however, induction of CXCL5 and CXCL6 may regulate other neutrophil responses...
  12. ncbi Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    Peter J Richards
    Cardiff University, Cardiff, UK
    Arthritis Rheum 54:1662-72. 2006
    ..The aim of this study was to evaluate the functional properties of gp130-RAPS...
  13. ncbi IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
    Ceri A Fielding
    Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:2189-95. 2008
    ....
  14. pmc IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
    Rachel M McLoughlin
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom
    Proc Natl Acad Sci U S A 102:9589-94. 2005
    ..Consequently, STAT3 plays a defining role in IL-6-mediated T cell migration...
  15. ncbi Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells
    Suzanne M Hurst
    Cardiff School of Biosciences, Cardiff University, Institute of Nephrology, University of Wales College of Medicine, United Kingdom
    J Immunol 169:5244-51. 2002
    ..Thus suggesting that OSM and sIL-6R release from infiltrating neutrophils may contribute to the temporal switch between neutrophil influx and mononuclear cell recruitment seen during acute inflammation...