R R McLean

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint B vitamins, homocysteine, and bone disease: epidemiology and pathophysiology
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Curr Osteoporos Rep 5:112-9. 2007
  2. ncbi request reprint Proinflammatory cytokines and osteoporosis
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Curr Osteoporos Rep 7:134-9. 2009
  3. pmc Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:2206-12. 2008
  4. ncbi request reprint Association of dietary and biochemical measures of vitamin K with quantitative ultrasound of the heel in men and women
    R R McLean
    National Heart Lung and Blood Institute, National Institutes of Health, USA
    Osteoporos Int 17:600-7. 2006
  5. pmc Meniscal damage associated with increased local subchondral bone mineral density: a Framingham study
    G H Lo
    Tufts New England Medical Center, Boston, MA 02111, USA
    Osteoarthritis Cartilage 16:261-7. 2008
  6. pmc Does dietary protein reduce hip fracture risk in elders? The Framingham Osteoporosis Study
    D Misra
    Department of Rheumatology, Boston University Medical Center, Boston, MA, USA
    Osteoporos Int 22:345-9. 2011
  7. ncbi request reprint Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis
    D Karasik
    Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, MA 02131, USA
    Osteoporos Int 13:796-802. 2002
  8. pmc Dietary protein intake and subsequent falls in older men and women: the Framingham Study
    E S Zoltick
    Boston University School of Public Health, Boston, MA, USA
    J Nutr Health Aging 15:147-52. 2011
  9. ncbi request reprint Homocysteine as a predictive factor for hip fracture in older persons
    Robert R McLean
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
    N Engl J Med 350:2042-9. 2004
  10. ncbi request reprint Second hip fracture in older men and women: the Framingham Study
    Sarah D Berry
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Arch Intern Med 167:1971-6. 2007

Detail Information

Publications16

  1. ncbi request reprint B vitamins, homocysteine, and bone disease: epidemiology and pathophysiology
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Curr Osteoporos Rep 5:112-9. 2007
    ..More controlled -trials are needed to determine whether treatment with B vitamins would reduce fracture rates among community-dwelling cohorts...
  2. ncbi request reprint Proinflammatory cytokines and osteoporosis
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Curr Osteoporos Rep 7:134-9. 2009
    ..Additional studies are required to establish if inflammation is an important risk factor for osteoporosis...
  3. pmc Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:2206-12. 2008
    ..Elevated homocysteine is a strong risk factor for osteoporotic fractures among elders, yet it may be a marker for low B-vitamin status...
  4. ncbi request reprint Association of dietary and biochemical measures of vitamin K with quantitative ultrasound of the heel in men and women
    R R McLean
    National Heart Lung and Blood Institute, National Institutes of Health, USA
    Osteoporos Int 17:600-7. 2006
    ..We therefore examined the association of vitamin K nutritional status measured in several different ways with QUS in men and women who participated in the Framingham Osteoporosis Study...
  5. pmc Meniscal damage associated with increased local subchondral bone mineral density: a Framingham study
    G H Lo
    Tufts New England Medical Center, Boston, MA 02111, USA
    Osteoarthritis Cartilage 16:261-7. 2008
    ..We hypothesized that knees with higher M:L BMD, consistent with increased medial subchondral BMD, would be associated with medial meniscal damage, and lower ratios with lateral meniscal damage...
  6. pmc Does dietary protein reduce hip fracture risk in elders? The Framingham Osteoporosis Study
    D Misra
    Department of Rheumatology, Boston University Medical Center, Boston, MA, USA
    Osteoporos Int 22:345-9. 2011
    ..We examined association between energy-adjusted protein intake and hip fracture risk in elders. The risk of hip fracture was reduced in upper quartiles of protein intake when compared with lowest quartile...
  7. ncbi request reprint Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis
    D Karasik
    Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, MA 02131, USA
    Osteoporos Int 13:796-802. 2002
    ..In conclusion, our results suggest that there may be genetic determinants for BUA on 1p36.3. These results should encourage further investigations of the genetic source of QUS variability and candidate polymorphisms in this region...
  8. pmc Dietary protein intake and subsequent falls in older men and women: the Framingham Study
    E S Zoltick
    Boston University School of Public Health, Boston, MA, USA
    J Nutr Health Aging 15:147-52. 2011
    ..The objective of this study was to test the association between dietary protein intake and risk of subsequent falls in a population-based cohort of elderly men and women...
  9. ncbi request reprint Homocysteine as a predictive factor for hip fracture in older persons
    Robert R McLean
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
    N Engl J Med 350:2042-9. 2004
    ..We examined the association between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study...
  10. ncbi request reprint Second hip fracture in older men and women: the Framingham Study
    Sarah D Berry
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Arch Intern Med 167:1971-6. 2007
    ..Older persons with hip fractures remain at increased risk of subsequent hip fractures. However, little is known about the frequency and characteristics of persons who sustain a second hip fracture...
  11. ncbi request reprint The ratio of medial to lateral tibial plateau bone mineral density and compartment-specific tibiofemoral osteoarthritis
    G H Lo
    Tufts New England Medical Center, Boston, MA 0211, USA
    Osteoarthritis Cartilage 14:984-90. 2006
    ..Bone is thought to play an important role in osteoarthritis (OA) pathophysiology. Our aim was to look at specific features of OA and their relation to the ratio of medial:lateral tibial plateau bone mineral density (M:L BMD Ratio)...
  12. ncbi request reprint Vitamin K intake and bone mineral density in women and men
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 77:512-6. 2003
    ..Low dietary vitamin K intake has been associated with an increased risk of hip fracture in men and women. Few data exist on the association between dietary vitamin K intake and bone mineral density (BMD)...
  13. ncbi request reprint Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status
    Robert R McLean
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
    J Bone Miner Res 19:410-8. 2004
    ..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status...
  14. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  15. pmc Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Clin Endocrinol Metab 93:40-6. 2008
    ..Although racial and ethnic differences in vitamin D status and bone mineral density (BMD) are recognized, less is known about how differences in vitamin D status impact BMD, especially among men...
  16. pmc Cross-calibration and comparison of variability in 2 bone densitometers in a research setting: the framingham experience
    David R Gagnon
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    J Clin Densitom 13:210-8. 2010
    ....