Research Topics
| James T McKennaSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Chronic ramelteon treatment in a mouse model of Alzheimer's diseaseJames Timothy McKenna
VA Boston Healthcare System Harvard Medical School, Brockton, MA 02301 5596, USA
Arch Ital Biol 150:5-14. 2012..The ability of long term melatonin treatment to improve cognition and attenuate neuropathology in AD mice did not generalize to this dosage of ramelteon...
Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepinessJames T McKenna
Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
J Sleep Res 17:365-75. 2008..The rMSLT provided a simple, objective, robust and direct measure of sleepiness that was as effective as conventional polysomnographic measures of sleepiness...- Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepinessJ T McKenna
VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Building 46, Brockton, MA 02301, USA
Neuroscience 146:1462-73. 2007..SI may be partially responsible for the symptom of daytime sleepiness observed in a number of clinical disorders, and this may be mediated by mechanisms involving BF AD... - Microdialysis elevation of adenosine in the basal forebrain produces vigilance impairments in the rat psychomotor vigilance taskMichael A Christie
VA Boston Healthcare System, Brockton, MA, USA
Sleep 31:1393-8. 2008..Here 300 microM of adenosine was dialyzed in the BF of rats, and the effect on vigilance was determined in the rat Psychomotor Vigilance Task (rPVT)... - GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasisLichao Chen
Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
Neuroreport 21:216-20. 2010..Our results suggest GAD67-GFP knock-in mice are an excellent tool for study of GABAergic neurons involved in sleep-wake regulation... - 24 hours of sleep deprivation in the rat increases sleepiness and decreases vigilance: introduction of the rat-psychomotor vigilance taskMichael A Christie
VA Boston Healthcare System and Harvard Medical School, Brockton, MA, USA
J Sleep Res 17:376-84. 2008..The rPVT closely resembles the human PVT test widely used in human sleep research and will assist investigation of the neurobiologic mechanisms that produce vigilance impairments after sleep disruption... - One week of exposure to intermittent hypoxia impairs attentional set-shifting in ratsJohn G McCoy
VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
Behav Brain Res 210:123-6. 2010..Instead, the deficit is likely to reflect impaired allocation of attentional resources of the working memory system... - Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark periodLichao Chen
Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
Eur J Neurosci 32:1528-36. 2010..The results indicate that a modest knockdown of OxR1 is sufficient to induce observable sleep changes. Moreover, orexin neurons, by acting on OxR1 in the LC, play a role in the diurnal gating of REM sleep... - Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apneaChristopher P Ward
VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Brockton, MA 02301, USA
Brain Res 1294:128-37. 2009.... - Control of sleep and wakefulnessRitchie E Brown
Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
Physiol Rev 92:1087-187. 2012.... 
Experimental sleep fragmentation impairs attentional set-shifting in ratsJohn G McCoy
VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
Sleep 30:52-60. 2007..To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats...- Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosineJaime L Tartar
VA Boston Healthcare System and Harvard Medical School, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
Neurosci Lett 469:1-5. 2010..Instead, the reduced excitability of CA1 pyramidal neurons observed here may contribute to the loss of hippocampal long-term potentiation and hippocampus-dependent cognitive impairments associated with sleep disruption... - Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentationJaime L Tartar
Harvard Medical School and VA Boston Healthcare System, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
Eur J Neurosci 23:2739-48. 2006..The results suggest that sleep fragmentation negatively impacts spatial learning. Loss of N-methyl-D-aspartate (NMDA) receptor-dependent LTP in the hippocampal CA1 region may be one mechanism involved in this deficit... - Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouseJames T McKenna
Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, Massachusetts, 02301, USA
J Comp Neurol 521:1225-50. 2013.... - c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulnessJ T McKenna
VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, MA, USA james
Brain Res Bull 80:382-8. 2009..These findings support and provide additional confirming data of previous reports that cholinergic neurons of BF play a role in vigilance state regulation by promoting wakefulness... - Animal models of narcolepsyLichao Chen
Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
CNS Neurol Disord Drug Targets 8:296-308. 2009..To facilitate further research, it is imperative that researchers reach a consensus concerning the evaluation of narcoleptic behavioral and EEG phenomenology in these models... - Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in miceRitchie E Brown
In Vitro Neurophysiology Section, Laboratory of Neuroscience, Harvard Medical School and VA Boston Healthcare System, 940 Belmont Street, Research 151 C, Brockton, MA 02301, USA
Eur J Neurosci 27:352-63. 2008..Orexinergic suppression of REM during waking is probably mediated in part via excitation of acetylcholine-inhibited GABAergic neurons... - Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving ratsR Tao
Boston VA Healthcare Harvard Medical School, Department of Psychiatry, Laboratory of Neuroscience, 940 Belmont Street, Brockton, MA 02301, USA
Neuroscience 141:1101-5. 2006..Orexins may have regionally selective effects on serotonin release in the CNS, implying a unique interaction between orexins and serotonin in the regulation of activities including sleep-wakefulness...
Research Grants
- Hypoxia-induced apoptosis in a model of sleep apneaJames McKenna; Fiscal Year: 2004..Overall, it is predicted that the biochemical and apoptotic consequences of IH will be more severe than that of SH, although cellular changes will be observed after both hypoxic exposures. ..