James T McKenna

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Chronic ramelteon treatment in a mouse model of Alzheimer's disease
    James Timothy McKenna
    VA Boston Healthcare System Harvard Medical School, Brockton, MA 02301 5596, USA
    Arch Ital Biol 150:5-14. 2012
  2. pmc Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness
    James T McKenna
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
    J Sleep Res 17:365-75. 2008
  3. pmc Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness
    J T McKenna
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Building 46, Brockton, MA 02301, USA
    Neuroscience 146:1462-73. 2007
  4. pmc Microdialysis elevation of adenosine in the basal forebrain produces vigilance impairments in the rat psychomotor vigilance task
    Michael A Christie
    VA Boston Healthcare System, Brockton, MA, USA
    Sleep 31:1393-8. 2008
  5. pmc GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis
    Lichao Chen
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroreport 21:216-20. 2010
  6. pmc 24 hours of sleep deprivation in the rat increases sleepiness and decreases vigilance: introduction of the rat-psychomotor vigilance task
    Michael A Christie
    VA Boston Healthcare System and Harvard Medical School, Brockton, MA, USA
    J Sleep Res 17:376-84. 2008
  7. pmc One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats
    John G McCoy
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Behav Brain Res 210:123-6. 2010
  8. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
  9. pmc Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea
    Christopher P Ward
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Brockton, MA 02301, USA
    Brain Res 1294:128-37. 2009
  10. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012

Research Grants

Detail Information

Publications19

  1. doi request reprint Chronic ramelteon treatment in a mouse model of Alzheimer's disease
    James Timothy McKenna
    VA Boston Healthcare System Harvard Medical School, Brockton, MA 02301 5596, USA
    Arch Ital Biol 150:5-14. 2012
    ..The ability of long term melatonin treatment to improve cognition and attenuate neuropathology in AD mice did not generalize to this dosage of ramelteon...
  2. pmc Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness
    James T McKenna
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
    J Sleep Res 17:365-75. 2008
    ..The rMSLT provided a simple, objective, robust and direct measure of sleepiness that was as effective as conventional polysomnographic measures of sleepiness...
  3. pmc Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness
    J T McKenna
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Building 46, Brockton, MA 02301, USA
    Neuroscience 146:1462-73. 2007
    ..SI may be partially responsible for the symptom of daytime sleepiness observed in a number of clinical disorders, and this may be mediated by mechanisms involving BF AD...
  4. pmc Microdialysis elevation of adenosine in the basal forebrain produces vigilance impairments in the rat psychomotor vigilance task
    Michael A Christie
    VA Boston Healthcare System, Brockton, MA, USA
    Sleep 31:1393-8. 2008
    ..Here 300 microM of adenosine was dialyzed in the BF of rats, and the effect on vigilance was determined in the rat Psychomotor Vigilance Task (rPVT)...
  5. pmc GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis
    Lichao Chen
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroreport 21:216-20. 2010
    ..Our results suggest GAD67-GFP knock-in mice are an excellent tool for study of GABAergic neurons involved in sleep-wake regulation...
  6. pmc 24 hours of sleep deprivation in the rat increases sleepiness and decreases vigilance: introduction of the rat-psychomotor vigilance task
    Michael A Christie
    VA Boston Healthcare System and Harvard Medical School, Brockton, MA, USA
    J Sleep Res 17:376-84. 2008
    ..The rPVT closely resembles the human PVT test widely used in human sleep research and will assist investigation of the neurobiologic mechanisms that produce vigilance impairments after sleep disruption...
  7. pmc One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats
    John G McCoy
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Behav Brain Res 210:123-6. 2010
    ..Instead, the deficit is likely to reflect impaired allocation of attentional resources of the working memory system...
  8. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
    ..The results indicate that a modest knockdown of OxR1 is sufficient to induce observable sleep changes. Moreover, orexin neurons, by acting on OxR1 in the LC, play a role in the diurnal gating of REM sleep...
  9. pmc Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea
    Christopher P Ward
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Brockton, MA 02301, USA
    Brain Res 1294:128-37. 2009
    ....
  10. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012
    ....
  11. ncbi request reprint Experimental sleep fragmentation impairs attentional set-shifting in rats
    John G McCoy
    VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
    Sleep 30:52-60. 2007
    ..To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats...
  12. pmc Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine
    Jaime L Tartar
    VA Boston Healthcare System and Harvard Medical School, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Neurosci Lett 469:1-5. 2010
    ..Instead, the reduced excitability of CA1 pyramidal neurons observed here may contribute to the loss of hippocampal long-term potentiation and hippocampus-dependent cognitive impairments associated with sleep disruption...
  13. pmc Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation
    Jaime L Tartar
    Harvard Medical School and VA Boston Healthcare System, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Eur J Neurosci 23:2739-48. 2006
    ..The results suggest that sleep fragmentation negatively impacts spatial learning. Loss of N-methyl-D-aspartate (NMDA) receptor-dependent LTP in the hippocampal CA1 region may be one mechanism involved in this deficit...
  14. pmc Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep
    Lichao Chen
    Research Service, VA Boston Healthcare System, Brockton, MA, USA
    Eur J Neurosci 37:957-63. 2013
    ..Orexin type 1 receptor mRNA level was unaffected. Our results indicate that removal of OxR2 neurotransmission in the lPMT enhances REM sleep by increasing the duration of REM episodes...
  15. pmc Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse
    James T McKenna
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, Massachusetts, 02301, USA
    J Comp Neurol 521:1225-50. 2013
    ....
  16. pmc c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulness
    J T McKenna
    VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, MA, USA james
    Brain Res Bull 80:382-8. 2009
    ..These findings support and provide additional confirming data of previous reports that cholinergic neurons of BF play a role in vigilance state regulation by promoting wakefulness...
  17. pmc Animal models of narcolepsy
    Lichao Chen
    Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    CNS Neurol Disord Drug Targets 8:296-308. 2009
    ..To facilitate further research, it is imperative that researchers reach a consensus concerning the evaluation of narcoleptic behavioral and EEG phenomenology in these models...
  18. pmc Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice
    Ritchie E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Harvard Medical School and VA Boston Healthcare System, 940 Belmont Street, Research 151 C, Brockton, MA 02301, USA
    Eur J Neurosci 27:352-63. 2008
    ..Orexinergic suppression of REM during waking is probably mediated in part via excitation of acetylcholine-inhibited GABAergic neurons...
  19. ncbi request reprint Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats
    R Tao
    Boston VA Healthcare Harvard Medical School, Department of Psychiatry, Laboratory of Neuroscience, 940 Belmont Street, Brockton, MA 02301, USA
    Neuroscience 141:1101-5. 2006
    ..Orexins may have regionally selective effects on serotonin release in the CNS, implying a unique interaction between orexins and serotonin in the regulation of activities including sleep-wakefulness...

Research Grants1

  1. Hypoxia-induced apoptosis in a model of sleep apnea
    James McKenna; Fiscal Year: 2004
    ..Overall, it is predicted that the biochemical and apoptotic consequences of IH will be more severe than that of SH, although cellular changes will be observed after both hypoxic exposures. ..