Research Topics
Genomes and Genes
| Monica McGrathSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Telomere length and risk of Parkinson's diseaseHao Wang
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Mov Disord 23:302-5. 2008..the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD...
Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States)Monica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 18:1123-30. 2007..These data suggest that these three polymorphisms are not important in determining genetic susceptibility to endometrial cancer, although larger sample sizes are needed to confirm these findings...- Androgen receptor polymorphisms and endometrial cancer riskMonica McGrath
Department of Epidemiology, Harvard School of Public Health, 181 Longwood Avenue, Boston, MA 02115, USA
Int J Cancer 118:1261-8. 2006..supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html)... - Hormonal and reproductive factors and the risk of bladder cancer in womenMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Epidemiol 163:236-44. 2006..Findings suggest that menopausal status and age at menopause may play a role in modifying bladder cancer risk among women... - Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and womenMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
BMC Cancer 6:239. 2006..Glutathione S-transferases (GSTs) also detoxify tobacco smoke constituents, and polymorphisms within the GSTM1 and GSTT1 genes can result in a complete lack of enzyme activity... - Telomere length, cigarette smoking, and bladder cancer risk in men and womenMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 16:815-9. 2007..We also observed a significant difference in telomere length across categories of pack-years of smoking (P = 0.01). These findings suggest that truncated telomeres are associated with an increased risk of bladder cancer... - Novel breast cancer risk alleles and endometrial cancer riskMonica McGrath
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
Int J Cancer 123:2961-4. 2008..The molecular mechanisms underlying these differences remain to be defined... - Genetic variation in CYP11A1 and StAR in relation to endometrial cancer riskKathryn Terry
Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
Gynecol Oncol 117:255-9. 2010..Given the role of estrogens in endometrial carcinogenesis, we hypothesized that genetic variation in StAR and CYP11A1 genes may influence endometrial cancer risk... - Telomere length and genetic analyses in population-based studies of endometrial cancer riskJennifer Prescott
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer 116:4275-82. 2010..When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic... - MDM2 SNP309 is associated with endometrial cancer riskKathryn Terry
Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:983-6. 2008..87; 95% confidence interval, 1.29-2.73) for endometrial cancer. We observed no association between age at diagnosis and genotype. Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer... - Association between catechol-O-methyltransferase and phobic anxietyMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Psychiatry 161:1703-5. 2004..The authors assessed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and scores on the phobic anxiety scale of the Crown-Crisp Experimental Index... - Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer riskMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Gynecol Oncol 120:174-8. 2011..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer... - Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer riskMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Pharmacogenet Genomics 19:239-43. 2009..Our data suggest that these UGT polymorphisms do not contribute significantly to endometrial cancer risk... - Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer riskStalo Karageorgi
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Gynecol Oncol 121:54-8. 2011..Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide polymorphisms (SNPs) in genes HSD17b2 and HSD17b4 may alter the enzyme activity, estradiol levels and risk of disease... - A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritisElizabeth W Karlson
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Res Ther 11:R97. 2009.... - Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibilityMonica McGrath
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 25:559-65. 2004..Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. However, further studies are warranted to elucidate the role of CYP1B1 in endometrial cancer... - The functional UGT1A1 promoter polymorphism decreases endometrial cancer riskYannick Duguay
Canada Research Chair in Pharmacogenomics, Pharmacogenomics Laboratory, Faculty of Pharmacy, Centre Hospitalier de l Université Laval CHUL Research Center, Hotel Dieu de Quebec, Laval University, Quebec, Canada
Cancer Res 64:1202-7. 2004..05)]. These observations suggest that lower expression of UGT1A1 decreases the risk of endometrial cancer by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of E(2), in the endometrium...