Monica McGrath

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States)
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:1123-30. 2007
  2. ncbi request reprint Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:559-65. 2004
  3. ncbi request reprint Association between catechol-O-methyltransferase and phobic anxiety
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Psychiatry 161:1703-5. 2004
  4. pmc Novel breast cancer risk alleles and endometrial cancer risk
    Monica McGrath
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
    Int J Cancer 123:2961-4. 2008
  5. pmc Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
    Gynecol Oncol 117:255-9. 2010
  6. pmc Telomere length and genetic analyses in population-based studies of endometrial cancer risk
    Jennifer Prescott
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 116:4275-82. 2010
  7. pmc MDM2 SNP309 is associated with endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:983-6. 2008
  8. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
  9. pmc Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pharmacogenet Genomics 19:239-43. 2009
  10. pmc Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 121:54-8. 2011

Detail Information

Publications17

  1. ncbi request reprint Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States)
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:1123-30. 2007
    ..These data suggest that these three polymorphisms are not important in determining genetic susceptibility to endometrial cancer, although larger sample sizes are needed to confirm these findings...
  2. ncbi request reprint Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:559-65. 2004
    ..Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. However, further studies are warranted to elucidate the role of CYP1B1 in endometrial cancer...
  3. ncbi request reprint Association between catechol-O-methyltransferase and phobic anxiety
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Psychiatry 161:1703-5. 2004
    ..The authors assessed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and scores on the phobic anxiety scale of the Crown-Crisp Experimental Index...
  4. pmc Novel breast cancer risk alleles and endometrial cancer risk
    Monica McGrath
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
    Int J Cancer 123:2961-4. 2008
    ..The molecular mechanisms underlying these differences remain to be defined...
  5. pmc Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
    Gynecol Oncol 117:255-9. 2010
    ..Given the role of estrogens in endometrial carcinogenesis, we hypothesized that genetic variation in StAR and CYP11A1 genes may influence endometrial cancer risk...
  6. pmc Telomere length and genetic analyses in population-based studies of endometrial cancer risk
    Jennifer Prescott
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 116:4275-82. 2010
    ..When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic...
  7. pmc MDM2 SNP309 is associated with endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:983-6. 2008
    ..87; 95% confidence interval, 1.29-2.73) for endometrial cancer. We observed no association between age at diagnosis and genotype. Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer...
  8. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
    ..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer...
  9. pmc Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pharmacogenet Genomics 19:239-43. 2009
    ..Our data suggest that these UGT polymorphisms do not contribute significantly to endometrial cancer risk...
  10. pmc Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 121:54-8. 2011
    ..Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide polymorphisms (SNPs) in genes HSD17b2 and HSD17b4 may alter the enzyme activity, estradiol levels and risk of disease...
  11. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  12. ncbi request reprint Androgen receptor polymorphisms and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, 181 Longwood Avenue, Boston, MA 02115, USA
    Int J Cancer 118:1261-8. 2006
    ..supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html)...
  13. ncbi request reprint Telomere length, cigarette smoking, and bladder cancer risk in men and women
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:815-9. 2007
    ..We also observed a significant difference in telomere length across categories of pack-years of smoking (P = 0.01). These findings suggest that truncated telomeres are associated with an increased risk of bladder cancer...
  14. pmc Telomere length and risk of Parkinson's disease
    Hao Wang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 23:302-5. 2008
    ..the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD...
  15. pmc Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    BMC Cancer 6:239. 2006
    ..Glutathione S-transferases (GSTs) also detoxify tobacco smoke constituents, and polymorphisms within the GSTM1 and GSTT1 genes can result in a complete lack of enzyme activity...
  16. ncbi request reprint Hormonal and reproductive factors and the risk of bladder cancer in women
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 163:236-44. 2006
    ..Findings suggest that menopausal status and age at menopause may play a role in modifying bladder cancer risk among women...
  17. ncbi request reprint The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk
    Yannick Duguay
    Canada Research Chair in Pharmacogenomics, Pharmacogenomics Laboratory, Faculty of Pharmacy, Centre Hospitalier de l Université Laval CHUL Research Center, Hotel Dieu de Quebec, Laval University, Quebec, Canada
    Cancer Res 64:1202-7. 2004
    ..05)]. These observations suggest that lower expression of UGT1A1 decreases the risk of endometrial cancer by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of E(2), in the endometrium...

Research Grants1

  1. Polymorphisms and Haplotypes in the IGF Pathway and Endometrial Cancer Risk
    Monica McGrath; Fiscal Year: 2007
    ..We will have > 85% power to detect a relative risk 1.50 or greater for the main effects of most of the genotypes and haplotypes of interest. ..