Nathan J McDannold

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 72:3652-63. 2012
  2. ncbi request reprint MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 31:1527-37. 2005
  3. ncbi request reprint Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity
    N McDannold
    Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Phys Med Biol 51:793-807. 2006
  4. pmc Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Ave LMRC, 007c, Boston, MA 02115, USA
    Radiology 240:263-72. 2006
  5. ncbi request reprint Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits
    Nathan J McDannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, 221 Longwood Ave, LMRC 521, Boston, MA 02115, USA
    Radiology 241:95-106. 2006
  6. ncbi request reprint Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience
    Nathan Mcdannold
    Harvard Medical School, Brigham and Women s Hospital, Department of Radiology, Boston, Massachusetts 02115, USA
    Med Phys 33:4307-13. 2006
  7. pmc Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 33:584-90. 2007
  8. pmc Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 34:834-40. 2008
  9. pmc Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 34:930-7. 2008
  10. pmc Magnetic resonance acoustic radiation force imaging
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 35:3748-58. 2008

Research Grants

Detail Information

Publications41

  1. pmc Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 72:3652-63. 2012
    ..These results therefore support clinical testing of this noninvasive-targeted drug delivery method...
  2. ncbi request reprint MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 31:1527-37. 2005
    ..These findings indicate that this method is safe for targeted drug delivery, at least when compared with the currently available invasive methods...
  3. ncbi request reprint Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity
    N McDannold
    Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Phys Med Biol 51:793-807. 2006
    ....
  4. pmc Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Ave LMRC, 007c, Boston, MA 02115, USA
    Radiology 240:263-72. 2006
    ..To retrospectively evaluate magnetic resonance (MR) imaging-based thermometry and thermal dosimetry during focused ultrasound treatments of uterine leiomyomas (ie, fibroids)...
  5. ncbi request reprint Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits
    Nathan J McDannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, 221 Longwood Ave, LMRC 521, Boston, MA 02115, USA
    Radiology 241:95-106. 2006
    ....
  6. ncbi request reprint Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience
    Nathan Mcdannold
    Harvard Medical School, Brigham and Women s Hospital, Department of Radiology, Boston, Massachusetts 02115, USA
    Med Phys 33:4307-13. 2006
    ..This simple method to evaluate the performance appeared to be sensitive to small changes in system performance, which was adequately stable over a four-year time period...
  7. pmc Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 33:584-90. 2007
    ..However, under the experimental conditions used in this study, Optison produced a larger effect for the same acoustic pressure amplitude...
  8. pmc Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 34:834-40. 2008
    ..It also suggests that lower frequency sonication produces less red blood cell extravasation per unit area...
  9. pmc Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 34:930-7. 2008
    ..This data suggests that over the range of parameters tested, BBB disruption is not affected by PRF or ultrasound contrast agent dose. However, both the BBB disruption magnitude and its threshold depend on the burst length...
  10. pmc Magnetic resonance acoustic radiation force imaging
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 35:3748-58. 2008
    ..MR-ARFI has potential for elastography or to guide ultrasound therapies that use low-power pulsed ultrasound exposures, such as drug delivery...
  11. pmc Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 28:1026-32. 2008
    ..To clinically assess a previously described method (Rieke et.al., Magn Reson Med 2004) to produce more motion-robust MRI-based temperature images using data acquired during MRI-guided focused ultrasound surgery (MRgFUS) of uterine fibroids...
  12. pmc Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosurgery 66:323-32; discussion 332. 2010
    ..This work evaluated the clinical feasibility of transcranial magnetic resonance imaging-guided focused ultrasound surgery...
  13. pmc Blood-brain barrier disruption and vascular damage induced by ultrasound bursts combined with microbubbles can be influenced by choice of anesthesia protocol
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 37:1259-70. 2011
    ..These experiments may also have been influenced by the recently reported findings that the circulation time for perfluorocarbon microbubbles is substantially reduced when oxygen is used as the carrier gas...
  14. ncbi request reprint Quantitative MRI-based temperature mapping based on the proton resonant frequency shift: review of validation studies
    N McDannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Hyperthermia 21:533-46. 2005
    ..In this paper, these validation studies will be reviewed. In addition, clinical studies that have shown this method feasible in human treatments will be overviewed...
  15. ncbi request reprint MRI monitoring of the thermal ablation of tissue: effects of long exposure times
    N McDannold
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 13:421-7. 2001
    ..The thermal dose model predicted the extent of tissue damage well for subsequent one minute sonications. These results will have implications for MRI guidance of thermal therapies with long exposure times...
  16. ncbi request reprint Usefulness of MR imaging-derived thermometry and dosimetry in determining the threshold for tissue damage induced by thermal surgery in rabbits
    N J McDannold
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Longwood Medical Research Center, 007c, Boston, MA 02115, USA
    Radiology 216:517-23. 2000
    ..To investigate in vivo the feasibility of using magnetic resonance (MR) imaging-derived temperature and thermal dose measurements to find the threshold of thermal tissue damage...
  17. ncbi request reprint Magnetic resonance image-guided thermal ablations
    N J McDannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Top Magn Reson Imaging 11:191-202. 2000
    ..These methods of using MRI for planning, guiding, and monitoring thermal therapies are reviewed...
  18. ncbi request reprint MRI-guided focused ultrasound surgery in the brain: tests in a primate model
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Magn Reson Med 49:1188-91. 2003
    ..The capabilities demonstrated in this study will be of benefit for clinical ultrasound therapies in the brain...
  19. ncbi request reprint Temperature monitoring with line scan echo planar spectroscopic imaging
    N McDannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02155, USA
    Med Phys 28:346-55. 2001
    ..A new magnetic resonance imaging method, line scan echo planar spectroscopic imaging (LSEPSI), is shown capable of providing rapid, internally referenced temperature monitoring from water and fat chemical shifts...
  20. ncbi request reprint MRI evaluation of thermal ablation of tumors with focused ultrasound
    - McDannold
    Department of Physics and Astronomy, Tufts University, Medford, MA 02155, USA
    J Magn Reson Imaging 8:91-100. 1998
    ..The temperature rise and lesion size varied significantly. Regions of tissue coagulation calculated from MR data correlated well with post-therapy imaging...
  21. ncbi request reprint The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 29:356-65. 2002
    ..Even with this underestimation of the power, this method will be useful because it will allow an estimate of the proper power to use during FUS surgery without exact knowledge of the tissue parameters...
  22. ncbi request reprint Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, 221 Longwood Ave, LMRC 007C, Boston, MA 02115, USA
    Radiology 230:743-52. 2004
    ....
  23. ncbi request reprint MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 51:913-23. 2004
    ..The temperature information was better than the applied acoustic power or energy for predicting the damage than the ultrasound parameters. MRI was sensitive in detecting threshold-level damage...
  24. pmc The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound
    Juyoung Park
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave Boston, MA 02115, USA
    J Control Release 162:134-42. 2012
    ..The results of this study provide information needed to take into account the dynamics BBB disruption over time after FUS...
  25. pmc Ultrafast 1D MR thermometry using phase or frequency mapping
    Chang Sheng Mei
    Department of Physics, Boston College, Chestnut Hill, MA, USA
    MAGMA 25:5-14. 2012
    ..To develop an ultrafast MRI-based temperature monitoring method for application during rapid ultrasound exposures in moving organs...
  26. pmc Renal ultrafiltration changes induced by focused US
    Krisztina Fischer
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Focused Ultrasound Laboratory, 221 Longwood Ave, Room 515, Boston, MA 02215, USA
    Radiology 253:697-705. 2009
    ..To determine if focused ultrasonography (US) combined with a diagnostic microbubble-based US contrast agent can be used to modulate glomerular ultrafiltration and size selectivity...
  27. ncbi request reprint Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols
    Fiona M Fennessy
    Department of Radiology, Harvard Medical School Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Radiology 243:885-93. 2007
    ..To prospectively assess patient response (after 12 months) to magnetic resonance (MR) imaging-guided focused ultrasound surgery in treatment of uterine leiomyomas by using two treatment protocols...
  28. pmc Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success
    Zsuzsanna M Lénárd
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Radiology 249:187-94. 2008
    ..To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging-guided focused ultrasound surgery...
  29. pmc Focused ultrasound modulates region-specific brain activity
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 56:1267-75. 2011
    ..It is anticipated that the use of this technology will have an impact on brain research and may offer novel therapeutic interventions in various neurological conditions and psychiatric disorders...
  30. pmc Targeted and reversible blood-retinal barrier disruption via focused ultrasound and microbubbles
    Juyoung Park
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e42754. 2012
    ..More severe retinal damage was observed at 1.1 MPa. These results demonstrate that focused ultrasound and microbubbles can offer a noninvasive and targeted means to transiently disrupt the BRB for ocular drug delivery...
  31. pmc Multiresolution MRI temperature monitoring in a reduced field of view
    Mohammed H Aljallad
    Department of Physics, University of Massachusetts Lowell, Lowell, MA, USA
    Magn Reson Imaging 29:1205-14. 2011
    ..The purpose was to develop a new magnetic resonance imaging technique for fast temperature monitoring with extended volume coverage...
  32. pmc Combining two-dimensional spatially selective RF excitation, parallel imaging, and UNFOLD for accelerated MR thermometry imaging
    Chang Sheng Mei
    Department of Physics, Boston College, Chestnut Hill, Massachusetts, USA
    Magn Reson Med 66:112-22. 2011
    ..1°c ± 0.6; r = 0.98; p > 0.05)...
  33. pmc Focused ultrasound surgery in oncology: overview and principles
    Clare M C Tempany
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Room 050, L1, Boston, MA 02129, USA
    Radiology 259:39-56. 2011
    ..In this article the background, principles, technical devices, and clinical cancer applications of image-guided FUS are reviewed...
  34. ncbi request reprint Temperature monitoring in fat with MRI
    K Hynynen
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Magn Reson Med 43:901-4. 2000
    ..This can be very important for breast tumor surgery, fat ablation, and for treating deep seated tumors through superficial fat layers. Magn Reson Med 43:901-904, 2000...
  35. ncbi request reprint MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Int J Hyperthermia 20:725-37. 2004
    ..Overall, this emerging modality holds significant potential for non-invasive tumour treatment of both benign and malignant tumours...
  36. ncbi request reprint Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 220:640-6. 2001
    ..To determine if focused ultrasound beams can be used to locally open the blood-brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) imaging can be used to monitor this procedure...
  37. doi request reprint Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo
    Jonathan A Kopechek
    Department of Mechanical Engineering, Boston University, Boston, MA, USA
    J Healthc Eng 4:109-26. 2013
    ..These results suggest that PSNE could dramatically improve the efficiency and clinical feasibility of MRgHIFU...
  38. ncbi request reprint Non-invasive opening of BBB by focused ultrasound
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acta Neurochir Suppl 86:555-8. 2003
    ..v.. After the sacrifice of the animals blue spots were found in the brain in the sonicated locations. This method may have potential for targeted delivery of macromolecules in the brain...
  39. ncbi request reprint Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning
    K Mahoney
    Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 46:1785-98. 2001
    ..0 to 1.7 times the experimental results, again varying with mode. Thus, a significant improvement in the treatment planning can be obtained by using actual measured ultrasound field distributions in combination with backward projection...
  40. ncbi request reprint Apoptosis in ultrasound-produced threshold lesions in the rabbit brain
    N Vykhodtseva
    Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 27:111-7. 2001
    ..By 48 h after the sonications, the number of apoptotic cells had increased up to 17 +/- 9%. The impact of this finding for therapy needs to be explored further...
  41. pmc Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models
    Scott B Raymond
    The Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 3:e2175. 2008
    ..Furthermore, this technique may be used to deliver a wide variety of small and large molecules to the brain for imaging and therapy in other neurodegenerative diseases...

Research Grants1

  1. Novel MRI Contrast Agent for Monitoring Thermal Ablation
    Nathan Mcdannold; Fiscal Year: 2006
    ....