B A McCormick
Affiliation: Harvard University
- Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediatorBeth A McCormick
Department of Pediatric Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
FEBS J 274:3513-8. 2007..Thus, the objective of this review was to highlight the recent findings that implicate hepoxilin A(3) as a key regulator of mucosal inflammation...
- Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalkC V Srikanth
Department of Pediatric Gastroenterology and Nutrition, Mucosal Immunology Laboratories, Massachusetts General Hospital, Charlestown, MA 02129, USA
Interdiscip Perspect Infect Dis 2008:626827. 2008..Although it is only the beginning, it promises to be an exciting era in the study of these host-microbe relationships...
- Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epitheliumB A McCormick
Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Infect Immun 66:4237-43. 1998..Our results indicate that the ability of Shigella to elicit transepithelial signaling to neutrophils from the basolateral membrane of epithelial cells represents a mechanism involved in Shigella-elicited enteritis in humans...
- The use of transepithelial models to examine host-pathogen interactionsBeth A McCormick
Department of Pediatric Gastroenterology, Division of Mucosal Immunology, Massachusetts General Hospital and Harvard Medical School CNY, 114 16th Street 114 3503, Charlestown, MA 02129, USA
Curr Opin Microbiol 6:77-81. 2003....
- Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverineB A McCormick
Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital East, Charlestown 02129, USA
Cell Microbiol 1:143-55. 1999..coli (EPEC) to induce PMN migration. These observations not only provide insight into mechanisms of S. flexneri pathogen evolution and pathogenesis, but also suggest a potential for the use of cadaverine in the treatment of dysentery...
- Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signalingI M Fernandez
Mucosal Immunology Laboratories, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
J Infect Dis 184:743-53. 2001....
- The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cellsA K Criss
Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Sci 114:1331-41. 2001....
- Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2B J Cherayil
Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Infect Immun 68:5567-74. 2000..These observations suggest that iNOS expression is regulated by signals activated by SopE2 (and possibly SopE) and that the role of SipB, SipC, and SipD in this process is to facilitate translocation of the relevant effector...
- Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migrationB P Hurley
Mucosal Immunology Laboratory, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, MA 02129, USA
Clin Exp Immunol 151:297-305. 2008..Given the complexities of these interactions, our findings are important to consider with respect to adhesion molecules that may be targeted for potential drug development...
- New insights on molecular pathways utilized by salmonella species in cell bindingB A McCormick
Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Front Biosci 1:d131-45. 1996..in cell binding that are important not only in the processes of Salmonella internalization but also in the generation of signals which lead to active states of intestinal inflammation...
- Adhesive interactions in angiogenesis and metastasisB A McCormick
Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115
Pharmacol Ther 53:239-60. 1992....
- Regulation of Salmonella-induced neutrophil transmigration by epithelial ADP-ribosylation factor 6A K Criss
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 276:48431-9. 2001....