B A McCormick

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator
    Beth A McCormick
    Department of Pediatric Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FEBS J 274:3513-8. 2007
  2. pmc Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk
    C V Srikanth
    Department of Pediatric Gastroenterology and Nutrition, Mucosal Immunology Laboratories, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Interdiscip Perspect Infect Dis 2008:626827. 2008
  3. pmc Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium
    B A McCormick
    Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Infect Immun 66:4237-43. 1998
  4. ncbi The use of transepithelial models to examine host-pathogen interactions
    Beth A McCormick
    Department of Pediatric Gastroenterology, Division of Mucosal Immunology, Massachusetts General Hospital and Harvard Medical School CNY, 114 16th Street 114 3503, Charlestown, MA 02129, USA
    Curr Opin Microbiol 6:77-81. 2003
  5. ncbi Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine
    B A McCormick
    Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital East, Charlestown 02129, USA
    Cell Microbiol 1:143-55. 1999
  6. ncbi Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling
    I M Fernandez
    Mucosal Immunology Laboratories, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Infect Dis 184:743-53. 2001
  7. ncbi The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells
    A K Criss
    Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Sci 114:1331-41. 2001
  8. pmc Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2
    B J Cherayil
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Infect Immun 68:5567-74. 2000
  9. pmc Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration
    B P Hurley
    Mucosal Immunology Laboratory, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, MA 02129, USA
    Clin Exp Immunol 151:297-305. 2008
  10. ncbi New insights on molecular pathways utilized by salmonella species in cell binding
    B A McCormick
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Front Biosci 1:d131-45. 1996

Collaborators

Detail Information

Publications12

  1. ncbi Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator
    Beth A McCormick
    Department of Pediatric Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FEBS J 274:3513-8. 2007
    ..Thus, the objective of this review was to highlight the recent findings that implicate hepoxilin A(3) as a key regulator of mucosal inflammation...
  2. pmc Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk
    C V Srikanth
    Department of Pediatric Gastroenterology and Nutrition, Mucosal Immunology Laboratories, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Interdiscip Perspect Infect Dis 2008:626827. 2008
    ..Although it is only the beginning, it promises to be an exciting era in the study of these host-microbe relationships...
  3. pmc Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium
    B A McCormick
    Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Infect Immun 66:4237-43. 1998
    ..Our results indicate that the ability of Shigella to elicit transepithelial signaling to neutrophils from the basolateral membrane of epithelial cells represents a mechanism involved in Shigella-elicited enteritis in humans...
  4. ncbi The use of transepithelial models to examine host-pathogen interactions
    Beth A McCormick
    Department of Pediatric Gastroenterology, Division of Mucosal Immunology, Massachusetts General Hospital and Harvard Medical School CNY, 114 16th Street 114 3503, Charlestown, MA 02129, USA
    Curr Opin Microbiol 6:77-81. 2003
    ....
  5. ncbi Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine
    B A McCormick
    Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital East, Charlestown 02129, USA
    Cell Microbiol 1:143-55. 1999
    ..coli (EPEC) to induce PMN migration. These observations not only provide insight into mechanisms of S. flexneri pathogen evolution and pathogenesis, but also suggest a potential for the use of cadaverine in the treatment of dysentery...
  6. ncbi Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling
    I M Fernandez
    Mucosal Immunology Laboratories, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Infect Dis 184:743-53. 2001
    ....
  7. ncbi The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells
    A K Criss
    Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Sci 114:1331-41. 2001
    ....
  8. pmc Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2
    B J Cherayil
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Infect Immun 68:5567-74. 2000
    ..These observations suggest that iNOS expression is regulated by signals activated by SopE2 (and possibly SopE) and that the role of SipB, SipC, and SipD in this process is to facilitate translocation of the relevant effector...
  9. pmc Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration
    B P Hurley
    Mucosal Immunology Laboratory, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, MA 02129, USA
    Clin Exp Immunol 151:297-305. 2008
    ..Given the complexities of these interactions, our findings are important to consider with respect to adhesion molecules that may be targeted for potential drug development...
  10. ncbi New insights on molecular pathways utilized by salmonella species in cell binding
    B A McCormick
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Front Biosci 1:d131-45. 1996
    ..in cell binding that are important not only in the processes of Salmonella internalization but also in the generation of signals which lead to active states of intestinal inflammation...
  11. ncbi Adhesive interactions in angiogenesis and metastasis
    B A McCormick
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115
    Pharmacol Ther 53:239-60. 1992
    ....
  12. ncbi Regulation of Salmonella-induced neutrophil transmigration by epithelial ADP-ribosylation factor 6
    A K Criss
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:48431-9. 2001
    ....