Andrea McClatchey

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing
    Banumathi K Cole
    Massachusetts General Hospital East, 149 CNY 13th St, Charlestown, MA 02129, USA
    Mol Cell Biol 28:1274-84. 2008
  2. pmc ERM proteins at a glance
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research, Harvard Medical School Department of Pathology, 149 13th Street, Charlestown, MA 02129, USA
    J Cell Sci 127:3199-204. 2014
  3. pmc Contact-dependent inhibition of EGFR signaling by Nf2/Merlin
    Marcello Curto
    MGH Center for Cancer Research, Harvard Medical School Department of Pathology, Charlestown, MA 02129, USA
    J Cell Biol 177:893-903. 2007
  4. pmc Nf2/Merlin: a coordinator of receptor signalling and intercellular contact
    M Curto
    Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Br J Cancer 98:256-62. 2008
  5. doi request reprint Contact inhibition (of proliferation) redux
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School Department of Pathology, Charlestown, MA, USA
    Curr Opin Cell Biol 24:685-94. 2012
  6. pmc SPRED proteins provide a NF-ty link to Ras suppression
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 26:1515-9. 2012
  7. pmc Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
    A I McClatchey
    Department of Biology and the Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 12:1121-33. 1998
  8. pmc NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
    Dominique Lallemand
    MGH Cancer Center and Harvard Medical School Department of Pathology, Charlestown, Massachusetts 02129, USA
    Genes Dev 17:1090-100. 2003
  9. ncbi request reprint Merlin and ERM proteins: unappreciated roles in cancer development?
    Andrea I McClatchey
    Massachusetts General Hospital Cancer Center, Harvard Medical School Department of Pathology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 3:877-83. 2003
  10. ncbi request reprint Neurofibromatosis
    Andrea I McClatchey
    Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Annu Rev Pathol 2:191-216. 2007

Research Grants

  1. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea I McClatchey; Fiscal Year: 2010
  2. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2005
  3. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2006
  4. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2007
  5. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2009
  6. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2009

Collaborators

Detail Information

Publications29

  1. pmc Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing
    Banumathi K Cole
    Massachusetts General Hospital East, 149 CNY 13th St, Charlestown, MA 02129, USA
    Mol Cell Biol 28:1274-84. 2008
    ....
  2. pmc ERM proteins at a glance
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research, Harvard Medical School Department of Pathology, 149 13th Street, Charlestown, MA 02129, USA
    J Cell Sci 127:3199-204. 2014
    ..J. Cell Sci. 127, 3205-3215). 'Integrins and epithelial cell polarity' by Jessica Lee and Charles Streuli (J. Cell Sci. 127, 3217-3225). ..
  3. pmc Contact-dependent inhibition of EGFR signaling by Nf2/Merlin
    Marcello Curto
    MGH Center for Cancer Research, Harvard Medical School Department of Pathology, Charlestown, MA 02129, USA
    J Cell Biol 177:893-903. 2007
    ..These studies define a new mechanism of tumor suppression, provide mechanistic insight into the poorly understood phenomenon of contact-dependent inhibition of proliferation, and suggest a therapeutic strategy for NF2-mutant tumors...
  4. pmc Nf2/Merlin: a coordinator of receptor signalling and intercellular contact
    M Curto
    Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Br J Cancer 98:256-62. 2008
    ..Finally, an integrated model for merlin and the Ezrin, Radixin, and Moesin (ERM) proteins functioning in the regulation of cellular interfaces is proposed...
  5. doi request reprint Contact inhibition (of proliferation) redux
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School Department of Pathology, Charlestown, MA, USA
    Curr Opin Cell Biol 24:685-94. 2012
    ..Here we discuss recent progress in elucidating the roles that cell-cell adhesion molecules play as receptors for CIP and in characterising the intracellular signaling pathways that mediate adhesion-dependent proliferative inhibition...
  6. pmc SPRED proteins provide a NF-ty link to Ras suppression
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 26:1515-9. 2012
    ..1421-1426) present evidence that Spred1 recruits neurofibromin to the membrane, where it dampens growth factor-induced Ras activity, providing a satisfying explanation for the overlapping features of two human diseases...
  7. pmc Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
    A I McClatchey
    Department of Biology and the Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 12:1121-33. 1998
    ..Together, our results suggest an important role for the NF2 tumor suppressor, and perhaps the ERM family in tumor formation and metastasis...
  8. pmc NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
    Dominique Lallemand
    MGH Cancer Center and Harvard Medical School Department of Pathology, Charlestown, Massachusetts 02129, USA
    Genes Dev 17:1090-100. 2003
    ..Our studies indicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated cell:cell contact...
  9. ncbi request reprint Merlin and ERM proteins: unappreciated roles in cancer development?
    Andrea I McClatchey
    Massachusetts General Hospital Cancer Center, Harvard Medical School Department of Pathology, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 3:877-83. 2003
  10. ncbi request reprint Neurofibromatosis
    Andrea I McClatchey
    Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Annu Rev Pathol 2:191-216. 2007
    ..An important outcome of the study of neurofibromatosis-associated tumorigenesis has been insight into the more general molecular and cellular bases of nervous system tumors...
  11. ncbi request reprint Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin
    Andrea I McClatchey
    Massachusetts General Hospital, Center for Cancer Research and Harvard Medical School, Department of Pathology, Charlestown, Massachusetts 02129, USA
    Genes Dev 19:2265-77. 2005
    ..Varying use of this organizing activity by different types of cells could provide an explanation for the unique spectrum of tumors associated with NF2 deficiency in mammals...
  12. ncbi request reprint Tumor suppressor mutations in mice: the next generation
    A I McClatchey
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Curr Opin Genet Dev 8:304-10. 1998
    ....
  13. doi request reprint TORC1 is essential for NF1-associated malignancies
    Cory M Johannessen
    Genetics Division, Department of Medicine, Brigham and Women s Hospital, Ludwig Center at Dana Farber Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:56-62. 2008
    ....
  14. ncbi request reprint Ezrin...a metastatic detERMinant?
    Marcello Curto
    MGH Cancer Center and Harvard Medical School Department of Pathology, Charlestown, MA 02129, USA
    Cancer Cell 5:113-4. 2004
    ..Ultimately, a better understanding of exactly how Ezrin confers metastatic advantage will provide important insight into this key problem in cancer biology...
  15. ncbi request reprint Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine
    Ichiko Saotome
    MGH Cancer Center and Harvard Medical School Department of Pathology, 149 13th Street, Charlestown, MA 02129, USA
    Dev Cell 6:855-64. 2004
    ..These in vivo studies highlight the critical function of Ezrin in the formation of a multicellular epithelium rather than an individual epithelial cell...
  16. pmc Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex
    Andrea I McClatchey
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School Department of Pathology, 149 13th Street, Charlestown, MA 02129, USA
    Trends Cell Biol 19:198-206. 2009
    ..We also propose a model that could account for the intricacies of Merlin function across model organisms...
  17. ncbi request reprint Comparative pathology of nerve sheath tumors in mouse models and humans
    Anat O Stemmer-Rachamimov
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:3718-24. 2004
    ..A novel classification scheme for peripheral nerve sheath tumors in murine models was therefore devised...
  18. pmc The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex
    Andrew B Gladden
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Dev Cell 19:727-39. 2010
    ..Our studies reveal that Merlin can associate directly with α-catenin and link it to Par3, thereby providing an essential link between the AJ and the Par3 polarity complex during junctional maturation...
  19. pmc Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
    Samira Benhamouche
    Department of Pathology, Massachusetts General Hospital Center for Cancer Research, Harvard Medical School, Charlestown, MA 02129, USA
    Genes Dev 24:1718-30. 2010
    ..Together, our findings uncover a critical role for Nf2/Merlin in controlling homeostasis of the liver stem cell niche...
  20. doi request reprint Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors
    Hon Kit Wong
    Department of Radiation Oncology, Steele Laboratory, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA
    Cancer Res 70:3483-93. 2010
    ..This study shows that anti-VEGF therapy normalizes the vasculature of schwannoma xenografts in nude mice and successfully controls the tumor growth, probably by reestablishing a natural balance between VEGF and semaphorin 3 signaling...
  21. ncbi request reprint Expression of the cytoskeleton linker protein ezrin in human cancers
    Benjamin Bruce
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Clin Exp Metastasis 24:69-78. 2007
    ....
  22. pmc Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma
    Zachary S Morris
    Massachusetts General Hospital Center for Cancer Research and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:9767-72. 2009
    ..These studies give added credence to the role of EGFR signaling and perhaps Nf2 deficiency in RCC and describe a rare and valuable mouse model for exploring the molecular basis of this disease...
  23. ncbi request reprint Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture
    Jonas Larsson
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Stem Cell 3:221-7. 2008
    ..Nf2/merlin is critical for maintaining normal structure and function of the hematopoietic stem cell niche. It limits both bone and vascular components, and our model suggests that it thereby constrains stem cell number and position...
  24. ncbi request reprint The neurofibroma cell of origin: SKPs expand the playing field
    Zachary S Morris
    Massachusetts General Hospital Center for Cancer Research and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA
    Cell Stem Cell 4:371-2. 2009
    ..In this issue of Cell Stem Cell, Le et al. (2009) demonstrate that skin-derived precursors (SKPs) can initiate dermal neurofibromas and highlight the importance of the microenvironment in the formation of this complex tumor...
  25. ncbi request reprint Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy
    Scott R Plotkin
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
    Nat Clin Pract Oncol 5:487-91. 2008
    ..A 48-year-old man presented to a neurologist with complaints of bilateral hearing loss and tinnitus. The patient was a member of a large family affected by neurofibromatosis type 2 and first noted hearing loss 10 years before presentation...
  26. ncbi request reprint DOCK4, a GTPase activator, is disrupted during tumorigenesis
    Vijay Yajnik
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Cell 112:673-84. 2003
    ..DOCK4 therefore encodes a CDM family member that regulates intercellular junctions and is disrupted during tumorigenesis...
  27. ncbi request reprint A mouse model recapitulating molecular features of human mesothelioma
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:8090-5. 2005
    ....
  28. ncbi request reprint Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum
    William A Weiss
    Department of Neurology, University of California, 521 Parnassus Avenue, San Francisco, California, CA 94143 0114, USA
    Oncogene 21:7453-63. 2002
    ..Recommendations were also made for preclinical validation of these models in cancer therapeutics, and for incorporation of surrogate markers of tumor burden to facilitate preclinical evaluation of new therapies...
  29. ncbi request reprint Microvilli defects in retinas of ezrin knockout mice
    Vera L Bonilha
    Department of Ophthalmic Research, The Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Exp Eye Res 82:720-9. 2006
    ..Finally, photoreceptors in the ezrin knockout animals show substantial retardation in development as compared to their wild type littermates...

Research Grants7

  1. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea I McClatchey; Fiscal Year: 2010
    ..These studies will advance our understanding of the molecular cause of NF2 and of the biology of ErbB receptors that have been widely implicated in human cancer. ..
  2. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2005
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..
  3. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2006
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..
  4. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2007
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..
  5. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2009
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..
  6. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2009
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..