R W McCarley

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
    Kevin M Spencer
    Research Service, Veterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Research 151C, 150 S, Huntington Ave, Boston, MA 02130, USA
    BMC Neurosci 10:85. 2009
  2. ncbi request reprint Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state
    R E Strecker
    Department of Psychiatry, VA Medical Center and Harvard Medical School, Psychiatry, 116A, 940 Belmont St, Brockton, MA 02301, USA
    Behav Brain Res 115:183-204. 2000
  3. ncbi request reprint Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia
    Robert W McCarley
    Deprtment of Psychiatry, Harvard Medical School, Veterans Affairs Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Arch Gen Psychiatry 59:321-31. 2002
  4. ncbi request reprint Mechanisms and models of REM sleep control
    R W McCarley
    From the Laboratory of Neuroscience, Harvard Department of Psychiatry at the VA Boston Healthcare System, Brockton, MA 02301, USA
    Arch Ital Biol 142:429-67. 2004
  5. pmc Combining ERP and structural MRI information in first episode schizophrenia and bipolar disorder
    Robert W McCarley
    Harvard Department of Psychiatry, Massachusetts, USA
    Clin EEG Neurosci 39:57-60. 2008
  6. ncbi request reprint Neurobiology of REM and NREM sleep
    Robert W McCarley
    Neuroscience Laboratory, VA Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Sleep Med 8:302-30. 2007
  7. ncbi request reprint Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum
    E Arrigoni
    Harvard Medical School and Veterans Administration Medical Center, Department of Psychiatry, Brockton, Massachusetts 02401, USA
    J Neurosci 21:1076-85. 2001
  8. pmc First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe
    D F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, Mass, USA
    Arch Gen Psychiatry 55:173-80. 1998
  9. ncbi request reprint Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats
    M M Thakkar
    Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School and VA Medical Center, 940 Belmont Street, Brockton, MA 02301, USA
    Arch Ital Biol 139:313-28. 2001
  10. pmc c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulness
    J T McKenna
    VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, MA, USA james
    Brain Res Bull 80:382-8. 2009

Research Grants

  1. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT W MC CARLEY; Fiscal Year: 2010
  2. OREXIN AND THE CONTROL OF SLEEP AND WAKEFULNESS
    ROBERT MC CARLEY; Fiscal Year: 2005
  3. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2003
  4. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2006
  5. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2007
  6. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2009
  7. SYNAPTIC BASIS OF SLEEP CYCLE CONTROL
    ROBERT W MC CARLEY; Fiscal Year: 2010
  8. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2009
  9. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2009
  10. SYNAPTIC BASIS OF SLEEP CYCLE CONTROL
    ROBERT MC CARLEY; Fiscal Year: 2009

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
    Kevin M Spencer
    Research Service, Veterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Research 151C, 150 S, Huntington Ave, Boston, MA 02130, USA
    BMC Neurosci 10:85. 2009
    ..A 5-dipole model was fit from the HC grand average ASSR, with 2 pairs of superior temporal dipoles and a deep midline dipole. Time-frequency decomposition was performed on the scalp EEG and source data...
  2. ncbi request reprint Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state
    R E Strecker
    Department of Psychiatry, VA Medical Center and Harvard Medical School, Psychiatry, 116A, 940 Belmont St, Brockton, MA 02301, USA
    Behav Brain Res 115:183-204. 2000
    ..In summary, a growing body of evidence supports the role of AD as a mediator of the sleepiness following prolonged wakefulness, a role in which its inhibitory actions on the BF wakefulness-promoting neurons may be especially important...
  3. ncbi request reprint Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia
    Robert W McCarley
    Deprtment of Psychiatry, Harvard Medical School, Veterans Affairs Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Arch Gen Psychiatry 59:321-31. 2002
    ..The present study investigated whether the left temporal P300-left posterior STG volume association is selectively present in first-episode schizophrenia...
  4. ncbi request reprint Mechanisms and models of REM sleep control
    R W McCarley
    From the Laboratory of Neuroscience, Harvard Department of Psychiatry at the VA Boston Healthcare System, Brockton, MA 02301, USA
    Arch Ital Biol 142:429-67. 2004
    ..Finally, with respect to orexin and REM sleep, it is hypothesized that orexinergic activity may be a principal factor controlling REM sleep's absence from the active period in strongly circadian animals such as rat and man...
  5. pmc Combining ERP and structural MRI information in first episode schizophrenia and bipolar disorder
    Robert W McCarley
    Harvard Department of Psychiatry, Massachusetts, USA
    Clin EEG Neurosci 39:57-60. 2008
    ..Knowledge of those locations and brain signals affected early should help understand the basic physiological defect underlying this progression, with potential implications for new therapeutic interventions...
  6. ncbi request reprint Neurobiology of REM and NREM sleep
    Robert W McCarley
    Neuroscience Laboratory, VA Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Sleep Med 8:302-30. 2007
    ..Finally, the results of a new series of experimental paradigms in rodents to measure the neurocognitive effects of sleep loss and sleep interruption (modeling sleep apnea) provide animal model data congruent with those in humans...
  7. ncbi request reprint Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum
    E Arrigoni
    Harvard Medical School and Veterans Administration Medical Center, Department of Psychiatry, Brockton, Massachusetts 02401, USA
    J Neurosci 21:1076-85. 2001
    ..Furthermore, an alteration of adenosine kinase activity modifies the degree of this inhibitory tone...
  8. pmc First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe
    D F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, Mass, USA
    Arch Gen Psychiatry 55:173-80. 1998
    ..This P300 asymmetry suggests left temporal lobe dysfunction at the onset of schizophrenia...
  9. ncbi request reprint Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats
    M M Thakkar
    Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School and VA Medical Center, 940 Belmont Street, Brockton, MA 02301, USA
    Arch Ital Biol 139:313-28. 2001
    ..The data suggest further that orexin-A has a significant role in the regulation of arousal/wakefulness, in addition to the previously described role of orexin in the regulation and expression of REM sleep and REM sleep-related phenomena...
  10. pmc c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulness
    J T McKenna
    VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, MA, USA james
    Brain Res Bull 80:382-8. 2009
    ..These findings support and provide additional confirming data of previous reports that cholinergic neurons of BF play a role in vigilance state regulation by promoting wakefulness...
  11. pmc Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 108:65-78. 2001
    ..These results underscore the importance of temporal-prefrontal pathways in the symptomatology of schizophrenia, and they suggest an association between prefrontal abnormalities and negative symptoms...
  12. pmc Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness
    J T McKenna
    VA Boston Healthcare System and Harvard Medical School, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Building 46, Brockton, MA 02301, USA
    Neuroscience 146:1462-73. 2007
    ..SI may be partially responsible for the symptom of daytime sleepiness observed in a number of clinical disorders, and this may be mediated by mechanisms involving BF AD...
  13. pmc Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention
    P G Nestor
    Department of Psychiatry, Harvard Medical School, Brockton VAMC 116A, 940 Belmont Street, Brockton, MA 02401, USA
    Biol Psychol 57:23-46. 2001
    ..We propose a similar failure of NMDA-mediated recurrent inhibition as a candidate biological substrate for attention and semantic anomalies of schizophrenia...
  14. pmc The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions
    A V Kalinchuk
    Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System, 1400 V F W Parkway, West Roxbury, MA 02132, USA
    Neuroscience 157:238-53. 2008
    ....
  15. pmc Identification of neural circuits underlying P300 abnormalities in schizophrenia
    B F O'Donnell
    Department of Psychiatry, Harvard Medical School, Brockton, MA, USA
    Psychophysiology 36:388-98. 1999
    ....
  16. pmc A functional magnetic resonance imaging study of auditory mismatch in schizophrenia
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 158:938-43. 2001
    ..CONCLUSIONS: This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia...
  17. pmc Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins
    R E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, VA Medical Center Brockton, Research 151C, 940, Belmont Street, Brockton, MA 02301, USA
    Neuroscience 143:739-55. 2006
    ..Some or all carbachol-excited neurons are presumably REM-on neurons...
  18. ncbi request reprint P300 topography differs in schizophrenia and manic psychosis
    D F Salisbury
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 45:98-106. 1999
    ..The frontal reductions in bipolar psychosis may reflect abnormalities in a hypothetical frontal generator, consonant with reports of altered frontal lobe function in mania...
  19. ncbi request reprint Prefrontal gray matter volume reduction in first episode schizophrenia
    Y Hirayasu
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Brockton VA Medical Center and Harvard Medical School, Brockton, MA 02301, USA
    Cereb Cortex 11:374-81. 2001
    ..White matter volumes did not differ among groups. These data suggest that prefrontal cortical gray matter volume reduction is selectively present at first hospitalization in schizophrenia but not affective psychosis...
  20. ncbi request reprint REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation
    M M Thakkar
    Department of Psychiatry, Harvard Medical School and VA Medical Center, Brockton, MA 02301, USA
    Sleep Res Online 2:112-20. 1999
    ..More work is needed to provide precise localization of the most effective site of orexin-induced inhibition of REM sleep phenomena...
  21. ncbi request reprint Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats
    M M Thakkar
    Department of Psychiatry, Harvard Medical School, Brockton VA Medical Center, 940 Belmont Street, Brockton, MA 02401, USA
    Neuroscience 122:1107-13. 2003
    ....
  22. pmc Diffusion tractography of the fornix in schizophrenia
    J Fitzsimmons
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 107:39-46. 2009
    ..We applied these techniques to quantify fornix diffusion anisotropy in schizophrenia...
  23. pmc Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects
    R W McCarley
    Harvard Medical School, Department of Psychiatry, Brockton, MA 02401, USA
    Eur Arch Psychiatry Clin Neurosci 249:69-82. 1999
    ..g. cat-dog, a result compatible with behavioral data. Other N400 data strongly and directly suggest that schizophrenics do not efficiently utilize context...
  24. pmc Parametric manipulations of auditory stimuli differentially affect P3 amplitude in schizophrenics and controls
    D F Salisbury
    Harvard Medical School, Department of Psychiatry, Brockton Veterans Affairs Medical Center
    Psychophysiology 31:29-36. 1994
    ....
  25. ncbi request reprint Intracellular recordings of pontine medial gigantocellular tegmental field neurons in the naturally sleeping cat: behavioral state-related activity and soma size difference in order of recruitment
    K Ito
    Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School and Brockton VA Medical Center, 940 Belmont Street, Brockton, MA 02301, USA
    Neuroscience 114:23-37. 2002
    ....
  26. pmc Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, United States
    Schizophr Res 106:125-31. 2008
    ..Moreover, none of these studies has investigated corpus callosum systematically, using anatomical subdivisions...
  27. pmc Superior temporal gyrus volume abnormalities and thought disorder in left-handed schizophrenic men
    D P Holinger
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 156:1730-5. 1999
    ....
  28. pmc Event-related potentials elicited during a context-free homograph task in normal versus schizophrenic subjects
    D F Salisbury
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Psychophysiology 37:456-63. 2000
    ....
  29. ncbi request reprint Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat
    R Basheer
    Department of Psychiatry, Havard Medical School and VA Medical Center, Brockton, MA 02401, USA
    Neuroscience 104:731-9. 2001
    ....
  30. pmc Button-pressing affects P300 amplitude and scalp topography
    D F Salisbury
    Department of Psychiatry, Cognitive Neuroscience Laboratory, McLean Hospital NBG-21, Harvard Medical School, 115 Mill Street, Belmont, MA 02178-9106, USA
    Clin Neurophysiol 112:1676-84. 2001
    ..Also, P300 topography in button-pressing tasks is confounded by motor potentials. The distortion can be corrected with a motor potential estimate. Motor potentials can occlude differences in P300 topography between groups...
  31. ncbi request reprint Pontine cholinergic neurons show Fos-like immunoreactivity associated with cholinergically induced REM sleep
    P J Shiromani
    VA Medical Center, Brockton, MA 02401, USA
    Brain Res Mol Brain Res 38:77-84. 1996
    ..These findings indicate that during REMc a transcriptional cascade involving c-fos occurs in a subpopulation of pontine cholinergic neurons...
  32. ncbi request reprint Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study
    R E Strecker
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Research, 151C, 940 Belmont Street, Brockton, MA 02301, USA
    Neuroscience 113:663-70. 2002
    ..However, the invariance of histamine levels during sleep deprivation suggests that changes in histamine level do not relay information about sleep drive to the sleep-promoting neurons of the preoptic/anterior hypothalamic area...
  33. pmc Complex receptor mediation of acute ketamine application on in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation abnormalities in schizophrenia
    J M McNally
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, 940 Belmont Street, Research 151C, Brockton, MA 02301, USA
    Neuroscience 199:51-63. 2011
    ..These in vitro findings may help explain the complexities of gamma findings in clinical studies of Sz and prove useful in developing new therapeutic strategies...
  34. pmc An fMRI study of semantic processing in men with schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 20:1923-33. 2003
    ....
  35. ncbi request reprint Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats
    R Tao
    Boston VA Healthcare Harvard Medical School, Department of Psychiatry, Laboratory of Neuroscience, 940 Belmont Street, Brockton, MA 02301, USA
    Neuroscience 141:1101-5. 2006
    ..Orexins may have regionally selective effects on serotonin release in the CNS, implying a unique interaction between orexins and serotonin in the regulation of activities including sleep-wakefulness...
  36. pmc Pituitary volume in schizophrenia spectrum disorders
    F Romo-Nava
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 146:301-7. 2013
    ..However, previous magnetic resonance imaging (MRI) studies assessing pituitary volume (PV) in SSD are conflicting. The main objective of this study was to examine further PV in SSD...
  37. ncbi request reprint Topographic abnormalities of P3 in schizotypal personality disorder
    D F Salisbury
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston, USA
    Biol Psychiatry 40:165-72. 1996
    ..Asymmetry of P3 amplitude, with left-sided deficit, may be associated with the schizophrenia diathesis, but overall P3 reductions may be more associated with chronic effects...
  38. ncbi request reprint Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation
    R Basheer
    Harvard Medical School and V.A. Medical Center, Department of Psychiatry, West Roxbury, MA 02132, USA
    Neuroreport 12:1577-80. 2001
    ..Based on the significant increase in the A1 but not in A2A receptor, we hypothesize that the effects of sleep deprivation-induced increased adenosine are mediated by A1 receptor in basal forebrain of rats...
  39. pmc Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 123:153-9. 2010
    ..This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia...
  40. pmc DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 26:1109-18. 2005
    ....
  41. pmc Delta oscillations induced by ketamine increase energy levels in sleep-wake related brain regions
    M Dworak
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, West Roxbury, MA, USA
    Neuroscience 197:72-9. 2011
    ....
  42. ncbi request reprint ERP assessment of visual and auditory language processing in schizophrenia
    M A Niznikiewicz
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    J Abnorm Psychol 106:85-94. 1997
    ..These results suggest that language abnormalities in schizophrenia are related to a dysfunction in the language system and not to a general cognitive dysfunction, and may be related to poor use of context in patients with schizophrenia...
  43. doi request reprint Abnormal inhibitory processes in semantic networks in schizophrenia
    M Niznikiewicz
    Boston VA Medical Center, Boston, MA, USA
    Int J Psychophysiol 75:133-40. 2010
    ..Furthermore, reduced N400 in the unrelated condition found in this study suggests that the abnormality was related to inefficient early inhibitory processes...
  44. ncbi request reprint Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 814, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Neuroscience 140:403-13. 2006
    ..Both of these effects occur via postsynaptic A1 receptors, but are mediated downstream by two separate mechanisms...
  45. doi request reprint Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds
    E C del Re
    1 VA Boston Healthcare System, Brockton, MA, USA 2 Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Transl Psychiatry 4:e346. 2014
    ..Our results suggest pleiotropic effects of ZNF804A on risk for SZ and neural mechanisms that are indexed by the novel P300b ERP component. ..
  46. pmc A review of MRI findings in schizophrenia
    M E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 49:1-52. 2001
    ..abstract truncated)..
  47. pmc Sleep active cortical neurons expressing neuronal nitric oxide synthase are active after both acute sleep deprivation and chronic sleep restriction
    M R Zielinski
    Department of Psychiatry, Harvard Medical School and Veterans Affairs Boston Healthcare System, West Roxbury, MA 02132, USA
    Neuroscience 247:35-42. 2013
    ..However, since these neurons were active after CSR when SWA was not enhanced, these findings suggest that mechanisms downstream of their activation are altered during CSR...
  48. pmc Voxel-based morphometric analysis of gray matter in first episode schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Massachusetts, USA
    Neuroimage 17:1711-9. 2002
    ..They further suggest the importance of comparing VBM findings with more traditional ROI analyses until the reasons for the differences between methods are determined...
  49. ncbi request reprint The P3 auditory event-related brain potential indexes major personality traits
    R J Gurrera
    Department of Psychiatry, Harvard Medical School and Brockton DVAMC, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 49:922-9. 2001
    ..Our results suggest that processes indexed by auditory P3 amplitude are related to these broad personality dimensions in healthy individuals...
  50. pmc Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study
    Noriomi Kuroki
    Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    Am J Psychiatry 163:2103-10. 2006
    ..However, the middle and inferior temporal gyri have received little investigation, especially in first-episode schizophrenia...
  51. pmc Attentional networks and cingulum bundle in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Schizophr Res 90:308-15. 2007
    ..In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration...
  52. ncbi request reprint Adenosine and sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain
    Vijay Ramesh
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, West Roxbury, Massachusetts, USA
    J Neurochem 100:1351-63. 2007
    ..Together, these data suggest a role in sleep homeostasis for the SD-induced activation of NF-kappaB in cholinergic basal forebrain, and that transcription factor NF-kappaB may code for factor(s) that play a role in sleep homeostasis...
  53. pmc The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study
    Ronald J Gurrera
    Schizophr Res 90:360-2. 2007
  54. ncbi request reprint Another chapter in the adenosine story
    Robert E Strecker
    Sleep 29:426-8. 2006
  55. pmc REM sleep changes in rats induced by siRNA-mediated orexin knockdown
    Lichao Chen
    Department of Psychiatry, Harvard Medical School, Boston VA Healthcare System, 940 Belmont Street, Brockton, MA 02301, USA, and Department of Neurology, Harry Truman Memorial VA Hospital, Columbia, MO 65203, USA
    Eur J Neurosci 24:2039-48. 2006
    ..Our results indicate that siRNA can be usefully employed in behavioural studies to complement other loss-of-function approaches. Moreover, these data suggest that the orexin system plays a role in the diurnal gating of REM sleep...
  56. ncbi request reprint Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 63:1090-100. 2006
    ..Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD)...
  57. pmc Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation
    Jaime L Tartar
    Harvard Medical School and VA Boston Healthcare System, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Eur J Neurosci 23:2739-48. 2006
    ..The results suggest that sleep fragmentation negatively impacts spatial learning. Loss of N-methyl-D-aspartate (NMDA) receptor-dependent LTP in the hippocampal CA1 region may be one mechanism involved in this deficit...
  58. ncbi request reprint Basal forebrain and saporin cholinergic lesions: the devil dwells in delivery details
    Anna V Kalinchuk
    Sleep 29:1385-7; discussion 1387-9. 2006
  59. pmc Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, United States
    Schizophr Res 91:103-6. 2007
    ..STG and FG volume reductions may each make distinct contributions to symptoms and cognitive deficits of schizophrenia...
  60. pmc A cross-sectional and longitudinal magnetic resonance imaging study of cingulate gyrus gray matter volume abnormalities in first-episode schizophrenia and first-episode affective psychosis
    Min Seong Koo
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 65:746-60. 2008
    ..However, it is unclear whether these gray matter abnormalities show a subregional specificity to either disorder and whether they show postonset progression...
  61. pmc Age-related deficits in fronto-temporal connections in schizophrenia: a diffusion tensor imaging study
    Gudrun Rosenberger
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, United States
    Schizophr Res 102:181-8. 2008
    ..Using diffusion tensor imaging tractography, we investigated the relationship between age and fiber integrity in patients with schizophrenia vs. healthy adults...
  62. pmc Gamma-band auditory steady-state responses are impaired in first episode psychosis
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Brockton 02301, USA
    Biol Psychiatry 64:369-75. 2008
    ..Here we examined whether gamma ASSR deficits are also present at first hospitalization for psychosis...
  63. pmc Sensory-evoked gamma oscillations in chronic schizophrenia
    Kevin M Spencer
    Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 63:744-7. 2008
    ..We investigated these issues by examining the VGO and AGO in chronic schizophrenic (SZ) and matched healthy control (HC) subjects...
  64. pmc Early nicotine withdrawal and transdermal nicotine effects on neurocognitive performance in schizophrenia
    Christopher G AhnAllen
    Center for Alcohol and Addictions Studies, Brown University, 121 South Main St, Providence, RI, 02912, USA
    Schizophr Res 100:261-9. 2008
    ....
  65. pmc Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI study
    Motoaki Nakamura
    Clinical Neuroscience Division, Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton Division, Boston, USA
    Biol Psychiatry 62:773-83. 2007
    ....
  66. pmc Auditory processing abnormalities in schizotypal personality disorder: an fMRI experiment using tones of deviant pitch and duration
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A RC, 940 Belmont St, Brockton, MA 02401, United States
    Schizophr Res 103:26-39. 2008
    ..The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD...
  67. ncbi request reprint Episodic memory and neuroimaging of hippocampus and fornix in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Psychiatry Res 155:21-8. 2007
    ..However, increased hippocampal volume correlated, in the negative direction, with lower scores for executive functioning and IQ in the control subset. Implications of these results are discussed...
  68. ncbi request reprint Experimental sleep fragmentation impairs attentional set-shifting in rats
    John G McCoy
    VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
    Sleep 30:52-60. 2007
    ..To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats...
  69. pmc Functional neuroimaging of word priming in males with chronic schizophrenia
    S Duke Han
    Department of Psychology, Loyola University Chicago, Chicago, IL 60626, USA
    Neuroimage 35:273-82. 2007
    ..This may reflect a disease-related disturbance in functional connectivity of lexical activation, which in turn may be associated with clinical symptomatology...
  70. pmc Functional and structural deficits in brain regions subserving face perception in schizophrenia
    Toshiaki Onitsuka
    Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 163:455-62. 2006
    ....
  71. pmc The startle reflex in schizophrenia: habituation and personality correlates
    Sare J Akdag
    Department of Psychology, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
    Schizophr Res 64:165-73. 2003
    ..The relationship of these findings to cognitive disturbances in schizophrenia is considered and directions for future research are discussed...
  72. ncbi request reprint Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Arch Gen Psychiatry 60:1069-77. 2003
    ..Results of previous volumetric magnetic resonance imaging investigations indicate that gray matter volume reductions in neocortical regions may be specific to schizophrenia...
  73. pmc A MRI study of fusiform gyrus in schizotypal personality disorder
    Chandlee C Dickey
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, and Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 64:35-9. 2003
    ..This suggests that future studies may be useful in determining the functional competence of this gyrus in SPD...
  74. pmc Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Mass, USA
    Arch Gen Psychiatry 60:766-75. 2003
    ....
  75. pmc Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
    Kiyoto Kasai
    Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 160:156-64. 2003
    ....
  76. pmc An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia
    Jane E Anderson
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Brockton Veterans Affairs Medical Center and Harvard Medical School, Boston, MA 02301, USA
    Schizophr Res 58:123-34. 2002
    ..The reduction in the anterior amygdala/hippocampal complex was an additional temporal lobe finding. These results underscore the role of temporal lobe structures in the pathophysiology of schizophrenia...
  77. pmc Semantic dysfunction in women with schizotypal personality disorder
    Margaret A Niznikiewicz
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 159:1767-74. 2002
    ..The N400 component of the EEG event-related potentials was used as a probe of semantic processes...
  78. ncbi request reprint Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging study
    Chang Uk Lee
    Department of Psychiatry 116A, VA Boston Healthcare System, Brockton Division, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Arch Gen Psychiatry 59:775-81. 2002
    ..of postmortem studies have suggested that fusiform gyrus volume is reduced in schizophrenia, but there have been no in vivo structural studies of the fusiform gyrus in schizophrenia using magnetic resonance imaging...
  79. pmc Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
    Chandlee C Dickey
    Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
    Am J Psychiatry 159:1521-7. 2002
    ..In a further exploration, the authors studied two components of the superior temporal gyrus: Heschl's gyrus and the planum temporale...
  80. ncbi request reprint Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons
    Radhika Basheer
    Department of Psychiatry, Harvard Medical School, Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
    J Neurosci 22:7680-6. 2002
    ..These data suggest a potential role for a calcium-signaling pathway in adenosine-induced long-term effects of sleep deprivation and a key role for cholinergic neurons in this process...
  81. pmc Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data
    Martha E Shenton
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, VA Boston Healthcare System, Brockton Division, 940 Belmont Street, Harvard Medical School, Brockton, MA 02301, USA
    Psychiatry Res 115:15-35. 2002
    ..An evaluation of shape deformations also suggests local abnormalities in the amygdala-hippocampal complex in schizophrenia...
  82. ncbi request reprint Mismatch negativity in chronic schizophrenia and first-episode schizophrenia
    Dean F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA, USA
    Arch Gen Psychiatry 59:686-94. 2002
    ..The MMN is reported to be reduced in patients with chronic schizophrenia. However, it is unknown whether MMN is reduced in patients with first-episode schizophrenia (at first hospitalization)...
  83. ncbi request reprint Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons
    Mahesh M Thakkar
    Department of Psychiatry, Harvard Medical School and Boston VA Healthcare System, 940 Belmont Street, Brockton, MA 02301, USA
    Brain Res 945:276-80. 2002
    ....
  84. pmc MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Dept of Psychiatry, VA Boston Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Am J Psychiatry 159:1190-7. 2002
    ....
  85. pmc Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System Brockton Division, MA 02301, USA
    Am J Psychiatry 159:813-20. 2002
    ..Here the authors focus on fiber tracts forming temporal-frontal connections...
  86. ncbi request reprint Disruption of neural systems of visual attention in schizophrenia
    Geoffrey F Potts
    Psychology, MS 25, Rice University, 6100 Main St, Houston, TX 77005, USA
    Arch Gen Psychiatry 59:418-24. 2002
    ..If neural systems supporting attention are specifically disrupted in schizophrenia, the attention-sensitive P2a and N2b should be differentially reduced in patients, compared with the P300, in a visual attention task...
  87. pmc Semantic bias, homograph comprehension, and event-related potentials in schizophrenia
    Dean F Salisbury
    Cognitive Neuroscience Laboratory NBG21, Harvard Medical School at McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Clin Neurophysiol 113:383-95. 2002
    ..Combined behavioral and event-related potential (ERP) data can indicate the nature and timing of such abnormalities...
  88. pmc An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
    Chandlee C Dickey
    VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Am J Psychiatry 160:2198-201. 2003
    ..This is the first structural magnetic resonance imaging study to examine a group of female subjects with schizotypal personality disorder...
  89. pmc Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 54:1171-80. 2003
    ..These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities...
  90. pmc Reduction of caudate nucleus volumes in neuroleptic-naïve female subjects with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, and Harvard Medical School, Boston, MA 02401, USA
    Biol Psychiatry 60:40-8. 2006
    ....
  91. ncbi request reprint Connectivity among semantic associates: an fMRI study of semantic priming
    Cynthia G Wible
    Clinical Neuroscience Division, Laboratory of Neuroscience, Harvard Medical School, Boston, MA, USA
    Brain Lang 97:294-305. 2006
    ..fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing...
  92. pmc Fornix integrity and hippocampal volume in male schizophrenic patients
    Noriomi Kuroki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, Brockton, Massachusetts, USA
    Biol Psychiatry 60:22-31. 2006
    ..Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia...
  93. pmc The application of DTI to investigate white matter abnormalities in schizophrenia
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Ann N Y Acad Sci 1064:134-48. 2005
    ..With the development of DTI, we are now able to investigate white matter abnormalities in schizophrenia...
  94. pmc Word priming in schizophrenia: associational and semantic influences
    Paul G Nestor
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 82:139-42. 2006
    ..Schizophrenic patients may show an associational bias, restricting semantic integration and contributing to their disturbed thinking...
  95. ncbi request reprint Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity
    Radhika Basheer
    Department of Psychiatry, Harvard Medical School Boston VA Healthcare System, West Roxbury, Massachusetts 02301, USA
    J Neurosci Res 82:650-8. 2005
    ..These changes in proteins in the basal forebrain during short-term sleep deprivation are suggestive of changes in the substrate for neuronal transmission and plasticity...
  96. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
    ..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD)...
  97. ncbi request reprint Auditory P3 indexes personality traits and cognitive function in healthy men and women
    Ronald J Gurrera
    Harvard Medical School, Department of Psychiatry, Boston MA, USA
    Psychiatry Res 133:215-28. 2005
    ..The physiological significance of these relationships is not yet clear, but these results suggest that neural assemblies indexed by P3 may subserve both elemental cognition and healthy personality function...
  98. pmc A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder
    Martina M Voglmaier
    Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA 02139, USA
    Schizophr Res 74:43-9. 2005
    ..The results suggest a less severe pattern of cognitive deficits in women with SPD compared to men, consistent with hypotheses of gender differences in cognitive function in schizophrenia...
  99. pmc Neural synchrony indexes disordered perception and cognition in schizophrenia
    Kevin M Spencer
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont Street, Brockton, MA 02301, USA
    Proc Natl Acad Sci U S A 101:17288-93. 2004
    ..These data provide support for linking dysfunctional neural circuitry and the core symptoms of schizophrenia...
  100. pmc Neuropsychological correlates of diffusion tensor imaging in schizophrenia
    Paul G Nestor
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston Veterans Affairs Health Care System Brockton Division, Brockton, MA 02301, USA
    Neuropsychology 18:629-37. 2004
    ..The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia...
  101. pmc Method for combining information from white matter fiber tracking and gray matter parcellation
    Hae Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    AJNR Am J Neuroradiol 25:1318-24. 2004
    ..We conclude that this new method for combining structural and DT imaging data is useful for understanding cortical connectivity and the localization of fiber tracts and their relationship with cortical anatomy and brain abnormalities...

Research Grants49

  1. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT W MC CARLEY; Fiscal Year: 2010
    ....
  2. OREXIN AND THE CONTROL OF SLEEP AND WAKEFULNESS
    ROBERT MC CARLEY; Fiscal Year: 2005
    ....
  3. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2003
    ..g., P300 and N400). Finally, we predict less severe abnormalities in female than male SPD subjects. Our long-term goal is to link the clinical manifestations of SPD to brain structural and functional abnormalities. ..
  4. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2006
    ..abstract_text> ..
  5. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2007
    ..We believe the feasibility of our ambitious goal of linking biology with cognitive and clinical symptoms is validated by our group's extensive experience with these methods in schizophrenia and in SPD. ..
  6. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2009
    ....
  7. SYNAPTIC BASIS OF SLEEP CYCLE CONTROL
    ROBERT W MC CARLEY; Fiscal Year: 2010
    ..By doing this we hope to lay the foundation for a rational treatment of insomnia and other sleep disorders. ..
  8. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2009
    ....
  9. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2009
    ..We believe the feasibility of our ambitious goal of linking biology with cognitive and clinical symptoms is validated by our group's extensive experience with these methods in schizophrenia and in SPD. ..
  10. SYNAPTIC BASIS OF SLEEP CYCLE CONTROL
    ROBERT MC CARLEY; Fiscal Year: 2009
    ..By doing this we hope to lay the foundation for a rational treatment of insomnia and other sleep disorders. ..
  11. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2007
    ....
  12. Vulnerability to Progression Schizophrenia
    ROBERT MC CARLEY; Fiscal Year: 2007
    ....
  13. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2002
    ..We will retest chronic SZ 1.5 and 3yr later; predicting that progression of abnormalities will be less than in the first episode SZ. ..
  14. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 1993
    ....
  15. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 1992
    ....