Sarkis K Mazmanian
Affiliation: Harvard University
- An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune systemSarkis K Mazmanian
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 122:107-18. 2005..These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system...
- The love-hate relationship between bacterial polysaccharides and the host immune systemSarkis K Mazmanian
Division of Biology, California Institute of Technology, Mail Code 156 29, 1200 East California Boulevard, Pasadena, California 91125, USA
Nat Rev Immunol 6:849-58. 2006..This process seems to contribute to the overall health of the host by offering protection against various diseases and might provide supporting evidence at a molecular level for the 'hygiene hypothesis' of allergic immune disorders...
- Regulation of surface architecture by symbiotic bacteria mediates host colonizationCui Hua Liu
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 105:3951-6. 2008..These findings suggest a model whereby display of multiple capsular polysaccharides provides essential functions for bacterial colonization during host-symbiont mutualism...
- Communicable ulcerative colitis induced by T-bet deficiency in the innate immune systemWendy S Garrett
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cell 131:33-45. 2007..These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD...
- Capsular polysaccharides of symbiotic bacteria modulate immune responses during experimental colitisSarkis K Mazmanian
California Institute of Technology, Pasadena, CA, USA
J Pediatr Gastroenterol Nutr 46:E11-2. 2008
- A microbial symbiosis factor prevents intestinal inflammatory diseaseSarkis K Mazmanian
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Nature 453:620-5. 2008..Harnessing the immunomodulatory capacity of symbiosis factors such as PSA might potentially provide therapeutics for human inflammatory disorders on the basis of entirely novel biological principles...
- Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulenceHelene Bierne
Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
Mol Microbiol 43:869-81. 2002..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
- On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritisIng Marie Jonsson
Department of Rheumatology, University of Goteborg, Sweden
J Infect Dis 185:1417-24. 2002..These results suggest that sortase mutant staphylococci are significantly less virulent than the parent strain, Newman: the sortase mutant has decreased ability to reach target organs and, once there, to induce an inflammatory response...