Sarkis K Mazmanian

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
  2. ncbi request reprint The love-hate relationship between bacterial polysaccharides and the host immune system
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Mail Code 156 29, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Immunol 6:849-58. 2006
  3. pmc Regulation of surface architecture by symbiotic bacteria mediates host colonization
    Cui Hua Liu
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:3951-6. 2008
  4. pmc Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 131:33-45. 2007
  5. doi request reprint Capsular polysaccharides of symbiotic bacteria modulate immune responses during experimental colitis
    Sarkis K Mazmanian
    California Institute of Technology, Pasadena, CA, USA
    J Pediatr Gastroenterol Nutr 46:E11-2. 2008
  6. doi request reprint A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
  7. ncbi request reprint Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
  8. ncbi request reprint On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis
    Ing Marie Jonsson
    Department of Rheumatology, University of Goteborg, Sweden
    J Infect Dis 185:1417-24. 2002

Collaborators

Detail Information

Publications8

  1. ncbi request reprint An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
    ..These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system...
  2. ncbi request reprint The love-hate relationship between bacterial polysaccharides and the host immune system
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Mail Code 156 29, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Immunol 6:849-58. 2006
    ..This process seems to contribute to the overall health of the host by offering protection against various diseases and might provide supporting evidence at a molecular level for the 'hygiene hypothesis' of allergic immune disorders...
  3. pmc Regulation of surface architecture by symbiotic bacteria mediates host colonization
    Cui Hua Liu
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:3951-6. 2008
    ..These findings suggest a model whereby display of multiple capsular polysaccharides provides essential functions for bacterial colonization during host-symbiont mutualism...
  4. pmc Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 131:33-45. 2007
    ..These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD...
  5. doi request reprint Capsular polysaccharides of symbiotic bacteria modulate immune responses during experimental colitis
    Sarkis K Mazmanian
    California Institute of Technology, Pasadena, CA, USA
    J Pediatr Gastroenterol Nutr 46:E11-2. 2008
  6. doi request reprint A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
    ..Harnessing the immunomodulatory capacity of symbiosis factors such as PSA might potentially provide therapeutics for human inflammatory disorders on the basis of entirely novel biological principles...
  7. ncbi request reprint Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  8. ncbi request reprint On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis
    Ing Marie Jonsson
    Department of Rheumatology, University of Goteborg, Sweden
    J Infect Dis 185:1417-24. 2002
    ..These results suggest that sortase mutant staphylococci are significantly less virulent than the parent strain, Newman: the sortase mutant has decreased ability to reach target organs and, once there, to induce an inflammatory response...