Diane Mathis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
    Zhibin Chen
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:1387-97. 2005
  2. pmc TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    Jamie Wong
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 204:2039-45. 2007
  3. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
  4. pmc Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
    Reinhard Obst
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 201:1555-65. 2005
  5. pmc Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    Hisse Martien van Santen
    Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 200:1221-30. 2004
  6. pmc Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
    Hsin Jung Wu
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1911-22. 2007
  7. pmc The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    Sokol Haxhinasto
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 205:565-74. 2008
  8. pmc Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model
    Paul A Monach
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:2968-74. 2007
  9. pmc Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    Daniel Gray
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 204:2521-8. 2007
  10. pmc Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model
    Shannon Turley
    Section of Immunology and Immunogenetics, Joslin Diabetes Center and Dept of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Pl, Boston, MA 02215, USA
    J Exp Med 198:1527-37. 2003

Collaborators

Detail Information

Publications75

  1. pmc Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
    Zhibin Chen
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:1387-97. 2005
    ..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes...
  2. pmc TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    Jamie Wong
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 204:2039-45. 2007
    ..Sequencing large numbers of peripheral BDC(+)Valpha2(+) cells showed that little to no conversion occurs in response to this pancreatic autoantigen...
  3. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
    ....
  4. pmc Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
    Reinhard Obst
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 201:1555-65. 2005
    ....
  5. pmc Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    Hisse Martien van Santen
    Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 200:1221-30. 2004
    ..Thus, selective survival, rather than induced differentiation, may explain the apparent enrichment observed here and in previous studies...
  6. pmc Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
    Hsin Jung Wu
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1911-22. 2007
    ..These findings highlight potential applications of CpG-ODNs and downstream molecules as antiinflammatory agents...
  7. pmc The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    Sokol Haxhinasto
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 205:565-74. 2008
    ..Activated AKT, in contrast, did not affect established Foxp3 expression in T reg cells. These results place AKT at a nexus of signaling pathways whose proper activation has a strong and broad impact on the onset of T reg specification...
  8. pmc Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model
    Paul A Monach
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:2968-74. 2007
    ..The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation...
  9. pmc Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    Daniel Gray
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 204:2521-8. 2007
    ..We further speculate that the speedy apoptosis of Aire-expressing MECs may be a mechanism to promote cross-presentation of the array of peripheral-tissue antigens they produce...
  10. pmc Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model
    Shannon Turley
    Section of Immunology and Immunogenetics, Joslin Diabetes Center and Dept of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Pl, Boston, MA 02215, USA
    J Exp Med 198:1527-37. 2003
    ....
  11. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
  12. ncbi request reprint Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
    C Benoist
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA, USA
    Nat Immunol 2:797-801. 2001
    ..Nonetheless, many of the associations appear less than convincing and, even for those that seem to be on solid footing, there is no real understanding of the underlying mechanism(s)...
  13. ncbi request reprint A plaidoyer for 'systems immunology'
    Christophe Benoist
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunol Rev 210:229-34. 2006
    ..We propose that distinct standards are needed for validation, evaluation, and visualization of global analyses, such that in-depth descriptions of cellular responses may complement the gene/factor-centric approaches currently in favor...
  14. ncbi request reprint Mast cells in autoimmune disease
    Christophe Benoist
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 420:875-8. 2002
    ..Several recent observations indicate that they may also have a key role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies...
  15. doi request reprint Aire
    Diane Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School and the Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA
    Annu Rev Immunol 27:287-312. 2009
    ....
  16. pmc Genetic influences on the end-stage effector phase of arthritis
    H Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    J Exp Med 194:321-30. 2001
    ..The clarity of these results argues that our focus on the terminal effector phase of arthritis in the K/BxN model will bear fruit...
  17. pmc A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
    C Benoist
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Res 2:90-4. 2000
    ....
  18. pmc Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2325-30. 2007
    ..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis...
  19. ncbi request reprint Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
  20. ncbi request reprint The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
    ..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
  21. ncbi request reprint Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand
    Natalia Martin-Orozco
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Immunol 171:6954-60. 2003
    ..Thus, the OX40/OX40L axis has the paradoxical effect of dampening the early activation and migration of autoimmune T cells, but sustains the long-term progression to autoimmune destruction...
  22. ncbi request reprint Particularities of the vasculature can promote the organ specificity of autoimmune attack
    Bryce A Binstadt
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:284-92. 2006
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders...
  23. pmc Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation
    Reinhard Obst
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:15460-5. 2007
    ..These results suggest that antigen persistence may be an important discriminator of immunogenic and tolerogenic antigen exposure...
  24. pmc The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms
    Bryce A Binstadt
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:16758-63. 2009
    ..Elucidating how a single systemic autoimmune disease engages distinct immune effector pathways to damage different target tissues is essential for optimizing the treatment of such disorders...
  25. pmc PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    Daniela Cipolletta
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 486:549-53. 2012
    ....
  26. pmc Genomic definition of multiple ex vivo regulatory T cell subphenotypes
    Markus Feuerer
    Department of Pathology, Harvard Medical School, and Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5919-24. 2010
    ..Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFbeta in vitro, but instead they resembled a CD103(+)Klrg1(+) subphenotype preferentially generated in response to lymphopenia...
  27. pmc B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients
    Irina Gavanescu
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:13009-14. 2008
    ....
  28. ncbi request reprint Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Immunity 27:786-800. 2007
    ..Thus, a higher level of regulation upstream of Foxp3 determines the lineage, distinct from elements downstream of Foxp3 that are essential for its regulatory properties...
  29. pmc The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice
    Phillip D Holler
    Section on Immunology and Immunogenetics, Joslin Diabetes Center
    Proc Natl Acad Sci U S A 104:7187-92. 2007
    ....
  30. pmc Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
    Vincent Butty
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2348-59. 2008
    ....
  31. pmc Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
    Mireia Guerau-de-Arellano
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 206:1245-52. 2009
    ..Aire-controlled mechanisms of central tolerance are largely dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autoreactive T cells that might emerge...
  32. pmc Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1
    Paul A Monach
    Joslin Diabetes Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 62:753-64. 2010
    ..In this study, we developed a system with which to test the importance of the production of specific factors by neutrophils in a mouse model of arthritis...
  33. ncbi request reprint Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells
    Jamie Wong
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 178:7032-41. 2007
    ..In conclusion, the Treg repertoire is broad, with distinct composition and characteristics, yet significantly overlapping and sharing structural constraints with the repertoire of conventional CD4(+) T cells...
  34. pmc How defects in central tolerance impinge on a deficiency in regulatory T cells
    Zhibin Chen
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:14735-40. 2005
    ..Yet, the range of affected sites was not noticeably extended, and, surprisingly, many organs, or regions of organs, remained untouched, suggesting additional important mechanisms to enforce immunological self-tolerance...
  35. ncbi request reprint Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview
    Michael Matos
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Diabetes 53:2310-21. 2004
    ..Interferon-gamma dominated the changes in gene expression to a striking degree, because close to one-half of the induced transcripts issued from interferon-gamma-regulated genes...
  36. ncbi request reprint Defective central tolerance induction in NOD mice: genomics and genetics
    Silvia Zucchelli
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 22:385-96. 2005
    ..Intersection of the data from the two approaches points to a small set of attractive candidate genes...
  37. pmc Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis
    Haochu Huang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:4658-63. 2010
    ..Rituximab targets the former and spares the latter...
  38. pmc A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis
    Paul A Monach
    Section on Immunology and Immunogenetics, the Joslin Diabetes Center, Boston, Massachusetts, USA
    Proc Natl Acad Sci U S A 106:15867-72. 2009
    ..Thus, autoantibodies to many determinants (whether deposited as "neoantigens" or normal constituents of the extracellular matrix) have the potential to contribute to arthritic inflammation...
  39. pmc The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
    Anna Morena D'Alise
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19857-62. 2008
    ..That the immune dysregulation in this T1D model is rooted in the ability of effector T cells to be regulated, rather than in Tregs themselves, has implications for proposed therapeutic interventions...
  40. pmc Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
    Andrew S Koh
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:13016-21. 2010
    ....
  41. ncbi request reprint T-cell compartments of prediabetic NOD mice
    Stuart P Berzins
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:327-34. 2003
    ..These factors are therefore unlikely to be involved in the loss of tolerance that leads to autoimmunity within this strain...
  42. pmc An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
    JAIME DARCE
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 36:731-41. 2012
    ..Thus, specific subfunctions of Treg cells and the immune diseases they regulate can be influenced by FoxP3's molecular interactions, which result in divergent immunoregulation...
  43. pmc A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice
    Hirotsugu Suwanai
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:9305-10. 2010
    ..These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds...
  44. ncbi request reprint The K/BxN mouse model of inflammatory arthritis: theory and practice
    Paul Monach
    Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA, USA
    Methods Mol Med 136:269-82. 2007
    ....
  45. pmc Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model
    Jonathan P Jacobs
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:1921-32. 2010
    ..We undertook analysis of chemokines and their receptors in the effector phase of arthritis using the K/BxN mouse serum-transfer model...
  46. pmc Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    Hsin Jung Wu
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 32:815-27. 2010
    ..Thus, a single commensal microbe, via its ability to promote a specific Th cell subset, can drive an autoimmune disease...
  47. pmc The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription
    Emily S Venanzi
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:15860-5. 2008
    ..This variable self may be beneficial in preventing uniform holes in the T-cell repertoire in individuals of a species, but at the cost of variable susceptibility to autoimmunity...
  48. ncbi request reprint Gene expression microarrays: glimpses of the immunological genome
    Gordon Hyatt
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 7:686-91. 2006
    ..Bold outlooks and new methods for data analysis and presentation should yield additional insight into the complexities of the immune system...
  49. pmc Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
    Matthieu Giraud
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:535-40. 2012
    ..Thus, transcript mapping and ChIP-seq data indicate that Aire activates ectopic transcription not through specific recognition of PTA gene promoters but by releasing stalled polymerases...
  50. pmc Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunity 29:758-70. 2008
    ..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA...
  51. doi request reprint The K/BxN arthritis model
    Paul A Monach
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Immunol . 2008
    ..This unit describes detailed methods for the maintenance of a K/BxN colony, induction of arthritis by serum transfer, clinical evaluation of arthritis, and measurement of anti-GPI antibodies...
  52. pmc Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes
    Markus Feuerer
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:18181-6. 2007
    ..Thus, NOD mice do not have a global defect in the generation or maintenance of Tregs; if anything, they show the opposite...
  53. ncbi request reprint Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected
    Emily S Venanzi
    Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Immunol 179:5693-700. 2007
    ..In short, the lymphotoxin pathway drives the developmental rather than selectional properties of thymic stromal cells...
  54. pmc Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
    Rene Maehr
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 115:2934-43. 2005
    ..Our results identify Cat L as an enzyme whose activity is essential for the development of type I diabetes in the NOD mouse...
  55. ncbi request reprint Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
    Junko Nishio
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Science 311:1775-8. 2006
    ....
  56. pmc IL-17-producing T cells can augment autoantibody-induced arthritis
    Jonathan P Jacobs
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:21789-94. 2009
    ....
  57. pmc Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity
    Laurent Poirot
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:8102-7. 2004
    ..NOD and B6.H-2g7 mice exhibit extensive variation in NK receptor expression, reminiscent of analogous human molecules. NK cells can be important players in type 1 diabetes, a role that was previously underappreciated...
  58. pmc CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    Ann E Herman
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 199:1479-89. 2004
    ..Thus, CD4+CD25+69- Tregs operate directly in the autoimmune lesion and are dependent on ICOS to keep it in a nondestructive state...
  59. ncbi request reprint Good riddance: Thymocyte clonal deletion prevents autoimmunity
    Emily S Venanzi
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Curr Opin Immunol 16:197-202. 2004
    ..The importance of thymic peripheral antigen expression and clonal deletion to self-tolerance is demonstrated in the autoimmune diseases autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy and type-1 diabetes mellitus...
  60. pmc The transcriptional landscape of αβ T cell differentiation
    Michael Mingueneau
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:619-32. 2013
    ..The transcripts newly identified as encoding candidate mediators of key transitions help define the 'known unknowns' of thymocyte differentiation...
  61. pmc Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 173:1693-701. 2008
    ..Studies performed using mast cell-deficient strains must consider the capacity of associated abnormalities to either expose or compensate for the missing mast cell lineage...
  62. pmc Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes
    Vincent Butty
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, MA 02215, USA
    Proc Natl Acad Sci U S A 104:570-5. 2007
    ....
  63. doi request reprint Aire's partners in the molecular control of immunological tolerance
    Jakub Abramson
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 140:123-35. 2010
    ..These findings suggest a model to explain Aire's widespread targeting and induction of weakly transcribed chromatin regions...
  64. pmc Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance
    Siyoung Yang
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:1833-8. 2013
    ..Thus, Aire's two PHDs seem to play distinct roles in the scenario by which it assures immunological tolerance...
  65. pmc Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
    Jennifer Villasenor
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:15854-9. 2008
    ....
  66. pmc Transcriptional impact of Aire varies with cell type
    Mireia Guerau-de-Arellano
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:14011-6. 2008
    ....
  67. pmc Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints
    Junko Nishio
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 207:1879-89. 2010
    ..The strong perturbations induced by anti-CD3 overcame these niche limitations, in a process dependent on receptors for interleukin-2 (IL-2) and IL-7...
  68. pmc Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    Markus Feuerer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts, USA
    Nat Med 15:930-9. 2009
    ..These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential...
  69. pmc Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
    Stuart E Turvey
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:2454-61. 2005
    ....
  70. pmc Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen
    Haochu Huang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3734-9. 2006
    ..These studies portray, in a single system, the range of tolerance mechanisms applied to potentially pathogenic B cells, and serve as a base for dissecting where T cell help intervenes and where therapeutic agents impinge...
  71. pmc How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
    Markus Feuerer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 31:654-64. 2009
    ..Thus, Treg cells regulate pancreatic autoimmunity in situ through control of a central innate immune system player, NK cells...
  72. pmc Danger-free autoimmune disease in Aire-deficient mice
    Daniel H D Gray
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:18193-8. 2007
    ..Together, these data suggest that the stochastic genesis of dangerous T cell clones can initiate autoimmune disease without the need for environmental stimulation, underlining the importance of Aire-dependent thymic deletion...
  73. pmc Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
    Irina Gavanescu
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, 44 Binney Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:4583-7. 2007
    ....
  74. ncbi request reprint Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells
    Tetsuya Yamagata
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Immunol 5:597-605. 2004
    ..The resulting CD8 alpha alpha T cells showed a rapid effector cytokine response. Hence, T cells displaying self-reactive receptors can have the gene expression profile and phenotypic characteristics of innate immune cells...
  75. pmc Imaging inflammation of the pancreatic islets in type 1 diabetes
    Maria C Denis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:12634-9. 2004
    ..We could detect the onset and evolution of insulitis in vivo and in real time, permitting us to study the natural history of diabetes in individual animals...