Research Topics
Genomes and Genes
| Diane MathisSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?C Benoist
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA, USA
Nat Immunol 2:797-801. 2001..Nonetheless, many of the associations appear less than convincing and, even for those that seem to be on solid footing, there is no real understanding of the underlying mechanism(s)...- Mast cells in autoimmune diseaseChristophe Benoist
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 420:875-8. 2002..Several recent observations indicate that they may also have a key role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies... - A plaidoyer for 'systems immunology'Christophe Benoist
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Immunol Rev 210:229-34. 2006..We propose that distinct standards are needed for validation, evaluation, and visualization of global analyses, such that in-depth descriptions of cellular responses may complement the gene/factor-centric approaches currently in favor... 
AireDiane Mathis
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School and the Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA
Annu Rev Immunol 27:287-312. 2009....
Genetic influences on the end-stage effector phase of arthritisH Ji
Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
J Exp Med 194:321-30. 2001..The clarity of these results argues that our focus on the terminal effector phase of arthritis in the K/BxN model will bear fruit...- A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?C Benoist
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Arthritis Res 2:90-4. 2000.... - Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1Peter A Nigrovic
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:2325-30. 2007..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis... - The cellular mechanism of Aire control of T cell toleranceMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 23:227-39. 2005..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops... - Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activationReinhard Obst
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:15460-5. 2007..These results suggest that antigen persistence may be an important discriminator of immunogenic and tolerogenic antigen exposure... - PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cellsDaniela Cipolletta
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 486:549-53. 2012.... - B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patientsIrina Gavanescu
Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:13009-14. 2008.... - Particularities of the vasculature can promote the organ specificity of autoimmune attackBryce A Binstadt
Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 7:284-92. 2006..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders... - Where CD4+CD25+ T reg cells impinge on autoimmune diabetesZhibin Chen
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 202:1387-97. 2005..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes... - Genomic definition of multiple ex vivo regulatory T cell subphenotypesMarkus Feuerer
Department of Pathology, Harvard Medical School, and Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:5919-24. 2010..Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFbeta in vitro, but instead they resembled a CD103(+)Klrg1(+) subphenotype preferentially generated in response to lymphopenia... - Modifier loci condition autoimmunity provoked by Aire deficiencyWenyu Jiang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 202:805-15. 2005.... - Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunityMireia Guerau-de-Arellano
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 206:1245-52. 2009..Aire-controlled mechanisms of central tolerance are largely dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autoreactive T cells that might emerge... - Gene expression microarrays: glimpses of the immunological genomeGordon Hyatt
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Immunol 7:686-91. 2006..Bold outlooks and new methods for data analysis and presentation should yield additional insight into the complexities of the immune system... - The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanismsBryce A Binstadt
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 106:16758-63. 2009..Elucidating how a single systemic autoimmune disease engages distinct immune effector pathways to damage different target tissues is essential for optimizing the treatment of such disorders... - Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1Paul A Monach
Joslin Diabetes Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 62:753-64. 2010..In this study, we developed a system with which to test the importance of the production of specific factors by neutrophils in a mouse model of arthritis... - Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)Vincent Butty
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 57:2348-59. 2008.... - Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cellsHisse Martien van Santen
Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
J Exp Med 200:1221-30. 2004..Thus, selective survival, rather than induced differentiation, may explain the apparent enrichment observed here and in previous studies... - Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritisHaochu Huang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 107:4658-63. 2010..Rituximab targets the former and spares the latter... - Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signatureJonathan A Hill
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Immunity 27:786-800. 2007..Thus, a higher level of regulation upstream of Foxp3 determines the lineage, distinct from elements downstream of Foxp3 that are essential for its regulatory properties... - The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 micePhillip D Holler
Section on Immunology and Immunogenetics, Joslin Diabetes Center
Proc Natl Acad Sci U S A 104:7187-92. 2007.... - Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligandNatalia Martin-Orozco
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
J Immunol 171:6954-60. 2003..Thus, the OX40/OX40L axis has the paradoxical effect of dampening the early activation and migration of autoimmune T cells, but sustains the long-term progression to autoimmune destruction... - Global relevance of Aire binding to hypomethylated lysine-4 of histone-3Andrew S Koh
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:13016-21. 2010.... - A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritisPaul A Monach
Section on Immunology and Immunogenetics, the Joslin Diabetes Center, Boston, Massachusetts, USA
Proc Natl Acad Sci U S A 106:15867-72. 2009..Thus, autoantibodies to many determinants (whether deposited as "neoantigens" or normal constituents of the extracellular matrix) have the potential to contribute to arthritic inflammation... - The defect in T-cell regulation in NOD mice is an effect on the T-cell effectorsAnna Morena D'Alise
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:19857-62. 2008..That the immune dysregulation in this T1D model is rooted in the ability of effector T cells to be regulated, rather than in Tregs themselves, has implications for proposed therapeutic interventions... - An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetesJAIME DARCE
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
Immunity 36:731-41. 2012..Thus, specific subfunctions of Treg cells and the immune diseases they regulate can be influenced by FoxP3's molecular interactions, which result in divergent immunoregulation... - Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cellsJamie Wong
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Immunol 178:7032-41. 2007..In conclusion, the Treg repertoire is broad, with distinct composition and characteristics, yet significantly overlapping and sharing structural constraints with the repertoire of conventional CD4(+) T cells... - Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cellsHsin Jung Wu
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Immunity 32:815-27. 2010..Thus, a single commensal microbe, via its ability to promote a specific Th cell subset, can drive an autoimmune disease... - Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine modelJonathan P Jacobs
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 62:1921-32. 2010..We undertook analysis of chemokines and their receptors in the effector phase of arthritis using the K/BxN mouse serum-transfer model... - A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic miceHirotsugu Suwanai
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 107:9305-10. 2010..These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds... - Projection of an immunological self shadow within the thymus by the aire proteinMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Science 298:1395-401. 2002..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity... - The K/BxN mouse model of inflammatory arthritis: theory and practicePaul Monach
Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA, USA
Methods Mol Med 136:269-82. 2007.... - Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cellsMatthieu Giraud
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 109:535-40. 2012..Thus, transcript mapping and ChIP-seq data indicate that Aire activates ectopic transcription not through specific recognition of PTA gene promoters but by releasing stalled polymerases... - The K/BxN arthritis modelPaul A Monach
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
Curr Protoc Immunol . 2008..This unit describes detailed methods for the maintenance of a K/BxN colony, induction of arthritis by serum transfer, clinical evaluation of arthritis, and measurement of anti-GPI antibodies... - IL-17-producing T cells can augment autoantibody-induced arthritisJonathan P Jacobs
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:21789-94. 2009.... - Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetesMarkus Feuerer
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:18181-6. 2007..Thus, NOD mice do not have a global defect in the generation or maintenance of Tregs; if anything, they show the opposite... - Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talkHsin Jung Wu
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 204:1911-22. 2007..These findings highlight potential applications of CpG-ODNs and downstream molecules as antiinflammatory agents... - Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnectedEmily S Venanzi
Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, MA 02215, USA
J Immunol 179:5693-700. 2007..In short, the lymphotoxin pathway drives the developmental rather than selectional properties of thymic stromal cells... - Antigen persistence is required throughout the expansion phase of a CD4(+) T cell responseReinhard Obst
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 201:1555-65. 2005.... - Cathepsin L is essential for onset of autoimmune diabetes in NOD miceRene Maehr
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 115:2934-43. 2005..Our results identify Cat L as an enzyme whose activity is essential for the development of type I diabetes in the NOD mouse... - Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contributionJunko Nishio
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
Science 311:1775-8. 2006.... - Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi CellsJonathan A Hill
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Immunity 29:758-70. 2008..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA... - Aire's partners in the molecular control of immunological toleranceJakub Abramson
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Cell 140:123-35. 2010..These findings suggest a model to explain Aire's widespread targeting and induction of weakly transcribed chromatin regions... - Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancyPeter A Nigrovic
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 173:1693-701. 2008..Studies performed using mast cell-deficient strains must consider the capacity of associated abnormalities to either expose or compensate for the missing mast cell lineage... - Defective central tolerance induction in NOD mice: genomics and geneticsSilvia Zucchelli
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 22:385-96. 2005..Intersection of the data from the two approaches points to a small set of attractive candidate genes... - The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cellsSokol Haxhinasto
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
J Exp Med 205:565-74. 2008..Activated AKT, in contrast, did not affect established Foxp3 expression in T reg cells. These results place AKT at a nexus of signaling pathways whose proper activation has a strong and broad impact on the onset of T reg specification... - Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overviewMichael Matos
Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
Diabetes 53:2310-21. 2004..Interferon-gamma dominated the changes in gene expression to a striking degree, because close to one-half of the induced transcripts issued from interferon-gamma-regulated genes... - Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genesVincent Butty
Section on Immunology and Immunogenetics, Joslin Diabetes Center, MA 02215, USA
Proc Natl Acad Sci U S A 104:570-5. 2007.... - How defects in central tolerance impinge on a deficiency in regulatory T cellsZhibin Chen
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 102:14735-40. 2005..Yet, the range of affected sites was not noticeably extended, and, surprisingly, many organs, or regions of organs, remained untouched, suggesting additional important mechanisms to enforce immunological self-tolerance... - The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcriptionEmily S Venanzi
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:15860-5. 2008..This variable self may be beneficial in preventing uniform holes in the T-cell repertoire in individuals of a species, but at the cost of variable susceptibility to autoimmunity... - Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiatedJennifer Villasenor
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:15854-9. 2008.... - Transcriptional impact of Aire varies with cell typeMireia Guerau-de-Arellano
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:14011-6. 2008.... - Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigenHaochu Huang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 103:3734-9. 2006..These studies portray, in a single system, the range of tolerance mechanisms applied to potentially pathogenic B cells, and serve as a base for dissecting where T cell help intervenes and where therapeutic agents impinge... - Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunityLaurent Poirot
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:8102-7. 2004..NOD and B6.H-2g7 mice exhibit extensive variation in NK receptor expression, reminiscent of analogous human molecules. NK cells can be important players in type 1 diabetes, a role that was previously underappreciated... - Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraintsJunko Nishio
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 207:1879-89. 2010..The strong perturbations induced by anti-CD3 overcame these niche limitations, in a process dependent on receptors for interleukin-2 (IL-2) and IL-7... - Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunityIrina Gavanescu
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, 44 Binney Street, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:4583-7. 2007.... - Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetesStuart E Turvey
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 115:2454-61. 2005.... - TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic isletsJamie Wong
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 204:2039-45. 2007..Sequencing large numbers of peripheral BDC(+)Valpha2(+) cells showed that little to no conversion occurs in response to this pancreatic autoantigen... - Danger-free autoimmune disease in Aire-deficient miceDaniel H D Gray
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:18193-8. 2007..Together, these data suggest that the stochastic genesis of dangerous T cell clones can initiate autoimmune disease without the need for environmental stimulation, underlining the importance of Aire-dependent thymic deletion... - Good riddance: Thymocyte clonal deletion prevents autoimmunityEmily S Venanzi
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Curr Opin Immunol 16:197-202. 2004..The importance of thymic peripheral antigen expression and clonal deletion to self-tolerance is demonstrated in the autoimmune diseases autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy and type-1 diabetes mellitus... - How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic isletsMarkus Feuerer
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Immunity 31:654-64. 2009..Thus, Treg cells regulate pancreatic autoimmunity in situ through control of a central innate immune system player, NK cells... - Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersMarkus Feuerer
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts, USA
Nat Med 15:930-9. 2009..These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential... - Imaging inflammation of the pancreatic islets in type 1 diabetesMaria C Denis
Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:12634-9. 2004..We could detect the onset and evolution of insulitis in vivo and in real time, permitting us to study the natural history of diabetes in individual animals... - Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cellsTetsuya Yamagata
Section on Immunology and Immunogenetics, Joslin Diabetes Center; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
Nat Immunol 5:597-605. 2004..The resulting CD8 alpha alpha T cells showed a rapid effector cytokine response. Hence, T cells displaying self-reactive receptors can have the gene expression profile and phenotypic characteristics of innate immune cells...