Diane Mathis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Immunometabolism: an emerging frontier
    Diane Mathis
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 11:81. 2011
  2. ncbi request reprint Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
  3. ncbi request reprint Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview
    Michael Matos
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Diabetes 53:2310-21. 2004
  4. pmc Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
    Mireia Guerau-de-Arellano
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 206:1245-52. 2009
  5. pmc B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients
    Irina Gavanescu
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:13009-14. 2008
  6. ncbi request reprint The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
  7. pmc The immune system's involvement in obesity-driven type 2 diabetes
    Chengyi Jenny Shu
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States
    Semin Immunol 24:436-42. 2012
  8. pmc Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
    Andrew S Koh
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:13016-21. 2010
  9. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
  10. ncbi request reprint Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells
    Luis Vence
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 53:2797-803. 2004

Research Grants

  1. The molecular mechanism of Aire: partnering with DNA-PK
    Diane J Mathis; Fiscal Year: 2011
  2. Initiation of autoimmune diabetes
    Diane Mathis; Fiscal Year: 2007
  3. aire a zinc-finger protein that controls autoimmunity
    Diane Mathis; Fiscal Year: 2007
  4. Arthritogenic Igs
    Diane Mathis; Fiscal Year: 2009
  5. aire a zinc-finger protein that controls autoimmunity
    Diane J Mathis; Fiscal Year: 2010
  6. ARTHRITOGENIC IGS--WHAT ARE THEY? WHY ARE THEY MADE?
    Diane Mathis; Fiscal Year: 2004
  7. Initiation of autoimmune diabetes
    Diane Mathis; Fiscal Year: 2004
  8. AIRE, a zinc-finger protein that controls autoimmunity
    Diane Mathis; Fiscal Year: 2005

Detail Information

Publications76

  1. doi request reprint Immunometabolism: an emerging frontier
    Diane Mathis
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 11:81. 2011
    ..The multilevel interactions between the metabolic and immune systems suggest pathogenic mechanisms that may underlie many of the downstream complications of obesity and offer substantial therapeutic promise...
  2. ncbi request reprint Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
  3. ncbi request reprint Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview
    Michael Matos
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Diabetes 53:2310-21. 2004
    ..Interferon-gamma dominated the changes in gene expression to a striking degree, because close to one-half of the induced transcripts issued from interferon-gamma-regulated genes...
  4. pmc Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
    Mireia Guerau-de-Arellano
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 206:1245-52. 2009
    ..Aire-controlled mechanisms of central tolerance are largely dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autoreactive T cells that might emerge...
  5. pmc B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients
    Irina Gavanescu
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:13009-14. 2008
    ....
  6. ncbi request reprint The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
    ..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
  7. pmc The immune system's involvement in obesity-driven type 2 diabetes
    Chengyi Jenny Shu
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States
    Semin Immunol 24:436-42. 2012
    ..This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease...
  8. pmc Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
    Andrew S Koh
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:13016-21. 2010
    ....
  9. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
    ....
  10. ncbi request reprint Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells
    Luis Vence
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 53:2797-803. 2004
    ..5/NOD(lpr/lpr) splenocytes proliferated less vigorously than those from control mice in the presence of islet extracts, which reflects their inability to produce interleukin-2, resulting in weaker pathogenicity...
  11. pmc How defects in central tolerance impinge on a deficiency in regulatory T cells
    Zhibin Chen
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:14735-40. 2005
    ..Yet, the range of affected sites was not noticeably extended, and, surprisingly, many organs, or regions of organs, remained untouched, suggesting additional important mechanisms to enforce immunological self-tolerance...
  12. ncbi request reprint Back to central tolerance
    Diane Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 USA
    Immunity 20:509-16. 2004
    ..However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes...
  13. pmc Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation
    Reinhard Obst
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:15460-5. 2007
    ..These results suggest that antigen persistence may be an important discriminator of immunogenic and tolerogenic antigen exposure...
  14. ncbi request reprint Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand
    Natalia Martin-Orozco
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Immunol 171:6954-60. 2003
    ..Thus, the OX40/OX40L axis has the paradoxical effect of dampening the early activation and migration of autoimmune T cells, but sustains the long-term progression to autoimmune destruction...
  15. pmc Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    Hisse Martien van Santen
    Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 200:1221-30. 2004
    ..Thus, selective survival, rather than induced differentiation, may explain the apparent enrichment observed here and in previous studies...
  16. pmc Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
    Jonathan Sitrin
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 210:1153-65. 2013
    ..Our findings highlight the need to consider potential effects on NK cells when designing therapeutic strategies based on manipulation of IL-2 levels or targets...
  17. pmc Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
    Irina Gavanescu
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, 44 Binney Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:4583-7. 2007
    ....
  18. doi request reprint The K/BxN arthritis model
    Paul A Monach
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Immunol . 2008
    ..This unit describes detailed methods for the maintenance of a K/BxN colony, induction of arthritis by serum transfer, clinical evaluation of arthritis, and measurement of anti-GPI antibodies...
  19. pmc The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    Sokol Haxhinasto
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 205:565-74. 2008
    ..Activated AKT, in contrast, did not affect established Foxp3 expression in T reg cells. These results place AKT at a nexus of signaling pathways whose proper activation has a strong and broad impact on the onset of T reg specification...
  20. ncbi request reprint Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
    Junko Nishio
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Science 311:1775-8. 2006
    ....
  21. ncbi request reprint Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Immunity 27:786-800. 2007
    ..Thus, a higher level of regulation upstream of Foxp3 determines the lineage, distinct from elements downstream of Foxp3 that are essential for its regulatory properties...
  22. ncbi request reprint A plaidoyer for 'systems immunology'
    Christophe Benoist
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunol Rev 210:229-34. 2006
    ..We propose that distinct standards are needed for validation, evaluation, and visualization of global analyses, such that in-depth descriptions of cellular responses may complement the gene/factor-centric approaches currently in favor...
  23. pmc Transcriptional impact of Aire varies with cell type
    Mireia Guerau-de-Arellano
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:14011-6. 2008
    ....
  24. pmc Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    Daniel Gray
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 204:2521-8. 2007
    ..We further speculate that the speedy apoptosis of Aire-expressing MECs may be a mechanism to promote cross-presentation of the array of peripheral-tissue antigens they produce...
  25. doi request reprint Aire
    Diane Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School and the Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA
    Annu Rev Immunol 27:287-312. 2009
    ....
  26. ncbi request reprint A decade of AIRE
    Diane Mathis
    The Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Immunol 7:645-50. 2007
    ....
  27. ncbi request reprint Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected
    Emily S Venanzi
    Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Immunol 179:5693-700. 2007
    ..In short, the lymphotoxin pathway drives the developmental rather than selectional properties of thymic stromal cells...
  28. ncbi request reprint Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells
    Tetsuya Yamagata
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Immunol 5:597-605. 2004
    ..The resulting CD8 alpha alpha T cells showed a rapid effector cytokine response. Hence, T cells displaying self-reactive receptors can have the gene expression profile and phenotypic characteristics of innate immune cells...
  29. pmc Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model
    Shannon Turley
    Section of Immunology and Immunogenetics, Joslin Diabetes Center and Dept of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Pl, Boston, MA 02215, USA
    J Exp Med 198:1527-37. 2003
    ....
  30. pmc Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity
    Laurent Poirot
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:8102-7. 2004
    ..NOD and B6.H-2g7 mice exhibit extensive variation in NK receptor expression, reminiscent of analogous human molecules. NK cells can be important players in type 1 diabetes, a role that was previously underappreciated...
  31. pmc Imaging inflammation of the pancreatic islets in type 1 diabetes
    Maria C Denis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:12634-9. 2004
    ..We could detect the onset and evolution of insulitis in vivo and in real time, permitting us to study the natural history of diabetes in individual animals...
  32. ncbi request reprint T-cell compartments of prediabetic NOD mice
    Stuart P Berzins
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:327-34. 2003
    ..These factors are therefore unlikely to be involved in the loss of tolerance that leads to autoimmunity within this strain...
  33. ncbi request reprint Mast cells in autoimmune disease
    Christophe Benoist
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 420:875-8. 2002
    ..Several recent observations indicate that they may also have a key role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies...
  34. doi request reprint The Immunological Genome Project: networks of gene expression in immune cells
    Tracy S P Heng
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Immunol 9:1091-4. 2008
    ..The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells...
  35. ncbi request reprint B-cell signaling: protein kinase Cdelta puts the brakes on
    Diane Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Curr Biol 12:R554-6. 2002
    ..The result is a state of non-responsiveness, termed anergy, that represents one form of immunological self-tolerance...
  36. pmc Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells
    Ananda W Goldrath
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 195:1515-22. 2002
    ..Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments...
  37. ncbi request reprint Good riddance: Thymocyte clonal deletion prevents autoimmunity
    Emily S Venanzi
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Curr Opin Immunol 16:197-202. 2004
    ..The importance of thymic peripheral antigen expression and clonal deletion to self-tolerance is demonstrated in the autoimmune diseases autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy and type-1 diabetes mellitus...
  38. doi request reprint Immunological goings-on in visceral adipose tissue
    Diane Mathis
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 17:851-9. 2013
    ..This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme...
  39. pmc Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance
    Siyoung Yang
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:1833-8. 2013
    ..Thus, Aire's two PHDs seem to play distinct roles in the scenario by which it assures immunological tolerance...
  40. pmc Treg cells, life history, and diversity
    Christophe Benoist
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 4:a007021. 2012
    ..We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings...
  41. pmc A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice
    Hirotsugu Suwanai
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:9305-10. 2010
    ..These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds...
  42. doi request reprint Aire's partners in the molecular control of immunological tolerance
    Jakub Abramson
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 140:123-35. 2010
    ..These findings suggest a model to explain Aire's widespread targeting and induction of weakly transcribed chromatin regions...
  43. pmc How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
    Markus Feuerer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 31:654-64. 2009
    ..Thus, Treg cells regulate pancreatic autoimmunity in situ through control of a central innate immune system player, NK cells...
  44. doi request reprint Levees of immunological tolerance
    Diane Mathis
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:3-6. 2010
    ..Yet it is possible that important tolerance mechanisms remain to be discovered, perhaps an explanation for the so-far disappointing clinical translation to the prevention and cure of autoimmune diseases...
  45. pmc Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
    Reinhard Obst
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 201:1555-65. 2005
    ....
  46. pmc The molecular program induced in T cells undergoing homeostatic proliferation
    Ananda W Goldrath
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:16885-90. 2004
    ....
  47. pmc Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
    Zhibin Chen
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:1387-97. 2005
    ..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes...
  48. ncbi request reprint Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    ..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
  49. ncbi request reprint Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis
    Jonathan P Jacobs
    Joslin Diabetes Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 50:2685-94. 2004
    ..This study assessed the role of OPN in the K/BxN serum-transfer model of autoantibody-induced arthritis...
  50. pmc Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    Chance John Luckey
    Joslin Diabetes Center, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3304-9. 2006
    ..These observations provide evidence that the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level...
  51. ncbi request reprint Gene expression microarrays: glimpses of the immunological genome
    Gordon Hyatt
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 7:686-91. 2006
    ..Bold outlooks and new methods for data analysis and presentation should yield additional insight into the complexities of the immune system...
  52. pmc Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2325-30. 2007
    ..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis...
  53. ncbi request reprint How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
    Isao Matsumoto
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02115, USA
    Nat Immunol 3:360-5. 2002
    ..This may constitute a generic scenario of arthritogenesis, in which extra-articular proteins coat the cartilage or joint extracellular matrix...
  54. pmc Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen
    Haochu Huang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3734-9. 2006
    ..These studies portray, in a single system, the range of tolerance mechanisms applied to potentially pathogenic B cells, and serve as a base for dissecting where T cell help intervenes and where therapeutic agents impinge...
  55. pmc Danger-free autoimmune disease in Aire-deficient mice
    Daniel H D Gray
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:18193-8. 2007
    ..Together, these data suggest that the stochastic genesis of dangerous T cell clones can initiate autoimmune disease without the need for environmental stimulation, underlining the importance of Aire-dependent thymic deletion...
  56. ncbi request reprint Defective central tolerance induction in NOD mice: genomics and genetics
    Silvia Zucchelli
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 22:385-96. 2005
    ..Intersection of the data from the two approaches points to a small set of attractive candidate genes...
  57. doi request reprint Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?
    Li Li
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115
    J Immunol 191:3694-704. 2013
    ....
  58. doi request reprint Regulatory T cells in nonlymphoid tissues
    Dalia Burzyn
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:1007-13. 2013
    ..In this Review, we summarize recent findings in this new field, discussing knowns and unknowns about the origin, phenotype, function and memory of nonlymphoid tissue-resident Treg cells. ..
  59. pmc The transcriptional landscape of αβ T cell differentiation
    Michael Mingueneau
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:619-32. 2013
    ..The transcripts newly identified as encoding candidate mediators of key transitions help define the 'known unknowns' of thymocyte differentiation...
  60. pmc PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    Daniela Cipolletta
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 486:549-53. 2012
    ....
  61. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
  62. pmc Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes
    Markus Feuerer
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:18181-6. 2007
    ..Thus, NOD mice do not have a global defect in the generation or maintenance of Tregs; if anything, they show the opposite...
  63. pmc Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
    Jennifer Villasenor
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:15854-9. 2008
    ....
  64. pmc Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 173:1693-701. 2008
    ..Studies performed using mast cell-deficient strains must consider the capacity of associated abnormalities to either expose or compensate for the missing mast cell lineage...
  65. pmc Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunity 29:758-70. 2008
    ..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA...
  66. pmc The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
    Anna Morena D'Alise
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19857-62. 2008
    ..That the immune dysregulation in this T1D model is rooted in the ability of effector T cells to be regulated, rather than in Tregs themselves, has implications for proposed therapeutic interventions...
  67. pmc The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms
    Bryce A Binstadt
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:16758-63. 2009
    ..Elucidating how a single systemic autoimmune disease engages distinct immune effector pathways to damage different target tissues is essential for optimizing the treatment of such disorders...
  68. pmc IL-17-producing T cells can augment autoantibody-induced arthritis
    Jonathan P Jacobs
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:21789-94. 2009
    ....
  69. ncbi request reprint Particularities of the vasculature can promote the organ specificity of autoimmune attack
    Bryce A Binstadt
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:284-92. 2006
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders...
  70. pmc Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis
    Haochu Huang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:4658-63. 2010
    ..Rituximab targets the former and spares the latter...
  71. pmc Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
    Stuart E Turvey
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:2454-61. 2005
    ....
  72. doi request reprint A special population of regulatory T cells potentiates muscle repair
    Dalia Burzyn
    Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 155:1282-95. 2013
    ..Thus, Treg cells and their products may provide new therapeutic opportunities for wound repair and muscular dystrophies...
  73. pmc Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
    Nadia R Cohen
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:90-9. 2013
    ..Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes...
  74. pmc Differential splicing across immune system lineages
    Ayla Ergun
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:14324-9. 2013
    ..g., Ptprc). Computational analysis predicted specific associations between AS exons and splicing regulators, which were verified by detection of the hnRPLL/Ptprc connection. ..
  75. pmc Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells
    Ei Wakamatsu
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:1023-8. 2013
    ....
  76. doi request reprint Consortium biology in immunology: the perspective from the Immunological Genome Project
    Christophe Benoist
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 12:734-40. 2012
    ..We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project...

Research Grants30

  1. The molecular mechanism of Aire: partnering with DNA-PK
    Diane J Mathis; Fiscal Year: 2011
    ..abstract_text> ..
  2. Initiation of autoimmune diabetes
    Diane Mathis; Fiscal Year: 2007
    ..of autoimmune diabetes Potential human relevance immediately suggests itself: might similar elements play a role in the striking increase in diagnosis of fulminant Type-1 diabetes in children under five years of age? ..
  3. aire a zinc-finger protein that controls autoimmunity
    Diane Mathis; Fiscal Year: 2007
    ..e. thymically) mediated immunological tolerance, potentially improving prospects for preventive or curative therapy for autoimmune diseases such as type-1 diabetes and multiple sclerosis. ..
  4. Arthritogenic Igs
    Diane Mathis; Fiscal Year: 2009
    ..Second, they will allow a more informed assessment of the relationship between K/BxN and human arthritis. ..
  5. aire a zinc-finger protein that controls autoimmunity
    Diane J Mathis; Fiscal Year: 2010
    ..e. thymically) mediated immunological tolerance, potentially improving prospects for preventive or curative therapy for autoimmune diseases such as type-1 diabetes and multiple sclerosis. ..
  6. ARTHRITOGENIC IGS--WHAT ARE THEY? WHY ARE THEY MADE?
    Diane Mathis; Fiscal Year: 2004
    ..We anticipate that these studies will provide important clues to the pathogenesis of arthritis in the K/BxN model and, hopefully, by extrapolation, in human patients. ..
  7. Initiation of autoimmune diabetes
    Diane Mathis; Fiscal Year: 2004
    ....
  8. AIRE, a zinc-finger protein that controls autoimmunity
    Diane Mathis; Fiscal Year: 2005
    ..isolate and characterize dendritic cells from aire-deficient patients. We anticipate that results from these studies will provide new insights into the mechanisms of tolerance induction and the development of autoimmunity. ..