Research Topics
Species | Diane MathisSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Immunometabolism: an emerging frontierDiane Mathis
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 11:81. 2011..The multilevel interactions between the metabolic and immune systems suggest pathogenic mechanisms that may underlie many of the downstream complications of obesity and offer substantial therapeutic promise...
Projection of an immunological self shadow within the thymus by the aire proteinMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Science 298:1395-401. 2002..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...- Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overviewMichael Matos
Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
Diabetes 53:2310-21. 2004..Interferon-gamma dominated the changes in gene expression to a striking degree, because close to one-half of the induced transcripts issued from interferon-gamma-regulated genes... 
B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patientsIrina Gavanescu
Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:13009-14. 2008....- Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunityMireia Guerau-de-Arellano
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 206:1245-52. 2009..Aire-controlled mechanisms of central tolerance are largely dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autoreactive T cells that might emerge... - The cellular mechanism of Aire control of T cell toleranceMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 23:227-39. 2005..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops... - Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activationReinhard Obst
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:15460-5. 2007..These results suggest that antigen persistence may be an important discriminator of immunogenic and tolerogenic antigen exposure... - Back to central toleranceDiane Mathis
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215 USA
Immunity 20:509-16. 2004..However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes... - Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cellsLuis Vence
Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Diabetes 53:2797-803. 2004..5/NOD(lpr/lpr) splenocytes proliferated less vigorously than those from control mice in the presence of islet extracts, which reflects their inability to produce interleukin-2, resulting in weaker pathogenicity... - Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cellsHisse Martien van Santen
Section of Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
J Exp Med 200:1221-30. 2004..Thus, selective survival, rather than induced differentiation, may explain the apparent enrichment observed here and in previous studies... - Modifier loci condition autoimmunity provoked by Aire deficiencyWenyu Jiang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 202:805-15. 2005.... - Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligandNatalia Martin-Orozco
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
J Immunol 171:6954-60. 2003..Thus, the OX40/OX40L axis has the paradoxical effect of dampening the early activation and migration of autoimmune T cells, but sustains the long-term progression to autoimmune destruction... - Global relevance of Aire binding to hypomethylated lysine-4 of histone-3Andrew S Koh
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:13016-21. 2010.... - How defects in central tolerance impinge on a deficiency in regulatory T cellsZhibin Chen
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 102:14735-40. 2005..Yet, the range of affected sites was not noticeably extended, and, surprisingly, many organs, or regions of organs, remained untouched, suggesting additional important mechanisms to enforce immunological self-tolerance... - The Immunological Genome Project: networks of gene expression in immune cellsTracy S P Heng
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Nat Immunol 9:1091-4. 2008..The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells... - Transcriptional impact of Aire varies with cell typeMireia Guerau-de-Arellano
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:14011-6. 2008.... - The K/BxN arthritis modelPaul A Monach
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
Curr Protoc Immunol . 2008..This unit describes detailed methods for the maintenance of a K/BxN colony, induction of arthritis by serum transfer, clinical evaluation of arthritis, and measurement of anti-GPI antibodies... - Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contributionJunko Nishio
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
Science 311:1775-8. 2006.... - A plaidoyer for 'systems immunology'Christophe Benoist
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Immunol Rev 210:229-34. 2006..We propose that distinct standards are needed for validation, evaluation, and visualization of global analyses, such that in-depth descriptions of cellular responses may complement the gene/factor-centric approaches currently in favor... - The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cellsSokol Haxhinasto
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
J Exp Med 205:565-74. 2008..Activated AKT, in contrast, did not affect established Foxp3 expression in T reg cells. These results place AKT at a nexus of signaling pathways whose proper activation has a strong and broad impact on the onset of T reg specification... - Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signatureJonathan A Hill
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Immunity 27:786-800. 2007..Thus, a higher level of regulation upstream of Foxp3 determines the lineage, distinct from elements downstream of Foxp3 that are essential for its regulatory properties... - Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunityIrina Gavanescu
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, 44 Binney Street, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:4583-7. 2007.... - A decade of AIREDiane Mathis
The Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Rev Immunol 7:645-50. 2007.... - Proliferative arrest and rapid turnover of thymic epithelial cells expressing AireDaniel Gray
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 204:2521-8. 2007..We further speculate that the speedy apoptosis of Aire-expressing MECs may be a mechanism to promote cross-presentation of the array of peripheral-tissue antigens they produce... - Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes modelShannon Turley
Section of Immunology and Immunogenetics, Joslin Diabetes Center and Dept. of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Pl, Boston, MA 02215, USA
J Exp Med 198:1527-37. 2003.... - Good riddance: Thymocyte clonal deletion prevents autoimmunityEmily S Venanzi
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Curr Opin Immunol 16:197-202. 2004..The importance of thymic peripheral antigen expression and clonal deletion to self-tolerance is demonstrated in the autoimmune diseases autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy and type-1 diabetes mellitus... - Mast cells in autoimmune diseaseChristophe Benoist
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 420:875-8. 2002..Several recent observations indicate that they may also have a key role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies... - B-cell signaling: protein kinase Cdelta puts the brakes onDiane Mathis
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Curr Biol 12:R554-6. 2002..The result is a state of non-responsiveness, termed anergy, that represents one form of immunological self-tolerance... - Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cellsTetsuya Yamagata
Section on Immunology and Immunogenetics, Joslin Diabetes Center; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
Nat Immunol 5:597-605. 2004..The resulting CD8 alpha alpha T cells showed a rapid effector cytokine response. Hence, T cells displaying self-reactive receptors can have the gene expression profile and phenotypic characteristics of innate immune cells... - Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunityLaurent Poirot
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:8102-7. 2004..NOD and B6.H-2g7 mice exhibit extensive variation in NK receptor expression, reminiscent of analogous human molecules. NK cells can be important players in type 1 diabetes, a role that was previously underappreciated... - Imaging inflammation of the pancreatic islets in type 1 diabetesMaria C Denis
Section on Immunology and Immunogenetics, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:12634-9. 2004..We could detect the onset and evolution of insulitis in vivo and in real time, permitting us to study the natural history of diabetes in individual animals... - Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cellsAnanda W Goldrath
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 195:1515-22. 2002..Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments... - Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnectedEmily S Venanzi
Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, MA 02215, USA
J Immunol 179:5693-700. 2007..In short, the lymphotoxin pathway drives the developmental rather than selectional properties of thymic stromal cells... - AireDiane Mathis
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School and the Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA
Annu Rev Immunol 27:287-312. 2009.... - T-cell compartments of prediabetic NOD miceStuart P Berzins
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 52:327-34. 2003..These factors are therefore unlikely to be involved in the loss of tolerance that leads to autoimmunity within this strain... - A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic miceHirotsugu Suwanai
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 107:9305-10. 2010..These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds... - Levees of immunological toleranceDiane Mathis
Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 11:3-6. 2010..Yet it is possible that important tolerance mechanisms remain to be discovered, perhaps an explanation for the so-far disappointing clinical translation to the prevention and cure of autoimmune diseases... - Aire's partners in the molecular control of immunological toleranceJakub Abramson
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Cell 140:123-35. 2010..These findings suggest a model to explain Aire's widespread targeting and induction of weakly transcribed chromatin regions... - How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic isletsMarkus Feuerer
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Immunity 31:654-64. 2009..Thus, Treg cells regulate pancreatic autoimmunity in situ through control of a central innate immune system player, NK cells... - Danger-free autoimmune disease in Aire-deficient miceDaniel H D Gray
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:18193-8. 2007..Together, these data suggest that the stochastic genesis of dangerous T cell clones can initiate autoimmune disease without the need for environmental stimulation, underlining the importance of Aire-dependent thymic deletion... - Defective central tolerance induction in NOD mice: genomics and geneticsSilvia Zucchelli
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 22:385-96. 2005..Intersection of the data from the two approaches points to a small set of attractive candidate genes... - Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritisJonathan P Jacobs
Joslin Diabetes Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
Arthritis Rheum 50:2685-94. 2004..This study assessed the role of OPN in the K/BxN serum-transfer model of autoantibody-induced arthritis... - Antigen persistence is required throughout the expansion phase of a CD4(+) T cell responseReinhard Obst
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 201:1555-65. 2005.... - Arthritis critically dependent on innate immune system playersHong Ji
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Immunity 16:157-68. 2002..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response... - How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune diseaseIsao Matsumoto
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1 Joslin Place, Boston, MA 02115, USA
Nat Immunol 3:360-5. 2002..This may constitute a generic scenario of arthritogenesis, in which extra-articular proteins coat the cartilage or joint extracellular matrix... - Where CD4+CD25+ T reg cells impinge on autoimmune diabetesZhibin Chen
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 202:1387-97. 2005..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes... - Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cellsChance John Luckey
Joslin Diabetes Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 103:3304-9. 2006..These observations provide evidence that the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level... - Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigenHaochu Huang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 103:3734-9. 2006..These studies portray, in a single system, the range of tolerance mechanisms applied to potentially pathogenic B cells, and serve as a base for dissecting where T cell help intervenes and where therapeutic agents impinge... - Gene expression microarrays: glimpses of the immunological genomeGordon Hyatt
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Immunol 7:686-91. 2006..Bold outlooks and new methods for data analysis and presentation should yield additional insight into the complexities of the immune system... - Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1Peter A Nigrovic
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:2325-30. 2007..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis... - The molecular program induced in T cells undergoing homeostatic proliferationAnanda W Goldrath
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:16885-90. 2004.... - PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cellsDaniela Cipolletta
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 486:549-53. 2012.... - Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritisHong Ji
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 196:77-85. 2002..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes... - Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritisHaochu Huang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 107:4658-63. 2010..Rituximab targets the former and spares the latter... - Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancyPeter A Nigrovic
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 173:1693-701. 2008..Studies performed using mast cell-deficient strains must consider the capacity of associated abnormalities to either expose or compensate for the missing mast cell lineage... - IL-17-producing T cells can augment autoantibody-induced arthritisJonathan P Jacobs
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:21789-94. 2009.... - The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanismsBryce A Binstadt
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 106:16758-63. 2009..Elucidating how a single systemic autoimmune disease engages distinct immune effector pathways to damage different target tissues is essential for optimizing the treatment of such disorders... - Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetesMarkus Feuerer
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:18181-6. 2007..Thus, NOD mice do not have a global defect in the generation or maintenance of Tregs; if anything, they show the opposite... - The defect in T-cell regulation in NOD mice is an effect on the T-cell effectorsAnna Morena D'Alise
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:19857-62. 2008..That the immune dysregulation in this T1D model is rooted in the ability of effector T cells to be regulated, rather than in Tregs themselves, has implications for proposed therapeutic interventions... - Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi CellsJonathan A Hill
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Immunity 29:758-70. 2008..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA... - Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetesStuart E Turvey
Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 115:2454-61. 2005.... - Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiatedJennifer Villasenor
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:15854-9. 2008.... - Particularities of the vasculature can promote the organ specificity of autoimmune attackBryce A Binstadt
Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 7:284-92. 2006..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders... - Treg cells, life history, and diversityChristophe Benoist
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cold Spring Harb Perspect Biol 4:a007021. 2012..We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings... - Consortium biology in immunology: the perspective from the Immunological Genome ProjectChristophe Benoist
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 12:734-40. 2012..We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project...
Research Grants
- The molecular mechanism of Aire: partnering with DNA-PKDiane J Mathis; Fiscal Year: 2011..abstract_text> ..
- Initiation of autoimmune diabetesDiane Mathis; Fiscal Year: 2007..of autoimmune diabetes Potential human relevance immediately suggests itself: might similar elements play a role in the striking increase in diagnosis of fulminant Type-1 diabetes in children under five years of age? ..
- aire a zinc-finger protein that controls autoimmunityDiane Mathis; Fiscal Year: 2007..e. thymically) mediated immunological tolerance, potentially improving prospects for preventive or curative therapy for autoimmune diseases such as type-1 diabetes and multiple sclerosis. ..
- Arthritogenic IgsDiane Mathis; Fiscal Year: 2009..Second, they will allow a more informed assessment of the relationship between K/BxN and human arthritis. ..
- aire a zinc-finger protein that controls autoimmunityDiane J Mathis; Fiscal Year: 2010..e. thymically) mediated immunological tolerance, potentially improving prospects for preventive or curative therapy for autoimmune diseases such as type-1 diabetes and multiple sclerosis. ..
- ARTHRITOGENIC IGS--WHAT ARE THEY? WHY ARE THEY MADE?Diane Mathis; Fiscal Year: 2004..We anticipate that these studies will provide important clues to the pathogenesis of arthritis in the K/BxN model and, hopefully, by extrapolation, in human patients. ..
- Initiation of autoimmune diabetesDiane Mathis; Fiscal Year: 2004....
- AIRE, a zinc-finger protein that controls autoimmunityDiane Mathis; Fiscal Year: 2005..isolate and characterize dendritic cells from aire-deficient patients. We anticipate that results from these studies will provide new insights into the mechanisms of tolerance induction and the development of autoimmunity. ..