J A J Martyn

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Basic principles of neuromuscular transmission
    J A J Martyn
    Harvard Medical School, Director Clinical and Biological Pharmacology Laboratory, Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA
    Anaesthesia 64:1-9. 2009
  2. doi request reprint Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Clinical and Biochemical Pharmacology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    Anesthesiology 109:137-48. 2008
  3. ncbi request reprint Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006
  4. ncbi request reprint Pharmacodynamics of mivacurium chloride in 13- to 18-yr-old adolescents with thermal injury
    J A J Martyn
    Department of Anesthesiology and Critical Care, Harvard Medical School, Massachusetts General Hospital and Shriners Hospital for Children, Boston, MA 02114, USA
    Br J Anaesth 89:580-5. 2002
  5. ncbi request reprint Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance
    Sulpicio G Soriano
    Harvard Medical School and Children s Hospital, Boston, Massachusetts 02115, USA
    Clin Pharmacokinet 43:71-81. 2004
  6. ncbi request reprint Long-term effects of botulinum toxin on neuromuscular function
    Christiane G Frick
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 106:1139-46. 2007
  7. ncbi request reprint Chronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers
    Christiane G Frick
    Department of Anesthesia and Critical Care, Shriners Hospital for Children and Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA
    Intensive Care Med 34:561-7. 2008
  8. ncbi request reprint Nitric oxide is not a mediator of inflammation-induced resistance to atracurium
    Heidrun Fink
    Klinik für Anaesthesiologie der Technischen Universität München, Munich, Germany
    Anesth Analg 101:1362-7. 2005
  9. ncbi request reprint Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis
    Loukas G Astrakas
    Department of Surgery, Massachusetts General Hospital, Shriners Burns Institute and Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 19:1431-40. 2005
  10. ncbi request reprint A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice
    Masaki Fujimoto
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 6604, Charlestown, MA 02129, USA
    Diabetes 54:1340-8. 2005

Collaborators

  • A A Tzika
  • Sulpicio G Soriano
  • Christiane G Frick
  • Shingo Yasuhara
  • Hiroki Sugita
  • Masao Kaneki
  • Takashi Yasukawa
  • Heidrun Fink
  • Masaki Fujimoto
  • Michiko Sugita
  • Manfred Blobner
  • Nobuyuki Shimizu
  • Loukas G Astrakas
  • Peter Luppa
  • TaeHyung Han
  • Ronald G Tompkins
  • Eriko Tokunaga
  • Munetaka Hirose
  • Ralph Bogdanski
  • Hidetaka Ota
  • Igor Goljer
  • Katie E Padfield
  • Kohjiro Ueki
  • George Dai
  • Yong Ming Yu
  • Suresh Gopalan
  • Michael N Mindrinos
  • Laurence G Rahme
  • Kaiko Kunii
  • Qunhao Zhang
  • JiYoung Bae
  • Stephanie L Lee
  • KwangMin Kim
  • HyeongSeok Kim
  • Ying Zhu
  • Naveen Tipirneni
  • Takashi Matsui
  • Barbara Mayer
  • Hilkea Rosenbrock
  • Jochen Metzger
  • Yoko Yasuhara
  • Anthony Rosenzweig
  • Yoshihiro Kuroda
  • Yoshinori Marunaka
  • Yoshifumi Tanaka
  • Chieko Koike

Detail Information

Publications20

  1. doi request reprint Basic principles of neuromuscular transmission
    J A J Martyn
    Harvard Medical School, Director Clinical and Biological Pharmacology Laboratory, Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA
    Anaesthesia 64:1-9. 2009
    ..The responses of these receptors to suxamethonium and non-depolarising neuromuscular blocking drugs are different and explain some of the aberrant responses to neuromuscular blocking drugs...
  2. doi request reprint Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Clinical and Biochemical Pharmacology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    Anesthesiology 109:137-48. 2008
    ..Multipronged therapies aimed at rectifying obesity-induced anomalies in both central nervous system and peripheral tissues may prove to be beneficial...
  3. ncbi request reprint Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006
    ....
  4. ncbi request reprint Pharmacodynamics of mivacurium chloride in 13- to 18-yr-old adolescents with thermal injury
    J A J Martyn
    Department of Anesthesiology and Critical Care, Harvard Medical School, Massachusetts General Hospital and Shriners Hospital for Children, Boston, MA 02114, USA
    Br J Anaesth 89:580-5. 2002
    ..We hypothesized that decreased PCHE activity would decrease metabolism of mivacurium, and counteract the receptor-related resistance following burns...
  5. ncbi request reprint Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance
    Sulpicio G Soriano
    Harvard Medical School and Children s Hospital, Boston, Massachusetts 02115, USA
    Clin Pharmacokinet 43:71-81. 2004
    ....
  6. ncbi request reprint Long-term effects of botulinum toxin on neuromuscular function
    Christiane G Frick
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 106:1139-46. 2007
    ..The authors investigated the long-term effects of botulinum toxin on muscle function, expression of nicotinic acetylcholine receptors (nAChRs), and their interaction with muscle relaxant, atracurium...
  7. ncbi request reprint Chronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers
    Christiane G Frick
    Department of Anesthesia and Critical Care, Shriners Hospital for Children and Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA
    Intensive Care Med 34:561-7. 2008
    ..We examined the effects of a chronic infection with Escherichia coli on muscle function, muscle mass, and the expression of nicotinic acetylcholine receptors (AChRs)...
  8. ncbi request reprint Nitric oxide is not a mediator of inflammation-induced resistance to atracurium
    Heidrun Fink
    Klinik für Anaesthesiologie der Technischen Universität München, Munich, Germany
    Anesth Analg 101:1362-7. 2005
    ....
  9. ncbi request reprint Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis
    Loukas G Astrakas
    Department of Surgery, Massachusetts General Hospital, Shriners Burns Institute and Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 19:1431-40. 2005
    ..Together, our results provide new insight into the local physiological changes that occur in skeletal muscle after severe burn trauma...
  10. ncbi request reprint A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice
    Masaki Fujimoto
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 6604, Charlestown, MA 02129, USA
    Diabetes 54:1340-8. 2005
    ..These results suggest that iNOS plays a role in fasting hyperglycemia and contributes to hepatic insulin resistance in ob/ob mice...
  11. ncbi request reprint Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells
    Hiroki Sugita
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Shriners Hospital for Children, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 280:14203-11. 2005
    ..These findings indicate that iNOS reduces IRS-1 expression in skeletal muscle via proteasome-mediated degradation and thereby may contribute to obesity-related insulin resistance...
  12. ncbi request reprint S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance
    Takashi Yasukawa
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Shriners Hospital for Children, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 280:7511-8. 2005
    ..These data suggest that S-nitrosylation-mediated inactivation may contribute to the pathogenesis of iNOS- and/or oxidative stress-involved insulin resistance...
  13. ncbi request reprint Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle
    Hiroki Sugita
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA, USA
    Am J Physiol Endocrinol Metab 288:E585-91. 2005
    ....
  14. ncbi request reprint Neuromuscular pharmacodynamics of rocuronium in patients with major burns
    TaeHyung Han
    Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University School of Medicine, 94 200 YongDungPo Dong, YongDungPo Ku, Seoul, Korea 150 719
    Anesth Analg 99:386-92, table of contents. 2004
    ..Resistance to the neuromuscular effects of rocuronium was partially overcome by increasing the dose. A dose up to 1.2 mg/kg provides good tracheal intubating conditions after major burns...
  15. ncbi request reprint Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells
    Takashi Yasukawa
    Harvard Medical School, and Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesthesiology 100:1615-9. 2004
  16. ncbi request reprint Up-regulation of acetylcholine receptors during subchronic infusion of pancuronium is caused by a posttranscriptional mechanism related to disuse
    Heidrun Fink
    Department of Anasthesia and Critical Care, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 32:509-13. 2004
    ..This study investigated the early effects of competitive acetylcholine receptor block with the reversible, competitive muscle relaxant, pancuronium...
  17. ncbi request reprint Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis
    Shingo Yasuhara
    Department of Anesthesiology and Critical Care, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Histochem Cytochem 51:873-85. 2003
    ..These studies confirm the consistency of the comet assay for detection of apoptosis in single cells and provide evidence for its applicability as an additional method to detect apoptosis in parenchymal cells...
  18. ncbi request reprint Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors
    Heidrun Fink
    Research Fellow, Klinik für Anaesthesiologie der Technischen Universität München, Klinikum rechts der Isar, Germany
    Anesthesiology 98:82-8. 2003
    ..The authors therefore investigated the pharmacodynamics of atracurium and its relation to the expression of nicotinic acetylcholine receptors and alpha1 -acid glycoprotein in a rat model of systemic inflammation...
  19. pmc Mechanism of suppression of insulin signalling with lignocaine
    Munetaka Hirose
    Department of Anaesthesiology, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto 602 8566, Japan
    Br J Pharmacol 136:76-80. 2002
    ..The inhibitory effect of lignocaine on tyrosine kinase activity of the IR underlies the suppression of insulin signalling with lignocaine...
  20. ncbi request reprint Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance
    Hiroki Sugita
    Department of Anesthesia and Critical Care, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Endocrinol Metab 282:E386-94. 2002
    ..The protective effect of aminoguanidine on insulin resistance is probably by attenuation of hepatic glucose output via its inhibition of key enzymes for glycogenolysis and gluconeogenesis, including glycogen phosphorylase and PEPCK...