Vladimir Marshansky

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function
    Vladimir Marshansky
    Program in Membrane Biology, Center for Systems Biology, Simches Research Center, CPZN No 8212, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Curr Opin Cell Biol 20:415-26. 2008
  2. pmc Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution
    Maria Merkulova
    Program in Membrane Biology and Nephrology Division, Center for Systems Biology, Simches Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 300:C1442-55. 2011
  3. doi request reprint Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO
    Maria Merkulova
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biochim Biophys Acta 1797:1398-409. 2010
  4. pmc The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
    Hiroyuki Hosokawa
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 288:5896-913. 2013
  5. pmc Sensing, signaling and sorting events in kidney epithelial cell physiology
    Dennis Brown
    Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Traffic 10:275-84. 2009
  6. ncbi request reprint Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis
    Teodor G Paunescu
    Program in Membrane Biology Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 287:C149-62. 2004
  7. pmc Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo
    Zun Liu
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Thier 10, Boston, Massachusetts 02114, USA
    Endocrinology 152:1222-33. 2011
  8. ncbi request reprint Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway
    Richard Bouley
    Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 288:C1390-401. 2005
  9. ncbi request reprint Eukaryotic V-ATPase: novel structural findings and functional insights
    Vladimir Marshansky
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Simches Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA Department of Medicine, Harvard Medical School, Boston, MA 02114, USA Kadmon Pharmaceuticals Corporation, Alexandria Center for Life Science, 450 East 29th Street, New York, NY 10016, USA Electronic address
    Biochim Biophys Acta 1837:857-79. 2014
  10. ncbi request reprint V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
    Andres Hurtado-Lorenzo
    Program in Membrane Biology and Nephrology Division, Richard Simches Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Nat Cell Biol 8:124-36. 2006

Collaborators

Detail Information

Publications18

  1. doi request reprint The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function
    Vladimir Marshansky
    Program in Membrane Biology, Center for Systems Biology, Simches Research Center, CPZN No 8212, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Curr Opin Cell Biol 20:415-26. 2008
    ..Here, we will review these studies with emphasis on novel direct roles of V-ATPase in the regulation of vesicular trafficking events...
  2. pmc Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution
    Maria Merkulova
    Program in Membrane Biology and Nephrology Division, Center for Systems Biology, Simches Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 300:C1442-55. 2011
    ....
  3. doi request reprint Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO
    Maria Merkulova
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biochim Biophys Acta 1797:1398-409. 2010
    ....
  4. pmc The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
    Hiroyuki Hosokawa
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 288:5896-913. 2013
    ..Thus, here we have uncovered an evolutionarily conserved function of the V-ATPase as a novel cytohesin-signaling receptor...
  5. pmc Sensing, signaling and sorting events in kidney epithelial cell physiology
    Dennis Brown
    Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Traffic 10:275-84. 2009
    ....
  6. ncbi request reprint Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis
    Teodor G Paunescu
    Program in Membrane Biology Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 287:C149-62. 2004
    ..These findings indicate that in addition to its role in the acidification of intracellular organelles, the B2 isoform could also contribute to transepithelial proton secretion and the maintenance of acid-base homeostasis...
  7. pmc Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo
    Zun Liu
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Thier 10, Boston, Massachusetts 02114, USA
    Endocrinology 152:1222-33. 2011
    ..Hence, transgenic XLαs expression in the proximal tubule enhanced Gsα-mediated responses, indicating that XLαs can mimic Gsα in vivo...
  8. ncbi request reprint Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway
    Richard Bouley
    Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital East, 149 13th St, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 288:C1390-401. 2005
    ..This degradative pathway may be an adaptive response to allow receptor-ligand association in the hypertonic and acidic environment of the renal medulla...
  9. ncbi request reprint Eukaryotic V-ATPase: novel structural findings and functional insights
    Vladimir Marshansky
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Simches Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA Department of Medicine, Harvard Medical School, Boston, MA 02114, USA Kadmon Pharmaceuticals Corporation, Alexandria Center for Life Science, 450 East 29th Street, New York, NY 10016, USA Electronic address
    Biochim Biophys Acta 1837:857-79. 2014
    ..Finally, future prospects for structural and functional studies of the eukaryotic V-ATPase will be discussed. ..
  10. ncbi request reprint V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
    Andres Hurtado-Lorenzo
    Program in Membrane Biology and Nephrology Division, Richard Simches Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Nat Cell Biol 8:124-36. 2006
    ....
  11. pmc N-terminal domain of the V-ATPase a2-subunit displays integral membrane protein properties
    Maria Merkulova
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Simches Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Protein Sci 19:1850-62. 2010
    ..We propose that a2N(1-402) should be categorized as an integral monotopic domain of the a2-subunit isoform of the V-ATPase...
  12. pmc Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ
    Zhenjie Zhuang
    Massachusetts General Hospital, Center for Systems Biology, Simches Research Bldg, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 300:F199-206. 2011
    ....
  13. pmc Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking
    Dennis Brown
    Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Biol 212:1762-72. 2009
    ..Recent information about these pH-sensing mechanisms, which include the role of the V-ATPase itself as a pH sensor and the soluble adenylyl cyclase as a bicarbonate sensor, will be addressed in this review...
  14. ncbi request reprint Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ
    Jaafar El-Annan
    Program in Membrane Biology and Renal Unit, Massachusetts General Hospital, Boston, MA 02129 2020, USA
    Am J Physiol Cell Physiol 286:C768-78. 2004
    ..The results provide a framework on which to base and interpret future studies on the role of Arf GTPases in the multitude of cellular trafficking events that occur in renal tubular epithelial cells...
  15. ncbi request reprint Physiological importance of endosomal acidification: potential role in proximal tubulopathies
    Vladimir Marshansky
    Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston 02129 2020, USA
    Curr Opin Nephrol Hypertens 11:527-37. 2002
    ....
  16. ncbi request reprint Renal vacuolar H+-ATPase
    Carsten A Wagner
    Institute of Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Physiol Rev 84:1263-314. 2004
    ..This regulation is at least in part mediated by various hormones and protein-protein interactions between regulatory proteins and multiple subunits of the pump...
  17. ncbi request reprint Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice
    Simonetta Lisi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, I 56124 Pisa, Italy
    Am J Physiol Cell Physiol 290:C1160-7. 2006
    ..In conclusion, RAP is required for the establishment of Tg reservoirs, but its absence does not affect hormone secretion...
  18. ncbi request reprint Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy
    Johanne Tremblay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Transplantation 74:1425-33. 2002
    ..The therapy has been shown to have a beneficial effect in models of inflammation and vascular diseases. This study tested the hypothesis that IMT can prevent renal ischemia-reperfusion (I/R) injury in rats...