Marneros A. A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis. J Invest Dermatol. 2018;: pubmed publisher
..This study implicates a specific transcript variant of NEDD4, NEDD4-TV3, as a regulator of NF-κB/STAT3-mediated inflammation and provides evidence that an increase in NEDD4-TV3 promotes keloid formation. ..
Ablonczy Z, Dahrouj M, Marneros A. Progressive dysfunction of the retinal pigment epithelium and retina due to increased VEGF-A levels. FASEB J. 2014;28:2369-79 pubmed publisher
..The data support a central role of increased VEGF-A not only in the pathogenesis of neovascular but also of nonexudative AMD. ..
Marneros A. Genetics of aplasia cutis reveal novel regulators of skin morphogenesis. J Invest Dermatol. 2015;135:666-672 pubmed publisher
..These findings reveal novel molecular mechanisms that are involved in skin formation during development. ..
Marneros A. VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration. Adv Exp Med Biol. 2016;854:79-85 pubmed publisher
..These findings suggest that inhibiting the NLRP3 inflammasome or pathways that regulate it may provide novel therapeutic approaches for the treatment of both forms of AMD. ..
Marneros A. Increased VEGF-A promotes multiple distinct aging diseases of the eye through shared pathomechanisms. EMBO Mol Med. 2016;8:208-31 pubmed publisher
..These findings suggest a shared pathogenic role of VEGF-A-induced andÂ NLRP3 inflammasome-mediated IL-1Î² activation for multiple distinct ocular aging diseases. ..