A G Marneros

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    EMBO J 23:89-99. 2004
  2. ncbi request reprint The role of collagen-derived proteolytic fragments in angiogenesis
    A G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Matrix Biol 20:337-45. 2001
  3. ncbi request reprint Keloids--clinical diagnosis, pathogenesis, and treatment options
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Dtsch Dermatol Ges 2:905-13. 2004
  4. ncbi request reprint Physiological role of collagen XVIII and endostatin
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    FASEB J 19:716-28. 2005
  5. ncbi request reprint Age-dependent iris abnormalities in collagen XVIII/endostatin deficient mice with similarities to human pigment dispersion syndrome
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 44:2367-72. 2003
  6. ncbi request reprint Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome
    A G Marneros
    Department of Cell Biology, Harvard Medical School, Boston MA 02115, USA
    Cytogenet Cell Genet 92:213-6. 2001
  7. ncbi request reprint Clinical genetics of familial keloids
    A G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Arch Dermatol 137:1429-34. 2001
  8. pmc Lack of collagen XVIII/endostatin results in eye abnormalities
    Naomi Fukai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:1535-44. 2002
  9. pmc Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 188 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 167:1451-9. 2005
  10. ncbi request reprint Endogenous endostatin inhibits choroidal neovascularization
    Alexander G Marneros
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 21:3809-18. 2007

Collaborators

Detail Information

Publications11

  1. pmc Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    EMBO J 23:89-99. 2004
    ..Consistent with such a role, the ultrastructural organization of collagen XVIII/endostatin in basement membranes, including Bruch's membrane, shows that it is part of basement membrane molecular networks...
  2. ncbi request reprint The role of collagen-derived proteolytic fragments in angiogenesis
    A G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Matrix Biol 20:337-45. 2001
    ..Furthermore, NC1 domain fragments of the most abundant basement membrane collagen, type IV collagen, have been shown to inhibit induced vessel growth...
  3. ncbi request reprint Keloids--clinical diagnosis, pathogenesis, and treatment options
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Dtsch Dermatol Ges 2:905-13. 2004
    ..We provide an overview of the pathogenetic mechanisms of keloid formation in the context of their clinical characteristics and current therapeutic approaches...
  4. ncbi request reprint Physiological role of collagen XVIII and endostatin
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    FASEB J 19:716-28. 2005
    ..These recent findings demonstrate an important role for collagen XVIII/endostatin in cell-matrix interactions in certain tissues that may be compensated for in other tissues expressing this collagen...
  5. ncbi request reprint Age-dependent iris abnormalities in collagen XVIII/endostatin deficient mice with similarities to human pigment dispersion syndrome
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 44:2367-72. 2003
    ..In this study we investigated ocular structures in collagen XVIII/endostatin (Col18a1(-/-))-deficient mice to elucidate the role of this extracellular matrix component in the eye...
  6. ncbi request reprint Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome
    A G Marneros
    Department of Cell Biology, Harvard Medical School, Boston MA 02115, USA
    Cytogenet Cell Genet 92:213-6. 2001
    ..No disease causing mutation was identified in PTPRH in affected individuals, suggesting the existence of an as yet not identified gene on 19q13.4 as a second PJS gene...
  7. ncbi request reprint Clinical genetics of familial keloids
    A G Marneros
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Arch Dermatol 137:1429-34. 2001
    ..Most keloids occur sporadically, but some cases are familial. However, the genetics of keloid formation have only rarely been documented, and the mode of inheritance is not known...
  8. pmc Lack of collagen XVIII/endostatin results in eye abnormalities
    Naomi Fukai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:1535-44. 2002
    ..The findings provide an explanation for high myopia, vitreoretinal degeneration and retinal detachment seen in patients with Knobloch syndrome caused by loss-of-function mutations in collagen XVIII...
  9. pmc Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 188 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 167:1451-9. 2005
    ..Thus, hypoxia-inducible factor-1alpha-independent expression of VEGF is essential for choroid development...
  10. ncbi request reprint Endogenous endostatin inhibits choroidal neovascularization
    Alexander G Marneros
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 21:3809-18. 2007
    ..Endostatin may have a regulatory role in the pathogenesis of CNV and could be used therapeutically to inhibit growth and leakage of CNV lesions...
  11. ncbi request reprint Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, Boston, USA
    J Invest Dermatol 122:1126-32. 2004
    ..This study provides the first genetic evidence for keloid susceptibility loci and serves as a basis for the identification of responsible genes...