Christos Mantzoros

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial
    Nicole M Wedick
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Nutr J 11:86. 2012
  2. pmc Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals
    Hyun Seuk Moon
    MD, DSC, Professor of Medicine, Harvard Medical School, JP9B52A, 150 South Huntington Avenue, Boston, Massachusetts 02130
    Endocr Rev 34:377-412. 2013
  3. pmc Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway
    Joo Pin Foo
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 36:935-42. 2013
  4. doi request reprint Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice
    Hyun Seuk Moon
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02130, USA
    Gut 62:561-70. 2013
  5. pmc The role of adiponectin in cancer: a review of current evidence
    Maria Dalamaga
    Laboratory of Clinical Biochemistry, Attikon General University Hospital, University of Athens, School of Medicine, 12462 Athens, Greece
    Endocr Rev 33:547-94. 2012
  6. pmc Secretion patterns of circulating osteoprotegerin and response to acute and chronic energy deprivation in young healthy adults
    Konstantinos N Aronis
    Division of Endocrinology, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 97:2765-72. 2012
  7. pmc Leptin as a modulator of neuroendocrine function in humans
    Sami M Khan
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Yonsei Med J 53:671-9. 2012
  8. pmc Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial
    Nicole M Wedick
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Nutr J 10:93. 2011
  9. pmc The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 676 N St Clair st suite 850, Chicago, IL 60611, USA
    BMC Med Genet 12:52. 2011
  10. pmc Short-term energy deprivation alters activin a and follistatin but not inhibin B levels of lean healthy women in a leptin-independent manner
    Vasiliki A Moragianni
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02130, USA
    J Clin Endocrinol Metab 96:3750-8. 2011

Research Grants

  1. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2011
  2. The Role of Leptin in the Maintenance of a Reduced Body Weight
    Christos S Mantzoros; Fiscal Year: 2010
  3. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos Mantzoros; Fiscal Year: 2007
  4. Clinical trial of leptin for hypothalamic amenorrhea
    Christos Mantzoros; Fiscal Year: 2005
  5. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos Mantzoros; Fiscal Year: 2004
  6. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2010

Detail Information

Publications119 found, 100 shown here

  1. pmc The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial
    Nicole M Wedick
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Nutr J 11:86. 2012
    ..The objective of this study was to evaluate the effects of caffeinated and decaffeinated coffee on SHBG and sex hormone levels...
  2. pmc Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals
    Hyun Seuk Moon
    MD, DSC, Professor of Medicine, Harvard Medical School, JP9B52A, 150 South Huntington Avenue, Boston, Massachusetts 02130
    Endocr Rev 34:377-412. 2013
    ....
  3. pmc Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway
    Joo Pin Foo
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 36:935-42. 2013
    ..We aim to elucidate day-night pattern of FGF-21 levels and its relationship to FFA, to assess whether energy deprivation alters its circulating patterns, and to examine whether leptin may mediate these changes...
  4. doi request reprint Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice
    Hyun Seuk Moon
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02130, USA
    Gut 62:561-70. 2013
    ..No previous studies have directly investigated the mechanistic effects of adiponectin on colon cancer in the settings of obesity, a high-fat diet and/or adiponectin deficiency...
  5. pmc The role of adiponectin in cancer: a review of current evidence
    Maria Dalamaga
    Laboratory of Clinical Biochemistry, Attikon General University Hospital, University of Athens, School of Medicine, 12462 Athens, Greece
    Endocr Rev 33:547-94. 2012
    ..Understanding of these mechanisms may be important for the development of preventive and therapeutic strategies against obesity-associated malignancies...
  6. pmc Secretion patterns of circulating osteoprotegerin and response to acute and chronic energy deprivation in young healthy adults
    Konstantinos N Aronis
    Division of Endocrinology, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 97:2765-72. 2012
    ....
  7. pmc Leptin as a modulator of neuroendocrine function in humans
    Sami M Khan
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Yonsei Med J 53:671-9. 2012
    ..Accumulating evidence from proof of concept studies suggests that leptin administration, in replacement doses, may ameliorate neuroendocrine abnormalities in individuals who suffer from these conditions...
  8. pmc Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial
    Nicole M Wedick
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Nutr J 10:93. 2011
    ..The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes...
  9. pmc The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 676 N St Clair st suite 850, Chicago, IL 60611, USA
    BMC Med Genet 12:52. 2011
    ..Our objective was to evaluate tissue expression of FTO in breast and the role of FTO SNPs in predicting breast cancer risk...
  10. pmc Short-term energy deprivation alters activin a and follistatin but not inhibin B levels of lean healthy women in a leptin-independent manner
    Vasiliki A Moragianni
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02130, USA
    J Clin Endocrinol Metab 96:3750-8. 2011
    ..Activin A, inhibin B, and follistatin (FST) also regulate the hypothalamic-pituitary-gonadal axis in humans. It remains unknown whether energy deprivation affects these hormone levels in a leptin-dependent or -independent manner...
  11. pmc Leptin in human physiology and pathophysiology
    Christos S Mantzoros
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Physiol Endocrinol Metab 301:E567-84. 2011
    ..Results from ongoing studies are expected to further increase our understanding of the role of leptin and the potential clinical applications of leptin or its analogs in human therapeutics...
  12. ncbi request reprint Adiponectin: a link between obesity and cancer
    Diana Barb
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Stoneman 816, Boston, MA 02215, USA
    Expert Opin Investig Drugs 15:917-31. 2006
    ....
  13. pmc Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies
    Nicholas Mitsiades
    Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:E2023-8. 2011
    ..Circulating adiponectin has been inversely associated with risk for several malignancies. Its association with thyroid cancer has not yet been evaluated...
  14. pmc Circulating clusterin (apolipoprotein J) levels do not have any day/night variability and are positively associated with total and LDL cholesterol levels in young healthy individuals
    Konstantinos N Aronis
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:E1871-5. 2011
    ..Clusterin has been associated with several pathologies, including cardiovascular disease and neoplasias. However, little is known about its physiology and its association with metabolic and anthropometric parameters in humans...
  15. pmc Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin A and follistatin but not myostatin in healthy males
    Maria T Vamvini
    Division of Endocrinology, Diabetes, and Metabolism, Harvard Medical School and Harvard School of Public Health, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:3416-23. 2011
    ..Little is known, however, about their day/night patterns of secretion and their physiological regulation by energy availability...
  16. pmc Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Pediatrics 123:682-9. 2009
    ....
  17. ncbi request reprint Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relativ
    Jean L Chan
    D Sc, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 90:1625-31. 2005
    ..Further studies are warranted to assess the implications of acquired relative hypoleptinemia and/or r-metHuLeptin administration on the immunosuppression associated with energy- and leptin-deficient states in humans...
  18. ncbi request reprint Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 90:4542-8. 2005
    ..Low adiponectin levels, by regulating insulin resistance and metabolic profile, may contribute to the markedly increased risk of atherosclerosis in diabetic subjects...
  19. pmc Maternal diet and cord blood leptin and adiponectin concentrations at birth
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST816, Boston, MA 02215, USA
    Clin Nutr 29:622-6. 2010
    ....
  20. pmc Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans
    Hyun Seuk Moon
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Mol Cancer Ther 10:2234-43. 2011
    ..These novel mechanistic studies provide for the first time in vitro and ex vivo evidence for a causal role of adiponectin in endometrial cancer...
  21. pmc Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients
    Eun Seok Kang
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 97:E129-35. 2012
    ..Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM...
  22. ncbi request reprint The role of leptin in human obesity and disease: a review of current evidence
    C S Mantzoros
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 130:671-80. 1999
    ..To review recent advances in the pathophysiology and potential clinical applications of leptin, an adipose tissue-derived hormone...
  23. ncbi request reprint Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls
    C S Mantzoros
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cancer 80:523-6. 1999
    ..73-4.21) for the second control-defined tertile and 1.54 (0.46-5.16) for the third control-defined tertile relative to the first. Thus, leptin does not appear to increase the risk of pre-menopausal breast cancer in situ substantially...
  24. ncbi request reprint Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia
    Jennifer H Lee
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Stoneman 816, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 288:E625-32. 2005
    ..We conclude that transcriptional regulation of resistin in WAT does not correlate with circulating resistin levels and that circulating resistin is unlikely to play a major endocrine role in insulin resistance or glycemia in mice...
  25. ncbi request reprint Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 29:1501-5. 2006
    ..The purpose of this study was to examine the associations of dietary fibers and glycemic load with plasma adiponectin in diabetic women and investigate the modification effect of obesity...
  26. doi request reprint Gestational glucose tolerance and cord blood leptin levels predict slower weight gain in early infancy
    Margaret Parker
    Division of Newborn Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Pediatr 158:227-33. 2011
    ..To determine the extent to which known prenatal and perinatal predictors of childhood obesity also predict weight gain in early infancy...
  27. ncbi request reprint Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance
    Lais U Monzillo
    Clinical Research Center, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Obes Res 11:1048-54. 2003
    ..To study the effect of weight loss in response to a lifestyle modification program on the circulating levels of adipose tissue derived cytokines (adipokines) in obese individuals with insulin resistance...
  28. ncbi request reprint Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:335-43. 2004
    ....
  29. ncbi request reprint Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects
    Jennifer H Lee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:4848-56. 2003
    ..We conclude that circulating resistin is unlikely to play a major role in insulin resistance or energy homeostasis in humans...
  30. doi request reprint Absence of relationship between steroid hormone levels and prostate cancer tumor grade
    David J Sher
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Urology 73:356-61; discussion 361-2. 2009
    ..To analyze the relationship between plasma testosterone and estradiol levels on prostate biopsy and radical prostatectomy Gleason scores in a cohort of patients with newly diagnosed prostate cancer...
  31. ncbi request reprint Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes
    Greeshma K Shetty
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Care 27:2450-7. 2004
    ....
  32. ncbi request reprint Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans
    Jean L Chan
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 51:2105-12. 2002
    ..This may have important implications for the biological activity of leptin in disease states associated with abnormal leptin levels (e.g., obesity and anorexia nervosa)...
  33. pmc The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    Jean L Chan
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 111:1409-21. 2003
    ..The role of leptin in normalizing several starvation-induced neuroendocrine changes may have important implications for the pathophysiology and treatment of eating disorders and obesity...
  34. ncbi request reprint Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:4823-31. 2003
    ..Further studies are needed to fully elucidate the physiology of adiponectin in humans and its role in the pathogenesis of insulin-resistant states...
  35. ncbi request reprint Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:2838-43. 2003
    ..These data suggest that adiponectin and sOB-R levels might be influenced by common regulatory factors and challenge the notion that cortisol may have a direct inhibitory effect on adiponectin in humans...
  36. ncbi request reprint Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity
    Dominique D Pierroz
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 51:1337-45. 2002
    ..In conclusion, treatment with a melanocortin agonist is a promising therapeutic approach to DIO and associated insulin resistance...
  37. ncbi request reprint Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns
    Christos Mantzoros
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Eur J Endocrinol 151:741-6. 2004
    ..To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics...
  38. pmc Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function
    Jessica L Fargnoli
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, ST816, Boston, Massachusetts 02115, USA
    Eur J Endocrinol 162:281-8. 2010
    ..It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfunction, and/or insulin secretion or insulinemia...
  39. ncbi request reprint Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides
    John W Bullen
    Beth Israel Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 287:E662-70. 2004
    ..The role of additional molecules discovered by microarray analysis needs to be further explored in the future...
  40. pmc Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes
    Tricia Y Li
    Department of Nutrition, and 4Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 139:1333-8. 2009
    ..These data suggest that frequent nut and peanut butter consumption is associated with a significantly lower CVD risk in women with type 2 diabetes...
  41. ncbi request reprint Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Obesity (Silver Spring) 15:2217-24. 2007
    ....
  42. ncbi request reprint Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes Care 29:207-11. 2006
    ..To evaluate the dietary predictors for the markers of systemic inflammation and endothelial dysfunction in patients with type 2 diabetes...
  43. ncbi request reprint Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice
    John W Bullen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 292:E1079-86. 2007
    ..Thus advanced age and high-fat feeding, both of which are factors that predispose humans to obesity and insulin resistance, are associated with decreasing adiponectin and increasing AdipoR1 and/or AdipoR2 levels...
  44. ncbi request reprint Circulating melanin-concentrating hormone, agouti-related protein, and alpha-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration
    Alina Gavrila
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 90:1047-54. 2005
    ..These findings suggest that serum MCH and possibly AGRP levels could serve as useful peripheral markers of changes in energy homeostasis and thus merit additional investigation...
  45. ncbi request reprint Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training
    Matthias Bluher
    Division of Endocrinology, ST 816, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 91:2310-6. 2006
    ..Adiponectin, an adipocyte-secreted hormone, is associated with insulin resistance and the metabolic syndrome...
  46. ncbi request reprint Adiponectin and breast cancer risk
    Christos Mantzoros
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:1102-7. 2004
    ..Future studies are needed to prove causality and provide further insights into both the mechanisms underlying the actions of this hormone and its potential role in breast cancer...
  47. ncbi request reprint A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes
    Iris Shai
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Diabetes Care 28:1376-82. 2005
    ..Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by adipose tissue and other cells, might play a role in insulin resistance...
  48. ncbi request reprint Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation
    Sarah Crunkhorn
    Research Division, Joslin Diabetes Center, Division of Endocrinology, Department of Medicine and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 282:15439-50. 2007
    ..These data indicate that obesity and saturated fatty acids decrease PGC-1 and mitochondrial gene expression and function via p38 MAPK-dependent transcriptional pathways...
  49. doi request reprint Relationship between serum adiponectin and prostate cancer grade
    David J Sher
    Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA
    Prostate 68:1592-8. 2008
    ..We evaluated the relationship between serum adiponectin and Gleason score (GS) in a prospective series of patients seen in a single institution...
  50. pmc Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women
    Christin Heidemann
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02215, USA
    Circulation 118:230-7. 2008
    ..The impact of overall dietary patterns that reflect actual eating behaviors on mortality caused by cardiovascular or other chronic diseases is largely unknown...
  51. ncbi request reprint Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence
    Diana Barb
    Division of Endocrinology, Diabetes and Metabolism and Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 86:s858-66. 2007
    ..Further studies are needed to fully elucidate the potential role of adiponectin in cancer diagnostics and therapeutics...
  52. ncbi request reprint Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women
    Christin Heidemann
    Harvard School of Public Health, Massachusetts General Hospital, Brigham and Women s Hospital, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 149:307-16. 2008
    ..Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes...
  53. ncbi request reprint Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes
    Catherine J Williams
    Department of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02115, USA
    Diabetes Care 30:1233-40. 2007
    ..We aim to determine whether sleep duration and/or snoring are associated with biomarkers of CVD in women with type 2 diabetes...
  54. ncbi request reprint Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels
    Yuan Yuan Zhang
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Atherosclerosis 191:121-7. 2007
    ..To investigate this hypothesis, we examined the effect of genetic variability at the leptin receptor (LEPR) locus on the plasma levels of fibrinogen and CRP--two markers of inflammation and susceptibility to atherosclerosis...
  55. ncbi request reprint Responsiveness to peripherally administered melanocortins in lean and obese mice
    Susann Bluher
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 53:82-90. 2004
    ....
  56. pmc Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes
    Aoife M Brennan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:926-31. 2009
    ..We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors...
  57. ncbi request reprint Insulin resistance and vascular dysfunction in nondiabetic Asian Indians
    Annaswamy Raji
    Division of Endocrinology, Diabetes, and Metabolism, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 89:3965-72. 2004
    ..These abnormalities may contribute to the increased risk of diabetes and cardiovascular disease in this population...
  58. doi request reprint Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice
    Dae Ho Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02216, USA
    Am J Physiol Endocrinol Metab 302:E552-60. 2012
    ..If these data are confirmed in humans, INT131 could be used for treating type 2 diabetes without loss in bone mass...
  59. ncbi request reprint Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
    Elizabeth Papathanassoglou
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:7745-52. 2006
    ..Taken together, our data further support the notion that nutritional status acting via leptin-dependent mechanisms may alter the nature and vigor of the immune response...
  60. ncbi request reprint Breast-feeding, adipokines, and childhood obesity
    Matthew W Gillman
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 18:730-2. 2007
    ..It is possible that adipokine exposure in infancy determines later weight status, but fundamental research is needed on associations of circulating adipokines with excess weight gain and on determinants of adipokine levels...
  61. pmc Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies
    Joanne Kotsopoulos
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:938-46. 2010
    ..Temporal variability of biomarkers should be evaluated before their use in epidemiologic studies...
  62. pmc Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans
    Janice J Hwang
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:945-51. 2008
    ..Thus, we examined whether amylin and pancreatic polypeptide are regulated by caloric intake and/or short- and long-term energy deprivation and whether any potential regulation is mediated by changes in leptin levels...
  63. pmc Leptin in human physiology and therapeutics
    Tina A Dardeno
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States
    Front Neuroendocrinol 31:377-93. 2010
    ..Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated...
  64. pmc Adverse metabolic and cardiovascular consequences of circadian misalignment
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4453-8. 2009
    ..These findings demonstrate the adverse cardiometabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work...
  65. ncbi request reprint Adherence to healthy eating patterns is associated with higher circulating total and high-molecular-weight adiponectin and lower resistin concentrations in women from the Nurses' Health Study
    Jessica L Fargnoli
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 88:1213-24. 2008
    ..Adherence to a healthy dietary pattern, such as the Alternate Healthy Eating Index (AHEI), is associated with a lower risk of diabetes and atherosclerosis...
  66. ncbi request reprint Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:1688-94. 2005
    ..Because both adiposity and insulin resistance have been associated with risk of colorectal cancer, we hypothesized that adiponectin is associated with colorectal carcinogenesis...
  67. ncbi request reprint Plasma adiponectin concentrations and risk of incident breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Third Floor, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:1510-6. 2007
    ..Therefore, we conducted a prospective case-control study nested within the Nurses' Health Study (NHS) and NHSII cohorts examining the association between plasma adiponectin concentrations and breast cancer risk...
  68. ncbi request reprint Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers
    Barbara E Wolfe
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Endocrinol (Oxf) 61:332-8. 2004
    ..An additional goal was to help clarify the contribution of restricted caloric intake to altered plasma adipokine levels in the eating disorders anorexia nervosa and bulimia nervosa...
  69. ncbi request reprint Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 90:1618-24. 2005
    ..These findings do not support an etiopathogenic role for leptin in proinflammatory states associated with leptin excess such as obesity and have direct relevance for the potential future therapeutic use of r-metHuLeptin in humans...
  70. ncbi request reprint Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Diabetes 55:1512-6. 2006
    ..In conclusion, ADIPOQ promoter polymorphism -11365C-->G was associated with plasma adiponectin levels, whereas polymorphisms -4034A-->C and +276G-->T were associated with CVD risk in diabetic patients...
  71. ncbi request reprint The emerging role of leptin in humans
    Theodore Kelesidis
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Pediatr Endocrinol Rev 3:239-48. 2006
    ..Leptin's potential role in the therapy of several disease states, including hypothalamic amenorrhea, anorexia nervosa and syndromes of insulin resistance is under intensive investigation...
  72. ncbi request reprint Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
    Jennifer H Lee
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Stoneman 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 91:2605-11. 2006
    ..A subset of patients with predominant lipoatrophy has low levels of the adipocyte-secreted hormone leptin...
  73. pmc Independent circadian and sleep/wake regulation of adipokines and glucose in humans
    Steven A Shea
    Medical Chronobiology Program, Brigham and Women s Hospital, Sleep Disorders Research Program at Beth Israel Deaconess Medical Center, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 90:2537-44. 2005
    ....
  74. ncbi request reprint Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells
    Dezheng Zhao
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Biochem 97:1317-27. 2006
    ..Ghrelin may participate in the pathophysiology of colonic inflammation by inducing PKC-dependent NF-kappaB activation and IL-8 production at the colonocyte level...
  75. ncbi request reprint Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:161-4. 2007
    ..These associations did not differ by age, body mass index, or waist-to-hip ratio. Overall, higher levels of insulin and c-peptide were not associated with a higher risk of breast cancer among predominantly premenopausal women...
  76. ncbi request reprint Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy
    Carol L Addy
    Department of Internal Medicine, Endocrinology Hypertension Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:627-36. 2003
    ..Thus, adiponectin replacement may be a potential treatment option to ameliorate the metabolic changes observed in this patient population...
  77. ncbi request reprint Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice
    Susann Bluher
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    Diabetes 53:2787-96. 2004
    ..CNTF(Ax15) has delayed and persistent effects in diet-induced obese C57BL/6J mice, which account for a reduction in body weight over and above what would be expected based on decreased foot intake alone...
  78. pmc Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 59:611-8. 2010
    ....
  79. pmc Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk
    Virginia G Kaklamani
    Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cancer Res 68:3178-84. 2008
    ..89; P(trend) = 0.001). This is the first report of an association between functionally relevant variants of the adiponectin pathway and breast cancer risk. The results warrant further studies of the adiponectin pathway in breast cancer...
  80. pmc Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy-induced metabolic syndrome and lipodystrophy
    Sotiris Tsiodras
    Division of Infectious Diseases, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 58:854-9. 2009
    ..Further clinical studies are needed to confirm our data in different populations and to explore the underlying mechanisms...
  81. doi request reprint Effect of valsartan on left ventricular anatomy and systolic function and aortic elasticity
    Lalita Khaodhiar
    Microcirculation Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Metabolism 58:682-8. 2009
    ..014) in the T2DM patients. Valsartan treatment for 6 months decreased the diameter and wall thickness of the ascending aorta in patients with T2DM, but may decrease AC of the abdominal aorta...
  82. pmc Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Clin Endocrinol Metab 93:2819-27. 2008
    ..Objective: The objective of the study was to determine whether changes in levels of leptin, a key mediator of the adaptation to starvation, regulate the GH-IGF system during energy deficit...
  83. pmc Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study
    Catherine J Williams
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Diabetes Care 31:504-7. 2008
    ..High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations...
  84. pmc Narrative review: the role of leptin in human physiology: emerging clinical applications
    Theodore Kelesidis
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:93-100. 2010
    ..The applications of leptin continue to grow and will hopefully soon be used therapeutically...
  85. pmc Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:8481-6. 2006
    ..Studies involving more severe and/or chronic leptin deficiency are needed to precisely define the lower limit of normal leptin levels for each of leptin's physiologic targets...
  86. ncbi request reprint Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:328-35. 2006
    ....
  87. ncbi request reprint Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays
    Matthias Bluher
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Diabetes Care 30:280-5. 2007
    ..Our objective was to compare total adiponectin with HMW adiponectin as predictors of metabolic variables and insulin sensitivity at both baseline and after an exercise intervention...
  88. pmc Leptin and soluble leptin receptor in follicular fluid
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Assist Reprod Genet 20:495-501. 2003
    ..The relationship between intrafollicular leptin and the soluble leptin receptor, ovarian hormones, and oocyte quality was examined to determine potential factors contributing to this finding...
  89. ncbi request reprint Exercise and vitamin E intake are independently associated with metabolic abnormalities in human immunodeficiency virus-positive subjects: a cross-sectional study
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Infect Dis 36:1593-601. 2003
    ....
  90. ncbi request reprint Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies
    Antje Körner
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 92:1041-8. 2007
    ..Obesity is a major risk factor for breast cancer. We hypothesized that obesity-induced decreases in total and/or high-molecular-weight (HMW) adiponectin levels may underlie this association...
  91. ncbi request reprint Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications
    Aoife M Brennan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST816, Boston, MA 02215, USA
    Nat Clin Pract Endocrinol Metab 2:318-27. 2006
    ..In addition, elucidation of the mechanisms underlying leptin resistance, which characterizes hyperleptinemic states such as human obesity and diabetes, might provide novel therapeutic targets for these prevalent clinical problems...
  92. ncbi request reprint Serum levels of insulin-like growth factor-1 and insulin-like growth factor-1 binding proteins after radical prostatectomy
    Glenn J Bubley
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Urol 168:2249-52. 2002
    ..In fact, it is possible that altered levels of these proteins observed in subjects at risk for prostate cancer are the result of prostate cancer rather than related to its cause...
  93. ncbi request reprint Peptide YY levels are elevated after gastric bypass surgery
    Jean L Chan
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 14:194-8. 2006
    ..Peptide YY (PYY) is a gut-derived hormone with anorectic properties. We sought to determine whether gastric bypass surgery alters PYY levels or response to glucose...
  94. ncbi request reprint The role of the IGF system in cancer: from basic to clinical studies and clinical applications
    Stergios J Moschos
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Oncology 63:317-32. 2002
    ..These data indicate that IGF dysregulation should now be considered as an important independent factor for cancer risk, and a potential target for novel antineoplastic therapies and/or preventative strategies in high-risk groups...
  95. ncbi request reprint Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Clin Endocrinol Metab 92:2307-11. 2007
    ..In addition, the effect of potential variability across different leptin assays on concentration-dependent pharmacokinetic parameters remains unknown...
  96. pmc Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative
    Virginia G Kaklamani
    Division Hematology Oncology, Department of Medicine, Northwestern University, 676 North St Clair Street, Suite 850, Chicago, IL, 60611, USA
    Breast Cancer Res Treat 139:461-8. 2013
    ..As the rates of obesity and diabetes increase in African Americans and Hispanics, adiponectin and its functional SNPs may aid in breast cancer risk assessment...
  97. doi request reprint Early growth and development of later life metabolic disorders
    Joo Pin Foo
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Nestle Nutr Inst Workshop Ser 71:75-84. 2013
    ....
  98. doi request reprint A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones
    Mary Ellen Taplin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 101:1084-9. 2008
    ..To evaluate mifepristone (RU-486) in patients with castration-resistant prostate cancer (CRPC), with a correlative assessment of serum androgens and androgen metabolites..
  99. ncbi request reprint Leptin mediates Clostridium difficile toxin A-induced enteritis in mice
    Andreas Mykoniatis
    Divisions of Gastroenterology and Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Gastroenterology 124:683-91. 2003
    ..We examined the role of leptin in the inflammatory diarrhea induced by toxin A from Clostridium difficile, the causative agent of antibiotic-related colitis...
  100. ncbi request reprint Minimal effect of a low-fat/high soy diet for asymptomatic, hormonally naive prostate cancer patients
    Dimitrios Spentzos
    Divisions of Hematology Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 9:3282-7. 2003
    ..The primary end point was PSA reduction by 50%. Secondary end points were PSA doubling time and time to progression (TTP). Serum was analyzed for changes in the sex hormone and insulin-like growth factor (IGF-I) axes...
  101. pmc Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin
    Konstantinos N Aronis
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston Veterans Affairs Healthcare System, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:E1634-9. 2011
    ..No previous studies exist on pref-1 in women with exercise-induced hypothalamic amenorrhea (HA), which similar to anorexia nervosa, is an energy-deficiency state associated with hypoleptinemia...

Research Grants19

  1. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2011
    ..abstract_text> ..
  2. The Role of Leptin in the Maintenance of a Reduced Body Weight
    Christos S Mantzoros; Fiscal Year: 2010
    ..Understanding the mechanisms and developing effective therapies to combat this phenomenon is of huge public health importance. ..
  3. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos Mantzoros; Fiscal Year: 2007
    ..Thus, findings of this study to elucidate leptin physiology may also have applications in the pathophysiology (and possibly therapeutics) of other leptin related diseases, including obesity, a major public health problem. ..
  4. Clinical trial of leptin for hypothalamic amenorrhea
    Christos Mantzoros; Fiscal Year: 2005
    ..Support is needed to finalize key study design issues, establish collaborative arrangements for a multi-center study, develop an infrastructure for conducting a RCT, and plan subject recruitment strategies. ..
  5. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos Mantzoros; Fiscal Year: 2004
    ....
  6. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2010
    ..abstract_text> ..