JoAnn Manson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint The Women's Health Initiative: the latest findings from long-term follow-up
    JoAnn Manson
    Brigham and Women s Hospital, Harvard Medical School, Harvard School of Public Health, MA, USA
    Womens Health (Lond Engl) 10:125-8. 2014
  2. doi request reprint Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    JAMA 310:1353-68. 2013
  3. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
  4. doi request reprint The kronos early estrogen prevention study
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Womens Health (Lond Engl) 9:9-11. 2013
  5. doi request reprint The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Metabolism 62:S15-9. 2013
  6. pmc The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012
  7. pmc Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98102, USA
    Genome Med 2:48. 2010
  8. pmc Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
  9. pmc Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
    Hiroyuki Katayama
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
    Genome Med 1:47. 2009
  10. pmc Estrogen and progesterone-related gene variants and colorectal cancer risk in women
    Jennifer H Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:78. 2011

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. doi request reprint The Women's Health Initiative: the latest findings from long-term follow-up
    JoAnn Manson
    Brigham and Women s Hospital, Harvard Medical School, Harvard School of Public Health, MA, USA
    Womens Health (Lond Engl) 10:125-8. 2014
    b>JoAnn Manson speaks to Hannah Branch, Commissioning Editor Dr JoAnn Manson is board-certified endocrinologist, epidemiologist and specialist in women's health and preventive medicine...
  2. doi request reprint Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    JAMA 310:1353-68. 2013
    ..Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention...
  3. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
    ..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored...
  4. doi request reprint The kronos early estrogen prevention study
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Womens Health (Lond Engl) 9:9-11. 2013
    ....
  5. doi request reprint The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Metabolism 62:S15-9. 2013
    ..The proposed personalized approach to HT decision making has the potential to improve the quality of health care...
  6. pmc The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012
    ....
  7. pmc Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98102, USA
    Genome Med 2:48. 2010
    ..CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier: NCT00000611...
  8. pmc Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
    ..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated...
  9. pmc Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
    Hiroyuki Katayama
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
    Genome Med 1:47. 2009
    ..CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier: NCT00000611...
  10. pmc Estrogen and progesterone-related gene variants and colorectal cancer risk in women
    Jennifer H Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:78. 2011
    ..Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited...
  11. pmc Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women
    Yiqing Song
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 10:4. 2009
    ..However, it is unclear whether common genetic variation in TRPM6 and TRPM7 contributes to risk of type 2 diabetes...
  12. doi request reprint Prenatal exposure to sex steroid hormones and behavioral/cognitive outcomes
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 57:S16-21. 2008
    ..This article reviews the evidence that early-life exposure to sex steroid hormones contributes to sexually dimorphic behavior and cognitive abilities in humans...
  13. ncbi request reprint Estimating the number of deaths due to obesity: can the divergent findings be reconciled?
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 16:168-76. 2007
  14. pmc Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 17:683-91. 2010
    ..We compared CAC scores after trial completion between women randomized to calcium/vitamin D supplementation and women randomized to placebo...
  15. ncbi request reprint Estrogen therapy and coronary-artery calcification
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 356:2591-602. 2007
    ..We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial...
  16. doi request reprint Pain: sex differences and implications for treatment
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 59:S16-20. 2010
    ..Additional research is needed to clarify the mechanisms for sex differences in pain and to develop new treatment modalities that improve pain management for both men and women...
  17. ncbi request reprint Invited commentary: hormone therapy and risk of coronary heart disease why renew the focus on the early years of menopause?
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 166:511-7. 2007
    ..The reduction in vasomotor symptoms must be weighed against other risks and benefits of treatment, but coronary disease is typically not a major factor in the equation for women who are recently menopausal...
  18. ncbi request reprint Estrogen plus progestin and the risk of coronary heart disease
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 349:523-34. 2003
    ..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)...
  19. ncbi request reprint A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women
    J E Manson
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 341:650-8. 1999
    ..The role of walking, as compared with vigorous exercise, in the prevention of coronary heart disease remains controversial, and data for women on this topic are sparse...
  20. ncbi request reprint Walking compared with vigorous exercise for the prevention of cardiovascular events in women
    JoAnn E Manson
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston 02215, USA
    N Engl J Med 347:716-25. 2002
    ..The role of walking, as compared with vigorous exercise, in the prevention of cardiovascular disease remains controversial. Data for women who are members of minority racial or ethnic groups are particularly sparse...
  21. ncbi request reprint Vasectomy and subsequent cardiovascular disease in US physicians
    J E Manson
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Contraception 59:181-6. 1999
    ..12 (0.94-1.35) for angina/revascularization. These results provide reassuring evidence that vasectomy does not materially increase the risk of subsequent cardiovascular disease, even 15 or more years following the procedure...
  22. ncbi request reprint Sex differences in career progress and satisfaction in an academic medical center
    JoAnn Manson
    Division of Preventative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Am Med Womens Assoc 57:194. 2002
  23. ncbi request reprint Does vitamin E supplementation prevent cardiovascular events?
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Womens Health (Larchmt) 12:123-36. 2003
    ....
  24. doi request reprint Vitamin D and the heart: why we need large-scale clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Cleve Clin J Med 77:903-10. 2010
    ..Recruitment is now under way for the Vitamin D and Omega-3 Trial (VITAL), the first large-scale randomized clinical trial of these nutritional agents for the primary prevention of cancer and cardiovascular disease...
  25. doi request reprint Update in hormone therapy use in menopause
    Hugh S Taylor
    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 96:255-64. 2011
    ..Finally, we discuss new advances in hormone therapy that will likely lead to a more favorable benefit-to-risk ratio, enabling safer effective menopausal symptom relief...
  26. ncbi request reprint C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
    ..Insulin resistance is associated with chronic subclinical inflammation, and both conditions are linked with increased risk for type 2 diabetes mellitus and atherothrombotic cardiovascular disease...
  27. ncbi request reprint Prospective study of major dietary patterns and stroke risk in women
    Teresa T Fung
    Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02115, USA
    Stroke 35:2014-9. 2004
    ..Many foods have been suggested to influence the risk of stroke. However, no previous studies have examined the relationship between overall dietary patterns and risk of stroke...
  28. ncbi request reprint Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Circulation 111:480-7. 2005
    ..To the best of our knowledge, no studies have looked at this association among women. Anxiety may influence CHD mortality by increasing the risk of ventricular arrhythmia and SCD...
  29. pmc Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men
    Thomas S Bowman
    VA Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center MAVERIC, Boston, MA, USA
    Prev Med 45:436-41. 2007
    ..To determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men...
  30. ncbi request reprint Changes in caffeine intake and long-term weight change in men and women
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Cambridge, MA, USA
    Am J Clin Nutr 83:674-80. 2006
    ..The long-term effects of caffeine intake on weight have not been examined prospectively...
  31. ncbi request reprint Association between body mass index and CKD in apparently healthy men
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Kidney Dis 46:871-80. 2005
    ..Conversely, their association with the development of CKD is less clear...
  32. pmc Sweetened beverage consumption and risk of coronary heart disease in women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Am J Clin Nutr 89:1037-42. 2009
    ..Previous studies have linked full-calorie sugar-sweetened beverages (SSBs) with greater weight gain and an increased risk of type 2 diabetes...
  33. ncbi request reprint The association between magnesium intake and fasting insulin concentration in healthy middle-aged women
    Teresa T Fung
    Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02215, USA
    J Am Coll Nutr 22:533-8. 2003
    ..We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women...
  34. ncbi request reprint Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:328-35. 2006
    ....
  35. ncbi request reprint Dietary intake of whole and refined grain breakfast cereals and weight gain in men
    Lydia A Bazzano
    Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts, USA
    Obes Res 13:1952-60. 2005
    ..The aim of this study was to prospectively assess the association between whole and refined grain breakfast cereal intakes and risk of overweight (BMI >or= 25 kg/m(2)) and weight gain...
  36. ncbi request reprint Relation between markers of systemic vascular inflammation and smoking in women
    Edmund A Bermudez
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 89:1117-9. 2002
  37. ncbi request reprint A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  38. ncbi request reprint Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  39. ncbi request reprint Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women
    Edmund A Bermudez
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 22:1668-73. 2002
    ..Interleukin-6 (IL-6) and C-reactive protein (CRP) are markers of systemic vascular inflammation that herald atherothrombosis and may have important interrelationships with traditional cardiovascular risk factors...
  40. ncbi request reprint Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 27:59-65. 2004
    ..Higher intake of magnesium appears to improve glucose and insulin homeostasis; however, there are sparse prospective data on the association between magnesium intake and incidence of type 2 diabetes...
  41. ncbi request reprint Low-carbohydrate-diet score and the risk of coronary heart disease in women
    Thomas L Halton
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 355:1991-2002. 2006
    ..Low-carbohydrate diets have been advocated for weight loss and to prevent obesity, but the long-term safety of these diets has not been determined...
  42. pmc Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women
    Kathryn M Rexrode
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:1749-56. 2007
    ..Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2)...
  43. pmc Bidirectional association between depression and type 2 diabetes mellitus in women
    An Pan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 170:1884-91. 2010
    ..Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting...
  44. ncbi request reprint Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Arch Intern Med 166:357-65. 2006
    ..These trials did not address the role of unopposed estrogen for coronary protection...
  45. ncbi request reprint Dietary patterns, meat intake, and the risk of type 2 diabetes in women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, Mass 02115, USA
    Arch Intern Med 164:2235-40. 2004
    ..To examine the association between major dietary patterns and risk of type 2 diabetes mellitus in a cohort of women...
  46. pmc A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Am J Clin Nutr 88:1602-10. 2008
    ..High homocysteine concentrations may be neurotoxic and contribute to cognitive decline in older persons...
  47. ncbi request reprint Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 15:2051-60. 2007
    ..The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women...
  48. ncbi request reprint Chronic obstructive pulmonary disease, asthma, and risk of type 2 diabetes in women
    Jamal S Rana
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Diabetes Care 27:2478-84. 2004
    ..Increasing evidence points toward a role of inflammation in the pathogenesis of type 2 diabetes. We wanted to determine the relation of COPD and asthma with the development of type 2 diabetes...
  49. pmc FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2472-80. 2008
    ..In conclusion, common genetic variants in the intron 1 of FTO gene may confer a modest susceptibility to obesity in an ethnicity-specific manner, but may be unlikely to contribute to a clinically significant diabetes risk...
  50. pmc Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...
  51. doi request reprint A prospective study of multivitamin supplement use and risk of breast cancer
    Ken Ishitani
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 167:1197-206. 2008
    ....
  52. pmc Low-carbohydrate-diet score and risk of type 2 diabetes in women
    Thomas L Halton
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 87:339-46. 2008
    ..Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known...
  53. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  54. ncbi request reprint Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02215, USA
    Ann Epidemiol 16:105-12. 2006
    ..We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women...
  55. ncbi request reprint A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, BrighamWomen s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes Care 27:2108-15. 2004
    ..The aim of this study was to prospectively assess the relation between red meat intake and incidence of type 2 diabetes...
  56. ncbi request reprint A prospective study of sugar intake and risk of type 2 diabetes in women
    Sok Ja Janket
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 26:1008-15. 2003
    ..The contribution of sugar intake to the pathogenesis of type 2 diabetes has not been settled in the context of primary prevention because of limited prospective data...
  57. ncbi request reprint Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 291:1978-86. 2004
    ..Endothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also precede development of diabetes...
  58. ncbi request reprint Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women
    S Goya Wannamethee
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Arch Intern Med 163:1329-36. 2003
    ..To examine the relationship between alcohol consumption and the incidence of type 2 diabetes mellitus among relatively young and middle-aged women...
  59. ncbi request reprint Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS)
    Peter J Mason
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    Circulation 109:1623-9. 2004
    ..In apparently healthy people, the relation between blood pressure and risk of subsequent cardiovascular disease (CVD) is linear. In persons with CVD, the relation is uncertain...
  60. ncbi request reprint Hemoglobin A1c level and future cardiovascular events among women
    Gavin J Blake
    Cardiovascular Division, The Center for Cardiovascular Disease Prevention, and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 164:757-61. 2004
    ..We sought to test this hypothesis prospectively in a cohort of women without overt cardiovascular disease...
  61. pmc Obesity as compared with physical activity in predicting risk of coronary heart disease in women
    Tricia Y Li
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 113:499-506. 2006
    ..The comparative importance of physical inactivity and obesity as predictors of coronary heart disease (CHD) risk remains unsettled...
  62. pmc Common variants in cardiac ion channel genes are associated with sudden cardiac death
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
    Circ Arrhythm Electrophysiol 3:222-9. 2010
    ....
  63. pmc Measures of obesity and cardiovascular risk among men and women
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 52:605-15. 2008
    ....
  64. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  65. ncbi request reprint Kidney dysfunction, inflammation, and coronary events: a prospective study
    Eric L Knight
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 15:1897-903. 2004
    ..These findings warrant further investigation in other populations...
  66. ncbi request reprint Effects of estrogen plus progestin on health-related quality of life
    Jennifer Hays
    Center for Women s Health, Department of Medicine, Baylor College of Medicine, Houston 77025, USA
    N Engl J Med 348:1839-54. 2003
    ..The Women's Health Initiative (WHI) and other clinical trials indicate that significant health risks are associated with combination hormone use. Less is known about the effect of hormone therapy on health-related quality of life...
  67. ncbi request reprint Adiposity compared with physical inactivity and risk of type 2 diabetes in women
    Jamal S Rana
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Diabetes Care 30:53-8. 2007
    ..The relative contribution of adiposity and physical inactivity to the risk of developing type 2 diabetes remains controversial...
  68. ncbi request reprint Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women
    Tobias Pischon
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 25:1654-8. 2005
    ..Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart disease (CHD) are scarce and controversial...
  69. ncbi request reprint Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:2926-32. 2005
    ..To examine whether and to what extent intakes of calcium and vitamin D are related to the metabolic syndrome in middle-aged or older women...
  70. ncbi request reprint A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 115:1858-65. 2007
    ..We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women...
  71. ncbi request reprint Postmenopausal hormone therapy: new questions and the case for new clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:139-47. 2006
    ....
  72. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  73. pmc Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus
    Manas Kaushik
    Departments of Nutrition, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 90:613-20. 2009
    ..The role of long-chain omega-3 (n-3) fatty acids (LCFAs) in the development of T2DM remains unresolved. Objective: We examined the association between dietary LCFAs and incidence of T2DM in 3 prospective cohorts of women and men...
  74. ncbi request reprint A prospective study of dairy intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 29:1579-84. 2006
    ..Although studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse...
  75. ncbi request reprint Coffee consumption and risk for type 2 diabetes mellitus
    Eduardo Salazar-Martinez
    Harvard School of Public Health, Channing Laboratory, Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Ann Intern Med 140:1-8. 2004
    ..In small, short-term studies, acute administration of caffeine decreases insulin sensitivity and impairs glucose tolerance...
  76. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  77. ncbi request reprint Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    JAMA 288:980-7. 2002
    ..Several inflammatory biomarkers, including CRP, are associated with increased cardiovascular risk. However, whether the effect of HRT on CRP represents a clinical hazard is unknown...
  78. ncbi request reprint Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study
    Christine M Albert
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Intern Med 162:1382-7. 2002
    ..Since components of nuts may have antiarrhythmic properties, part of the benefit may be due to a reduction in sudden cardiac death...
  79. ncbi request reprint Is C-reactive protein specific for vascular disease in women?
    Nader Rifai
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 136:529-33. 2002
    ..C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic individuals. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain...
  80. pmc Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women
    Melissa E Weinberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Metabolism 55:1473-80. 2006
    ..7 kg/m2. An androgenic hormone profile is associated with both the individual components of the metabolic syndrome and clustering of metabolic abnormalities in postmenopausal women...
  81. ncbi request reprint A prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes
    Biljana Miljanovic
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes 53:2883-92. 2004
    ..Lipid-lowering treatment among type 1 diabetic subjects, recommended to prevent cardiovascular disease, may also decrease risk of CSME, an important cause of vision loss...
  82. pmc Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial
    Julie Lin
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2338-43. 2008
    ..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation...
  83. pmc Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 30:1747-52. 2007
    ..However, prospective data regarding its relation to diabetes risk in ethnically diverse populations are limited...
  84. ncbi request reprint Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase
    Joline W J Beulens
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 56:2388-94. 2007
    ..We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes...
  85. doi request reprint Sexual satisfaction and cardiovascular disease: the Women's Health Initiative
    Jennifer S McCall-Hosenfeld
    VA Boston Healthcare System, Boston, MA, USA
    Am J Med 121:295-301. 2008
    ..We investigated whether dissatisfaction with sexual activity, a domain of female sexual dysfunction, is associated with prevalent and incident cardiovascular disease in postmenopausal women...
  86. ncbi request reprint Inflammatory markers and the risk of coronary heart disease in men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:2599-610. 2004
    ..The value of these inflammatory markers as independent predictors remains controversial...
  87. ncbi request reprint Long-term aspirin use and mortality in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 0214, USA
    Arch Intern Med 167:562-72. 2007
    ..The influence of long-term use of aspirin on total mortality in women remains uncertain...
  88. ncbi request reprint Potato and french fry consumption and risk of type 2 diabetes in women
    Thomas L Halton
    Department of Nutrition and Epidemiology, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 83:284-90. 2006
    ..Potatoes, a high glycemic form of carbohydrate, are hypothesized to increase insulin resistance and risk of type 2 diabetes...
  89. pmc Low dose aspirin and cognitive function in the women's health study cognitive cohort
    Jae Hee Kang
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMJ 334:987. 2007
    ..To determine whether low dose aspirin protects women aged 65 or more against cognitive decline...
  90. ncbi request reprint Depressive symptoms and risk of type 2 diabetes in women
    Cassandra Arroyo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 27:129-33. 2004
    ..To explore the relationship between depressive symptoms and incidence of type 2 diabetes in women...
  91. ncbi request reprint A randomized trial of vitamin E supplementation and cognitive function in women
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 166:2462-8. 2006
    ..Oxidative stress may play a key role in the development of cognitive impairment. Long-term supplementation with vitamin E, a strong antioxidant, may provide cognitive benefits...
  92. pmc Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort
    Cathy C Lee
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Clin Chem 55:351-60. 2009
    ....
  93. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  94. ncbi request reprint Iron intake and the risk of type 2 diabetes in women: a prospective cohort study
    Swapnil Rajpathak
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes Care 29:1370-6. 2006
    ..Epidemiological studies suggest that high body iron stores are associated with insulin resistance and type 2 diabetes. The aim of this study was to evaluate the association between dietary intake of iron and the risk of type 2 diabetes...
  95. ncbi request reprint Glycemic index, glycemic load, and risk of type 2 diabetes
    Walter Willett
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:274S-80S. 2002
    ....
  96. ncbi request reprint Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational Study
    Robert D Langer
    Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0978, La Jolla, CA 92093 0978, USA
    Thromb Haemost 93:1108-16. 2005
    ..Some associations differed between women with and without incident CHD, especially for EP, where inflammatory and thrombotic markers were higher in cases. These associations remain speculative pending confirmation in randomized trials...
  97. pmc Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative
    Ian H De Boer
    Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Diabetes Care 31:701-7. 2008
    ..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women...
  98. doi request reprint Genetic variation of the androgen receptor and risk of myocardial infarction and ischemic stroke in women
    Kathryn M Rexrode
    Stroke 39:1590-2. 2008
    ..Some studies suggest an association between AR gene variation and risk of cardiovascular disease (CVD) in men; however, the relationship has not been examined in women...
  99. ncbi request reprint Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality
    Jorg Muntwyler
    Department of Internal Medicine, University Hospital of Zurich, Switzerland
    Arch Intern Med 162:1472-6. 2002
    ..Although basic research suggests that vitamins may have an important role in the prevention of cardiovascular diseases (CVD), the data from cohort studies and clinical trials are inconclusive...
  100. ncbi request reprint Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Barbara V Howard
    MedStar Research Institute Howard University, Washington, DC, USA
    JAMA 295:655-66. 2006
    ..Multiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed...
  101. ncbi request reprint Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
    ..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...