JoAnn Manson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Metabolism 62:S15-9. 2013
  2. ncbi The kronos early estrogen prevention study
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Womens Health (Lond Engl) 9:9-11. 2013
  3. ncbi The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012
  4. ncbi Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98102, USA
    Genome Med 2:48. 2010
  5. ncbi Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
  6. ncbi Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
    Hiroyuki Katayama
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
    Genome Med 1:47. 2009
  7. ncbi Estrogen and progesterone-related gene variants and colorectal cancer risk in women
    Jennifer H Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:78. 2011
  8. ncbi Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women
    Yiqing Song
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 10:4. 2009
  9. ncbi Invited commentary: hormone therapy and risk of coronary heart disease why renew the focus on the early years of menopause?
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 166:511-7. 2007
  10. ncbi Estrogen plus progestin and the risk of coronary heart disease
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 349:523-34. 2003

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Metabolism 62:S15-9. 2013
    ..The proposed personalized approach to HT decision making has the potential to improve the quality of health care...
  2. ncbi The kronos early estrogen prevention study
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Womens Health (Lond Engl) 9:9-11. 2013
    ....
  3. ncbi The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012
    ....
  4. ncbi Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98102, USA
    Genome Med 2:48. 2010
    ..CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier: NCT00000611...
  5. ncbi Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
    ..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated...
  6. ncbi Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
    Hiroyuki Katayama
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
    Genome Med 1:47. 2009
    ..CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier: NCT00000611...
  7. ncbi Estrogen and progesterone-related gene variants and colorectal cancer risk in women
    Jennifer H Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:78. 2011
    ..Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited...
  8. ncbi Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women
    Yiqing Song
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 10:4. 2009
    ..However, it is unclear whether common genetic variation in TRPM6 and TRPM7 contributes to risk of type 2 diabetes...
  9. ncbi Invited commentary: hormone therapy and risk of coronary heart disease why renew the focus on the early years of menopause?
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 166:511-7. 2007
    ..The reduction in vasomotor symptoms must be weighed against other risks and benefits of treatment, but coronary disease is typically not a major factor in the equation for women who are recently menopausal...
  10. ncbi Estrogen plus progestin and the risk of coronary heart disease
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 349:523-34. 2003
    ..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)...
  11. ncbi Estimating the number of deaths due to obesity: can the divergent findings be reconciled?
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 16:168-76. 2007
  12. ncbi Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 17:683-91. 2010
    ..We compared CAC scores after trial completion between women randomized to calcium/vitamin D supplementation and women randomized to placebo...
  13. ncbi Estrogen therapy and coronary-artery calcification
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 356:2591-602. 2007
    ..We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial...
  14. ncbi Prenatal exposure to sex steroid hormones and behavioral/cognitive outcomes
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 57:S16-21. 2008
    ..This article reviews the evidence that early-life exposure to sex steroid hormones contributes to sexually dimorphic behavior and cognitive abilities in humans...
  15. ncbi Does vitamin E supplementation prevent cardiovascular events?
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Womens Health (Larchmt) 12:123-36. 2003
    ....
  16. ncbi Sex differences in career progress and satisfaction in an academic medical center
    JoAnn Manson
    Division of Preventative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Am Med Womens Assoc 57:194. 2002
  17. ncbi A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women
    J E Manson
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 341:650-8. 1999
    ..The role of walking, as compared with vigorous exercise, in the prevention of coronary heart disease remains controversial, and data for women on this topic are sparse...
  18. ncbi Vasectomy and subsequent cardiovascular disease in US physicians
    J E Manson
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Contraception 59:181-6. 1999
    ..12 (0.94-1.35) for angina/revascularization. These results provide reassuring evidence that vasectomy does not materially increase the risk of subsequent cardiovascular disease, even 15 or more years following the procedure...
  19. ncbi Walking compared with vigorous exercise for the prevention of cardiovascular events in women
    JoAnn E Manson
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston 02215, USA
    N Engl J Med 347:716-25. 2002
    ..The role of walking, as compared with vigorous exercise, in the prevention of cardiovascular disease remains controversial. Data for women who are members of minority racial or ethnic groups are particularly sparse...
  20. ncbi Vitamin D and the heart: why we need large-scale clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Cleve Clin J Med 77:903-10. 2010
    ..Recruitment is now under way for the Vitamin D and Omega-3 Trial (VITAL), the first large-scale randomized clinical trial of these nutritional agents for the primary prevention of cancer and cardiovascular disease...
  21. ncbi Pain: sex differences and implications for treatment
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 59:S16-20. 2010
    ..Additional research is needed to clarify the mechanisms for sex differences in pain and to develop new treatment modalities that improve pain management for both men and women...
  22. ncbi Update in hormone therapy use in menopause
    Hugh S Taylor
    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 96:255-64. 2011
    ..Finally, we discuss new advances in hormone therapy that will likely lead to a more favorable benefit-to-risk ratio, enabling safer effective menopausal symptom relief...
  23. ncbi C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, 900 Commonwealth Ave E, Boston, Mass 02215-1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
    ..These data provide additional support for previously reported associations between subclinical inflammation and the risk of type 2 diabetes and cardiovascular disease...
  24. ncbi Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Circulation 111:480-7. 2005
    ..To the best of our knowledge, no studies have looked at this association among women. Anxiety may influence CHD mortality by increasing the risk of ventricular arrhythmia and SCD...
  25. ncbi Prospective study of major dietary patterns and stroke risk in women
    Teresa T Fung
    Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02115, USA
    Stroke 35:2014-9. 2004
    ..Many foods have been suggested to influence the risk of stroke. However, no previous studies have examined the relationship between overall dietary patterns and risk of stroke...
  26. ncbi Changes in caffeine intake and long-term weight change in men and women
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Cambridge, MA, USA
    Am J Clin Nutr 83:674-80. 2006
    ..001). CONCLUSION: Increases in caffeine intake may lead to a small reduction in long-term weight gain...
  27. ncbi Sweetened beverage consumption and risk of coronary heart disease in women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Am J Clin Nutr 89:1037-42. 2009
    ..Previous studies have linked full-calorie sugar-sweetened beverages (SSBs) with greater weight gain and an increased risk of type 2 diabetes...
  28. ncbi Association between body mass index and CKD in apparently healthy men
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02120, USA
    Am J Kidney Dis 46:871-80. 2005
    ..06 to 1.53). CONCLUSION: In this large cohort of initially healthy men, BMI was associated significantly with increased risk for CKD after 14 years. Strategies to decrease CKD risk might include prevention of overweight and obesity...
  29. ncbi The association between magnesium intake and fasting insulin concentration in healthy middle-aged women
    Teresa T Fung
    Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02215, USA
    J Am Coll Nutr 22:533-8. 2003
    ..We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women...
  30. ncbi Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men
    Thomas S Bowman
    VA Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center MAVERIC, Boston, MA, USA
    Prev Med 45:436-41. 2007
    ..To determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men...
  31. ncbi Dietary intake of whole and refined grain breakfast cereals and weight gain in men
    Lydia A Bazzano
    Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts, USA
    Obes Res 13:1952-60. 2005
    ..78 and 0.88; 95% confidence interval, 0.67 to 0.91 and 0.76 to 1.00, respectively). DISCUSSION: BMI and weight gain were inversely associated with intake of breakfast cereals, independently of other risk factors...
  32. ncbi Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:328-35. 2006
    ..Close adherence to a Mediterranean-type diet is associated with higher adiponectin concentrations...
  33. ncbi Relation between markers of systemic vascular inflammation and smoking in women
    Edmund A Bermudez
    Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts, USA
    Am J Cardiol 89:1117-9. 2002
  34. ncbi Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  35. ncbi A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ....
  36. ncbi Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 27:59-65. 2004
    ..5 pmol/l among those at the highest quartile (P = 0.03 for trend). CONCLUSIONS: These findings support a protective role of higher intake of magnesium in reducing the risk of developing type 2 diabetes, especially in overweight women...
  37. ncbi Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women
    Edmund A Bermudez
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 22:1668-73. 2002
    ..Interleukin-6 (IL-6) and C-reactive protein (CRP) are markers of systemic vascular inflammation that herald atherothrombosis and may have important interrelationships with traditional cardiovascular risk factors...
  38. ncbi Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Arch Intern Med 166:357-65. 2006
    ..These trials did not address the role of unopposed estrogen for coronary protection...
  39. ncbi Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women
    Kathryn M Rexrode
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:1749-56. 2007
    ..Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2)...
  40. ncbi Dietary patterns, meat intake, and the risk of type 2 diabetes in women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, Mass 02115, USA
    Arch Intern Med 164:2235-40. 2004
    ..To examine the association between major dietary patterns and risk of type 2 diabetes mellitus in a cohort of women...
  41. ncbi Bidirectional association between depression and type 2 diabetes mellitus in women
    An Pan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 170:1884-91. 2010
    ..Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting...
  42. ncbi Low-carbohydrate-diet score and the risk of coronary heart disease in women
    Thomas L Halton
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 355:1991-2002. 2006
    ..When vegetable sources of fat and protein are chosen, these diets may moderately reduce the risk of coronary heart disease...
  43. ncbi A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Am J Clin Nutr 88:1602-10. 2008
    ..High homocysteine concentrations may be neurotoxic and contribute to cognitive decline in older persons...
  44. ncbi Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 15:2051-60. 2007
    ..The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women...
  45. ncbi Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...
  46. ncbi Low-carbohydrate-diet score and risk of type 2 diabetes in women
    Thomas L Halton
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 87:339-46. 2008
    ..Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known...
  47. ncbi A prospective study of multivitamin supplement use and risk of breast cancer
    Ken Ishitani
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 167:1197-206. 2008
    ....
  48. ncbi Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  49. ncbi FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2472-80. 2008
    ..In conclusion, common genetic variants in the intron 1 of FTO gene may confer a modest susceptibility to obesity in an ethnicity-specific manner, but may be unlikely to contribute to a clinically significant diabetes risk...
  50. ncbi Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 291:1978-86. 2004
    ..Endothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also precede development of diabetes...
  51. ncbi A prospective study of sugar intake and risk of type 2 diabetes in women
    Sok-Ja Janket
    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 26:1008-15. 2003
    ..These prospective data support the recent American Diabetes Association's guideline that a moderate amount of sugar can be incorporated in a healthy diet...
  52. ncbi Chronic obstructive pulmonary disease, asthma, and risk of type 2 diabetes in women
    Jamal S Rana
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Diabetes Care 27:2478-84. 2004
    ..Differences in the inflammation and cytokine profile between COPD and asthma might explain why COPD, but not asthma, is associated with increased risk of type 2 diabetes...
  53. ncbi Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA 02215, USA
    Ann Epidemiol 16:105-12. 2006
    ..CONCLUSIONS: SHBG and total testosterone were inversely associated with CRP among HT nonusers in this study. The relationship between SHBG and CRP was more strongly inverse among leaner women...
  54. ncbi A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, BrighamWomen's Hospital, Harvard Medical School, 900 Commonwealth Ave. East, Boston, MA 02215, USA
    Diabetes Care 27:2108-15. 2004
    ..CONCLUSIONS: Our data indicate that higher consumption of total red meat, especially various processed meats, may increase risk of developing type 2 diabetes in women...
  55. ncbi Obesity as compared with physical activity in predicting risk of coronary heart disease in women
    Tricia Y Li
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 113:499-506. 2006
    ..CONCLUSIONS: Obesity and physical inactivity independently contribute to the development of CHD in women. These data underscore the importance of both maintaining a healthy weight and regular physical activity in preventing CHD...
  56. ncbi Hemoglobin A1c level and future cardiovascular events among women
    Gavin J Blake
    Cardiovascular Division, The Center for Cardiovascular Disease Prevention, and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 164:757-61. 2004
    ..We sought to test this hypothesis prospectively in a cohort of women without overt cardiovascular disease...
  57. ncbi Kidney dysfunction, inflammation, and coronary events: a prospective study
    Eric L Knight
    Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 15:1897-903. 2004
    ..These findings warrant further investigation in other populations...
  58. ncbi Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS)
    Peter J Mason
    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02215-1204, USA
    Circulation 109:1623-9. 2004
    ..CONCLUSIONS: In this population of women with CVD, we observed a strong, continuous, and linear association between SBP and risk of secondary CVD events. SBP was the blood pressure measure most strongly related to CVD risk...
  59. ncbi Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women
    Tobias Pischon
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 25:1654-8. 2005
    ..Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart disease (CHD) are scarce and controversial...
  60. ncbi Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:2926-32. 2005
    ..To examine whether and to what extent intakes of calcium and vitamin D are related to the metabolic syndrome in middle-aged or older women...
  61. ncbi Common variants in cardiac ion channel genes are associated with sudden cardiac death
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
    Circ Arrhythm Electrophysiol 3:222-9. 2010
    ....
  62. ncbi A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 115:1858-65. 2007
    ..We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women...
  63. ncbi Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women
    S Goya Wannamethee
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Arch Intern Med 163:1329-36. 2003
    ..To examine the relationship between alcohol consumption and the incidence of type 2 diabetes mellitus among relatively young and middle-aged women...
  64. ncbi Adiposity compared with physical inactivity and risk of type 2 diabetes in women
    Jamal S Rana
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Diabetes Care 30:53-8. 2007
    ..The relative contribution of adiposity and physical inactivity to the risk of developing type 2 diabetes remains controversial...
  65. ncbi Effects of estrogen plus progestin on health-related quality of life
    Jennifer Hays
    Center for Women s Health, Department of Medicine, Baylor College of Medicine, Houston 77025, USA
    N Engl J Med 348:1839-54. 2003
    ..The Women's Health Initiative (WHI) and other clinical trials indicate that significant health risks are associated with combination hormone use. Less is known about the effect of hormone therapy on health-related quality of life...
  66. ncbi Postmenopausal hormone therapy: new questions and the case for new clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:139-47. 2006
    ....
  67. ncbi Measures of obesity and cardiovascular risk among men and women
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 52:605-15. 2008
    ....
  68. ncbi Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  69. ncbi Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial
    Julie Lin
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2338-43. 2008
    ..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation...
  70. ncbi Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  71. ncbi Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus
    Manas Kaushik
    Departments of Nutrition, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 90:613-20. 2009
    ..The role of long-chain omega-3 (n-3) fatty acids (LCFAs) in the development of T2DM remains unresolved. Objective: We examined the association between dietary LCFAs and incidence of T2DM in 3 prospective cohorts of women and men...
  72. ncbi Coffee consumption and risk for type 2 diabetes mellitus
    Eduardo Salazar-Martinez
    Harvard School of Public Health, Channing Laboratory, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts 02215, USA
    Ann Intern Med 140:1-8. 2004
    ..CONCLUSIONS: These data suggest that long-term coffee consumption is associated with a statistically significantly lower risk for type 2 diabetes...
  73. ncbi Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215-1204, USA
    JAMA 288:980-7. 2002
    ..However, use or nonuse of HRT had less importance as a predictor of cardiovascular risk than did baseline levels of either CRP or IL-6...
  74. ncbi Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study
    Christine M Albert
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Intern Med 162:1382-7. 2002
    ..Since components of nuts may have antiarrhythmic properties, part of the benefit may be due to a reduction in sudden cardiac death...
  75. ncbi Is C-reactive protein specific for vascular disease in women?
    Nader Rifai
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 136:529-33. 2002
    ..C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic individuals. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain...
  76. ncbi Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  77. ncbi A prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes
    Biljana Miljanovic
    Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Ave. East, Boston, MA 02215, USA
    Diabetes 53:2883-92. 2004
    ..Lipid-lowering treatment among type 1 diabetic subjects, recommended to prevent cardiovascular disease, may also decrease risk of CSME, an important cause of vision loss...
  78. ncbi A prospective study of dairy intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 29:1579-84. 2006
    ..Although studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse...
  79. ncbi Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women
    Melissa E Weinberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Metabolism 55:1473-80. 2006
    ..7 kg/m2. An androgenic hormone profile is associated with both the individual components of the metabolic syndrome and clustering of metabolic abnormalities in postmenopausal women...
  80. ncbi Potato and french fry consumption and risk of type 2 diabetes in women
    Thomas L Halton
    Department of Nutrition and Epidemiology, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 83:284-90. 2006
    ..CONCLUSIONS: Our findings suggest a modest positive association between the consumption of potatoes and the risk of type 2 diabetes in women. This association was more pronounced when potatoes were substituted for whole grains...
  81. ncbi Long-term aspirin use and mortality in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 0214, USA
    Arch Intern Med 167:562-72. 2007
    ..The influence of long-term use of aspirin on total mortality in women remains uncertain...
  82. ncbi Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 30:1747-52. 2007
    ..However, prospective data regarding its relation to diabetes risk in ethnically diverse populations are limited...
  83. ncbi Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase
    Joline W J Beulens
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 56:2388-94. 2007
    ..We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes...
  84. ncbi Sexual satisfaction and cardiovascular disease: the Women's Health Initiative
    Jennifer S McCall-Hosenfeld
    VA Boston Healthcare System, Boston, MA, USA
    Am J Med 121:295-301. 2008
    ..We investigated whether dissatisfaction with sexual activity, a domain of female sexual dysfunction, is associated with prevalent and incident cardiovascular disease in postmenopausal women...
  85. ncbi Inflammatory markers and the risk of coronary heart disease in men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:2599-610. 2004
    ..Although plasma lipid levels were more strongly associated with an increased risk than were inflammatory markers, the level of C-reactive protein remained a significant contributor to the prediction of coronary heart disease...
  86. ncbi Low dose aspirin and cognitive function in the women's health study cognitive cohort
    Jae Hee Kang
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMJ 334:987. 2007
    ..To determine whether low dose aspirin protects women aged 65 or more against cognitive decline...
  87. ncbi A randomized trial of vitamin E supplementation and cognitive function in women
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 166:2462-8. 2006
    ..Oxidative stress may play a key role in the development of cognitive impairment. Long-term supplementation with vitamin E, a strong antioxidant, may provide cognitive benefits...
  88. ncbi Depressive symptoms and risk of type 2 diabetes in women
    Cassandra Arroyo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 27:129-33. 2004
    ..To explore the relationship between depressive symptoms and incidence of type 2 diabetes in women...
  89. ncbi Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort
    Cathy C Lee
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Clin Chem 55:351-60. 2009
    ....
  90. ncbi Iron intake and the risk of type 2 diabetes in women: a prospective cohort study
    Swapnil Rajpathak
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes Care 29:1370-6. 2006
    ..Epidemiological studies suggest that high body iron stores are associated with insulin resistance and type 2 diabetes. The aim of this study was to evaluate the association between dietary intake of iron and the risk of type 2 diabetes...
  91. ncbi Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  92. ncbi Glycemic index, glycemic load, and risk of type 2 diabetes
    Walter Willett
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:274S-80S. 2002
    ....
  93. ncbi Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational Study
    Robert D Langer
    Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0978, La Jolla, CA 92093 0978, USA
    Thromb Haemost 93:1108-16. 2005
    ..Some associations differed between women with and without incident CHD, especially for EP, where inflammatory and thrombotic markers were higher in cases. These associations remain speculative pending confirmation in randomized trials...
  94. ncbi Dietary patterns and changes in body weight in women
    Matthias B Schulze
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Epidemiology, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Obesity (Silver Spring) 14:1444-53. 2006
    ..Our objective was to examine the association between adherence to dietary patterns and weight change in women...
  95. ncbi Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality
    Jorg Muntwyler
    Department of Internal Medicine, University Hospital of Zurich, Switzerland
    Arch Intern Med 162:1472-6. 2002
    ..Data from ongoing large randomized trials will be necessary to definitely establish small potential benefits of vitamin supplements on subsequent cardiovascular risk...
  96. ncbi Dietary pattern, inflammation, and incidence of type 2 diabetes in women
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Clin Nutr 82:675-84; quiz 714-5. 2005
    ..Inflammation is considered a key mechanism leading to type 2 diabetes, but dietary exposures that lead to inflammation and diabetes are largely unknown...
  97. ncbi Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    JAMA 295:629-42. 2006
    ..The hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial...
  98. ncbi Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
    ..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
  99. ncbi Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study
    Karen L Margolis
    Hennepin County Medical Center, and Berman Center for Outcomes and Clinical Research, 825 S Eighth Street, Minneapolis, MN 55404, USA
    Arch Intern Med 165:500-8. 2005
    ..Our objective was to describe the relation between the baseline white blood cell (WBC) count and future CVD events and mortality in postmenopausal women...
  100. ncbi Genetic variation of the androgen receptor and risk of myocardial infarction and ischemic stroke in women
    Kathryn M Rexrode
    Stroke 39:1590-2. 2008
    ..CONCLUSIONS: No association between AR genetic variation, as measured by haplotype-tagging single nucleotide polymorphisms and CAG repeat number, and risk of CVD was observed in women...
  101. ncbi Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Barbara V Howard
    MedStar Research Institute Howard University, Washington, DC, USA
    JAMA 295:655-66. 2006
    ..Multiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed...