Research Topics
| K G MansfieldSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Quantitative molecular assessment of chimerism across tissues in marmosets and tamarinsCarolyn G Sweeney
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
BMC Genomics 13:98. 2012..This has raised the intriguing possibility that chimerism may play an increasingly pervasive role in marmoset biology, ranging from natural behavioral implications to increased variability and complexity in biomedical studies...- Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapyBrigitte E Sanders-Beer
Southern Research Institute, Frederick, MD, USA
AIDS Res Ther 8:3. 2011..abstract:.. 
Enteropathogenic Escherichia coli and ulcerative colitis in cotton-top tamarins (Saguinus oedipus)K G Mansfield
New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772 9012, USA
J Infect Dis 184:803-7. 2001..0% vs. 27.2%; P<.005, chi(2) test) and higher histological scores of colonic inflammation (0.875 vs. 0.455, respectively; P<.05, Mann-Whitney rank sum test)...- Viral tropism and the pathogenesis of influenza in the Mammalian hostKeith G Mansfield
Harvard Medical School, 1 Pine Hill Dr, Southborough, MA 01772, USA
Am J Pathol 171:1089-92. 2007 - Workshop summary: detection, impact, and control of specific pathogens in animal resource facilitiesKeith G Mansfield
Division of Primate Resources, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9012, USA
ILAR J 51:171-9. 2010..This manuscript summarizes the presentations and conclusions of participants at the meeting; abstracts and a full conference report are available online (www.ncrr.nih.gov)... - Identification of enteropathogenic Escherichia coli in simian immunodeficiency virus-infected infant and adult rhesus macaquesK G Mansfield
Harvard Medical School, New England Regional Primate Research Center, P O Box 9102, Southborough, MA 01772 9012, USA
J Clin Microbiol 39:971-6. 2001..Further investigations with rhesus macaques may offer opportunities to study the impact of EPEC on AIDS pathogenesis and gastrointestinal dysfunction... - Induction of disseminated Mycobacterium avium in simian AIDS is dependent upon simian immunodeficiency virus strain and defective granuloma formationK G Mansfield
New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772 9012, USA
Am J Pathol 159:693-702. 2001.... - A diet high in saturated fat and cholesterol accelerates simian immunodeficiency virus disease progressionKeith G Mansfield
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Infect Dis 196:1202-10. 2007..Our findings may have important implications for HIV-infected individuals, because they suggest that dietary changes and manipulation of lipid metabolism could offer potential benefits by slowing disease progression... - Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivoR S Veazey
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 74:57-64. 2000..This finding suggests that SIV and, presumably, human immunodeficiency virus specifically infect, replicate in, and eliminate definable subsets of CD4(+) T cells in vivo... - Identification of an Enterocytozoon bieneusi-like microsporidian parasite in simian-immunodeficiency-virus-inoculated macaques with hepatobiliary diseaseK G Mansfield
New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Am J Pathol 150:1395-405. 1997..bieneusi of human origin. Extensive morphological and genetic similarities between the simian and human enterocytozoons suggest that experimentally infected macaques may serve as a useful model of microsporidial infection in AIDS... - Localization of persistent Enterocytozoon bieneusi infection in normal rhesus macaques (Macaca mulatta) to the hepatobiliary treeK G Mansfield
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Clin Microbiol 36:2336-8. 1998..In six of seven normal rhesus animals, E. bieneusi was detected by PCR in bile obtained through percutaneous cholecystocentesis but not by in situ hybridization performed on endoscopic biopsies of duodenum and proximal jejunum... - Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239Bin Jia
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
PLoS Pathog 5:e1000272. 2009.... - DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memoryMariana Manrique
Department of Medicine, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
AIDS Res Hum Retroviruses 24:505-19. 2008.... - Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeysSampa Santra
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:324-8. 2010.... 
Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccinationM Manrique
Department of Medicine, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts, USA
Mucosal Immunol 2:536-50. 2009....- Emergence and kinetics of simian immunodeficiency virus-specific CD8(+) T cells in the intestines of macaques during primary infectionR S Veazey
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 75:10515-9. 2001.... - Enterocytozoon bieneusi as a cause of proliferative serositis in simian immunodeficiency virus-infected immunodeficient macaques (Macaca mulatta)L V Chalifoux
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772 9012, USA
Arch Pathol Lab Med 124:1480-4. 2000..As in humans, E bieneusi frequently causes enteropathy and cholangiohepatitis in immunodeficient simian immunodeficiency virus (SIV)-infected macaques... - Simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeysJ E Schmitz
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Blood 98:3757-61. 2001..The present studies suggest that the CD8(+) CTL response in GI mucosal sites is comparable to that seen systemically in SIVmac-infected rhesus monkeys... - Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primatesFrederic M N Bertley
Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:3745-57. 2004..Taken together, these data indicate that nasal vaccination with SHIV-DNA plus IL-2/Ig DNA and rMVA can provide significant protection from disease progression... - Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:3643-50. 2008..This robust viral-specific cellular immune response in breast milk may contribute to control of breast milk virus replication... - Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery systemDavid T Evans
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772-9102, USA
J Virol 77:2400-9. 2003..Nevertheless, this study demonstrates the potential of mucosal priming by the Salmonella type III secretion system to direct SIV-specific cellular immune responses to the gastrointestinal mucosa in a primate model... - Systemic spironucleosis in 2 immunodeficient rhesus macaques (Macaca mulatta)C Bailey
Harvard Medical School, Department of Pathology, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA
Vet Pathol 47:488-94. 2010..This report is the first of extraintestinal infection with Spironucleus sp in higher mammals and expands the list of opportunistic infections found in immunocompromised rhesus macaques... - Viral and host correlates of serum resistin in simian AIDSL M Wachtman
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772, USA
AIDS Res Hum Retroviruses 24:34-42. 2008.... - Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infectionR S Veazey
Division of Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 74:11001-7. 2000..These findings suggest that chemokine receptor usage determines which cells are targeted for SIV infection and elimination in vivo... - Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus)A D Miller
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01760, USA
Vet Pathol 47:969-76. 2010..The tumors described in this population illustrate comparable features to human cases of small intestine carcinoma and may serve as a potential animal model for small intestinal carcinomas... - Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeysJinyan Liu
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 457:87-91. 2009..These findings have important implications for the development of next-generation T-cell-based vaccine candidates for HIV-1... - Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Infect Dis 190:998-1005. 2004.... - Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol dietJennifer H Yearley
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Lab Invest 89:657-67. 2009.... - Epizootic myocarditis associated with encephalomyocarditis virus in a group of rhesus macaques (Macaca mulatta)K Masek-Hammerman
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Vet Pathol 49:386-92. 2012..Encephalomyocarditis virus should be considered as a differential etiology in outbreaks of myocarditis and pulmonary edema in juvenile primates... - Necrotizing meningoencephalitis and pneumonitis in a simian immunodeficiency virus-infected rhesus macaque due to AcanthamoebaS V Westmoreland
Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
Vet Pathol 41:398-404. 2004..Although not previously reported, the potential transmission to humans, either through environmental contamination or contact with an infected animal, makes this disease a threat to laboratory animal care staff and pathologists... - Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccinationDavid R Kaufman
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 181:4188-98. 2008..Thus, i.m. vaccination can overcome immune compartmentalization and generate robust mucosal CD8(+) T lymphocyte memory. These data demonstrate that the systemic and mucosal immune systems are highly coordinated following vaccination... - Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infectionSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Infect Dis 201:302-10. 2010..Interestingly, the number and proportion of effector CD8(+) T lymphocytes in milk were increased during acute SIV infection, suggesting effective control of virus-mediated CD4(+) T lymphocyte destruction in the breast milk compartment... - Glycoprotein gene sequence variation in rhesus monkey rhadinovirusYoung C Shin
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
Virology 400:175-86. 2010..Our results demonstrate two distinct, distantly-related phylogenetic groupings of gH and gL of RRV despite a remarkable degree of sequence conservation within each individual phylogenetic group... - Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeysDan H Barouch
Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Nat Med 16:319-23. 2010..Polyvalent mosaic antigens therefore represent a promising strategy to expand cellular immunologic vaccine coverage for genetically diverse pathogens such as HIV-1... - Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5Katherine Masek-Hammerman
New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 017721, USA
J Virol 84:9810-6. 2010.... - Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 77:4396-400. 2003..These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies... - Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeysJinyan Liu
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Virol 82:4844-52. 2008..Moreover, qualitative differences in cellular immune responses may prove critical in determining the overall potency of heterologous rAd prime-boost regimens... - Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?Cynthia A Lemere
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Rejuvenation Res 11:321-32. 2008..Phospho-tau labeled dystrophic neurites and tangles, typically present in human AD, were absent in the tamarins. In conclusion, tamarins may represent a model of early AD pathology... - Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variantsDan H Barouch
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Immunol 6:247-52. 2005.... - Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Retrovirology 7:7. 2010..These findings suggest that a substantial fraction of milk viruses are produced by locally-infected cells, but are shaped by cellular immune pressures similar to that in the blood... - Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239David T Evans
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102
J Virol 79:7707-20. 2005..Given the extraordinary difficulty in protecting against SIV(mac)239, these results are encouraging and support further evaluation of lentiviruses that are limited to a single cycle of infection as a preclinical AIDS vaccine approach... - Histologic and immunohistochemical characterization of pheochromocytoma in 6 cotton-top tamarins (Saguinus oedipus)A D Miller
New England Regional Primate Research Center, Division of Comparative Pathology, Department of Pathology, Harvard Medical School, Southborough, MA 01772 9102, USA
Vet Pathol 46:1221-9. 2009.... - Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virusTomek Swigut
New England Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 78:13335-44. 2004..These results indicate that nef does serve to limit the virus-specific CD8 cellular response of the host and that the ability to downregulate MHC class I contributes importantly to the totality of nef function... - Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and DPeter Abbink
Research East Room 213, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
J Virol 81:4654-63. 2007..These studies substantially expand the portfolio of rare serotype rAd vectors that may prove useful as vaccine vectors for the developing world... - Cytomegalovirus-associated discrete gastrointestinal masses in macaques infected with the simian immunodeficiency virusE Hendricks Hutto
New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA
Vet Pathol 41:691-5. 2004..CMV should be considered a cause of discrete mass lesions in the gastrointestinal tract of SIV-infected macaques... - Naturally occurring Tyzzer's disease in cotton-top tamarins (Saguinus oedipus)Vito G Sasseville
New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Comp Med 57:125-7. 2007..Therefore, colitis caused by C. piliforme, although rare, should be included as a differential diagnosis in cotton-top tamarins and as a cause of postnatal mortality in this species... - Systemic AA amyloidosis in the common marmosetE Ludlage
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9012, USA
Vet Pathol 42:117-24. 2005..In this respect, the common marmoset provides a unique experimental model for study of the pathogenesis and treatment of AA and other forms of systemic amyloidosis... - Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunityDiane M Roberts
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 441:239-43. 2006..Such chimaeric viral vectors may have important practical implications for vaccination and gene therapy... - Immunogenicity of recombinant fiber-chimeric adenovirus serotype 35 vector-based vaccines in mice and rhesus monkeysAnjali Nanda
Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
J Virol 79:14161-8. 2005..Moreover, these studies demonstrate that capsid chimeric rAd vectors can be constructed to combine beneficial immunologic and serologic properties of different Ad serotypes... - Opportunistic infections in immunologically compromised nonhuman primatesLynn M Wachtman
Harvard Medical School, Southborough, MA 01772 9012, USA
ILAR J 49:191-208. 2008..We discuss risk reduction through the use of quarantine procedures, specific pathogen-free animals, and environmental controls... - Comparative pathobiology of Kaposi sarcoma-associated herpesvirus and related primate rhadinovirusesSusan V Westmoreland
Harvard Medical School, New England Primate Research Center, Southborough, MA, USA
Comp Med 58:31-42. 2008..This review examines the comparative pathobiology of KSHV, discusses the role of macaque rhadinoviruses as models of human disease, and outlines the derivation of specific pathogen-free animals... - Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primatesJoshua Kramer
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Am J Physiol Regul Integr Comp Physiol 296:R786-93. 2009..We conclude that New World monkeys are an inappropriate model for diabetes induction with STZ and that, with all primate species, it is important to consider the animals' age before diabetic induction with STZ is attempted... - Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switchingHilde Kari Guttormsen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Institute for Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:5903-8. 2008..Targeted chemical engineering of a carbohydrate to create a molecule less like host self may be a rational approach for improving other glycoconjugates... - Antigenic stimulation in the simian model of HIV infection yields dilated cardiomyopathy through effects of TNFalphaJennifer H Yearley
University of Massachusetts, Graduate School of Biomedical Sciences, Worcester, USA
AIDS 22:585-94. 2008..To investigate a role for endogenous myocardial cytokine production in the development of HIV-associated cardiomyopathy... - Alterations in expression of monocyte chemotactic protein-1 in the simian immunodeficiency virus model of disseminated Mycobacterium avium complexElizabeth E Hendricks
Department of Pathobiology and Veterinary Sciences, University of Connecticut, Storrs, Connecticut, USA
J Infect Dis 189:1714-20. 2004..We conclude that the pronounced increases in MCP-1 levels demonstrated in tissue and serum samples after M. avium inoculation may play a role in the development of disseminated mycobacterial disease... - Body-composition changes in the simian immunodeficiency virus-infected juvenile rhesus macaqueLisa M Freeman
Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA
J Infect Dis 189:2010-5. 2004..The purpose of the present study was to measure, as a model of wasting in acquired immunodeficiency syndrome (AIDS), longitudinal body-composition changes in macaques infected with simian immunodeficiency virus (SIV)... - Phenotypic variation in myocardial macrophage populations suggests a role for macrophage activation in SIV-associated cardiac diseaseJennifer H Yearley
Graduate School of Biomedical Sciences, University of Massachusetts, Worcester, MA 01655, USA
AIDS Res Hum Retroviruses 23:515-24. 2007.... - SIV-associated myocarditis: viral and cellular correlates of inflammation severityJennifer H Yearley
University of Massachusetts, Graduate School of Biomedical Sciences, Worcester, Massachusetts 01655, USA
AIDS Res Hum Retroviruses 22:529-40. 2006..001), suggesting an important immunoregulatory role for this population within the myocardium... - Oral papillomas and papilliform lesions in rhesus macaques (Macaca mulatta)Mary M Patterson
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Comp Med 55:75-9. 2005..Benign tumors of the oral epithelium in macaques have not been reported previously; they appear to be rare and of variable clinical significance... - GB virus B infection of the common marmoset (Callithrix jacchus) and associated liver pathologyJames R Jacob
Departments of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Gen Virol 85:2525-33. 2004.... - Wasting syndrome and disruption of the somatotropic axis in simian immunodeficiency virus-infected macaques with Mycobacterium avium complex infectionElizabeth E Hendricks
University of Connecticut, Department of Pathobiology and Veterinary Sciences, Storrs, CT, USA
J Infect Dis 190:2187-94. 2004..These data document alterations in the somatotropic axis secondary to experimental disseminated M. avium infection and suggest that similar changes may contribute to alterations in body composition during AIDS...