Dara Manoach

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)
    Katharine N Thakkar
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Brain 131:2464-78. 2008
  2. pmc Anomalous use of context during task preparation in schizophrenia: a magnetoencephalography study
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Biol Psychiatry 73:967-75. 2013
  3. pmc Does abnormal sleep impair memory consolidation in schizophrenia?
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital Charlestown, MA 02129, USA
    Front Hum Neurosci 3:21. 2009
  4. ncbi request reprint Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 37:599-610. 2007
  5. pmc Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stages
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, United States
    J Psychiatr Res 44:112-20. 2010
  6. ncbi request reprint Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 20:1670-84. 2003
  7. ncbi request reprint Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccade
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 27:1791-8. 2007
  8. ncbi request reprint Intact hemispheric specialization for spatial and shape working memory in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Schizophr Res 78:1-12. 2005
  9. ncbi request reprint A failure of sleep-dependent procedural learning in chronic, medicated schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital East, Rm 420, 36 First Avenue, Charlestown, MA 02129, USA
    Biol Psychiatry 56:951-6. 2004
  10. ncbi request reprint Hemispheric specialization of the lateral prefrontal cortex for strategic processing during spatial and shape working memory
    Dara S Manoach
    Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 21:894-903. 2004

Detail Information

Publications41

  1. pmc Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)
    Katharine N Thakkar
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Brain 131:2464-78. 2008
    ..Illuminating the mechanisms and clinical significance of abnormal response monitoring in ASD represents a fruitful avenue for further research...
  2. pmc Anomalous use of context during task preparation in schizophrenia: a magnetoencephalography study
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Biol Psychiatry 73:967-75. 2013
    ..Impaired ability to use contextual information to optimally prepare for tasks contributes to performance deficits in schizophrenia. We used magnetoencephalography and an antisaccade task to investigate the neural basis of this deficit...
  3. pmc Does abnormal sleep impair memory consolidation in schizophrenia?
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital Charlestown, MA 02129, USA
    Front Hum Neurosci 3:21. 2009
    ..Understanding this contribution may open new avenues to ameliorating cognitive dysfunction and thereby improve outcome in schizophrenia...
  4. ncbi request reprint Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 37:599-610. 2007
    ..Moreover, they suggest that anterior cingulate white matter abnormalities contribute to slower performance of volitional saccades and to inter-individual variability of saccadic latency in chronic, medicated schizophrenia...
  5. pmc Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stages
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, United States
    J Psychiatr Res 44:112-20. 2010
    ..They provide further evidence that sleep is an important contributor to cognitive deficits in schizophrenia...
  6. ncbi request reprint Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 20:1670-84. 2003
    ..This suggests that frontostriatal neural circuitry participates in selecting an appropriate response based on the contents of WM...
  7. ncbi request reprint Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccade
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 27:1791-8. 2007
    ..More generally, these results highlight the importance of trial history as a source of variability in both behavioral and neuroimaging studies...
  8. ncbi request reprint Intact hemispheric specialization for spatial and shape working memory in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Schizophr Res 78:1-12. 2005
    ..We hypothesized that reduced specialization in schizophrenia would reflect a failure to adopt optimal domain-specific strategies and would contribute to WM deficits...
  9. ncbi request reprint A failure of sleep-dependent procedural learning in chronic, medicated schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital East, Rm 420, 36 First Avenue, Charlestown, MA 02129, USA
    Biol Psychiatry 56:951-6. 2004
    ..This study tested the hypothesis that patients with schizophrenia have a deficit in sleep-dependent procedural learning...
  10. ncbi request reprint Hemispheric specialization of the lateral prefrontal cortex for strategic processing during spatial and shape working memory
    Dara S Manoach
    Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 21:894-903. 2004
    ..We designed spatial and shape WM tasks that are relatively easy to perform and that minimize both task-switching and manipulation demands. The tasks use identical stimuli and require the same motor response...
  11. pmc Deficient saccadic inhibition in Asperger's disorder and the social-emotional processing disorder
    D S Manoach
    Department of Psychiatry and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurol Neurosurg Psychiatry 75:1719-26. 2004
    ..SEPD has been shown to be associated with deficient saccadic inhibition...
  12. ncbi request reprint The inter-trial effects of stimulus and saccadic direction on prosaccades and antisaccades, in controls and schizophrenia patients
    Jason J S Barton
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Exp Brain Res 174:487-98. 2006
    ..These results suggest that saccades in humans are modulated by inter-trial effects attributable to both an 'inhibition of return'-like alternation advantage and directional plasticity...
  13. ncbi request reprint Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Brain 131:971-86. 2008
    ..Impairments in evaluating and learning from errors in schizophrenia may contribute to behaviour that is rigid and perseverative rather than optimally guided by outcomes, and may compromise performance across a wide range of tasks...
  14. ncbi request reprint Antisaccades and task-switching: interactions in controlled processing
    Mariya V Cherkasova
    Department of Neurology, KS452, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Exp Brain Res 144:528-37. 2002
    ..In either case, the paradoxical benefit of task-switching for antisaccades challenges current models of task-switching...
  15. ncbi request reprint Switching, plasticity, and prediction in a saccadic task-switch paradigm
    Jason J S Barton
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Exp Brain Res 168:76-87. 2006
    ..While our model of response-system plasticity can explain a number of effects of dominance asymmetry in switching, other models fail to account for the paradoxical set-switch benefit for antisaccades...
  16. pmc Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders
    Yigal Agam
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 52:336-47. 2010
    ..More generally, our findings suggest reduced cognitive control over behavior by the dACC in ASD...
  17. ncbi request reprint Task-switching with antisaccades versus no-go trials: a comparison of inter-trial effects
    Jason J S Barton
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    Exp Brain Res 172:114-9. 2006
    ....
  18. ncbi request reprint Schizophrenic subjects show deficient inhibition but intact task switching on saccadic tasks
    Dara S Manoach
    Department of Neurology, Human Vision and Eye Movement Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Biol Psychiatry 51:816-26. 2002
    ..g., the Wisconsin Card Sort Test [WCST]). We investigated inhibition and task switching using saccadic tasks to determine whether schizophrenic patients have selective impairments of these executive functions...
  19. pmc Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI
    Jonathan J Wisco
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
    Schizophr Res 94:317-27. 2007
    ..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia...
  20. pmc Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach
    Gregory G Brown
    Department of Psychiatry, University of California, San Diego, CA, USA
    Schizophr Bull 35:32-46. 2009
    ..The results show at both cognitive and neural levels that disordered memory scanning contributes to deficient SIRP performance among schizophrenia patients...
  21. ncbi request reprint What is perseverated in schizophrenia? Evidence of abnormal response plasticity in the saccadic system
    Jason J S Barton
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Abnorm Psychol 114:75-84. 2005
    ..Saccades in schizophrenia are characterized by perseveration of antisaccade-induced changes in the saccadic response system rather than failures to switch task set...
  22. pmc Body expressions of emotion do not trigger fear contagion in autism spectrum disorder
    Nouchine Hadjikhani
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Soc Cogn Affect Neurosci 4:70-8. 2009
    ..Our data suggest that emotion perception deficits in ASD may be due to compromised processing of the emotional component of observed actions...
  23. pmc Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:15700-5. 2005
    ..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses...
  24. ncbi request reprint Are patients with social developmental disorders prosopagnosic? Perceptual heterogeneity in the Asperger and socio-emotional processing disorders
    Jason J S Barton
    Department of Neurology, KS 452, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston MA 02215, USA
    Brain 127:1706-16. 2004
    ..Heterogeneity in the perceptual processing of faces may imply pathogenetic heterogeneity, with important implications for genetic and rehabilitative studies of SDD...
  25. pmc The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults
    Stefan Ehrlich
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Neuroimage 53:992-1000. 2010
    ..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures...
  26. pmc Multi-site characterization of an fMRI working memory paradigm: reliability of activation indices
    Anastasia Yendiki
    Athinoula A Martinos Center for Biomedical Imaging, Dept of Radiology, MGH, Dept of Radiology, Harvard Medical School, USA
    Neuroimage 53:119-31. 2010
    ....
  27. ncbi request reprint Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade task
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Schizophr Res 82:191-201. 2006
    ..We examined whether immediate error-related performance adjustments during the antisaccade task were intact in schizophrenia...
  28. ncbi request reprint Antisaccades and task switching: studies of control processes in saccadic function in normal subjects and schizophrenic patients
    Jason J S Barton
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 956:250-63. 2002
    ..It suggests either carryover inhibition by antisaccadic performance in the prior trial or facilitation of antisaccades by simultaneous performance of other cognitive operations...
  29. pmc Hemispheric differences in amygdala contributions to response monitoring
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neuroreport 20:398-402. 2009
    ....
  30. ncbi request reprint Motor cortical excitability in schizophrenia
    Alvaro Pascual-Leone
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Biol Psychiatry 52:24-31. 2002
    ..Transcranial magnetic stimulation (TMS) provides a method to examine cortico-cortical motor excitability and hemispheric asymmetry in unmedicated and medicated schizophrenia patients...
  31. ncbi request reprint Investigations of face expertise in the social developmental disorders
    Jason J S Barton
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Neurology 69:860-70. 2007
    ..Patients with social developmental disorders (SDD), also known as autism spectrum disorders, may have impaired recognition of facial identity or facial expressions...
  32. ncbi request reprint Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital East and Harvard Medical School, 36 First Avenue, Room 420, 02129, Charlestown, MA, USA
    Schizophr Res 60:285-98. 2003
    ..In combination with other techniques, neuroimaging can identify the neural circuitry responsible for WM deficits and elucidate the contribution of each anatomical component...
  33. ncbi request reprint Perception of facial expression and facial identity in subjects with social developmental disorders
    Rebecca L Hefter
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 65:1620-5. 2005
    ..The authors investigated whether this purported perceptual deficit was generalized to both facial expression and facial identity or whether these different types of facial perception were dissociated in SDDs...
  34. ncbi request reprint Spatiotemporal wavelet analysis for functional MRI
    Chris Long
    MGH HMS MIT Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 23:500-16. 2004
    ..Our spatiotemporal wavelet framework suggests a useful tool for the analysis of fMRI studies...
  35. pmc MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:17573-8. 2008
    ..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype...
  36. pmc A non-invasive method to relate the timing of neural activity to white matter microstructural integrity
    Steven M Stufflebeam
    Department of Radiology at the Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 42:710-6. 2008
    ..This preliminary report demonstrates a non-invasive, unbiased method to relate the timing information from evoked-response experiments to the biophysical properties of white matter measured with DTI...
  37. ncbi request reprint Task-switching in schizophrenia: active switching costs and passive carry-over effects in an antisaccade paradigm
    Cathleen Greenzang
    Department of Neurobiology, Harvard College, Cambridge, MA, USA
    Exp Brain Res 181:493-502. 2007
    ..Thus problems with executive control in schizophrenia may not affect specific task-switching operations...
  38. ncbi request reprint The relationship of saccadic peak velocity to latency: evidence for a new prosaccadic abnormality in schizophrenia
    Rajeev S Ramchandran
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Exp Brain Res 159:99-107. 2004
    ....
  39. ncbi request reprint The relation between antisaccade errors, fixation stability and prosaccade errors in schizophrenia
    Jason J S Barton
    Department of Neurology, University of British Columbia, Vancouver, BC, Canada
    Exp Brain Res 186:273-82. 2008
    ....
  40. pmc Where left becomes right: a magnetoencephalographic study of sensorimotor transformation for antisaccades
    So Young Moon
    Department of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neuroimage 36:1313-23. 2007
    ..These findings suggest that sensorimotor transformation is the product of coordinated activity across the intraparietal sulcus and frontal eye field, key components of a cortical network for saccadic generation...

Research Grants8

  1. FMRI AND TMS STUDIES OF WORKING MEMORY IN SCHIZOPHRENIA
    Dara Manoach; Fiscal Year: 2004
    ..abstract_text> ..
  2. Spatiotemporal dynamics of executive function in schizo
    Dara Manoach; Fiscal Year: 2004
    ..Identifying the neural processes underlying intact and deficient executive function will aid investigations of neuropathology and contribute to the development of more focused interventions and rehabilitative strategies. ..
  3. Spatiotemporal dynamics of executive function in schizo
    Dara Manoach; Fiscal Year: 2005
    ..Identifying the neural processes underlying intact and deficient executive function will aid investigations of neuropathology and contribute to the development of more focused interventions and rehabilitative strategies. ..
  4. Spatiotemporal dynamics of executive function in schizo
    Dara Manoach; Fiscal Year: 2006
    ..Identifying the neural processes underlying intact and deficient executive function will aid investigations of neuropathology and contribute to the development of more focused interventions and rehabilitative strategies. ..
  5. Spatiotemporal dynamics of contextual processing in schizophrenia
    Dara Manoach; Fiscal Year: 2007
    ..This research will identify the neural basis of both spared and impaired cognitive processes, guide investigations of neuropathology, and provide targets for intervention aimed at improving cognition in schizophrenia. ..
  6. Spatiotemporal dynamics of contextual processing in schizophrenia
    Dara Manoach; Fiscal Year: 2009
    ..This research will identify the neural basis of both spared and impaired cognitive processes, guide investigations of neuropathology, and provide targets for intervention aimed at improving cognition in schizophrenia. ..
  7. Spatiotemporal dynamics of contextual processing in schizophrenia
    Dara S Manoach; Fiscal Year: 2010
    ..This research will identify the neural basis of both spared and impaired cognitive processes, guide investigations of neuropathology, and provide targets for intervention aimed at improving cognition in schizophrenia. ..