Research Topics
Species | Dara ManoachSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Does abnormal sleep impair memory consolidation in schizophrenia?Dara S Manoach
Department of Psychiatry, Massachusetts General Hospital Charlestown, MA 02129, USA
Front Hum Neurosci 3:21. 2009..Understanding this contribution may open new avenues to ameliorating cognitive dysfunction and thereby improve outcome in schizophrenia...
Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccadeDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosci 27:1791-8. 2007..More generally, these results highlight the importance of trial history as a source of variability in both behavioral and neuroimaging studies...- Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophreniaDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Neuroimage 37:599-610. 2007..Moreover, they suggest that anterior cingulate white matter abnormalities contribute to slower performance of volitional saccades and to inter-individual variability of saccadic latency in chronic, medicated schizophrenia... - Intact hemispheric specialization for spatial and shape working memory in schizophreniaDara S Manoach
Department of Psychiatry, Massachusetts General Hospital East, Charlestown, MA 02129, USA
Schizophr Res 78:1-12. 2005..We hypothesized that reduced specialization in schizophrenia would reflect a failure to adopt optimal domain-specific strategies and would contribute to WM deficits... - A failure of sleep-dependent procedural learning in chronic, medicated schizophreniaDara S Manoach
Department of Psychiatry, Massachusetts General Hospital East, Rm 420, 36 First Avenue, Charlestown, MA 02129, USA
Biol Psychiatry 56:951-6. 2004..This study tested the hypothesis that patients with schizophrenia have a deficit in sleep-dependent procedural learning... - Deficient saccadic inhibition in Asperger's disorder and the social-emotional processing disorderD S Manoach
Department of Psychiatry and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
J Neurol Neurosurg Psychiatry 75:1719-26. 2004..SEPD has been shown to be associated with deficient saccadic inhibition... - Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stagesDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, United States
J Psychiatr Res 44:112-20. 2010..They provide further evidence that sleep is an important contributor to cognitive deficits in schizophrenia... - Hemispheric specialization of the lateral prefrontal cortex for strategic processing during spatial and shape working memoryDara S Manoach
Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 21:894-903. 2004..We designed spatial and shape WM tasks that are relatively easy to perform and that minimize both task-switching and manipulation demands. The tasks use identical stimuli and require the same motor response... - Identifying regional activity associated with temporally separated components of working memory using event-related functional MRIDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 20:1670-84. 2003..This suggests that frontostriatal neural circuitry participates in selecting an appropriate response based on the contents of WM... - The inter-trial effects of stimulus and saccadic direction on prosaccades and antisaccades, in controls and schizophrenia patientsJason J S Barton
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Exp Brain Res 174:487-98. 2006..These results suggest that saccades in humans are modulated by inter-trial effects attributable to both an 'inhibition of return'-like alternation advantage and directional plasticity... - Switching, plasticity, and prediction in a saccadic task-switch paradigmJason J S Barton
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Exp Brain Res 168:76-87. 2006..While our model of response-system plasticity can explain a number of effects of dominance asymmetry in switching, other models fail to account for the paradoxical set-switch benefit for antisaccades... - Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophreniaFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Brain 131:971-86. 2008..Impairments in evaluating and learning from errors in schizophrenia may contribute to behaviour that is rigid and perseverative rather than optimally guided by outcomes, and may compromise performance across a wide range of tasks... - Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)Katharine N Thakkar
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Brain 131:2464-78. 2008..Illuminating the mechanisms and clinical significance of abnormal response monitoring in ASD represents a fruitful avenue for further research... - Antisaccades and task-switching: interactions in controlled processingMariya V Cherkasova
Department of Neurology, KS452, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Exp Brain Res 144:528-37. 2002..In either case, the paradoxical benefit of task-switching for antisaccades challenges current models of task-switching... - Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disordersYigal Agam
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Neuroimage 52:336-47. 2010..More generally, our findings suggest reduced cognitive control over behavior by the dACC in ASD... - Task-switching with antisaccades versus no-go trials: a comparison of inter-trial effectsJason J S Barton
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Exp Brain Res 172:114-9. 2006.... - Schizophrenic subjects show deficient inhibition but intact task switching on saccadic tasksDara S Manoach
Department of Neurology, Human Vision and Eye Movement Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Biol Psychiatry 51:816-26. 2002..We hypothesize that inhibition and task switching are mediated by distinct neural networks, only one of which is dysfunctional in schizophrenia... - Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRIJonathan J Wisco
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
Schizophr Res 94:317-27. 2007..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia... - Body expressions of emotion do not trigger fear contagion in autism spectrum disorderNouchine Hadjikhani
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Soc Cogn Affect Neurosci 4:70-8. 2009..Our data suggest that emotion perception deficits in ASD may be due to compromised processing of the emotional component of observed actions... - Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approachGregory G Brown
Department of Psychiatry, University of California, San Diego, CA, USA
Schizophr Bull 35:32-46. 2009..The results show at both cognitive and neural levels that disordered memory scanning contributes to deficient SIRP performance among schizophrenia patients... - The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adultsStefan Ehrlich
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
Neuroimage 53:992-1000. 2010..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures... 
Multi-site characterization of an fMRI working memory paradigm: reliability of activation indicesAnastasia Yendiki
Athinoula A Martinos Center for Biomedical Imaging, Dept of Radiology, MGH, Dept of Radiology, Harvard Medical School, USA
Neuroimage 53:119-31. 2010....- Antisaccades and task switching: studies of control processes in saccadic function in normal subjects and schizophrenic patientsJason J S Barton
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 956:250-63. 2002..It suggests either carryover inhibition by antisaccadic performance in the prior trial or facilitation of antisaccades by simultaneous performance of other cognitive operations... - What is perseverated in schizophrenia? Evidence of abnormal response plasticity in the saccadic systemJason J S Barton
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Abnorm Psychol 114:75-84. 2005..Saccades in schizophrenia are characterized by perseveration of antisaccade-induced changes in the saccadic response system rather than failures to switch task set... - Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade taskFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Schizophr Res 82:191-201. 2006..We examined whether immediate error-related performance adjustments during the antisaccade task were intact in schizophrenia... - Are patients with social developmental disorders prosopagnosic? Perceptual heterogeneity in the Asperger and socio-emotional processing disordersJason J S Barton
Department of Neurology, KS 452, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston MA 02215, USA
Brain 127:1706-16. 2004..Heterogeneity in the perceptual processing of faces may imply pathogenetic heterogeneity, with important implications for genetic and rehabilitative studies of SDD... - Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commissionFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 102:15700-5. 2005..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses... - Hemispheric differences in amygdala contributions to response monitoringFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neuroreport 20:398-402. 2009.... - Perception of facial expression and facial identity in subjects with social developmental disordersRebecca L Hefter
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Neurology 65:1620-5. 2005..The results argue against hypotheses that the social dysfunction in social developmental disorder causes a generalized failure to acquire face-processing skills... - Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findingsDara S Manoach
Department of Psychiatry, Massachusetts General Hospital-East and Harvard Medical School, 36 First Avenue, Room 420, 02129, Charlestown, MA, USA
Schizophr Res 60:285-98. 2003..In combination with other techniques, neuroimaging can identify the neural circuitry responsible for WM deficits and elucidate the contribution of each anatomical component... - Investigations of face expertise in the social developmental disordersJason J S Barton
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Neurology 69:860-70. 2007..Patients with social developmental disorders (SDD), also known as autism spectrum disorders, may have impaired recognition of facial identity or facial expressions... - Motor cortical excitability in schizophreniaAlvaro Pascual-Leone
Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Biol Psychiatry 52:24-31. 2002.... - Spatiotemporal wavelet analysis for functional MRIChris Long
MGH HMS MIT Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 23:500-16. 2004..Our spatiotemporal wavelet framework suggests a useful tool for the analysis of fMRI studies... - MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> MetJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 105:17573-8. 2008..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype... - A non-invasive method to relate the timing of neural activity to white matter microstructural integritySteven M Stufflebeam
Department of Radiology at the Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 42:710-6. 2008..This preliminary report demonstrates a non-invasive, unbiased method to relate the timing information from evoked-response experiments to the biophysical properties of white matter measured with DTI... - The relationship of saccadic peak velocity to latency: evidence for a new prosaccadic abnormality in schizophreniaRajeev S Ramchandran
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Exp Brain Res 159:99-107. 2004.... - The relation between antisaccade errors, fixation stability and prosaccade errors in schizophreniaJason J S Barton
Department of Neurology, University of British Columbia, Vancouver, BC, Canada
Exp Brain Res 186:273-82. 2008.... - Where left becomes right: a magnetoencephalographic study of sensorimotor transformation for antisaccadesSo Young Moon
Department of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neuroimage 36:1313-23. 2007..These findings suggest that sensorimotor transformation is the product of coordinated activity across the intraparietal sulcus and frontal eye field, key components of a cortical network for saccadic generation... - Task-switching in schizophrenia: active switching costs and passive carry-over effects in an antisaccade paradigmCathleen Greenzang
Department of Neurobiology, Harvard College, Cambridge, MA, USA
Exp Brain Res 181:493-502. 2007..Thus problems with executive control in schizophrenia may not affect specific task-switching operations...
Research Grants
- FMRI AND TMS STUDIES OF WORKING MEMORY IN SCHIZOPHRENIADara Manoach; Fiscal Year: 2004..abstract_text> ..
- Spatiotemporal dynamics of executive function in schizoDara Manoach; Fiscal Year: 2006..Identifying the neural processes underlying intact and deficient executive function will aid investigations of neuropathology and contribute to the development of more focused interventions and rehabilitative strategies. ..
- Spatiotemporal dynamics of contextual processing in schizophreniaDara Manoach; Fiscal Year: 2007..This research will identify the neural basis of both spared and impaired cognitive processes, guide investigations of neuropathology, and provide targets for intervention aimed at improving cognition in schizophrenia. ..
- Spatiotemporal dynamics of contextual processing in schizophreniaDara S Manoach; Fiscal Year: 2010..This research will identify the neural basis of both spared and impaired cognitive processes, guide investigations of neuropathology, and provide targets for intervention aimed at improving cognition in schizophrenia. ..