Affiliation: Harvard University
- IRON fMRI measurements of CBV and implications for BOLD signalJoseph B Mandeville
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 62:1000-8. 2012..This article reviews the methodological advantages of the IRON method and how CBV measurements have informed our understanding of the BOLD response...
- fMRI of cocaine self-administration in macaques reveals functional inhibition of basal gangliaJoseph B Mandeville
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA, USA
Neuropsychopharmacology 36:1187-98. 2011....
- Spin-echo MRI underestimates functional changes in microvascular cerebral blood plasma volume using exogenous contrast agentJoseph B Mandeville
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital MGH, Massachusetts Institute of Technology MIT, Harvard Medical School HMS, Boston, Massachusetts, USA
Magn Reson Med 58:769-76. 2007....
- Vascular filters of functional MRI: spatial localization using BOLD and CBV contrastJ B Mandeville
NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Magn Reson Med 42:591-8. 1999..Magn Reson Med 42:591-598, 1999...
- Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 TJoseph B Mandeville
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston 02129, USA
Magn Reson Med 52:1272-81. 2004..The derived field dependencies for relative sensitivity and MRI estimates of the percentage change in CBV suggest that the benefits provided by exogenous agents will persist even at much higher magnetic fields than 9.4 T...
- Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brainJ B Mandeville
MGH NMR Center, Massachusetts General Hospital, Boston, Massachusetts, USA
Magn Reson Med 45:443-7. 2001..The use of contrast agent increased functional sensitivity in all parenchymal brain structures, with a strong but predictable dependence on the resting-state blood volume fraction. Magn Reson Med 45:443-447, 2001...
- MRI measurement of the temporal evolution of relative CMRO(2) during rat forepaw stimulationJ B Mandeville
MGH NMR Center, Massachusetts General Hospital, Boston, Massachusetts, USA
Magn Reson Med 42:944-51. 1999..A poststimulus undershoot in BOLD signal was quantitatively attributed to the temporal mismatch between changes in blood flow and volume, and not to the role of oxygen metabolism. Magn Reson Med 42:944-951, 1999...
- Visual field map clusters in macaque extrastriate visual cortexHauke Kolster
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 29:7031-9. 2009..This novel view on the functional topography of area MT/V5 and satellites indicates that field map clusters are evolutionarily preserved and may be a fundamental organizational principle of the Old World primate visual cortex...
- Transcription MRI: a new view of the living brainPhilip K Liu
Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Neuroscientist 14:503-20. 2008..Transcription MRI will lend itself to myriad applications in living organs...
- Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemiaYoung R Kim
Athinoula Martinos Center for Biomedical Imaging Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 39:439-47. 2008..We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic efficacy of delayed chronic lithium treatment using functional MRI...
- Event-related single-shot volumetric functional magnetic resonance inverse imaging of visual processingFa Hsuan Lin
MGH HST Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 42:230-47. 2008..Robust results from both single subject and group analyses demonstrate the sensitivity and feasibility of using volumetric InI in high temporal resolution investigations of human brain function...
- fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brainsYoung R Kim
Athinoula Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 27:142-53. 2007..Taken together, these data suggest that restoration of fMRI response magnitudes, temporal profiles, and correlations with structure may reveal the extent and specific traits of albumin treatment associated stroke recovery...
- Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepawY Iris Chen
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Room 2301, Charlestown, MA 02129, USA
Neurosci Lett 431:231-5. 2008..These data provide evidence for physiologic modulation caused by electroacupuncture at points near the median nerve...
- Early time points perfusion imagingKenneth K Kwong
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 54:1070-82. 2011..A recipe to run ET was presented, with attention paid to the noise problem around the time of arrival (TOA) of the contrast agent...
- Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in ratsYoung R Kim
NMR Center MGH, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 25:820-9. 2005..These results suggest that stroke affects not only local hemodynamics and coupling but also other factors including neural connectivity...
- Faces and objects in macaque cerebral cortexDoris Y Tsao
Athinoula A Martinos Center, Charlestown, Massachusetts 02129, USA
Nat Neurosci 6:989-95. 2003..Overall, our results suggest that humans and macaques share a similar brain architecture for visual object processing...
- Stereopsis activates V3A and caudal intraparietal areas in macaques and humansDoris Y Tsao
Massachusetts General Hospital, NMR Center, Athinoula A Martinos Center, Charlestown, Massachusetts 02129, USA
Neuron 39:555-68. 2003..Thus, in both primate species a small cluster of areas at the parieto-occipital junction appears to be specialized for stereopsis...
- Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRIScott D Packard
MGH-NMR Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neoplasia 5:330-8. 2003..Furthermore, reduced reactivity of tumor vessels to a single physiological perturbation, such as hypercarbia, should not be construed as a generalized reduction of functional activity of the tumor vascular bed...
- DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brainsChristina H Liu
Laboratory for Gene Transcript Targeting, Imaging and Repair, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 29:10663-70. 2009..The in vivo target specificity of these probes permits reliable MRI visualization of AMPH-induced differential elevations of fosB and Delta fosB mRNA in living brains...
- High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imagingJi-Kyung Choi
Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Synapse 60:152-7. 2006..The high spatial and temporal resolution of the phMRI technique lends itself well to further, more detailed, studies of nicotine dynamics...
- Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging studyRick M Dijkhuizen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosci 23:510-7. 2003....
- Remifentanil administration reveals biphasic phMRI temporal responses in rat consistent with dynamic receptor regulationChristina H Liu
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
Neuroimage 34:1042-53. 2007....
- Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonistsJi Kyung Choi
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
Psychopharmacology (Berl) 212:59-72. 2010..Dopamine D3 receptors (D3R) may be important therapeutic targets for both drug abuse and dyskinesias in Parkinson's disease; however, little is known about their functional circuitry...
- Repeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 TeslaFrancisca P Leite
Massachusetts Institute of Technology, Department of Nuclear Engineering, Cambridge, Massachusetts 02139, USA
Neuroimage 16:283-94. 2002..Overall, the contrast agent produced a dramatic improvement in functional brain imaging results in the awake, behaving primate at this field strength. (c) 2002 Elsevier Science (USA)...
- Characterization of event-related designs using BOLD and IRON fMRIFrancisca P Leite
Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02138, USA
Neuroimage 29:901-9. 2006..Small amounts of entropy can be traded for large gains in efficiency, particularly for the IRON method...
- Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobinJoseph P Culver
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuroimage 27:947-59. 2005..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms...
- Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulationAndrew M Siegel
Tufts University Bioengineering Center, Medford, MA 02155, USA
Phys Med Biol 48:1391-403. 2003....
- Iron fMRI: Improving Sensitivty and localizationJOSEPH MANDEVILLE; Fiscal Year: 2006..abstract_text> ..
- fMRI and neuronal activity in awake behaviorJOSEPH MANDEVILLE; Fiscal Year: 2006..Finally, we will test the neural-fMRI relationship in a higher-order region of visual cortex which appears to be specialized for processing faces and other visual objects. ..
- MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PETJOSEPH MANDEVILLE; Fiscal Year: 2002..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
- FMRI STUDY OF CNS PHYSIOLOGY DURING COCAINE RESPONSEJOSEPH MANDEVILLE; Fiscal Year: 2002..These studies seek to validate the physiological basis of a promising new technology for study of psychoactive drug action in brain and to increase our understanding of the neurobiology of cocaine. ..