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Species | Didier A MandelbrotSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Living donor practices in the United StatesDidier A Mandelbrot
Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Adv Chronic Kidney Dis 19:212-9. 2012..In this article, we review the current knowledge about living donor practices in the United States...
Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantationDidier A Mandelbrot
Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Nephrol Dial Transplant 23:2679-84. 2008..We report three patients whose soft-tissue calcification syndromes dramatically resolved after undergoing HSCT...
Validation of neutron activation as a novel method to determine glomerular filtration rateDidier A Mandelbrot
UMassMemorial Medical Center, Boston, MA, USA
Nephron Clin Pract 107:c117-22. 2007..In this study, we demonstrate that NA can be used to determine GFR by measuring the clearance of iohexol, and directly compare these results to a gold-standard method based on (99m)Tc-DTPA...- The medical evaluation of living kidney donors: a survey of US transplant centersD A Mandelbrot
Department of Medicine, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Transplant 7:2333-43. 2007..These findings highlight the need for more data on long-term outcomes in various types of donors with potential morbidities related to donation... - Practices and barriers in long-term living kidney donor follow-up: a survey of U.S. transplant centersDidier A Mandelbrot
The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Transplantation 88:855-60. 2009.... - B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4D A Mandelbrot
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 107:881-7. 2001..Finally, administration of CTLA4-Ig to CD28/CTLA4(-/-) cardiac allograft recipients significantly prolongs graft survival. These data support the existence of an additional receptor for B7 molecules that is neither CD28 nor CTLA4... - The role of CTLA-4 in regulating Th2 differentiationM A Oosterwegel
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 163:2634-9. 1999..Thus, the B7-CD28/CTLA-4 pathway plays a critical role in regulating Th2 differentiation in two ways: CD28 promotes Th2 differentiation while CTLA-4 limits Th2 differentiation... - CD28-independent costimulation of T cells in alloimmune responsesA Yamada
Laboratory of Immunogenetics and Transplantation and Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 167:140-6. 2001.... - Rejection of mouse cardiac allografts by costimulation in transD A Mandelbrot
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 167:1174-8. 2001..This is the first demonstration that costimulation in trans can mediate an immune response in vivo and has important therapeutic implications... - Evaluation of native kidney recovery after simultaneous liver-kidney transplantationJean M Francis
Department of Medicine, Boston University Medical Center, Boston, MA, USA
Transplantation 93:530-5. 2012..Identifying predictors of native kidney function recovery after SLK requires an accurate measure of the relative function of all three kidneys in patients with SLK... - A cross-sectional study of fatigue and sleep quality before and after kidney transplantationJames R Rodrigue
The Transplant Institute, Beth Israel Deaconess Center for Transplant Outcomes and Quality Improvement and Medical Center, Harvard Medical School, Boston, MA 02215, USA
Clin Transplant 25:E13-21. 2011..Fatigue and sleep disturbances are common before and after KTx, and study findings have important implications for their assessment and management... - Timing of sirolimus conversion influences recovery of renal function in liver transplant recipientsChristin C Rogers
Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA, USA
Clin Transplant 23:887-96. 2009..The only improvement in the LC group was from conversion to the three-month time point. We conclude that EC to SRL results in a profound improvement in eGFR that begins at three months and is sustained beyond one yr... - Willingness to pursue live-donor kidney transplantation among waitlisted patients infected with human immunodeficiency virus (HIV): a preliminary investigationJames R Rodrigue
Center for Transplant Outcomes and Quality Improvement, The Transplant Institute, Beth Israel Deaconess Medical Center and the Harvard Medical School, Boston, MA, USA
Transplantation 95:787-90. 2013.... - Liver transplant center risk toleranceScott R Johnson
The Transplant Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Clin Transplant 26:E269-76. 2012..Small volume centers must perform higher risk transplants to meet current CMS requirements and are at risk for adverse action secondary to chance alone... - The "House Calls" trial: a randomized controlled trial to reduce racial disparities in live donor kidney transplantation: rationale and designJames R Rodrigue
The Transplant Institute and The Center for Transplant Outcomes and Quality Improvement, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Contemp Clin Trials 33:811-8. 2012..Similar trials have been developed recently to broaden the evaluation of House Calls as an innovative disparity-reducing intervention in kidney transplantation... - Spouse caregivers of kidney transplant patients: quality of life and psychosocial outcomesJames R Rodrigue
The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Prog Transplant 20:335-42; quiz 343. 2010..Little is known about the quality of life, caregiving strain, and psychosocial functioning of these caregivers... - Measuring the expectations of kidney donors: initial psychometric properties of the Living Donation Expectancies QuestionnaireJames R Rodrigue
The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Transplantation 85:1230-4. 2008..0001), Personal Growth (P<0.01), Quid Pro Quo (P<0.0001), and Health Consequences (P<0.0001) expectations. The LDEQ has promise in evaluating donor candidates' expectations... - The living kidney donor evaluation: focus on renal issuesAjay Kher
Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Clin J Am Soc Nephrol 7:366-71. 2012.... - Web-based requests for living organ donors: who are the solicitors?James R Rodrigue
Department of Psychiatry, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Clin Transplant 22:749-53. 2008..Specifically, in some instances, a Good Samaritan's pursuit of living kidney donation may be based less on information potentially relevant to transplant outcome and more on the persuasiveness of the appeal... - A psychological intervention to improve quality of life and reduce psychological distress in adults awaiting kidney transplantationJames R Rodrigue
Center for Transplant Outcomes and Quality Improvement, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
Nephrol Dial Transplant 26:709-15. 2011..Effective psychological interventions to improve functioning in these areas are lacking... - CTLA-4 and T cell activationM A Oosterwegel
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Immunol 11:294-300. 1999..Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases... - Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allograftsD A Mandelbrot
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 163:3753-7. 1999..The indefinite survival of allografts into B7-1/B7-2-/- recipients further shows that the absence of B7 costimulation alone is sufficient to prevent rejection... - B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)D A Mandelbrot
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115
J Exp Med 189:435-40. 1999..This suggests that the inhibitory function of CTLA-4 can overcome strong CD28-mediated signaling in vivo... - Evaluating living kidney donors: relationship types, psychosocial criteria, and consent processes at US transplant programsJ R Rodrigue
Department of Psychiatry, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Transplant 7:2326-32. 2007..Whether greater consensus should be reached on these donor evaluation practices, especially in the context of more expansive use of living donor kidney transplantation, is discussed... - mTOR inhibition: the learning curve in kidney transplantationMatthew R Weir
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
Transpl Int 23:447-60. 2010..mTOR inhibitors also have been used as CNI-sparing agents both early and late post-transplant. Much debate remains over how to best utilize mTOR inhibition in kidney transplantation... - The evolving role of mTOR inhibition in transplantation toleranceGearoid McMahon
Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
J Am Soc Nephrol 22:408-15. 2011..Here we review the mechanisms by which mTOR inhibitors promote tolerance. We discuss the clinical relevance of these mechanisms and suggest how they might be used in the design of future protocols to induce tolerance... - Spotting the owl: surreptitious cytomegalovirus disease in a renal transplant recipientJoshua L Tarkan
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Clin Transplant 22:391-5. 2008..Potential pitfalls in making a prompt diagnosis are reviewed. The differential diagnosis of a large oral ulceration in a transplant recipient is broad, but should include CMV infection... - Neutron-activation analysis: a novel method for the assay of iohexolDavid A Albert
Division of Renal Medicine, Department of Medicine, University of Massachusetts Medical School, Worchester, MA 01655, USA
J Lab Clin Med 141:106-9. 2003..4% +/- 1.8%), with excellent intra- and interday reliability (mean coefficient of variation 4.1% +/- 1.6%). NAA is a feasible and reproducible method of detecting iohexol for the purpose of measuring GFR... - Outcomes with conversion from calcineurin inhibitors to sirolimus after renal transplantation in the context of steroid withdrawal or steroid continuationOgo I Egbuna
The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Transplantation 88:684-92. 2009..A number of studies have suggested that conversion from calcineurin inhibitors (CNI) to sirolimus (SRL) can improve graft function in renal transplant patients. None of these studies has converted patients to SRL in the absence of steroids... - Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantationV Patlolla
Department of Medicine, University of Massachusetts Medical School, MA, USA
Am J Transplant 7:1832-42. 2007..007). IL2R Abs remain an important option in the management of renal transplant patients, and may be particularly useful in specific patient subsets... - CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivoAkira Yamada
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:1357-64. 2005..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory... - Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherinK S Taraszka
Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Bringham and Women s Hospital, Boston, MA 02115, USA
J Exp Med 191:1555-67. 2000..These studies provide a conceptual basis for integrin-cadherin binding and extend the model that an Ig-like fold can serve as a scaffold for recognition...