Didier A Mandelbrot

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Living donor practices in the United States
    Didier A Mandelbrot
    Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Adv Chronic Kidney Dis 19:212-9. 2012
  2. ncbi request reprint The medical evaluation of living kidney donors: a survey of US transplant centers
    D A Mandelbrot
    Department of Medicine, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2333-43. 2007
  3. ncbi request reprint Validation of neutron activation as a novel method to determine glomerular filtration rate
    Didier A Mandelbrot
    UMassMemorial Medical Center, Boston, MA, USA
    Nephron Clin Pract 107:c117-22. 2007
  4. doi request reprint Practices and barriers in long-term living kidney donor follow-up: a survey of U.S. transplant centers
    Didier A Mandelbrot
    The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 88:855-60. 2009
  5. doi request reprint Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation
    Didier A Mandelbrot
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nephrol Dial Transplant 23:2679-84. 2008
  6. pmc B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    D A Mandelbrot
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:881-7. 2001
  7. ncbi request reprint The role of CTLA-4 in regulating Th2 differentiation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:2634-9. 1999
  8. ncbi request reprint Rejection of mouse cardiac allografts by costimulation in trans
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 167:1174-8. 2001
  9. ncbi request reprint CD28-independent costimulation of T cells in alloimmune responses
    A Yamada
    Laboratory of Immunogenetics and Transplantation and Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:140-6. 2001
  10. doi request reprint Evaluation of native kidney recovery after simultaneous liver-kidney transplantation
    Jean M Francis
    Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Transplantation 93:530-5. 2012

Detail Information

Publications39

  1. pmc Living donor practices in the United States
    Didier A Mandelbrot
    Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Adv Chronic Kidney Dis 19:212-9. 2012
    ..In this article, we review the current knowledge about living donor practices in the United States...
  2. ncbi request reprint The medical evaluation of living kidney donors: a survey of US transplant centers
    D A Mandelbrot
    Department of Medicine, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2333-43. 2007
    ..These findings highlight the need for more data on long-term outcomes in various types of donors with potential morbidities related to donation...
  3. ncbi request reprint Validation of neutron activation as a novel method to determine glomerular filtration rate
    Didier A Mandelbrot
    UMassMemorial Medical Center, Boston, MA, USA
    Nephron Clin Pract 107:c117-22. 2007
    ..In this study, we demonstrate that NA can be used to determine GFR by measuring the clearance of iohexol, and directly compare these results to a gold-standard method based on (99m)Tc-DTPA...
  4. doi request reprint Practices and barriers in long-term living kidney donor follow-up: a survey of U.S. transplant centers
    Didier A Mandelbrot
    The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 88:855-60. 2009
    ....
  5. doi request reprint Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation
    Didier A Mandelbrot
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nephrol Dial Transplant 23:2679-84. 2008
    ..We report three patients whose soft-tissue calcification syndromes dramatically resolved after undergoing HSCT...
  6. pmc B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    D A Mandelbrot
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:881-7. 2001
    ..Finally, administration of CTLA4-Ig to CD28/CTLA4(-/-) cardiac allograft recipients significantly prolongs graft survival. These data support the existence of an additional receptor for B7 molecules that is neither CD28 nor CTLA4...
  7. ncbi request reprint The role of CTLA-4 in regulating Th2 differentiation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:2634-9. 1999
    ..Thus, the B7-CD28/CTLA-4 pathway plays a critical role in regulating Th2 differentiation in two ways: CD28 promotes Th2 differentiation while CTLA-4 limits Th2 differentiation...
  8. ncbi request reprint Rejection of mouse cardiac allografts by costimulation in trans
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 167:1174-8. 2001
    ..This is the first demonstration that costimulation in trans can mediate an immune response in vivo and has important therapeutic implications...
  9. ncbi request reprint CD28-independent costimulation of T cells in alloimmune responses
    A Yamada
    Laboratory of Immunogenetics and Transplantation and Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:140-6. 2001
    ....
  10. doi request reprint Evaluation of native kidney recovery after simultaneous liver-kidney transplantation
    Jean M Francis
    Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Transplantation 93:530-5. 2012
    ..Identifying predictors of native kidney function recovery after SLK requires an accurate measure of the relative function of all three kidneys in patients with SLK...
  11. doi request reprint A cross-sectional study of fatigue and sleep quality before and after kidney transplantation
    James R Rodrigue
    The Transplant Institute, Beth Israel Deaconess Center for Transplant Outcomes and Quality Improvement and Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Transplant 25:E13-21. 2011
    ..Fatigue and sleep disturbances are common before and after KTx, and study findings have important implications for their assessment and management...
  12. doi request reprint Timing of sirolimus conversion influences recovery of renal function in liver transplant recipients
    Christin C Rogers
    Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Clin Transplant 23:887-96. 2009
    ..The only improvement in the LC group was from conversion to the three-month time point. We conclude that EC to SRL results in a profound improvement in eGFR that begins at three months and is sustained beyond one yr...
  13. pmc The decline in living kidney donation in the United States: random variation or cause for concern?
    James R Rodrigue
    1 Center for Transplant Outcomes and Quality Improvement The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 2 Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 3 Address correspondence to James R Rodrigue, Ph D, The Transplant Institute, Beth Israel Deaconess Medical Center, 110 Francis Street, 7th Floor, Boston, MA 02215
    Transplantation 96:767-73. 2013
    ..We conclude that the decline in living donation is not merely reflective of random variation but one that warrants action by the transplant centers, the broader transplant community, and the state and national governments. ..
  14. pmc Willingness to pursue live-donor kidney transplantation among waitlisted patients infected with human immunodeficiency virus (HIV): a preliminary investigation
    James R Rodrigue
    Center for Transplant Outcomes and Quality Improvement, The Transplant Institute, Beth Israel Deaconess Medical Center and the Harvard Medical School, Boston, MA, USA
    Transplantation 95:787-90. 2013
    ....
  15. doi request reprint Liver transplant center risk tolerance
    Scott R Johnson
    The Transplant Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Transplant 26:E269-76. 2012
    ..Small volume centers must perform higher risk transplants to meet current CMS requirements and are at risk for adverse action secondary to chance alone...
  16. ncbi request reprint Trajectories of perceived benefits in living kidney donors: association with donor characteristics and recipient outcomes
    James R Rodrigue
    1 Center for Transplant Outcomes and Quality Improvement, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 2 Harvard Medical School, Boston, MA 3 Transplant Center, Maine Medical Center, Portland, ME 4 Address correspondence to James R Rodrigue, Ph D, The Transplant Institute, Beth Israel Deaconess Medical Center, 110 Francis Street, 7th Floor, Boston, MA 02215
    Transplantation 97:762-8. 2014
    ..This study sought to identify trajectories of perceived benefit over the first 2 years after donation...
  17. doi request reprint A simultaneous liver-kidney transplant recipient with IgA nephropathy limited to native kidneys and BK virus nephropathy limited to the transplant kidney
    Manasa P Ujire
    The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Kidney Dis 62:331-4. 2013
    ..These findings confirm the predilection of BK virus nephropathy for transplant rather than native kidneys. ..
  18. doi request reprint Renal transplantation in the setting of early steroid withdrawal: a comparison of rabbit antithymocyte globulin induction dosing in two eras
    Christin C Rogers
    Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, Mass, USA
    Am J Nephrol 38:397-404. 2013
    ..Modern immunosuppression and rabbit antithymocyte globulin (rATG) have facilitated the success of early steroid withdrawal (ESW) protocols. Little data exist on optimal rATG dosing in ESW protocols...
  19. pmc The "House Calls" trial: a randomized controlled trial to reduce racial disparities in live donor kidney transplantation: rationale and design
    James R Rodrigue
    The Transplant Institute and The Center for Transplant Outcomes and Quality Improvement, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Contemp Clin Trials 33:811-8. 2012
    ..Similar trials have been developed recently to broaden the evaluation of House Calls as an innovative disparity-reducing intervention in kidney transplantation...
  20. ncbi request reprint Spouse caregivers of kidney transplant patients: quality of life and psychosocial outcomes
    James R Rodrigue
    The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Prog Transplant 20:335-42; quiz 343. 2010
    ..Little is known about the quality of life, caregiving strain, and psychosocial functioning of these caregivers...
  21. doi request reprint Measuring the expectations of kidney donors: initial psychometric properties of the Living Donation Expectancies Questionnaire
    James R Rodrigue
    The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 85:1230-4. 2008
    ..0001), Personal Growth (P<0.01), Quid Pro Quo (P<0.0001), and Health Consequences (P<0.0001) expectations. The LDEQ has promise in evaluating donor candidates' expectations...
  22. pmc Comorbidity burden and perioperative complications for living kidney donors in the United States
    Jesse D Schold
    Department of Quantitative Health Sciences, Glickman Urological and Kidney Institute, and, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Clin J Am Soc Nephrol 8:1773-82. 2013
    ..Research suggests minimal long-term health consequences after donation, but comprehensive studies are limited. The primary objective was to evaluate trends in comorbidity burden and complications among living donors...
  23. pmc The living kidney donor evaluation: focus on renal issues
    Ajay Kher
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 7:366-71. 2012
    ....
  24. doi request reprint Web-based requests for living organ donors: who are the solicitors?
    James R Rodrigue
    Department of Psychiatry, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Transplant 22:749-53. 2008
    ..Specifically, in some instances, a Good Samaritan's pursuit of living kidney donation may be based less on information potentially relevant to transplant outcome and more on the persuasiveness of the appeal...
  25. pmc A psychological intervention to improve quality of life and reduce psychological distress in adults awaiting kidney transplantation
    James R Rodrigue
    Center for Transplant Outcomes and Quality Improvement, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 26:709-15. 2011
    ..Effective psychological interventions to improve functioning in these areas are lacking...
  26. ncbi request reprint Evaluating living kidney donors: relationship types, psychosocial criteria, and consent processes at US transplant programs
    J R Rodrigue
    Department of Psychiatry, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2326-32. 2007
    ..Whether greater consensus should be reached on these donor evaluation practices, especially in the context of more expansive use of living donor kidney transplantation, is discussed...
  27. ncbi request reprint Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:3753-7. 1999
    ..The indefinite survival of allografts into B7-1/B7-2-/- recipients further shows that the absence of B7 costimulation alone is sufficient to prevent rejection...
  28. ncbi request reprint CTLA-4 and T cell activation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 11:294-300. 1999
    ..Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases...
  29. pmc B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115
    J Exp Med 189:435-40. 1999
    ..This suggests that the inhibitory function of CTLA-4 can overcome strong CD28-mediated signaling in vivo...
  30. doi request reprint Spotting the owl: surreptitious cytomegalovirus disease in a renal transplant recipient
    Joshua L Tarkan
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Transplant 22:391-5. 2008
    ..Potential pitfalls in making a prompt diagnosis are reviewed. The differential diagnosis of a large oral ulceration in a transplant recipient is broad, but should include CMV infection...
  31. doi request reprint The evolving role of mTOR inhibition in transplantation tolerance
    Gearoid McMahon
    Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 22:408-15. 2011
    ..Here we review the mechanisms by which mTOR inhibitors promote tolerance. We discuss the clinical relevance of these mechanisms and suggest how they might be used in the design of future protocols to induce tolerance...
  32. doi request reprint mTOR inhibition: the learning curve in kidney transplantation
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Transpl Int 23:447-60. 2010
    ..mTOR inhibitors also have been used as CNI-sparing agents both early and late post-transplant. Much debate remains over how to best utilize mTOR inhibition in kidney transplantation...
  33. pmc Development and validation of a questionnaire to assess fear of kidney failure following living donation
    James R Rodrigue
    Center for Transplant Outcomes and Quality Improvement, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA Harvard Medical School, Boston, MA, USA
    Transpl Int 27:570-5. 2014
    ..The Fear of Kidney Failure questionnaire is reliable, valid, and easy to use in the clinical setting...
  34. ncbi request reprint Neutron-activation analysis: a novel method for the assay of iohexol
    David A Albert
    Division of Renal Medicine, Department of Medicine, University of Massachusetts Medical School, Worchester, MA 01655, USA
    J Lab Clin Med 141:106-9. 2003
    ..4% +/- 1.8%), with excellent intra- and interday reliability (mean coefficient of variation 4.1% +/- 1.6%). NAA is a feasible and reproducible method of detecting iohexol for the purpose of measuring GFR...
  35. doi request reprint Outcomes with conversion from calcineurin inhibitors to sirolimus after renal transplantation in the context of steroid withdrawal or steroid continuation
    Ogo I Egbuna
    The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 88:684-92. 2009
    ..A number of studies have suggested that conversion from calcineurin inhibitors (CNI) to sirolimus (SRL) can improve graft function in renal transplant patients. None of these studies has converted patients to SRL in the absence of steroids...
  36. ncbi request reprint Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation
    V Patlolla
    Department of Medicine, University of Massachusetts Medical School, MA, USA
    Am J Transplant 7:1832-42. 2007
    ..007). IL2R Abs remain an important option in the management of renal transplant patients, and may be particularly useful in specific patient subsets...
  37. doi request reprint Immunosuppression after renal allograft failure: a survey of US practices
    George P Bayliss
    Department of Medicine, Rhode Island Hospital, Providence, RI, USA
    Clin Transplant 27:895-900. 2013
    ..Little data exist to guide the management of immunosuppression after renal graft failure. More aggressive tapering of immunosuppressive medications may reduce the risk of infection, but may increase the risk of rejection and sensitization...
  38. ncbi request reprint CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo
    Akira Yamada
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:1357-64. 2005
    ..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
  39. pmc Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin
    K S Taraszka
    Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Bringham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 191:1555-67. 2000
    ..These studies provide a conceptual basis for integrin-cadherin binding and extend the model that an Ig-like fold can serve as a scaffold for recognition...