D A Mandelbrot

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115
    J Exp Med 189:435-40. 1999
  2. pmc B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    D A Mandelbrot
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:881-7. 2001
  3. ncbi request reprint CD28-independent costimulation of T cells in alloimmune responses
    A Yamada
    Laboratory of Immunogenetics and Transplantation and Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:140-6. 2001
  4. ncbi request reprint Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:3753-7. 1999
  5. ncbi request reprint CTLA-4 and T cell activation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 11:294-300. 1999
  6. ncbi request reprint Rejection of mouse cardiac allografts by costimulation in trans
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 167:1174-8. 2001
  7. ncbi request reprint The role of CTLA-4 in regulating Th2 differentiation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:2634-9. 1999
  8. ncbi request reprint Evaluating living kidney donors: relationship types, psychosocial criteria, and consent processes at US transplant programs
    J R Rodrigue
    Department of Psychiatry, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2326-32. 2007
  9. ncbi request reprint The medical evaluation of living kidney donors: a survey of US transplant centers
    D A Mandelbrot
    Department of Medicine, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2333-43. 2007
  10. ncbi request reprint Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation
    V Patlolla
    Department of Medicine, University of Massachusetts Medical School, MA, USA
    Am J Transplant 7:1832-42. 2007

Detail Information

Publications10

  1. pmc B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115
    J Exp Med 189:435-40. 1999
    ..This suggests that the inhibitory function of CTLA-4 can overcome strong CD28-mediated signaling in vivo...
  2. pmc B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    D A Mandelbrot
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:881-7. 2001
    ..Finally, administration of CTLA4-Ig to CD28/CTLA4(-/-) cardiac allograft recipients significantly prolongs graft survival. These data support the existence of an additional receptor for B7 molecules that is neither CD28 nor CTLA4...
  3. ncbi request reprint CD28-independent costimulation of T cells in alloimmune responses
    A Yamada
    Laboratory of Immunogenetics and Transplantation and Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:140-6. 2001
    ....
  4. ncbi request reprint Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:3753-7. 1999
    ..The indefinite survival of allografts into B7-1/B7-2-/- recipients further shows that the absence of B7 costimulation alone is sufficient to prevent rejection...
  5. ncbi request reprint CTLA-4 and T cell activation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 11:294-300. 1999
    ..Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases...
  6. ncbi request reprint Rejection of mouse cardiac allografts by costimulation in trans
    D A Mandelbrot
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 167:1174-8. 2001
    ..This is the first demonstration that costimulation in trans can mediate an immune response in vivo and has important therapeutic implications...
  7. ncbi request reprint The role of CTLA-4 in regulating Th2 differentiation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:2634-9. 1999
    ..Thus, the B7-CD28/CTLA-4 pathway plays a critical role in regulating Th2 differentiation in two ways: CD28 promotes Th2 differentiation while CTLA-4 limits Th2 differentiation...
  8. ncbi request reprint Evaluating living kidney donors: relationship types, psychosocial criteria, and consent processes at US transplant programs
    J R Rodrigue
    Department of Psychiatry, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2326-32. 2007
    ..Whether greater consensus should be reached on these donor evaluation practices, especially in the context of more expansive use of living donor kidney transplantation, is discussed...
  9. ncbi request reprint The medical evaluation of living kidney donors: a survey of US transplant centers
    D A Mandelbrot
    Department of Medicine, The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 7:2333-43. 2007
    ..These findings highlight the need for more data on long-term outcomes in various types of donors with potential morbidities related to donation...
  10. ncbi request reprint Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation
    V Patlolla
    Department of Medicine, University of Massachusetts Medical School, MA, USA
    Am J Transplant 7:1832-42. 2007
    ..007). IL2R Abs remain an important option in the management of renal transplant patients, and may be particularly useful in specific patient subsets...