Harvey Mamon

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing
    Jin Li
    Department of Radiation Oncology, Divisions of Genomic Stability and DNA Repair, Physics and Radiation Therapy, Room JF514, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Med 14:579-84. 2008
  2. ncbi Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation
    H J Mamon
    Laboratory of Radiobiology Harvard School of Public Health 655 Huntington Avenue Boston MA 02115 USA
    Int J Radiat Biol 79:817-29. 2003
  3. ncbi A phase 2 trial of gemcitabine, 5-fluorouracil, and radiation therapy in locally advanced nonmetastatic pancreatic adenocarcinoma : cancer and Leukemia Group B (CALGB) 80003
    Harvey J Mamon
    Dana Farber Cancer Institute, Boston, Massachusetts Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer 117:2620-8. 2011
  4. ncbi Is radiation therapy required for patients with intermediate-risk rectal cancer?
    Harvey Mamon
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Adv Hematol Oncol 5:638-44, 585. 2007
  5. ncbi Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment
    E Castellanos-Rizaldos
    Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Clin Chem 58:1130-8. 2012
  6. ncbi DNA degradation test predicts success in whole-genome amplification from diverse clinical samples
    Fengfei Wang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Diagn 9:441-51. 2007
  7. ncbi Antiprimer quenching-based real-time PCR and its application to the analysis of clinical cancer samples
    Jin Li
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Clin Chem 52:624-33. 2006
  8. ncbi Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content
    Coren A Milbury
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Mol Diagn 13:220-32. 2011
  9. ncbi Differential strand separation at critical temperature: A minimally disruptive enrichment method for low-abundance unknown DNA mutations
    Minakshi Guha
    Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA and Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nucleic Acids Res 41:e50. 2013
  10. ncbi Automatic marker detection and 3D position reconstruction using cine EPID images for SBRT verification
    Sang June Park
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 36:4536-46. 2009

Collaborators

Detail Information

Publications15

  1. ncbi Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing
    Jin Li
    Department of Radiation Oncology, Divisions of Genomic Stability and DNA Repair, Physics and Radiation Therapy, Room JF514, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Med 14:579-84. 2008
    ..COLD-PCR will transform the capabilities of PCR-based genetic testing, including applications in cancer, infectious diseases and prenatal identification of fetal alleles in maternal blood...
  2. ncbi Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation
    H J Mamon
    Laboratory of Radiobiology Harvard School of Public Health 655 Huntington Avenue Boston MA 02115 USA
    Int J Radiat Biol 79:817-29. 2003
    ..Various cellular responses to radiation were analysed in cells with mutations in ATM or BRCA1 in an attempt to clarify which effects of ATM can be mediated through BRCA1...
  3. ncbi A phase 2 trial of gemcitabine, 5-fluorouracil, and radiation therapy in locally advanced nonmetastatic pancreatic adenocarcinoma : cancer and Leukemia Group B (CALGB) 80003
    Harvey J Mamon
    Dana Farber Cancer Institute, Boston, Massachusetts Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer 117:2620-8. 2011
    ..The purpose of this study was to assess the efficacy and safety of 5-fluorouracil (5FU) and gemcitabine administered concurrently with radiation in patients with locally advanced, nonmetastatic pancreatic cancer...
  4. ncbi Is radiation therapy required for patients with intermediate-risk rectal cancer?
    Harvey Mamon
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Adv Hematol Oncol 5:638-44, 585. 2007
    ..Current data permit identification of these patients, but no randomized studies have yet demonstrated that selected patients with locally advanced rectal cancer can safely be spared adjuvant or neoadjuvant radiation...
  5. ncbi Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment
    E Castellanos-Rizaldos
    Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Clin Chem 58:1130-8. 2012
    ..We present a temperature-tolerant (TT) approach (TT-COLD-PCR) that reduces this obstacle...
  6. ncbi DNA degradation test predicts success in whole-genome amplification from diverse clinical samples
    Fengfei Wang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Diagn 9:441-51. 2007
    ..Estimates of the percent information retained relative to snap-frozen DNA are derived for real-time PCR analysis. The assay is rapid and convenient and can be used widely to characterize DNA from any clinical sample of unknown quality...
  7. ncbi Antiprimer quenching-based real-time PCR and its application to the analysis of clinical cancer samples
    Jin Li
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Clin Chem 52:624-33. 2006
    ..CONCLUSION: The simplicity, versatility, reliability, and low cost of aQRT-PCR make it suitable for genetic analysis of clinical specimens...
  8. ncbi Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content
    Coren A Milbury
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Mol Diagn 13:220-32. 2011
    ..In summary, we demonstrate an efficient approach to increase screening capabilities from limited DNA material via multiplex-PCR and improve mutation detection sensitivity via COLD-PCR amplification...
  9. ncbi Differential strand separation at critical temperature: A minimally disruptive enrichment method for low-abundance unknown DNA mutations
    Minakshi Guha
    Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA and Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nucleic Acids Res 41:e50. 2013
    ..The simplicity, scalability and reliability of DISSECT make it a powerful method for mutation enrichment that integrates well with existing downstream detection methods...
  10. ncbi Automatic marker detection and 3D position reconstruction using cine EPID images for SBRT verification
    Sang June Park
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 36:4536-46. 2009
    ..The measured intrafractional tumor motion and the interfractional daily patient setup error can be used for off-line retrospective verification of SBRT...
  11. ncbi FDG-PET/CT tumor segmentation-derived indices of metabolic activity to assess response to neoadjuvant therapy and progression-free survival in esophageal cancer: correlation with histopathology results
    Marcelo Mamede
    Division of Nuclear Medicine, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Oncol 30:377-88. 2007
    ....
  12. ncbi Whole genome amplification of plasma-circulating DNA enables expanded screening for allelic imbalance in plasma
    Jin Li
    Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Brigham and Women's Hospital, Level L2, Radiation Therapy, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 8:22-30. 2006
    ....
  13. ncbi Treatment planning for resected abdominal tumors: differences in organ position between diagnostic and radiation-planning computed tomography scans
    Aileen B Chen
    Department of Radiation Oncology, Brigham and Women's Hospital/Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 63:1613-20. 2005
    ..These shifts should be considered during treatment planning for resected abdominal tumors...
  14. ncbi Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older
    R H Mak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Dis Esophagus 23:316-23. 2010
    ..In conclusion, elderly patients experienced substantial morbidity from chemoradiation, and long-term survival was low. Future efforts to improve treatment tolerability in the elderly are needed...
  15. ncbi Preferential amplification of apoptotic DNA from plasma: potential for enhancing detection of minor DNA alterations in circulating DNA
    Harvey Mamon
    Clin Chem 54:1582-4. 2008