Nikolaos Makris

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography
    N Makris
    Departments of Psychiatry and Neurology Services, Center for Neural Systems Investigations, Center for Morphometric Analysis, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA, 02129, USA
    Brain Imaging Behav 7:335-52. 2013
  2. pmc Human middle longitudinal fascicle: variations in patterns of anatomical connections
    N Makris
    Department of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Brain Struct Funct 218:951-68. 2013
  3. pmc Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences
    Nikos Makris
    Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 69:1-10. 2013
  4. pmc Characterization of the "deqi" response in acupuncture
    Kathleen K S Hui
    Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 7:33. 2007
  5. ncbi request reprint Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 15:854-69. 2005
  6. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
  7. pmc The occipitofrontal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Neuroimage 37:1100-11. 2007
  8. ncbi request reprint An introduction to MR imaging-based stroke morphometry
    Nikos Makris
    Department of Neurology, Harvard Medical School, Charlestown, MA, USA
    Neuroimaging Clin N Am 15:325-39, x. 2005
  9. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
  10. ncbi request reprint Decreased volume of left and total anterior insular lobule in schizophrenia
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:155-71. 2006

Research Grants

  1. Neuroimaging and Functional Senscence in Aging
    Nikolaos Makris; Fiscal Year: 2002

Collaborators

Detail Information

Publications68

  1. pmc Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography
    N Makris
    Departments of Psychiatry and Neurology Services, Center for Neural Systems Investigations, Center for Morphometric Analysis, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA, 02129, USA
    Brain Imaging Behav 7:335-52. 2013
    ....
  2. pmc Human middle longitudinal fascicle: variations in patterns of anatomical connections
    N Makris
    Department of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Brain Struct Funct 218:951-68. 2013
    ....
  3. pmc Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences
    Nikos Makris
    Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 69:1-10. 2013
    ....
  4. pmc Characterization of the "deqi" response in acupuncture
    Kathleen K S Hui
    Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 7:33. 2007
    ....
  5. ncbi request reprint Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 15:854-69. 2005
    ..Since DT-MRI allows the precise definition of only the stem portion of each fiber pathway, the origin and termination of the subdivisions of SLF are extrapolated from the available data in experimental material from non-human primates...
  6. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
    ..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability...
  7. pmc The occipitofrontal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Neuroimage 37:1100-11. 2007
    ..The OFF may have a role in visual spatial processing along with SLF II...
  8. ncbi request reprint An introduction to MR imaging-based stroke morphometry
    Nikos Makris
    Department of Neurology, Harvard Medical School, Charlestown, MA, USA
    Neuroimaging Clin N Am 15:325-39, x. 2005
    ..These samples highlight anatomic-based considerations regarding the nature of stroke and its repercussions within the brain parenchyma...
  9. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  10. ncbi request reprint Decreased volume of left and total anterior insular lobule in schizophrenia
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:155-71. 2006
    ....
  11. ncbi request reprint Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder
    Nikos Makris
    Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Health Sciences and Technology Athinoula A Martinos Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 17:1364-75. 2007
    ..This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF...
  12. ncbi request reprint Human cerebral cortex: a system for the integration of volume- and surface-based representations
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 33:139-53. 2006
    ..This system of topographical analysis of the cerebral cortex is consistent with current views of cortical development and neural systems organization of the human and non-human primate brain...
  13. ncbi request reprint Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging
    Nikos Makris
    Massachusetts General Hospital, USA
    J Cogn Neurosci 15:584-99. 2003
    ..The SAP technique makes it possible to represent multimodal structural and functional imaging data on the flattened surface of the cerebellar cortex as illustrated in one functional MRI experiment...
  14. ncbi request reprint Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections
    Nikos Makris
    Harvard Medical School Departments of Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 18:1210-20. 2008
    ..The demonstration of FA abnormalities in the CB and SLF II in adults with childhood ADHD provides further support for persistent structural abnormalities into adulthood...
  15. pmc Delineation of the middle longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Psychiatry, Center for Morphometric Analysis, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, 02129, USA
    Cereb Cortex 19:777-85. 2009
    ..Given the location of MdLF between the IPL (angular gyrus) and the STG, it is suggested that MdLF could have a role in language and attention functions...
  16. pmc The extreme capsule in humans and rethinking of the language circuitry
    Nikos Makris
    Departments of Psychiatry and Neurology, Harvard Medical School, Boston, MA 02129, USA
    Brain Struct Funct 213:343-58. 2009
    ....
  17. pmc Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study
    Nikos Makris
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Atten Disord 13:407-13. 2010
    ..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD...
  18. pmc Towards conceptualizing a neural systems-based anatomy of attention-deficit/hyperactivity disorder
    Nikos Makris
    Harvard Medical School Department of Psychiatry, Boston University School of Medicine, Boston, MA 02129, USA
    Dev Neurosci 31:36-49. 2009
    ..Characterizing these neural systems using neuroimaging could be critical for the description of structural endophenotypes, and may provide the capability of in vivo categorization and correlation with behavior and genes...
  19. pmc Methods of MRI-based structural imaging in the aging monkey
    N Makris
    Harvard Medical School Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Methods 50:166-77. 2010
    ....
  20. pmc White matter volume abnormalities and associations with symptomatology in schizophrenia
    Nikolaos Makris
    Athinoula A Martinos Imaging Center, Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA, United States
    Psychiatry Res 183:21-9. 2010
    ..These observations suggest a pattern of volume WM alterations associated with symptomatology in schizophrenia that may be related in part to predisposition to schizophrenia...
  21. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  22. pmc Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study
    Deborah J Walder
    Psychiatric Neuroscience Division, Harvard Medical School Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02120, USA
    Schizophr Res 90:295-301. 2007
    ....
  23. pmc Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorder
    Eve M Valera
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult Attention Deficit Hyperactivity Disorder, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 68:359-67. 2010
    ..Also, the neural substrates of these deficits are largely unknown for both youth and adults with ADHD. The present study examined subsecond sensorimotor timing and its neural substrates in ADHD adults...
  24. ncbi request reprint A diffusion tensor imaging study of white matter in obsessive-compulsive disorder
    Paul A Cannistraro
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Depress Anxiety 24:440-6. 2007
    ..This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance...
  25. pmc Role of the medial temporal lobes in relational memory: neuropsychological evidence from a cued recognition paradigm
    Irene P Kan
    Memory Disorders Research Center, Boston University School of Medicine, Boston VA Healthcare System, Boston, MA 02130, USA
    Neuropsychologia 45:2589-97. 2007
    ..These data provide further support for the idea that the hippocampus plays a critical role in relational memory, even when associative information need not be retrieved intentionally...
  26. ncbi request reprint Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary results
    Mitsuhiro Nishida
    Center for Morphometric Analysis, Department of Neurology, Massachusetts General Hospital, 34 Fruit Street, Boston, MA 02114, USA
    Neuroimage 32:1041-9. 2006
    ..These preliminary results are consistent with the heterochronous nature of cerebral development and provide initial estimates of regional brain growth and therefore regional vulnerability in the perinatal time period...
  27. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
    ..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
  28. ncbi request reprint Somatotopic activation in the human trigeminal pain pathway
    Alex F M DaSilva
    Center for Pain Functional Neuroimaging and Therapy Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:8183-92. 2002
    ..This approach will be useful for exploring central correlates of plasticity in models of experimental and clinical pain...
  29. doi request reprint A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  30. ncbi request reprint Evidence for reduced cerebellar volumes in trichotillomania
    Nancy J Keuthen
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 61:374-81. 2007
    ..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences...
  31. doi request reprint Frontal white matter and cingulum diffusion tensor imaging deficits in alcoholism
    Gordon J Harris
    Department of Neurology, Athinoula A Martinos Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Alcohol Clin Exp Res 32:1001-13. 2008
    ..In the present study, we examined the integrity of white matter tracts that are critical to frontal and limbic connectivity...
  32. pmc Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
    Brain Res 1287:84-103. 2009
    ..Our results suggest that acupuncture mobilizes the anti-correlated functional networks of the brain to mediate its actions, and that the effect is dependent on the psychophysical response...
  33. pmc An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder
    Heidi W Thermenos
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010
    ..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD...
  34. ncbi request reprint Selectively reduced regional cortical volumes in post-traumatic stress disorder
    Scott L Rauch
    Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 14:913-6. 2003
    ..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD...
  35. pmc Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:289-301. 2009
    ..Our protocol also demonstrates a fMRI approach to study habituation and other time-variant phenomena over longer time durations...
  36. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  37. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  38. ncbi request reprint A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
    Psychiatry Res 122:13-9. 2003
    ..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders...
  39. pmc Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  40. pmc Sex differences in the functional neuroanatomy of working memory in adults with ADHD
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 167:86-94. 2010
    ..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task...
  41. pmc Cerebellum, language, and cognition in autism and specific language impairment
    Steven M Hodge
    Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA
    J Autism Dev Disord 40:300-16. 2010
    ..These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention...
  42. ncbi request reprint Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging
    Jill M Goldstein
    Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:154-64. 2002
    ....
  43. pmc Sex differences in stress response circuitry activation dependent on female hormonal cycle
    Jill M Goldstein
    Department of Psychiatry, and Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Neurosci 30:431-8. 2010
    ....
  44. pmc Microstructural status of ipsilesional and contralesional corticospinal tract correlates with motor skill in chronic stroke patients
    Judith D Schaechter
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 30:3461-74. 2009
    ....
  45. pmc Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study
    Isabelle M Rosso
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 123:15-21. 2010
    ..We conducted a region-of-interest morphometric study of prefrontal subregions in adolescent and young adult relatives of schizophrenia patients...
  46. pmc Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia
    Isabelle M Rosso
    Neuroimaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Depress Anxiety 27:1104-10. 2010
    ..We examined whether AS was significantly correlated with right anterior insula volume and thickness among adults with specific animal phobia (SAP) and healthy comparison (HC) subjects...
  47. ncbi request reprint Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies
    Stephen V Faraone
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 60:125-40. 2003
    ....
  48. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  49. ncbi request reprint Automated brainstem co-registration (ABC) for MRI
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Neuroimage 32:1113-9. 2006
    ..The use of easily available and validated tools (AFNI and FSL) for this method should ease adoption by other investigators interested in brainstem data group analysis...
  50. ncbi request reprint Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging
    Larry J Seidman
    Harvard Medical School, Department of Psychiatry, Center for Morphometric Analysis, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Biol Psychiatry 60:1071-80. 2006
    ..This structural MRI study used an a priori region of interest approach...
  51. ncbi request reprint Neurophysiology and neuroanatomy of pitch perception: auditory cortex
    Mark Jude Tramo
    Department of Neurology, Harvard Medical School, and Massachusetts General Hospital, The Institute for Music and Brain Science, Boston, 02114, USA
    Ann N Y Acad Sci 1060:148-74. 2005
    ..Advancing knowledge about the neural coding of pitch is of fundamental importance to the future design of neurobionic therapies for hearing loss...
  52. pmc White matter abnormalities in dystonia normalize after botulinum toxin treatment
    Anne J Blood
    Department of Neurology, Massachusetts General Hospital, Charlestown 02129, and Harvard Medical School, Boston, Massachusetts, USA
    Neuroreport 17:1251-5. 2006
    ..This raises the possibility that we have observed activity-dependent white matter plasticity in the adult human brain...
  53. ncbi request reprint Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 61:935-45. 2007
    ..We tested the hypothesis that normal hypothalamic sexual dimorphism is disrupted in schizophrenia...
  54. ncbi request reprint Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Brigham and Women s Hospital, Connors Center for Women s Health and Gender Biology, Boston, Massachusetts 02115, USA
    J Neurosci 25:9309-16. 2005
    ..Findings have important implications for normal sex-specific physiological functioning and may contribute to understanding higher rates of mood and anxiety disorders in women and differential sensitivity to trauma than men...
  55. ncbi request reprint Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, MA 02120, USA
    Neuropsychology 19:509-19. 2005
    ..The findings suggest that combining men and women in fMRI studies of cognition may obscure or bias results...
  56. ncbi request reprint The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 27:479-96. 2005
    ..The study provides preliminary evidence for an integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 that correlates with the psychophysical response...
  57. ncbi request reprint Structural brain imaging of attention-deficit/hyperactivity disorder
    Larry J Seidman
    Pediatric Psychopharmacology Unit and Psychiatric Neuroscience Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Psychiatry 57:1263-72. 2005
    ..These results suggest that the brain is altered in a more widespread manner than has been previously hypothesized. Developmental studies are needed to address the evolution of this brain disorder into adulthood...
  58. ncbi request reprint Sequence-independent segmentation of magnetic resonance images
    Bruce Fischl
    Department of Radiology, MGH, Athinoula A Martinos Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 23:S69-84. 2004
    ..This sequence has the added benefit of allowing the explicit estimation of T2* and of reducing test-retest intensity variability...
  59. pmc Brain correlates of autonomic modulation: combining heart rate variability with fMRI
    Vitaly Napadow
    MGH MIT HMS Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02119, USA
    Neuroimage 42:169-77. 2008
    ..Our approach should be optimized and applied to study the human brain correlates of autonomic modulation for various stimuli in both physiological and pathological states...
  60. doi request reprint Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    George Bush
    Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 65:102-14. 2008
    ..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
  61. ncbi request reprint Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer
    Xiao Han
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuroimage 32:180-94. 2006
    ....
  62. ncbi request reprint White matter abnormalities in children with and at risk for bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Bipolar Disord 9:799-809. 2007
    ..To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder...
  63. ncbi request reprint MRI volumetric analysis in rasmussen encephalitis: a longitudinal study
    Masanori Takeoka
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, U S A
    Epilepsia 44:247-51. 2003
    ..We report a case of early-stage Rasmussen encephalitis with a relatively stable clinical course in whom we performed magnetic resonance imaging (MRI)-based volumetric analysis over an interval of 1 year, to assess for volumetric changes...
  64. pmc Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?
    Nikos Makris
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 60:174-88. 2008
    ..These observations suggest that brain structure abnormalities in addicts are related in part to drug use and in part to predisposition toward addiction...
  65. pmc Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Schizophr Bull 34:37-46. 2008
    ..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex...
  66. ncbi request reprint Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 24:193-205. 2005
    ....
  67. ncbi request reprint Abnormal asymmetry in language association cortex in autism
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, CNY 149, Room 6012, Boston, MA 02114, USA
    Ann Neurol 52:588-96. 2002
    ..In boys with autism, language and social/face processing-related regions displayed abnormal asymmetry. These structural abnormalities may relate to language and social disturbances observed in autism...
  68. ncbi request reprint Localization of white matter volume increase in autism and developmental language disorder
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
    Ann Neurol 55:530-40. 2004
    ....

Research Grants1

  1. Neuroimaging and Functional Senscence in Aging
    Nikolaos Makris; Fiscal Year: 2002
    ..abstract_text> ..