Stephane F Maison

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Efferent feedback minimizes cochlear neuropathy from moderate noise exposure
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 33:5542-52. 2013
  2. pmc Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 109:1525-34. 2013
  3. pmc Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 108:491-500. 2012
  4. pmc Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 32:344-55. 2012
  5. pmc Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:10315-26. 2006
  6. pmc Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:6751-62. 2010
  7. ncbi request reprint A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 97:3269-78. 2007
  8. pmc Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
    J Assoc Res Otolaryngol 10:50-63. 2009
  9. pmc Mice lacking adrenergic signaling have normal cochlear responses and normal resistance to acoustic injury but enhanced susceptibility to middle-ear infection
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 11:449-61. 2010
  10. ncbi request reprint Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurophysiol 90:2941-9. 2003

Collaborators

Detail Information

Publications21

  1. pmc Efferent feedback minimizes cochlear neuropathy from moderate noise exposure
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 33:5542-52. 2013
    ....
  2. pmc Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 109:1525-34. 2013
    ..The suppression remaining in BK nulls was blocked by strychnine, suggesting involvement of α9-/α10-cholinergic receptors, coupled to activation of the remaining SK2 channels...
  3. pmc Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 108:491-500. 2012
    ..Possible alternate pathways are discussed for the source of contra-noise-evoked effects at low ipsilateral levels...
  4. pmc Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 32:344-55. 2012
    ..In D4 and D5 knock-outs, the increased noise vulnerability was seen only in ABRs, consistent with a role for dopaminergic signaling in minimizing neural damage...
  5. pmc Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:10315-26. 2006
    ..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear...
  6. pmc Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:6751-62. 2010
    ....
  7. ncbi request reprint A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 97:3269-78. 2007
    ....
  8. pmc Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
    J Assoc Res Otolaryngol 10:50-63. 2009
    ..Our results suggest that GABAergic signaling in type II afferent neurons may be required for normal outer hair cell amplifier function at low sound levels and may also modulate outer hair cell responses to high-level sound...
  9. pmc Mice lacking adrenergic signaling have normal cochlear responses and normal resistance to acoustic injury but enhanced susceptibility to middle-ear infection
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 11:449-61. 2010
    ..However, adrenergic modulation of olivocochlear efferents does not mediate the protective effect of contralateral cochlear destruction on ipsilateral response to acoustic overexposure...
  10. ncbi request reprint Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurophysiol 90:2941-9. 2003
    ..This constitutes the most direct evidence to date for a functional role of the lateral OC system in the auditory periphery...
  11. pmc Cochlear efferent feedback balances interaural sensitivity
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, Massachusetts 02114, USA
    Nat Neurosci 9:1474-6. 2006
    ..Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space...
  12. pmc The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system
    Douglas E Vetter
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:20594-9. 2007
    ..Moreover, alpha10 nAChR subunits are required for normal olivocochlear activity because alpha9 homomeric nAChRs do not support maintenance of normal olivocochlear innervation or function in alpha10(-/-) mutant mice...
  13. ncbi request reprint Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurosci 22:10838-46. 2002
    ..These data demonstrate that efferent protection is mediated via the alpha9 nAChR in the outer hair cells and provide direct evidence for a protective role, in vivo, of a member of the nAChR family...
  14. pmc Efferent feedback slows cochlear aging
    M Charles Liberman
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, and Harvard Program in Speech and Hearing Bioscience and Technology, Boston, Massachusetts 02114
    J Neurosci 34:4599-607. 2014
    ..Since efferent reflex strength varies among individuals and can be measured noninvasively, a weak reflex may be an important risk factor, and prognostic indicator, for age-related hearing impairment. ..
  15. pmc Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Comp Neurol 455:406-16. 2003
    ....
  16. pmc Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurophysiol 97:2930-6. 2007
    ....
  17. pmc Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Neurophysiol 97:1775-85. 2007
    ..These findings suggest that the LOC modulates cochlear nerve excitability and protects the cochlea from neural damage in acute acoustic injury...
  18. pmc Sound-evoked olivocochlear activation in unanesthetized mice
    Anna R Chambers
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 13:209-17. 2012
    ..These findings demonstrate the utility of the CAS assay in the unanesthetized mouse and highlight the adverse effects of anesthesia when probing the functional status of descending control pathways within the auditory system...
  19. pmc Olivocochlear innervation maintains the normal modiolar-pillar and habenular-cuticular gradients in cochlear synaptic morphology
    Yanbo Yin
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 15:571-83. 2014
    ..Our spatial analysis also suggests that adjacent IHCs may contain a different synaptic mix, depending on whether their tilt in the radial plane places their synaptic pole closer to the pillar cells or to the modiolus. ..
  20. pmc A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction
    Nahid G Robertson
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 17:3426-34. 2008
    ..This is the only mouse model developed to date where hearing loss begins at such an advanced age, providing an opportunity to study both progressive age-related hearing loss and possible interventional therapies...
  21. ncbi request reprint Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse
    Gabor Keresztes
    Department of Otolaryngology Eaton Peabody Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Biol Chem 279:1581-4. 2004
    ..Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP...