Tomas Maira-Litran

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Synthesis and evaluation of a conjugate vaccine composed of Staphylococcus aureus poly-N-acetyl-glucosamine and clumping factor A
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e43813. 2012
  2. pmc Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Infect Immun 70:4433-40. 2002
  3. pmc Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Infect Immun 73:6752-62. 2005
  4. pmc Molecular basis for preferential protective efficacy of antibodies directed to the poorly acetylated form of staphylococcal poly-N-acetyl-beta-(1-6)-glucosamine
    Nuno Cerca
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 75:3406-13. 2007
  5. pmc Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide
    Nuno Cerca
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:7528-33. 2007
  6. pmc Poly-N-acetyl-β-(1-6)-glucosamine is a target for protective immunity against Acinetobacter baumannii infections
    Leticia V Bentancor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 80:651-6. 2012
  7. pmc Evaluation of the trimeric autotransporter Ata as a vaccine candidate against Acinetobacter baumannii infections
    Leticia V Bentancor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 80:3381-8. 2012
  8. pmc Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice
    Victoria L Campodónico
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Infect Immun 79:3455-64. 2011
  9. pmc Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
    David Skurnik
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3220-33. 2010
  10. pmc Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection
    Andrea Kropec
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Immun 73:6868-76. 2005

Collaborators

Detail Information

Publications17

  1. pmc Synthesis and evaluation of a conjugate vaccine composed of Staphylococcus aureus poly-N-acetyl-glucosamine and clumping factor A
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e43813. 2012
    ..In conclusion, ClfA is an immunogenic carrier protein that elicited anti-adhesive antibodies that fail to augment the OPK and protective activities of antibodies to the PNAG cell surface polysaccharide...
  2. pmc Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Infect Immun 70:4433-40. 2002
    ..These results further clarify the chemical structure of PS/A and help to differentiate it from PIA on the basis of immunogenicity, molecular size, and solubility...
  3. pmc Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Infect Immun 73:6752-62. 2005
    ..aureus infection, including capsular polysaccharide types 5 and 8 and an untypable strain...
  4. pmc Molecular basis for preferential protective efficacy of antibodies directed to the poorly acetylated form of staphylococcal poly-N-acetyl-beta-(1-6)-glucosamine
    Nuno Cerca
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 75:3406-13. 2007
    ..Retention of dPNAG on the surface of S. aureus is key to increased survival during bacteremia and also provides a molecular mechanism explaining the superior opsonic and protective activity of antibody to dPNAG...
  5. pmc Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide
    Nuno Cerca
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:7528-33. 2007
    ..coli strains expressing PNAG. PNAG expression by both Gram-negative and Gram-positive organisms could make this antigen a conserved vaccine target for multiple pathogenic species of bacteria...
  6. pmc Poly-N-acetyl-β-(1-6)-glucosamine is a target for protective immunity against Acinetobacter baumannii infections
    Leticia V Bentancor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 80:651-6. 2012
    ..This was true for all four A. baumannii strains tested. Overall, these results highlight the potential of PNAG as a vaccine component for active immunization or as a target for passive antibody immunotherapy...
  7. pmc Evaluation of the trimeric autotransporter Ata as a vaccine candidate against Acinetobacter baumannii infections
    Leticia V Bentancor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 80:3381-8. 2012
    ..The ability of Ata to engender anti-adhesive, bactericidal, opsonophagocytic, and protective antibodies validates its potential use as an antigenic target against MDR A. baumannii infections...
  8. pmc Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice
    Victoria L Campodónico
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Infect Immun 79:3455-64. 2011
    ..Conjugation of PMA to FLA appears to be a promising path for developing a broadly protective vaccine against P. aeruginosa...
  9. pmc Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
    David Skurnik
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3220-33. 2010
    ..aureus infections in humans could be due, in part, to interference in OPK when antibodies to CP and PNAG antigens are both present. This information could be used to better design S. aureus vaccine components...
  10. pmc Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection
    Andrea Kropec
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Immun 73:6868-76. 2005
    ..Thus, PNAG confers on S. aureus resistance to killing mediated by these innate host immune mediators. Overall, PNAG production by S. aureus appears to be a critical virulence factor as assessed in murine models of systemic infection...
  11. pmc Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
    Colette Cywes-Bentley
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2209-18. 2013
    ..Vaccination targeting PNAG could contribute to immunity against serious and diverse prokaryotic and eukaryotic pathogens, and the conserved production of PNAG suggests that it is a critical factor in microbial biology...
  12. pmc Identification of Ata, a multifunctional trimeric autotransporter of Acinetobacter baumannii
    Leticia V Bentancor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Bacteriol 194:3950-60. 2012
    ..baumannii cells to collagen type IV, and contributing to the survival of A. baumannii in a mouse model of lethal infection...
  13. ncbi Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide
    Tomas Maira-Litran
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Vaccine 22:872-9. 2004
    ..Animal studies have shown purified PNAG can elicit protective immunity against both CoNS and S. aureus, suggesting its potential as a broadly protective vaccine for many clinically important strains of staphylococci...
  14. pmc The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation
    Alexis H K Choi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Bacteriol 191:5953-63. 2009
    ..Biofilm-dependent production of PNAG could be an important virulence factor for this emerging pathogen that has few known virulence factors...
  15. pmc Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection
    David Skurnik
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Infect Dis 205:1709-18. 2012
    ....
  16. pmc Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccines
    Victoria L Campodónico
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Infect Immun 78:746-55. 2010
    ..aeruginosa based on flagellar antigens may require additional components beyond type a and type b proteins from prototype strains...
  17. ncbi Alterations in the Staphylococcus epidermidis biofilm transcriptome following interaction with whole human blood
    Angela França
    CEB IBB, Centro de Engenharia Biólogica, Instituto de Biotecnologia e Bioengenharia, Universidade do Minho, Braga, Portugal Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pathog Dis 70:444-8. 2014
    ..epidermidis exposure to human blood was an increased expression of genes involved in iron utilization. This finding suggests that iron acquisition is an important event for S. epidermidis survival in human blood...