Lisa M Maier

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:1541-7. 2009
  2. pmc Dynamics of central and peripheral immunomodulation in a murine glioma model
    Benjamin C Kennedy
    Department of Neurosurgery, Gabriele Bartoli Brain Tumor Research Laboratory Columbia University, New York, NY, USA
    BMC Immunol 10:11. 2009
  3. doi request reprint Autoimmunity risk alleles in costimulation pathways
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 229:322-36. 2009
  4. pmc IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000322. 2009
  5. pmc Allelic variant in CTLA4 alters T cell phosphorylation patterns
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:18607-12. 2007
  6. pmc IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:2435-43. 2009
  7. pmc The role of the CD58 locus in multiple sclerosis
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:5264-9. 2009
  8. ncbi request reprint Astrocytic regulation of human monocytic/microglial activation
    Alex M Kostianovsky
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:5425-32. 2008
  9. pmc Profound tumor-specific Th2 bias in patients with malignant glioma
    Shinji Shimato
    Department of Neurosurgery, Gabriele Bartoli Brain Tumor Research Laboratory, Columbia University, New York City, NY, USA
    BMC Cancer 12:561. 2012
  10. ncbi request reprint Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression
    Alex M Kostianovsky
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:6158-63. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:1541-7. 2009
    ..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS...
  2. pmc Dynamics of central and peripheral immunomodulation in a murine glioma model
    Benjamin C Kennedy
    Department of Neurosurgery, Gabriele Bartoli Brain Tumor Research Laboratory Columbia University, New York, NY, USA
    BMC Immunol 10:11. 2009
    ....
  3. doi request reprint Autoimmunity risk alleles in costimulation pathways
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 229:322-36. 2009
    ..The identification of allelic variants associated with disease risk followed by understanding their functional outcomes and affected pathways provides a rationale approach for drug design...
  4. pmc IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000322. 2009
    ..We demonstrate that multiple variants independently correlate with sIL-2RA levels...
  5. pmc Allelic variant in CTLA4 alters T cell phosphorylation patterns
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:18607-12. 2007
    ..Thus, allelic variation associated with autoimmune disease can alter the signaling threshold of CD4(+) T cells. These experiments provide a rational approach for the dissection of T cell-susceptibility genes in autoimmune diseases...
  6. pmc IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:2435-43. 2009
    ..Our results demonstrate that IL-27 plays a key role in human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a dual regulatory mechanism to control autoimmunity and tissue inflammation...
  7. pmc The role of the CD58 locus in multiple sclerosis
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:5264-9. 2009
    ....
  8. ncbi request reprint Astrocytic regulation of human monocytic/microglial activation
    Alex M Kostianovsky
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:5425-32. 2008
    ....
  9. pmc Profound tumor-specific Th2 bias in patients with malignant glioma
    Shinji Shimato
    Department of Neurosurgery, Gabriele Bartoli Brain Tumor Research Laboratory, Columbia University, New York City, NY, USA
    BMC Cancer 12:561. 2012
    ....
  10. ncbi request reprint Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression
    Alex M Kostianovsky
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:6158-63. 2007
    ....