Research Topics
Genomes and Genes | Lisa M MaierSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responsesLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 182:1541-7. 2009..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS...
Dynamics of central and peripheral immunomodulation in a murine glioma modelBenjamin C Kennedy
Department of Neurosurgery, Gabriele Bartoli Brain Tumor Research Laboratory Columbia University, New York, NY, USA
BMC Immunol 10:11. 2009....
Autoimmunity risk alleles in costimulation pathwaysLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 229:322-36. 2009..The identification of allelic variants associated with disease risk followed by understanding their functional outcomes and affected pathways provides a rationale approach for drug design...- IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor productionLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 5:e1000322. 2009..We demonstrate that multiple variants independently correlate with sIL-2RA levels... - Allelic variant in CTLA4 alters T cell phosphorylation patternsLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:18607-12. 2007..Thus, allelic variation associated with autoimmune disease can alter the signaling threshold of CD4(+) T cells. These experiments provide a rational approach for the dissection of T cell-susceptibility genes in autoimmune diseases... - IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cellsGopal Murugaiyan
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 183:2435-43. 2009..Our results demonstrate that IL-27 plays a key role in human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a dual regulatory mechanism to control autoimmunity and tissue inflammation... - The role of the CD58 locus in multiple sclerosisPhilip L De Jager
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:5264-9. 2009.... - Astrocytic regulation of human monocytic/microglial activationAlex M Kostianovsky
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:5425-32. 2008.... - Profound tumor-specific Th2 bias in patients with malignant gliomaShinji Shimato
Department of Neurosurgery, Gabriele Bartoli Brain Tumor Research Laboratory, Columbia University, New York City, NY, USA
BMC Cancer 12:561. 2012.... - Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppressionAlex M Kostianovsky
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 178:6158-63. 2007....