Research Topics
| Bertha MadrasSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophreniaBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
J Hist Neurosci 22:62-78. 2013..The collective work is generally viewed as providing a fundamental basis for the dopamine hypothesis of schizophrenia...- Office of National Drug Control Policy: a scientist in drug policy in Washington, DCBertha K Madras
Department of Psychiatry, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
Ann N Y Acad Sci 1187:370-402. 2010..This essay describes how a basic scientist was thrust into the epicenter, the political cauldron of our national drug control policy, and how the experience altered her professional trajectory and perspective... 
Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months laterBertha K Madras
Harvard Medical School NEPRC, 1 Pine Hill Drive, Southborough, MA 01772, USA
Drug Alcohol Depend 99:280-95. 2009..We compared illicit drug use at intake and 6 months after drug screening and interventions were administered...
Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivoBertha K Madras
Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
J Pharmacol Exp Ther 319:570-85. 2006..The therapeutic potential of dopamine transport inhibitors for Parkinson's disease warrants preclinical investigation...- Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitroBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
J Pharmacol Exp Ther 319:561-9. 2006..The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modafinil affects wakefulness by interacting with catecholamine transporters in brain... - The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)Bertha K Madras
Department of Psychiatry, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
Behav Brain Res 130:57-63. 2002..The feasibility of exploring these mechanisms in animal models or in human subjects is explored... - The dopamine transporter and attention-deficit/hyperactivity disorderBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Biol Psychiatry 57:1397-409. 2005..Thus, ADHD medications targeting DAT or NET might disperse dopamine widely and consign dopamine storage and release to regulation by noradrenergic, as well as dopaminergic neurons... - Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitorsBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
Eur J Pharmacol 479:41-51. 2003..These novel drugs compel a revision of current concepts of drug-monoamine transporter complex formation and open avenues for discovery of a new generation of therapeutic drugs... - Primate trace amine receptor 1 modulation by the dopamine transporterGregory M Miller
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Pharmacol Exp Ther 313:983-94. 2005.... - Dopamine transporter-dependent induction of C-Fos in HEK cellsServet M Yatin
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102, USA
Synapse 45:52-65. 2002.... - Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptationServet M Yatin
Harvard Medical School, New England Primate Research Center, Division of Neurochemistry, One Pine Hill Drive, Southborough, MA 01772 9102, USA
J Neurosci Methods 143:69-78. 2005..These findings present a cell system and methodology for investigating the potential contribution of monoamine transporters to pre-synaptic neuroadaptation... - In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporterThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1293-300. 2005..Interpretation of the latter finding awaits clarification of the issue of timing of drug administration and imaging to disentangle receptor occupancy from downregulation... - PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidateThomas J Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 163:387-95. 2006.... - Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitroZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
J Pharmacol Exp Ther 321:116-27. 2007.... - Cerebellar vermis involvement in cocaine-related behaviorsCarl M Anderson
Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 31:1318-26. 2006.... - Variants of the primate vesicular monoamine transporter-2Amy K Jassen
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772-9102, USA
Brain Res Mol Brain Res 139:251-7. 2005..We investigated this apparent mismatch between observed molecular size and predicted size... - MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitorChristopher D Verrico
Department of Psychiatry, Harvard Medical School and Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772 9102, USA
J Psychopharmacol 22:187-202. 2008..Reversal of impaired executive function by a NET inhibitor implicates the NET and norepinephrine in MDMA-induced cognitive impairment and may be relevant to therapeutic strategies... - MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatmentChristopher D Verrico
Department of Psychiatry, Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
Psychopharmacology (Berl) 189:489-503. 2007..In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT), followed by extensive 5-HT release... - Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptationDanqing Xiao
Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772-9102, USA
Brain Res 1067:67-77. 2006..The association of axonal guidance molecules with drug-induced reorganization of adult primate brain circuitry warrants investigation... - Receptor regulation of gene expression of axon guidance molecules: implications for adaptationAmy K Jassen
Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772-9102, USA
Mol Pharmacol 70:71-7. 2006.... - Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropaneThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 62:1059-61. 2007..The findings of in vivo neuroimaging of DAT in ADHD have been somewhat discrepant, however... - Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transportersDuy Phong Pham Huu
Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
Bioorg Med Chem 15:1067-82. 2007..The (1R)-configuration provided the eutomers... - Design and synthesis of an irreversible dopamine-sparing cocaine antagonistPeter C Meltzer
Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
Bioorg Med Chem 10:3583-91. 2002..In contrast, the epoxide 7 showed a greater inhibition of dopamine reuptake than cocaine binding at 24h (68% versus 18%)... - Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidatePeter C Meltzer
Organix Inc, 240 Salem Street, Woburn, Massachusetts 01801, USA
J Med Chem 46:1538-45. 2003..The threo isomers are potent and selective inhibitors of the DAT. This is the first generalization of the principle that the presence of nitrogen is not a necessity for DAT inhibition... - Repetitive behaviors in monkeys are linked to specific striatal activation patternsEsen Saka
Department of Neurology, Akdeniz University Hospital, 07059 Antalya, Turkey
J Neurosci 24:7557-65. 2004.... - A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brainPeter C Meltzer
Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
J Med Chem 46:3483-96. 2003..s... - Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transportersPeter C Meltzer
Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
Bioorg Med Chem Lett 14:6007-10. 2004..The 3,4-dichlorophenyl-8-thiabicyclo[3.2.1]oct-2-ene (4f) is particularly potent (IC50=4.5 nM) and selective (800-fold) with respect to inhibition of the serotonin transporter... - Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanesPeter C Meltzer
Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
Bioorg Med Chem Lett 13:4133-7. 2003..Compound 10, a diacetoxy prodrug for 7, substituted fully for cocaine in a rat drug-discrimination paradigm and is now undergoing further investigation as a potential medication for cocaine abuse... - The neurobiology of attention-deficit/hyperactivity disorderAlan J Fischman
Department of Radiology, Division of Nuclear Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1374-6. 2005 - Melatonin promotes sleep in three species of diurnal nonhuman primatesIrina V Zhdanova
Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Physiol Behav 75:523-9. 2002.... - 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitorsPeter C Meltzer
Organix Inc, 240 Salem Street, Woburn, Massachusetts 01801, USA
J Med Chem 49:1420-32. 2006..Among the most potent of these DAT/NET selective compounds are the 1-(3,4-dichlorophenyl)- (4u) and the 1-naphthyl- (4t) 2-pyrrolidin-1-yl-pentan-1-one analogues...
Research Grants
- EVALUATION OF NOVEL COCAINE MEDICATIONSBertha Madras; Fiscal Year: 2005..abstract_text> ..
- EVALUATION OF NOVEL COCAINE MEDICATIONSBertha Madras; Fiscal Year: 2001..This approach will provide lead compounds for further assessment as cocaine medications and strategies directly applicable to human studies. ..
- Cocaine-Molecular Targets/Brain Imaging and MedicationsBertha Madras; Fiscal Year: 2005..This integrated research program will provide fundamental information on the neurobiological mechanisms underlying the behavioral effects of psychostimulants and candidate medications to treat cocaine addiction...