Bertha Madras

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Hist Neurosci 22:62-78. 2013
  2. doi request reprint Office of National Drug Control Policy: a scientist in drug policy in Washington, DC
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
    Ann N Y Acad Sci 1187:370-402. 2010
  3. pmc Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later
    Bertha K Madras
    Harvard Medical School NEPRC, 1 Pine Hill Drive, Southborough, MA 01772, USA
    Drug Alcohol Depend 99:280-95. 2009
  4. ncbi request reprint Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:570-85. 2006
  5. ncbi request reprint Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:561-9. 2006
  6. ncbi request reprint The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
    Bertha K Madras
    Department of Psychiatry, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Behav Brain Res 130:57-63. 2002
  7. ncbi request reprint The dopamine transporter and attention-deficit/hyperactivity disorder
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Biol Psychiatry 57:1397-409. 2005
  8. ncbi request reprint Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Eur J Pharmacol 479:41-51. 2003
  9. ncbi request reprint Primate trace amine receptor 1 modulation by the dopamine transporter
    Gregory M Miller
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 313:983-94. 2005
  10. ncbi request reprint Dopamine transporter-dependent induction of C-Fos in HEK cells
    Servet M Yatin
    Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    Synapse 45:52-65. 2002

Research Grants

  1. EVALUATION OF NOVEL COCAINE MEDICATIONS
    Bertha Madras; Fiscal Year: 2005
  2. EVALUATION OF NOVEL COCAINE MEDICATIONS
    Bertha Madras; Fiscal Year: 2001
  3. Cocaine-Molecular Targets/Brain Imaging and Medications
    Bertha Madras; Fiscal Year: 2005

Collaborators

Detail Information

Publications31

  1. doi request reprint History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Hist Neurosci 22:62-78. 2013
    ..The collective work is generally viewed as providing a fundamental basis for the dopamine hypothesis of schizophrenia...
  2. doi request reprint Office of National Drug Control Policy: a scientist in drug policy in Washington, DC
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
    Ann N Y Acad Sci 1187:370-402. 2010
    ..This essay describes how a basic scientist was thrust into the epicenter, the political cauldron of our national drug control policy, and how the experience altered her professional trajectory and perspective...
  3. pmc Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later
    Bertha K Madras
    Harvard Medical School NEPRC, 1 Pine Hill Drive, Southborough, MA 01772, USA
    Drug Alcohol Depend 99:280-95. 2009
    ..We compared illicit drug use at intake and 6 months after drug screening and interventions were administered...
  4. ncbi request reprint Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:570-85. 2006
    ..The therapeutic potential of dopamine transport inhibitors for Parkinson's disease warrants preclinical investigation...
  5. ncbi request reprint Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:561-9. 2006
    ..The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modafinil affects wakefulness by interacting with catecholamine transporters in brain...
  6. ncbi request reprint The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
    Bertha K Madras
    Department of Psychiatry, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Behav Brain Res 130:57-63. 2002
    ..The feasibility of exploring these mechanisms in animal models or in human subjects is explored...
  7. ncbi request reprint The dopamine transporter and attention-deficit/hyperactivity disorder
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Biol Psychiatry 57:1397-409. 2005
    ..Thus, ADHD medications targeting DAT or NET might disperse dopamine widely and consign dopamine storage and release to regulation by noradrenergic, as well as dopaminergic neurons...
  8. ncbi request reprint Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Eur J Pharmacol 479:41-51. 2003
    ..These novel drugs compel a revision of current concepts of drug-monoamine transporter complex formation and open avenues for discovery of a new generation of therapeutic drugs...
  9. ncbi request reprint Primate trace amine receptor 1 modulation by the dopamine transporter
    Gregory M Miller
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 313:983-94. 2005
    ....
  10. ncbi request reprint Dopamine transporter-dependent induction of C-Fos in HEK cells
    Servet M Yatin
    Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    Synapse 45:52-65. 2002
    ....
  11. ncbi request reprint Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation
    Servet M Yatin
    Harvard Medical School, New England Primate Research Center, Division of Neurochemistry, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Neurosci Methods 143:69-78. 2005
    ..These findings present a cell system and methodology for investigating the potential contribution of monoamine transporters to pre-synaptic neuroadaptation...
  12. ncbi request reprint In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1293-300. 2005
    ..Interpretation of the latter finding awaits clarification of the issue of timing of drug administration and imaging to disentangle receptor occupancy from downregulation...
  13. ncbi request reprint PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 163:387-95. 2006
    ....
  14. ncbi request reprint Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:116-27. 2007
    ....
  15. ncbi request reprint Cerebellar vermis involvement in cocaine-related behaviors
    Carl M Anderson
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 31:1318-26. 2006
    ....
  16. ncbi request reprint Variants of the primate vesicular monoamine transporter-2
    Amy K Jassen
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Brain Res Mol Brain Res 139:251-7. 2005
    ..We investigated this apparent mismatch between observed molecular size and predicted size...
  17. doi request reprint MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor
    Christopher D Verrico
    Department of Psychiatry, Harvard Medical School and Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Psychopharmacol 22:187-202. 2008
    ..Reversal of impaired executive function by a NET inhibitor implicates the NET and norepinephrine in MDMA-induced cognitive impairment and may be relevant to therapeutic strategies...
  18. ncbi request reprint MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment
    Christopher D Verrico
    Department of Psychiatry, Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 189:489-503. 2007
    ..In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT), followed by extensive 5-HT release...
  19. ncbi request reprint Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation
    Danqing Xiao
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Brain Res 1067:67-77. 2006
    ..The association of axonal guidance molecules with drug-induced reorganization of adult primate brain circuitry warrants investigation...
  20. ncbi request reprint Receptor regulation of gene expression of axon guidance molecules: implications for adaptation
    Amy K Jassen
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Mol Pharmacol 70:71-7. 2006
    ....
  21. pmc Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 62:1059-61. 2007
    ..The findings of in vivo neuroimaging of DAT in ADHD have been somewhat discrepant, however...
  22. pmc Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters
    Duy Phong Pham-Huu
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem 15:1067-82. 2007
    ..The (1R)-configuration provided the eutomers...
  23. ncbi request reprint Design and synthesis of an irreversible dopamine-sparing cocaine antagonist
    Peter C Meltzer
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem 10:3583-91. 2002
    ..In contrast, the epoxide 7 showed a greater inhibition of dopamine reuptake than cocaine binding at 24h (68% versus 18%)...
  24. ncbi request reprint Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate
    Peter C Meltzer
    Organix Inc, 240 Salem Street, Woburn, Massachusetts 01801, USA
    J Med Chem 46:1538-45. 2003
    ..The threo isomers are potent and selective inhibitors of the DAT. This is the first generalization of the principle that the presence of nitrogen is not a necessity for DAT inhibition...
  25. ncbi request reprint Repetitive behaviors in monkeys are linked to specific striatal activation patterns
    Esen Saka
    Department of Neurology, Akdeniz University Hospital, 07059 Antalya, Turkey
    J Neurosci 24:7557-65. 2004
    ....
  26. ncbi request reprint A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain
    Peter C Meltzer
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    J Med Chem 46:3483-96. 2003
    ..s...
  27. ncbi request reprint Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters
    Peter C Meltzer
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem Lett 14:6007-10. 2004
    ..The 3,4-dichlorophenyl-8-thiabicyclo[3.2.1]oct-2-ene (4f) is particularly potent (IC50=4.5 nM) and selective (800-fold) with respect to inhibition of the serotonin transporter...
  28. ncbi request reprint Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes
    Peter C Meltzer
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem Lett 13:4133-7. 2003
    ..Compound 10, a diacetoxy prodrug for 7, substituted fully for cocaine in a rat drug-discrimination paradigm and is now undergoing further investigation as a potential medication for cocaine abuse...
  29. ncbi request reprint The neurobiology of attention-deficit/hyperactivity disorder
    Alan J Fischman
    Department of Radiology, Division of Nuclear Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1374-6. 2005
  30. ncbi request reprint Melatonin promotes sleep in three species of diurnal nonhuman primates
    Irina V Zhdanova
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Physiol Behav 75:523-9. 2002
    ....
  31. pmc 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors
    Peter C Meltzer
    Organix Inc, 240 Salem Street, Woburn, Massachusetts 01801, USA
    J Med Chem 49:1420-32. 2006
    ..Among the most potent of these DAT/NET selective compounds are the 1-(3,4-dichlorophenyl)- (4u) and the 1-naphthyl- (4t) 2-pyrrolidin-1-yl-pentan-1-one analogues...

Research Grants16

  1. EVALUATION OF NOVEL COCAINE MEDICATIONS
    Bertha Madras; Fiscal Year: 2005
    ..abstract_text> ..
  2. EVALUATION OF NOVEL COCAINE MEDICATIONS
    Bertha Madras; Fiscal Year: 2001
    ..This approach will provide lead compounds for further assessment as cocaine medications and strategies directly applicable to human studies. ..
  3. Cocaine-Molecular Targets/Brain Imaging and Medications
    Bertha Madras; Fiscal Year: 2005
    ..This integrated research program will provide fundamental information on the neurobiological mechanisms underlying the behavioral effects of psychostimulants and candidate medications to treat cocaine addiction...