Research Topics
Species | B K MadrasSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brainB K Madras
Department of Psychiatry, Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
Synapse 29:93-104. 1998....- Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brainB K Madras
Dept of Psychiatry, Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
Synapse 29:105-15. 1998..The selective binding of altropane to the dopamine-rich striatum within 30 min of i.v. administration indicates that it is uniquely suited for SPECT or PET imaging of the dopamine transporter and associated dopamine neurons... - Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brainB K Madras
Department of Psychiatry, Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
Synapse 29:116-27. 1998.... - Nitrogen-based drugs are not essential for blockade of monoamine transportersB K Madras
Department of Psychiatry, Harvard Medical School, NERPRC, Southborough, MA 01772 9102, USA
Synapse 24:340-8. 1996.... - Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?M Goulet
Harvard Medical School, Department of Psychiatry, Division of Neurochemistry, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102, USA
Synapse 42:129-40. 2001..Non-amines open avenues for developing a new generation of antidepressants... - Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transportersA J Fischman
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Synapse 29:128-41. 1998..The high selectivity and rapid striatal accumulation of the ligand allows for accurate quantitation of DAT sites in less than 2 hr. The results further demonstrate that [123I]altropane is an effective marker for PD... - Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disordersG M Miller
Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, One Pine Hill Drive, Southborough, MA 01772-9102, USA
Mol Psychiatry 6:50-8. 2001.... - Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivityG M Miller
Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, One Pine Hill Drive, 01772, Southborough, MA, USA
Brain Res Mol Brain Res 87:124-43. 2001.... - Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expressionG M Miller
Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
Mol Psychiatry 7:44-55. 2002..This report provides experimental evidence that variability in the length or the sequence of the 3'-UTR of the DAT gene may influence levels of DAT protein in the brain... - A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggressionG M Miller
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
Mol Psychiatry 9:99-108. 2004..The data support the use of nonhuman primates to investigate mu-opioid receptor genotype/phenotype relations of relevance to humans...