Jeffrey D Macklis
Affiliation: Harvard University
Poulopoulos A, Murphy A, Ozkan A, Davis P, Hatch J, Kirchner R, et al
. Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex. Nature. 2019;: pubmed publisher
Galazo M, Emsley J, Macklis J. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016;91:90-106 pubmed publisher
..These results confirm that we identified key controls over CThPN development and identify Fog2 as a critical control over CThPN diversity. ..
Wuttke T, Markopoulos F, Padmanabhan H, Wheeler A, Murthy V, Macklis J. Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation. Nat Neurosci. 2018;21:517-529 pubmed publisher
Greig L, Woodworth M, Greppi C, Macklis J. Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 2016;90:261-77 pubmed publisher
..Therefore, although thalamocortical axons invade appropriate cortical regions, they are unable to organize into properly configured sensory maps. Together, these data identify Ctip1 as a critical control over sensory area development. ..
Woodworth M, Greig L, Liu K, Ippolito G, Tucker H, Macklis J. Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep. 2016;15:999-1012 pubmed publisher
..Therefore, Ctip1 couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections. ..
Fame R, MacDonald J, Dunwoodie S, Takahashi E, Macklis J. Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016;36:6403-19 pubmed publisher
..Gaining insight into molecular development and heterogeneity of CPN will advance understanding of both diverse functions of CPN and of the remarkable range of neurodevelopmental deficits correlated with CPN/CC development. ..