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Genomes and Genes | Bryan MackenzieSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene familyBryan Mackenzie
Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Pflugers Arch 447:784-95. 2004..Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia...
Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)Bryan Mackenzie
Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Biochem J 403:59-69. 2007..We therefore propose that these variations serve as tissue-specific signals or cues to direct DMT1 to the appropriate subcellular compartments (e.g. in erythroid cells) or the plasma membrane (e.g. in intestine)...- Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brainHitomi Takanaga
Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Biochem Biophys Res Commun 337:892-900. 2005..SBAT1-mediated transport of BCAA, particularly leucine, may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons... - Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system iminoHitomi Takanaga
Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:8974-84. 2005..The human slc6a20 gene coding SIT1 is an appropriate target for investigation of hereditary forms of iminoaciduria in man... - Sodium-dependent ascorbic acid transporter family SLC23Hitomi Takanaga
Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Pflugers Arch 447:677-82. 2004..An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear... - Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxesBryan Mackenzie
Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, 02115, USA
Pflugers Arch 451:544-58. 2006.... - SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1Bryan Mackenzie
Membrane Biology Program and Renal Division, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Pflugers Arch 447:571-9. 2004..DMT1 is up-regulated dramatically in the intestine by dietary iron restriction and, despite high serum iron levels, is not appropriately down-regulated in hereditary hemochromatosis... - Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neuronsBryan Mackenzie
Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:23720-30. 2003.... - Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1Bryan Mackenzie
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, PO Box 670576, Cincinnati, Ohio 45267 0576, USA
Am J Physiol Cell Physiol 294:C451-9. 2008....