Bryan Mackenzie

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:784-95. 2004
  2. pmc Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Biochem J 403:59-69. 2007
  3. ncbi Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 337:892-900. 2005
  4. ncbi Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:8974-84. 2005
  5. ncbi Sodium-dependent ascorbic acid transporter family SLC23
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:677-82. 2004
  6. ncbi Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, 02115, USA
    Pflugers Arch 451:544-58. 2006
  7. ncbi SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:571-9. 2004
  8. ncbi Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:23720-30. 2003
  9. ncbi Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1
    Bryan Mackenzie
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, PO Box 670576, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Cell Physiol 294:C451-9. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:784-95. 2004
    ..Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia...
  2. pmc Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Biochem J 403:59-69. 2007
    ..We therefore propose that these variations serve as tissue-specific signals or cues to direct DMT1 to the appropriate subcellular compartments (e.g. in erythroid cells) or the plasma membrane (e.g. in intestine)...
  3. ncbi Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 337:892-900. 2005
    ..SBAT1-mediated transport of BCAA, particularly leucine, may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons...
  4. ncbi Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:8974-84. 2005
    ..The human slc6a20 gene coding SIT1 is an appropriate target for investigation of hereditary forms of iminoaciduria in man...
  5. ncbi Sodium-dependent ascorbic acid transporter family SLC23
    Hitomi Takanaga
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:677-82. 2004
    ..An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear...
  6. ncbi Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, 02115, USA
    Pflugers Arch 451:544-58. 2006
    ....
  7. ncbi SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pflugers Arch 447:571-9. 2004
    ..DMT1 is up-regulated dramatically in the intestine by dietary iron restriction and, despite high serum iron levels, is not appropriately down-regulated in hereditary hemochromatosis...
  8. ncbi Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons
    Bryan Mackenzie
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:23720-30. 2003
    ....
  9. ncbi Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1
    Bryan Mackenzie
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, PO Box 670576, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Cell Physiol 294:C451-9. 2008
    ....