Bryan T MacDonald

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Bone mass is inversely proportional to Dkk1 levels in mice
    Bryan T MacDonald
    Division of Neuroscience, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bone 41:331-9. 2007
  2. pmc Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies
    Sung Eun Kim
    F M Kirby Center, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 340:867-70. 2013
  3. pmc Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation
    Xinjun Zhang
    Department of Neurology, The F M Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 32:719-30. 2015
  4. pmc Disulfide bond requirements for active Wnt ligands
    Bryan T MacDonald
    From the F M Kirby Neurobiology Center, Boston Children s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 289:18122-36. 2014
  5. pmc A finger on the pulse of Wnt receptor signaling
    Bryan T MacDonald
    The F M Kirby Neurobiology Center, Boston Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell Res 22:1410-2. 2012
  6. pmc Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6
    Bryan T MacDonald
    F M Kirby Neurobiology Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23537. 2011
  7. pmc Lrp5 functions in bone to regulate bone mass
    Yajun Cui
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts, USA
    Nat Med 17:684-91. 2011
  8. ncbi request reprint En1 and Wnt7a interact with Dkk1 during limb development in the mouse
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 272:134-44. 2004
  9. ncbi request reprint Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6
    Bryan T MacDonald
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Development 131:2543-52. 2004
  10. ncbi request reprint Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Dev Biol 255:350-62. 2003

Collaborators

Detail Information

Publications10

  1. pmc Bone mass is inversely proportional to Dkk1 levels in mice
    Bryan T MacDonald
    Division of Neuroscience, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bone 41:331-9. 2007
    ..Thus DKK1 is a negative regulator of normal bone homeostasis in vivo. Our study suggests that manipulation of DKK1 function or expression may have therapeutic significance for the treatment of low bone mass disorders...
  2. pmc Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies
    Sung Eun Kim
    F M Kirby Center, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 340:867-70. 2013
    ..Our findings reveal mechanisms for scaffold regulation and morphogen signaling...
  3. pmc Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation
    Xinjun Zhang
    Department of Neurology, The F M Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 32:719-30. 2015
    ....
  4. pmc Disulfide bond requirements for active Wnt ligands
    Bryan T MacDonald
    From the F M Kirby Neurobiology Center, Boston Children s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 289:18122-36. 2014
    ..Finally, we modified existing expression vectors for 19 epitope-tagged human WNT proteins by removal of a tag-supplied ectopic cysteine, thereby generating tagged WNT ligands active in canonical and non-canonical signaling. ..
  5. pmc A finger on the pulse of Wnt receptor signaling
    Bryan T MacDonald
    The F M Kirby Neurobiology Center, Boston Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell Res 22:1410-2. 2012
    ..R-spondin binds to ZNRF3, in addition to transmembrane LGR4/5 receptors, to antagonize degradation of the Wnt receptors by ZNRF3, thereby resulting in increased Frizzled and LRP6 levels and a greater Wnt response...
  6. pmc Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6
    Bryan T MacDonald
    F M Kirby Neurobiology Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23537. 2011
    ..Our studies therefore uncover a new and important molecular tuning mechanism for differential regulation of LRP5 and LRP6 phosphorylation and signaling activity...
  7. pmc Lrp5 functions in bone to regulate bone mass
    Yajun Cui
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts, USA
    Nat Med 17:684-91. 2011
    ..These data indicate that Lrp5 signaling functions locally, and they suggest that increasing LRP5 signaling in mature bone cells may be a strategy for treating human disorders associated with low bone mass, such as osteoporosis...
  8. ncbi request reprint En1 and Wnt7a interact with Dkk1 during limb development in the mouse
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 272:134-44. 2004
    ..The failure of Wnt7a inactivation to completely correct the limb defects of Dkk1d/dEn1-/- double mutants indicates that Wnt7a is not the only gene regulated by En1 during development of the mouse limb...
  9. ncbi request reprint Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6
    Bryan T MacDonald
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Development 131:2543-52. 2004
    ..These compensatory interactions between Dkk1 and Lrp6 demonstrate the importance of correctly balancing positive and negative regulation of Wnt signaling during mammalian development...
  10. ncbi request reprint Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Dev Biol 255:350-62. 2003
    ..doubleridge thus exhibits an unusual limb phenotype combining abnormal compaction of the AER with normal dorsal/ventral patterning...