Bryan T MacDonald

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Bone mass is inversely proportional to Dkk1 levels in mice
    Bryan T MacDonald
    Division of Neuroscience, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bone 41:331-9. 2007
  2. ncbi Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6
    Bryan T MacDonald
    F M Kirby Neurobiology Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23537. 2011
  3. ncbi A finger on the pulse of Wnt receptor signaling
    Bryan T MacDonald
    The F M Kirby Neurobiology Center, Boston Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell Res 22:1410-2. 2012
  4. ncbi Lrp5 functions in bone to regulate bone mass
    Yajun Cui
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts, USA
    Nat Med 17:684-91. 2011
  5. ncbi Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6
    Bryan T MacDonald
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Development 131:2543-52. 2004
  6. ncbi En1 and Wnt7a interact with Dkk1 during limb development in the mouse
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 272:134-44. 2004
  7. ncbi Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Dev Biol 255:350-62. 2003

Collaborators

  • Xi He
  • Alexander G Robling
  • Qingyun Liu
  • MIRIAM MEISLER
  • Mikhail V Semenov
  • Maja Adamska
  • Yajun Cui
  • Michael Bader
  • Paul J Niziolek
  • Bart O Williams
  • Natalia Alenina
  • David R Powell
  • Ronald A Conlon
  • Christina M Jacobsen
  • Robert Brommage
  • Jan A Gossen
  • Faika Mseeh
  • Qi M Yang
  • Han Gerrits
  • Susann Matthes
  • Cassandra R Zylstra
  • Daniel R Robinson
  • Brian Zambrowicz
  • Matthew L Warman
  • Zhendong Zhong
  • Edward R Oliver
  • Zubair H Sarmast

Detail Information

Publications7

  1. ncbi Bone mass is inversely proportional to Dkk1 levels in mice
    Bryan T MacDonald
    Division of Neuroscience, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Bone 41:331-9. 2007
    ..Thus DKK1 is a negative regulator of normal bone homeostasis in vivo. Our study suggests that manipulation of DKK1 function or expression may have therapeutic significance for the treatment of low bone mass disorders...
  2. ncbi Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6
    Bryan T MacDonald
    F M Kirby Neurobiology Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23537. 2011
    ..Our studies therefore uncover a new and important molecular tuning mechanism for differential regulation of LRP5 and LRP6 phosphorylation and signaling activity...
  3. ncbi A finger on the pulse of Wnt receptor signaling
    Bryan T MacDonald
    The F M Kirby Neurobiology Center, Boston Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell Res 22:1410-2. 2012
    ..R-spondin binds to ZNRF3, in addition to transmembrane LGR4/5 receptors, to antagonize degradation of the Wnt receptors by ZNRF3, thereby resulting in increased Frizzled and LRP6 levels and a greater Wnt response...
  4. ncbi Lrp5 functions in bone to regulate bone mass
    Yajun Cui
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts, USA
    Nat Med 17:684-91. 2011
    ..These data indicate that Lrp5 signaling functions locally, and they suggest that increasing LRP5 signaling in mature bone cells may be a strategy for treating human disorders associated with low bone mass, such as osteoporosis...
  5. ncbi Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6
    Bryan T MacDonald
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Development 131:2543-52. 2004
    ..These compensatory interactions between Dkk1 and Lrp6 demonstrate the importance of correctly balancing positive and negative regulation of Wnt signaling during mammalian development...
  6. ncbi En1 and Wnt7a interact with Dkk1 during limb development in the mouse
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 272:134-44. 2004
    ..The failure of Wnt7a inactivation to completely correct the limb defects of Dkk1d/dEn1-/- double mutants indicates that Wnt7a is not the only gene regulated by En1 during development of the mouse limb...
  7. ncbi Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb
    Maja Adamska
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Dev Biol 255:350-62. 2003
    ..doubleridge thus exhibits an unusual limb phenotype combining abnormal compaction of the AER with normal dorsal/ventral patterning...