Qiufu Ma

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Population coding of somatic sensations
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosci Bull 28:91-9. 2012
  2. pmc RETouching upon mechanoreceptors
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 64:773-6. 2009
  3. pmc Transcriptional regulation of neuronal phenotype in mammals
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    J Physiol 575:379-87. 2006
  4. pmc Labeled lines meet and talk: population coding of somatic sensations
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3773-8. 2010
  5. pmc Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities
    Yi Xu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, Department of Neuroscience, Max Delbruck Center, 13125 Berlin, Germany, and Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 33:14738-48. 2013
  6. ncbi request reprint Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    Leping Cheng
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1510-5. 2005
  7. pmc Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors
    Claudia Lopes
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:9706-15. 2012
  8. pmc Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons
    Yi Xu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:4037-46. 2008
  9. ncbi request reprint Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    Leping Cheng
    The Dana Farber Cancer Institute, and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:510-7. 2004
  10. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010

Collaborators

Detail Information

Publications30

  1. pmc Population coding of somatic sensations
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosci Bull 28:91-9. 2012
    ..Thus, a better understanding of the neural network underlying labeled line crosstalk may provide new strategies to treat chronic pain and itch...
  2. pmc RETouching upon mechanoreceptors
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 64:773-6. 2009
    ..The studies further show that Ret signaling is essential for the development of these mechanoreceptors...
  3. pmc Transcriptional regulation of neuronal phenotype in mammals
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    J Physiol 575:379-87. 2006
    ....
  4. pmc Labeled lines meet and talk: population coding of somatic sensations
    Qiufu Ma
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3773-8. 2010
    ..Second, the generation of specific sensations often involves crosstalk among distinct labeled lines. These features suggest that population coding is the mechanism underlying somatic sensation...
  5. pmc Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities
    Yi Xu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, Department of Neuroscience, Max Delbruck Center, 13125 Berlin, Germany, and Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 33:14738-48. 2013
    ..Thus, our studies provide new insight into the ontogeny of spinal neurons processing distinct sensory modalities...
  6. ncbi request reprint Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    Leping Cheng
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1510-5. 2005
    ..These genetic studies suggest that Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1 to promote glutamatergic differentiation...
  7. pmc Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors
    Claudia Lopes
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:9706-15. 2012
    ..Collectively, these studies suggest that genetically Tlx3 acts in combination with Runx1 to control the development of a cohort of nociceptors, thermoceptors, and pruriceptors in mice...
  8. pmc Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons
    Yi Xu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:4037-46. 2008
    ..These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons...
  9. ncbi request reprint Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    Leping Cheng
    The Dana Farber Cancer Institute, and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:510-7. 2004
    ..Finally, excess GABA-mediated inhibition caused dysfunction of central respiratory circuits in Tlx3 mutant mice...
  10. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..Our studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress itch. Elimination of VGLUT2 in these nociceptors creates a mouse model of chronic neurogenic itch...
  11. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
    ..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch...
  12. ncbi request reprint Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain
    Chih Li Chen
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Neuron 49:365-77. 2006
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
  13. pmc A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development
    Hui Fu
    Department of Cancer Biology, Dana Farber Cancer Institute, and Departments of Neurobiology and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:11399-408. 2009
    ..Another transcription factor, Tcf4, plays an important role in maturation of oligodendrocyte progenitors...
  14. ncbi request reprint Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype
    Leping Cheng
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:9961-7. 2003
    ..2, drives 5-HT differentiation in the dorsal spinal cord. Our studies therefore define a molecular pathway necessary and sufficient to specify the serotonergic neurotransmitter phenotype...
  15. pmc Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors
    Shan Lou
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 33:870-82. 2013
    ..Thus, our studies provide new insight into the genetic program controlling C-LTMR development and call for a revisit for the physiological functions of C-LTMRs...
  16. ncbi request reprint Mouse brain organization revealed through direct genome-scale TF expression analysis
    Paul A Gray
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 306:2255-7. 2004
    ..We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database...
  17. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
    ..Our findings demonstrate a critical role of TLR3 in regulating sensory neuronal excitability, spinal cord synaptic transmission, and central sensitization. TLR3 may serve as a new target for developing anti-itch treatment...
  18. pmc Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system
    Lynn Mar
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 450 Brookline Ave, Boston, Massachusetts 02215, USA
    Mol Brain 5:3. 2012
    ..Here we describe Tac2-Cre mice that were generated to express the Cre recombinase gene from the Tac2 locus. Tachykinin 2 (Tac2) encodes a neurotransmitter, neurokinin B (NKB)...
  19. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management...
  20. doi request reprint Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:125-32. 2008
    ..Our study suggests a new line of evidence that specification of sensory subtypes is established progressively during perinatal and postnatal development...
  21. pmc Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain
    Omar Abdel Samad
    Department of Neurobiology, Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Mol Pain 6:45. 2010
    ..We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron phenotypes necessary for inflammatory and neuropathic pain...
  22. ncbi request reprint Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Neurosci 33:247-59. 2006
    ..We propose that this atlas of the cerebellar transcriptome and the panel of 24 validated markers will be generally useful in analyses of mutations affecting postnatal cerebellar development and neoplasia...
  23. pmc Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 14:123-34. 2008
    ..Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors...
  24. pmc Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons
    David P Roberson
    FM Kirby Neurobiology Center and Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
    Nat Neurosci 16:910-8. 2013
    ....
  25. pmc Regulation of motor neuron specification by phosphorylation of neurogenin 2
    Yong Chao Ma
    F M Kirby Neurobiology Center, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 58:65-77. 2008
    ....
  26. pmc Generation of somatic sensory neuron diversity and implications on sensory coding
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Curr Opin Neurobiol 21:52-60. 2011
    ..We will also discuss how this control mechanism provides a developmental perspective for the coding of somatic sensations...
  27. pmc Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Ying Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1220-33. 2002
    ..Together, our studies demonstrate a central role for Rnx and Tlx-1 in the development of two major classes of relay sensory neurons, somatic and visceral...
  28. doi request reprint Genetic Control of the Segregation of Pain-Related Sensory Neurons Innervating the Cutaneous versus Deep Tissues
    Fu Chia Yang
    Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA Department of Neurobiology, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA
    Cell Rep 5:1353-64. 2013
    ..Thus, this study provides insight into a genetic program controlling the segregation of cutaneous versus deep tissue pain pathways. ..
  29. ncbi request reprint Nociceptors--noxious stimulus detectors
    Clifford J Woolf
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuron 55:353-64. 2007
    ....
  30. ncbi request reprint Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons
    Rumiko Mizuguchi
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 9:770-8. 2006
    ..We propose that this switch in Ascl1 function enables the cogeneration of inhibitory and excitatory sensory interneurons from a common pool of dorsal progenitors...

Research Grants16

  1. Molecular control of spinal relay sensory neuron phenoypes and pain behaviors
    Qiufu Ma; Fiscal Year: 2010
    ..In the fullness of time, the work may allow us to determine whether the Tlx3-mediated core transcriptional program is a valid and novel therapeutic target for pain management. ..
  2. Regulation Trigeminal Neuron Differentiation&Projection
    Qiufu Ma; Fiscal Year: 2005
    ..These sublineage-specific genes will be candidate molecules that control cell subtype specification. ..
  3. Genetic Control of Nociceptive Sensory Neuron Development and Pain Behavior
    Qiufu Ma; Fiscal Year: 2010
    ..The predictions of these hypotheses will be tested by using a panel of genetic tools that we have already developed. In the fullness of time, the work may lead to a novel biological target and therapeutic approach for pain management. ..
  4. Genetic Control of Nociceptive Sensory Neuron Development and Pain Behavior
    Qiufu Ma; Fiscal Year: 2007
    ..The predictions of these hypotheses will be tested by using a panel of genetic tools that we have already developed. In the fullness of time, the work may lead to a novel biological target and therapeutic approach for pain management. ..
  5. Regulation of Glutamate and Gamma Aminobutyrate neuron development
    Qiufu Ma; Fiscal Year: 2007
    ..Accordingly the studies described here will have practical overtones for the management of these diseases. ..