J Ma

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A prospective study of plasma C-peptide and colorectal cancer risk in men
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:546-53. 2004
  2. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
  3. ncbi request reprint Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men
    J Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1330-6. 2001
  4. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
  5. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
  6. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    J Ma
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 94:2410-6. 1996
  7. ncbi request reprint Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death
    Christine M Albert
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston 02215 1204, USA
    Circulation 105:2595-9. 2002
  8. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
  9. pmc Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
  10. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004

Research Grants

Collaborators

Detail Information

Publications97

  1. ncbi request reprint A prospective study of plasma C-peptide and colorectal cancer risk in men
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:546-53. 2004
    ..We used the concentration of plasma C-peptide (an indicator of insulin production) to determine whether insulin and insulin resistance are associated with the risk of developing colorectal cancer...
  2. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
    ..We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study...
  3. ncbi request reprint Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men
    J Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1330-6. 2001
    ..A high ratio of IGF-I to IGF-binding protein-3 (IGFBP-3) has been linked to an increased risk of colorectal cancer...
  4. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
    ..This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment...
  5. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  6. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    J Ma
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 94:2410-6. 1996
    ..A common mutation in MTHFR recently has been identified...
  7. ncbi request reprint Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death
    Christine M Albert
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston 02215 1204, USA
    Circulation 105:2595-9. 2002
    ..Sudden cardiac death (SCD) is an important cause of mortality even among apparently healthy populations. However, our ability to identify those at risk for SCD in the general population is poor, and more specific markers are needed...
  8. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  9. pmc Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
    ..We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (reflecting insulin secretion) on prostate cancer-specific mortality after diagnosis...
  10. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  11. ncbi request reprint Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians
    A Elisabeth Hak
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Ave, Boston, Mass 02115 5804, USA
    Circulation 108:802-7. 2003
    ..Increased intake of carotenoids and vitamin E may protect against myocardial infarction (MI). However, prospective data on blood levels of carotenoids other than beta-carotene and vitamin E (tocopherol) and risk of MI are sparse...
  12. ncbi request reprint Body iron stores and their determinants in healthy postmenopausal US women
    Jian meng Liu
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 78:1160-7. 2003
    ..Data on the determinants of body iron stores in middle-aged women are sparse...
  13. ncbi request reprint Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 88:216-23. 2008
    ..Whereas dietary intake of long-chain n-3 fatty acids has been associated with risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood concentrations...
  14. pmc Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study
    X Zhang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
    Br J Cancer 106:1335-41. 2012
    ..Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive...
  15. ncbi request reprint Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study
    J M Chan
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 74:549-54. 2001
    ..The results of epidemiologic studies of this hypothesis are inconclusive...
  16. pmc Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
    B M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Cancer 97:98-104. 2007
    ..In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3...
  17. ncbi request reprint Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study
    Aimée E Paradis
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:172-3. 2003
  18. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  19. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001
    ..These results suggest that CYP17 genotype may possibly confer a small increased susceptibility to prostate cancer but is not a strong predictor of endogenous steroid hormone levels in men...
  20. ncbi request reprint Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 154:667-72. 2001
    ..It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies...
  21. ncbi request reprint A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 115:1858-65. 2007
    ..We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women...
  22. ncbi request reprint Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer
    Megan N Hall
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 16:314-21. 2007
    ..Aspirin also inhibits the cyclooxygenase-2 enzyme and may share with n-3 fatty acids a potential mechanism to decrease the risk of colorectal cancer...
  23. ncbi request reprint Cholesterol and the risk of ischemic stroke
    Thomas S Bowman
    Harvard University General Internal Medicine Fellowship Program, Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA 02130, USA
    Stroke 34:2930-4. 2003
    ....
  24. pmc Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels
    C Jesser
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 99:1743-7. 2008
    ..Meta-analysis of 12 studies of rs266882 and overall prostate cancer risk was null...
  25. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
    ..Moreover, the A870G genotype may enhance the protective effect of postmenopausal oestrogen use on the development of colorectal neoplasia...
  26. ncbi request reprint O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 17:721-31. 2006
    ..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix...
  27. ncbi request reprint Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects
    Jian Rong Han
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA 02118, USA
    Metabolism 56:985-91. 2007
    ..Collectively, our results suggest a link between moderate consumption of MCT and improved risk factors in moderately overweight humans in a low-cost, free-living setting...
  28. ncbi request reprint Prostate cancer risk and ESR1 TA, ESR2 CA repeat polymorphisms
    Matthew H McIntyre
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:2233-6. 2007
    ..Experimental evidence has suggested that estrogen receptor alpha (coded by the gene ESR1) might increase prostate cancer risk, whereas estrogen receptor beta (coded by the gene ESR2) might reduce prostate cancer risk...
  29. pmc A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 95:E121-7. 2010
    ..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes...
  30. ncbi request reprint Inflammatory markers and the risk of coronary heart disease in men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:2599-610. 2004
    ..The value of these inflammatory markers as independent predictors remains controversial...
  31. ncbi request reprint Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:1211-8. 2004
    ....
  32. ncbi request reprint High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing 100083, China, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 137:407-13. 2007
    ..Low plasma concentrations of folate, vitamins B-12 and B-6, older age, being male, and living in urban areas were all independently associated with elevated tHcy, with low folate as the strongest determinant...
  33. ncbi request reprint Dyslipidemia and the risk of incident hypertension in men
    Ruben O Halperin
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 47:45-50. 2006
    ..These prospective cohort data suggest that dyslipidemias may lead to the subsequent development of hypertension. Thus, plasma lipids may be useful in the identification of men at risk for hypertension...
  34. pmc Energetics in colorectal and prostate cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 28:4066-73. 2010
    ..This article will evaluate the emerging data on energy balance in patients with colorectal or prostate cancer...
  35. ncbi request reprint A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma
    H Grasemann
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biochem Biophys Res Commun 272:391-4. 2000
    ..Total serum IgE was not associated with any allele of the polymorphism. These findings provide support, from case-control association analysis, for NOS1 as a candidate gene for asthma...
  36. ncbi request reprint A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice
    J F Chen
    Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:9192-200. 1999
    ....
  37. ncbi request reprint A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1364-70. 2007
    ..Animal models suggest that n-3 fatty acids inhibit prostate cancer proliferation, whereas n-6 fatty acids promote it, but epidemiologic studies do not uniformly support these findings...
  38. ncbi request reprint Iron intake and the risk of type 2 diabetes in women: a prospective cohort study
    Swapnil Rajpathak
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes Care 29:1370-6. 2006
    ..Epidemiological studies suggest that high body iron stores are associated with insulin resistance and type 2 diabetes. The aim of this study was to evaluate the association between dietary intake of iron and the risk of type 2 diabetes...
  39. ncbi request reprint Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts
    Eva Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 67:5553-60. 2007
    ..Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk...
  40. pmc Immunohistochemical expression of BRCA1 and lethal prostate cancer
    Michelangelo Fiorentino
    Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:3136-9. 2010
    ..6; 95% confidence interval, 2.4-8.7). These findings strengthen the hypothesis that BRCA1 plays a role in cell cycle control and show that BRCA1 is a marker of clinical prostate cancer prognosis. Cancer Res; 70(8); 3136-9. (c)2010 AACR...
  41. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  42. pmc A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 88:1297-303. 2008
    ..Fish and seafood n-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis...
  43. ncbi request reprint Hypoxia-inducible factor-1alpha (HIF-1alpha) gene polymorphisms, circulating insulin-like growth factor binding protein (IGFBP)-3 levels and prostate cancer
    Haojie Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Prostate 67:1354-61. 2007
    ....
  44. pmc Excessive body iron stores are not associated with risk of coronary heart disease in women
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 138:2436-41. 2008
    ..05 (0.62, 1.77), 1.19 (0.69, 2.03), and 1.05 (0.60, 1.85; P-trend = 0.90) across quartiles. Our data do not support the hypothesis that excessive body iron stores are associated with risk of CHD...
  45. pmc Prospective study of plasma vitamin B6 and risk of colorectal cancer in men
    Jung Eun Lee
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1197-202. 2009
    ..92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; P(trend) = 0.01), respectively. In conclusion, vitamin B(6) may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers...
  46. pmc Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3?
    Jennifer R Stark
    ScD, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 27:3459-64. 2009
    ..82; biopsy C-statistic, 0.72). CONCLUSION Ignoring the predominance of Gleason pattern 4 in GS 7 cancers may conceal important prognostic information. A standardized review of GS can improve prediction of PCa survival...
  47. doi request reprint Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Clin Chem 54:1682-8. 2008
    ....
  48. pmc Plasma vitamin B(6) and risk of myocardial infarction in women
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 120:649-55. 2009
    ..We prospectively evaluated the relationships between fasting plasma levels of vitamin B(6), as pyridoxal phosphate, and subsequent myocardial infarction risk in women...
  49. pmc Plasma levels of acid-labile subunit, free insulin-like growth factor-I, and prostate cancer risk: a prospective study
    Lorelei A Mucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:484-91. 2010
    ..Given the role of the IGF system in prostate cancer, ALS may influence carcinogenesis by modulating IGF-I levels or bioavailability...
  50. pmc Plasma dehydroepiandrosterone and risk of myocardial infarction in women
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Chem 54:1190-6. 2008
    ..In this study we prospectively evaluated the relationships between plasma concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) and subsequent myocardial infarction in women...
  51. doi request reprint A prospective study of trans-fatty acid levels in blood and risk of prostate cancer
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:95-101. 2008
    ..Previous studies suggest a positive association between markers of trans-fatty acid intake and prostate cancer. We therefore prospectively evaluated the association between blood trans-fatty acid levels and risk of prostate cancer...
  52. pmc Aberrant cytoplasmic expression of p63 and prostate cancer mortality
    Preet K Dhillon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:595-600. 2009
    ..The mislocalized expression was associated with reduced apoptosis and higher proliferative activity and may suggest an oncogenic role in prostate cancer progression and survival...
  53. pmc Plasma total cysteine and total homocysteine and risk of myocardial infarction in women: a prospective study
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Harvard, MA, USA
    Am Heart J 159:599-604. 2010
    ..We prospectively evaluated relationships between fasting plasma concentrations of total cysteine and total homocysteine, and subsequent myocardial infarction (MI) in women...
  54. pmc Genetic variation in RNASEL associated with prostate cancer risk and progression
    Mara S Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 31:1597-603. 2010
    ..The results of this study support a link between RNASEL and prostate cancer and suggest that the association may be mediated through inflammation. These novel findings warrant replication in future studies...
  55. ncbi request reprint Prediagnostic plasma C-peptide and pancreatic cancer risk in men and women
    Dominique S Michaud
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:2101-9. 2007
    ..An association between serum insulin levels and pancreatic cancer risk was reported in a recent study, but the population was composed of heavy smokers and their findings may not be generalizable to nonsmokers...
  56. ncbi request reprint Plasma vitamin D metabolites and risk of colorectal cancer in women
    Diane Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1502-8. 2004
    ..We therefore examined risk in relation to plasma concentrations of these vitamin D metabolites...
  57. ncbi request reprint p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:1863-8. 2006
    ..09, 95% CI = 1.28-3.40) but not proximal colon or rectal cancers. Our results suggest that Arg72Pro may play a role in the early stages of colorectal neoplasia and possibly in progression to invasive disease, depending on site and sex...
  58. ncbi request reprint C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:750-5. 2006
    ..However, few studies have evaluated whether these factors are also associated with risk of colorectal adenoma, the main precursor lesion to colorectal cancer...
  59. ncbi request reprint Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: The Physicians' Health Study
    Nader Rifai
    Department of Laboratory Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 50:1364-71. 2004
    ..This study was designed to examine the ability of baseline Lp(a) concentration and apo(a) size to predict future severe angina pectoris in apparently healthy men...
  60. ncbi request reprint A prospective study of plasma selenium levels and prostate cancer risk
    Haojie Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:696-703. 2004
    ..We examined the association between pre-diagnostic plasma selenium levels and risk of prostate cancer in men enrolled in the Physicians' Health Study...
  61. ncbi request reprint Body iron stores in relation to risk of type 2 diabetes in apparently healthy women
    Rui Jiang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    JAMA 291:711-7. 2004
    ..Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload. However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a healthy population...
  62. ncbi request reprint The role of metastasis-associated protein 1 in prostate cancer progression
    Matthias D Hofer
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Res 64:825-9. 2004
    ..In summary, this study identified an association of MTA1 expression and prostate cancer progression...
  63. ncbi request reprint Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study
    Rui Jiang
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 79:70-5. 2004
    ..Excessive iron stores may promote insulin resistance and lead to the development of type 2 diabetes. However, prospective data relating iron intake and blood donations (determinants of body iron stores) to diabetes incidence are limited...
  64. ncbi request reprint A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 166:323-9. 2003
    ..Apolipoprotein E (apoE) plays an important role in lipid metabolism. Three common alleles in the APOE gene, E2/E3/E4, have been associated with lipoprotein disorders but their effects on myocardial infarction (MI) risk remain uncertain...
  65. ncbi request reprint Aspirin use in relation to risk of prostate cancer
    Michael F Leitzmann
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1108-11. 2002
    ....
  66. ncbi request reprint Blood levels of long-chain n-3 fatty acids and the risk of sudden death
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 346:1113-8. 2002
    ..Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history of cardiovascular disease is unknown...
  67. ncbi request reprint A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men
    Simin Liu
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 177:119-26. 2004
    ..However, whether genetic variations in the APOA1/C3/A4 gene cluster are associated with the risk of myocardial infarction (MI) remains uncertain and prospective data are sparse...
  68. ncbi request reprint Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 177:375-81. 2004
    ..tHcy is an independent risk predictor of CHD and modestly associated with TNF-receptors. However, the inflammatory biomarkers measured could not explain its role in CHD...
  69. ncbi request reprint Prediagnostic plasma vascular endothelial growth factor levels and risk of prostate cancer
    Haojie Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Room 452, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:1557-61. 2005
    ..Our results indicate that prediagnostic circulating VEGF levels are not associated with prostate cancer development and have limited value in predicting future risk of prostate cancer...
  70. ncbi request reprint HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Diabetes 54:3567-72. 2005
    ..Our data indicate significant effects of H63D and C282Y on body iron stores and suggest a potential interaction between HFE genotypes and heme iron intake in relation to the risk of type 2 diabetes...
  71. ncbi request reprint Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:684-92. 2005
    ..However, no previous epidemiologic studies have directly evaluated the association of plasma PLP with risk for colorectal neoplasia...
  72. ncbi request reprint APC Asp1822Val and Gly2502Ser polymorphisms and risk of colorectal cancer and adenoma
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:863-70. 2005
    ..No gene-environment interactions were observed with these risk factors or with other dietary risk factors previously hypothesized to interact with the APC Asp1822Val polymorphism...
  73. ncbi request reprint A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:850-5. 2005
    ..Although altering IGF-I levels may not be practical, the growing burden of obesity and consequently hyperinsulinemia, which seems increasingly important for colon cancer, may be a target for effective prevention...
  74. ncbi request reprint Lipoprotein (a) and coronary heart disease among women: beyond a cholesterol carrier?
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur Heart J 26:1633-9. 2005
    ..We assessed the role of Lp(a) in coronary heart diseases (CHD) by a recently developed assay that is not affected by the plasminogen-like Kringle-type-2 repeats...
  75. ncbi request reprint Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  76. pmc Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality
    Jennifer Rider Stark
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 124:2683-9. 2009
    ..02). Adjusted hazard ratios were 1.73 (95% CI: 0.86, 3.51) comparing the highest to lowest IL-6 level. Our study suggests that IL-6 may potentially be involved in the development or progression of prostate cancer...
  77. ncbi request reprint Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
    L M Hines
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    N Engl J Med 344:549-55. 2001
    ..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study...
  78. ncbi request reprint Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
    J Li
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:917-27. 1997
    ..We discuss a pathogenic pathway for familial Alzheimer's disease in which defective presenilin function causes chromosome missegregation during mitosis, resulting in apoptosis and/or trisomy 21 mosaicism...
  79. pmc TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity
    M C Liang
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Oncogene 29:1588-97. 2010
    ..Rapamycin may have unique benefit for patients with lung cancer, for whom the TSC1/TSC2 function is limited...
  80. pmc Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis
    Yin Cao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 4:486-501. 2011
    ..Its association with prostate cancer-specific mortality in diagnosed patients needs to be further evaluated...
  81. pmc Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies
    Jung Eun Lee
    Department of Food and Nutrition, Sookmyung Women s University, Seoul, Republic of Korea
    Cancer Prev Res (Phila) 4:735-43. 2011
    ..77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer...
  82. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites...
  83. ncbi request reprint Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study
    Frederica P Perera
    Division of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
    Carcinogenesis 23:1641-6. 2002
    ..The findings underscore the complex and important role of biological susceptibility as a determinant of risk from carcinogens found in tobacco smoke and other environmental compounds...
  84. ncbi request reprint Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
    ....
  85. ncbi request reprint Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Pharmacogenetics 12:339-42. 2002
    ..We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism...
  86. ncbi request reprint Multivariate assessment of lipid parameters as predictors of coronary heart disease among postmenopausal women: potential implications for clinical guidelines
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 110:2824-30. 2004
    ..Over the past decade, lipid measurements have been significantly improved and standardized. We evaluated the usefulness of multiple plasma lipid parameters in predicting coronary heart diseases (CHD) among women...
  87. ncbi request reprint Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice
    Min Xia
    Department of Clinical Nutrition, School of Public Health, Sun Yet sen University Northern Campus, Guangzhou, 510080, People s Republic of China
    J Nutr 133:744-51. 2003
    ..We concluded that the inhibition of atherosclerotic lesions of the black rice pigment fraction is attributed to the improvement in cholesterol accumulation and reduction in oxidative stress and inflammation...
  88. ncbi request reprint Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:929-37. 2007
    ..The relation between dairy product intake and the risk of ischemic heart disease (IHD) remains controversial...
  89. ncbi request reprint Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer
    Haojie Li
    Channing Laboratory, Department of Medicine Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 65:2498-504. 2005
    ..Both endogenous and exogenous antioxidants play an important and interdependent role in preventing clinically significant prostate cancer...
  90. ncbi request reprint Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 80:1043-9. 2004
    ..However, associations between fructose and the quantity and quality of total carbohydrate intake in relation to C-peptide concentrations have not been adequately examined...
  91. ncbi request reprint A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer
    Amanda Ewart-Toland
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
    Cancer Epidemiol Biomarkers Prev 13:759-64. 2004
    ..33, 95% CI 0.66-2.68). The C allele frequency in cases and controls were 39.9% and 38.5%, respectively. Our data suggest that the TGFB1 C-509T variant that affects expression of TGFbeta1 may play a role in advanced stage prostate cancer...
  92. ncbi request reprint Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine
    Chi Liu
    Department of Nutrition, School of Public Health, Sun Yat Sen University Northern Campus, Guangzhou 510080, PR China
    J Nutr 138:311-5. 2008
    ..The mechanisms underlying this effect may be related to the AdoHcy-mediated inhibition of DNA methylation in the aortic tissue...
  93. ncbi request reprint Supplementation of black rice pigment fraction improves antioxidant and anti-inflammatory status in patients with coronary heart disease
    Qing Wang
    Department of Clinical Nutrition, Sun Yat Sen University Northern Campus, 74 Zhongshan Road II Guangzhou, China 510080
    Asia Pac J Clin Nutr 16:295-301. 2007
    ..These results may suggest that BRF could exert cardioprotective effects on patients with CHD by improving plasma antioxidant status and inhibiting inflammatory factors...
  94. ncbi request reprint Geographical, seasonal and gender differences in folate status among Chinese adults
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing, China
    J Nutr 133:3630-5. 2003
    ..Further studies are needed to elucidate the factors that influence folate concentrations among middle-aged Chinese and to evaluate possible intervention strategies...
  95. ncbi request reprint Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 12:958-62. 2003
    ....
  96. ncbi request reprint Physical activity, diet and cardiovascular disease risks in Chinese women
    Jing Ma
    Department of Clinical Nutrition, School of Public Health, Zhon Shan University North Campus, 74 Zhongshan Road II, Guangzhou, 510080, People s Republic of China
    Public Health Nutr 6:139-46. 2003
    ..To investigate the relationship between different types and levels of physical activity and cardiovascular disease risk factors, including oxidative stress, blood lipids and insulin resistance, in a healthy female population in China...
  97. ncbi request reprint CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Veronica Wendy Setiawan
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007
    ..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility...

Research Grants6

  1. IRON STATUS AND RISK OF CHD AND COLON CANCER
    Jing Ma; Fiscal Year: 2002
    ....
  2. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Hence, the proposed project is highly cost-efficient. ..