In Kyoon Lyoo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 123:87-100. 2003
  2. ncbi In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease
    Blaise D Frederick
    McLean Hospital Brain Imaging Center, Belmont, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:1313-22. 2004
  3. ncbi Prefrontal and temporal gray matter density decreases in opiate dependence
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Psychopharmacology (Berl) 184:139-44. 2006
  4. ncbi White matter hyperintensities in subjects with bipolar disorder
    Kyung Heup Ahn
    Mclean Brain Imaging Center and Harvard Medical School, Belmont, MA, USA
    Psychiatry Clin Neurosci 58:516-21. 2004
  5. ncbi Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478 9106, USA
    Exp Clin Psychopharmacol 16:199-206. 2008
  6. ncbi Frontal lobe gray matter density decreases in bipolar I disorder
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 55:648-51. 2004
  7. ncbi Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Bipolar Disord 5:300-6. 2003
  8. ncbi Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
  9. ncbi Craving for alcohol and food during treatment for alcohol dependence: modulation by T allele of 1519T>C GABAAalpha6
    Doug Hyun Han
    Brain Imaging Center, McLean Hospital, Harvard Medical University, Belmont, Massachusetts 02478, USA
    Alcohol Clin Exp Res 32:1593-9. 2008
  10. ncbi White matter hyperintensities and their associations with suicidality in psychiatrically hospitalized children and adolescents
    Stefan Ehrlich
    McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 43:770-6. 2004

Collaborators

Detail Information

Publications60

  1. ncbi Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 123:87-100. 2003
    ....
  2. ncbi In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease
    Blaise D Frederick
    McLean Hospital Brain Imaging Center, Belmont, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:1313-22. 2004
    ..This change was not observed in patients whose memory loss and other cognitive declines were not attributed to Alzheimer's disease, suggesting that it may aid in the diagnosis or detection of Alzheimer's disease...
  3. ncbi Prefrontal and temporal gray matter density decreases in opiate dependence
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Psychopharmacology (Berl) 184:139-44. 2006
    ..There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects...
  4. ncbi White matter hyperintensities in subjects with bipolar disorder
    Kyung Heup Ahn
    Mclean Brain Imaging Center and Harvard Medical School, Belmont, MA, USA
    Psychiatry Clin Neurosci 58:516-21. 2004
    ..Differences of small-sized WMH abnormalities between groups were successfully detected using a large number of bipolar subjects and thinner sliced MR images with FLAIR...
  5. ncbi Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478 9106, USA
    Exp Clin Psychopharmacol 16:199-206. 2008
    ..These results suggest that TAU treatment may decrease symptoms of depression and improve mitochondrial functioning...
  6. ncbi Frontal lobe gray matter density decreases in bipolar I disorder
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 55:648-51. 2004
    ..Decreased gray matter density in the right inferior frontal gyrus, which processes nonverbal and intrinsic functions, supports nondominant hemisphere dysfunction as a component of bipolar disorder...
  7. ncbi Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Bipolar Disord 5:300-6. 2003
    ....
  8. ncbi Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
    ..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...
  9. ncbi Craving for alcohol and food during treatment for alcohol dependence: modulation by T allele of 1519T>C GABAAalpha6
    Doug Hyun Han
    Brain Imaging Center, McLean Hospital, Harvard Medical University, Belmont, Massachusetts 02478, USA
    Alcohol Clin Exp Res 32:1593-9. 2008
    ..We further hypothesized that the T allele of the 1519T>C GABA(A)alpha6 gene would modulate the extent of changes in craving for alcohol and food...
  10. ncbi White matter hyperintensities and their associations with suicidality in psychiatrically hospitalized children and adolescents
    Stefan Ehrlich
    McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 43:770-6. 2004
    ..The objective of this study was to compare white matter hyperintensities in psychiatrically hospitalized children and youth with and without a history of suicide attempt while controlling for other variables...
  11. ncbi Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study
    Ronald L Cowan
    Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 72:225-35. 2003
    ....
  12. ncbi Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats
    Perry F Renshaw
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 92:88-92. 2009
    ..Altered cholesterol levels can affect serotonergic neurotransmission, which might be involved in the clinical efficacy of standard antidepressants...
  13. ncbi A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence
    Doug Hyun Han
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Compr Psychiatry 49:387-92. 2008
    ..In the present study, the association between dopamine D2 polymorphisms, NS, and frontal executive function was studied...
  14. ncbi White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:135-45. 2004
    ..Also, there was a trend for lower WMH severity in substance-dependent women relative to the healthy comparison group, possibly due to estrogen's protective effect against cerebrovascular accidents...
  15. ncbi Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry
    Gail Musen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes 55:326-33. 2006
    ..Our study represents the first comprehensive study of gray matter density changes in type 1 diabetes and suggests that persistent hyperglycemia and acute severe hypoglycemia have an impact on brain structure...
  16. ncbi Disrupted white matter tract integrity of anterior cingulate in trauma survivors
    Minue J Kim
    McLean Hospital Brain Imaging Center, Harvard Medical School, Belmont, Massachusetts, USA
    Neuroreport 16:1049-53. 2005
    ..The outcome of the current study suggests that the disruption of the left anterior cingulate white matter tract integrity may play an important role in the pathophysiology of posttraumatic stress disorder...
  17. ncbi Subanalysis of the location of white matter hyperintensities and their association with suicidality in children and youth
    Stefan Ehrlich
    McLean Hospital, West Cottage, 115 Mill Street, Belmont, MA 02478, USA
    Ann N Y Acad Sci 1008:265-8. 2003
    ..This subanalysis of the specific locations of the WMH suggests that youth with deep WMH in the parietal lobe but not in the frontal lobe have a significantly higher prevalence of reported past suicide attempt...
  18. ncbi White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Compr Psychiatry 43:361-8. 2002
    ..The development of brain WMH, especially in the frontal lobes, may play a role in the pathophysiology of affective disorders in children and adolescents...
  19. ncbi Magnetic resonance spectroscopy: current and future applications in psychiatric research
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 51:195-207. 2002
    ..In this review, the current status of MRS applications in psychiatric research is reviewed, and new frontiers and possible future developments are discussed...
  20. ncbi Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder
    Seth D Friedman
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 56:340-8. 2004
    ..This study examined whether lithium (Li) and valproic acid (VPA) treatment modulated these chemicals...
  21. ncbi Regional cerebral cortical thinning in bipolar disorder
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center, Harvarrd Medical School, Boston, MA, USA
    Bipolar Disord 8:65-74. 2006
    ..This study was conducted to explore differences in cortical thickness between subjects with bipolar disorder and healthy comparison subjects using cortical surface-based analysis...
  22. ncbi Decreased N-acetyl-aspartate levels in anterior cingulate and hippocampus in subjects with post-traumatic stress disorder: a proton magnetic resonance spectroscopy study
    Byung Joo Ham
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Eur J Neurosci 25:324-9. 2007
    ....
  23. ncbi Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy
    Dajung J Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1182-8. 2007
    ..52, p=0.003). Our findings suggest that quetiapine's antimanic and antidepressant efficacy in patients with rapid cycling bipolar disorder may potentially be related to decreased lactate levels in frontal regions of the brain...
  24. ncbi Altered cingulate white matter connectivity in panic disorder patients
    Doug Hyun Han
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Psychiatr Res 42:399-407. 2008
    ..Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects...
  25. ncbi Advances in magnetic resonance imaging methods for the evaluation of bipolar disorder
    In Kyoon Lyoo
    Department of Psychiatry, Seoul National University, South Korea, Seoul, South Korea
    CNS Spectr 11:269-80. 2006
    ..Integrative issues and future directions in this relatively young field, including multi-modal approaches enabling us to produce more comprehensive results, are discussed...
  26. ncbi Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy study
    Young Hoon Sung
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, Seoul 110 744, Republic of Korea
    Drug Alcohol Depend 88:28-35. 2007
    ..In this study, the authors explored differences in brain metabolites between abstinent methamphetamine (MA) abusers and healthy comparison subjects and the associations between metabolite concentrations and clinical characteristics...
  27. ncbi Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study
    Byung Joo Ham
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:403-11. 2007
    ..Our data suggested in part that alterations of the GABA function and the energy metabolism in ACC and basal ganglia may play an important role in the pathophysiology of panic disorder...
  28. ncbi Decreased frontal white-matter integrity in abstinent methamphetamine abusers
    Ain Chung
    Interdisciplinary Program in Brain Science, Seoul National University, Seoul, Korea
    Int J Neuropsychopharmacol 10:765-75. 2007
    ..This finding may also be related to impairment in frontal executive function. In addition, the neurotoxic effect of MA on frontal WM may be less prominent in women than in men, possibly due to oestrogen's neuroprotective effect...
  29. ncbi A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 9:693-7. 2007
    ..Studies in first-episode (FE) manic patients have the potential to provide answers to these questions...
  30. ncbi Frontal glucose hypometabolism in abstinent methamphetamine users
    Seog Ju Kim
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, Seoul, Korea
    Neuropsychopharmacology 30:1383-91. 2005
    ..Our findings also suggest that the neurotoxic effect of MA on frontal lobes of the brain might be more prominent in men than in women...
  31. ncbi Attention deficit hyperactivity symptoms and internet addiction
    Hee Jeong Yoo
    Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, South Korea
    Psychiatry Clin Neurosci 58:487-94. 2004
    ..In addition, current findings suggest that the presence of ADHD symptoms, both in inattention and hyperactivity-impulsivity domains, may be one of the important risk factors for Internet addiction...
  32. ncbi Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers
    Seog Ju Kim
    Gil Medical Center, Gachon Medical School, Department of Psychiatry, Incheon, South Korea
    Int J Neuropsychopharmacol 9:221-8. 2006
    ..01) than short-term abstinent abusers, but more than the healthy comparison subjects. We report that methamphetamine abusers have prefrontal grey-matter deficit, which may, in part, recover with long-term abstinence...
  33. ncbi Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    ..Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings...
  34. ncbi Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine
    Donald C Goff
    Schizophrenia Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 51:493-7. 2002
    ....
  35. ncbi Intellect declines in healthy elderly subjects and cerebellum
    Jun-Young Lee
    Department of Psychiatry, Clinical Research Institute, Seoul National University College of Medicine and Hospital, Seoul, Korea
    Psychiatry Clin Neurosci 59:45-51. 2005
    ..The current study suggests that the cerebellum may play an important role in changes of intellectual capacity in old age...
  36. ncbi Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder
    Minue J Kim
    Department of Psychology, Seoul National University, Seoul, South Korea
    J Psychiatr Res 42:268-77. 2008
    ..The current study specifically focuses on the abnormal activity of the rostral anterior cingulate, using a paradigm which elicits an unexpected processing conflict caused by salient emotional stimuli...
  37. ncbi Psychosis of Alzheimer's disease: Gender differences in regional perfusion
    E K Moran
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Tilton 201, Boston, MA 02114, USA
    Neurobiol Aging 29:1218-25. 2008
    ....
  38. ncbi Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects
    Minyoung E Sim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Neuropsychopharmacology 32:2229-37. 2007
    ....
  39. ncbi The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients
    Minue J Kim
    McLean Hospital Brain Imaging Center, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:274-80. 2007
    ..This study was conducted to evaluate the prevalence of cavum septi pellucidi (CSP) enlargement in patients with bipolar disorder (BD) and healthy comparison subjects...
  40. ncbi The effect of internet video game play on clinical and extrapyramidal symptoms in patients with schizophrenia
    Doug Hyun Han
    Schizophr Res 103:338-40. 2008
  41. ncbi The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder
    Byeong Taek Lee
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1487-92. 2007
    ..Also, these findings suggest that the bilateral inferior orbitofrontal cortices and left amygdala may be preferentially recruited in MDD patients, but not in healthy individuals...
  42. ncbi Depression and Internet addiction in adolescents
    Jee Hyun Ha
    Department of Psychiatry, School of Medicine, Konkuk University, Seoul, South Korea
    Psychopathology 40:424-30. 2007
    ..Third, the relationship between Internet addiction and biogenetic temperament as assessed by the Temperament and Character Inventory was evaluated...
  43. ncbi Brain single photon emission computed tomography findings in depressive pseudodementia patients
    Maeng Je Cho
    Department of Neuropsychiatry, Clinical Research Institute, Seoul National University College of Medicine and Hospital, 28 Yongon Dong, Chongno Gu, Seoul, 110 744 South Korea
    J Affect Disord 69:159-66. 2002
    ....
  44. ncbi Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy
    Seog Ju Kim
    Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea
    Sleep 31:342-7. 2008
    ..To explore absolute concentrations of brain metabolites including gamma amino-butyric acid (GABA) in the medial prefrontal cortex and basal ganglia of young adults with narcolepsy...
  45. ncbi Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography
    Tak Youn
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongun-dong, Chongno-gu, 110-744, Seoul, Republic of Korea
    Biol Psychol 60:109-20. 2002
    ..The current study provides evidence linking each biogenetic temperament dimension with specific brain areas and provides a promising base for future personality research...
  46. ncbi Major depressive disorder with anger attacks and subcortical MRI white matter hyperintensities
    Dan V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Nerv Ment Dis 195:175-8. 2007
    ..Atypical and melancholic MDD subtypes were not significantly associated with brain WMH. In conclusion, subcortical brain vascular lesions may be more prevalent or severe in MDD with anger attacks...
  47. ncbi Shape changes of the corpus callosum in abstinent methamphetamine users
    Jungsu S Oh
    Interdisciplinary Program in Medical and Biological Engineering, Seoul National University, 28 Yongun-Dong Chongno-Gu, Seoul, South Korea
    Neurosci Lett 384:76-81. 2005
    ....
  48. ncbi Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia
    Byung Joo Ham
    Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea
    Neuropsychobiology 52:151-4. 2005
    ..However, there was no significant relationship between the 5-HTTLPR genotype and TAS-20 scores. This indicates a possible association between the COMT Val108/158Met gene polymorphism and alexithymia...
  49. ncbi Decreased blood flow of temporal regions of the brain in subjects with panic disorder
    Yujin S Lee
    Department of Psychiatry, Eunpyung Metropolitan Hospital, Seoul, Republic of Korea
    J Psychiatr Res 40:528-34. 2006
    ..CONCLUSION: We report that there is a decreased cerebral blood flow of temporal regions of the brain in panic disorder and that this decrease may, in part, reflect the clinical severity of panic disorder...
  50. ncbi Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
    Jaeuk Hwang
    Department of Psychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea
    Drug Alcohol Depend 82:177-81. 2006
    ..CONCLUSIONS: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence...
  51. ncbi Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study
    Hanik K Yoo
    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Eur J Neurosci 22:2089-94. 2005
    ..The current study reports a putaminal gray matter volume decrease in panic subjects, which may be related to the clinical severity of panic disorder...
  52. ncbi Biogenetic temperament and character and attention deficit hyperactivity disorder in Korean children
    Hee Jeong Yoo
    Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, South Korea
    Psychopathology 39:25-31. 2006
    ..CONCLUSIONS: There were significant correlations between ADHD symptoms and Novelty Seeking. Current findings suggest that Novelty Seeking and ADHD share biogenetic backgrounds...
  53. ncbi Three-year follow up of women with and without borderline personality disorder: development of Cloninger's character in adolescence
    Kyoo Seob Ha
    Clinical Research Institute, Seoul National University Hospital and Department of Psychiatry, Seoul National University College of Medicine and Hospital, Seoul, South Korea
    Psychiatry Clin Neurosci 58:42-7. 2004
    ..The character development of BPD patients was more fixed and immature than those of healthy comparison subjects...
  54. ncbi Brain white-matter hyperintensities and treatment outcome in major depressive disorder
    Dan V Iosifescu
    Massachusetts General Hospital, 50 Staniford Street, Suite 401, Boston, Massachusetts 02114, USA
    Br J Psychiatry 188:180-5. 2006
    ..CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression...
  55. ncbi The relationship between temperament and character and psychopathology in community children with overweight
    Jun Won Hwang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    J Dev Behav Pediatr 27:18-24. 2006
    ..Compared to nonoverweight and children at risk of overweight, overweight children had distinct patterns of temperament and character that were related to the specific psychopathology...
  56. ncbi Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients
    Young Sik Lee
    Department of Neuropsychiatry, College of Medicine, Chung Ang University Medical Center, Seoul National University Hospital, Korea
    Neuroreport 17:743-6. 2006
    ..These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase...
  57. ncbi Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder
    Jun Soo Kwon
    BK 21 Human Life Sciences, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea
    Psychiatry Res 122:37-47. 2003
    ..In particular, the frontal-subcortical circuits might mediate not only symptomatic expression but also cognitive expression in patients with OCD...
  58. ncbi Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
    Seog Ju Kim
    Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea
    Neuropsychobiology 54:120-5. 2006
    ..7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD...
  59. ncbi Basal ganglia shape alterations in bipolar disorder
    Jaeuk Hwang
    Department of Psychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea
    Am J Psychiatry 163:276-85. 2006
    ..The findings more generally demonstrate the sensitivity of the SPHARM analytic technique for detecting subtle anatomical shape differences in small brain regions in the absence of volume differences...
  60. ncbi Trait and state aspects of harm avoidance and its implication for treatment in major depressive disorder, dysthymic disorder, and depressive personality disorder
    Kelley Yost Abrams
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, South Korea
    Psychiatry Clin Neurosci 58:240-8. 2004
    ....