Genomes and Genes
Helen N Lyon
Affiliation: Harvard University
- The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohortsHelen N Lyon
Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
PLoS Genet 3:e61. 2007....
- The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNACharleston W K Chiang
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Hum Genet 130:607-21. 2011..While our conclusions were based on the specific technology and study design we employed, the approach presented here will be useful for evaluating the utility of other or future genome-wide genotyping platforms in pooled DNA studies...
- The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjectsJarred B McAteer
Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetes 57:1125-30. 2008..We therefore conducted a new meta-analysis that includes novel unpublished data from the ENPP1 Consortium and recent negative findings from large association studies to address the contribution of K121Q to type 2 diabetes...
- Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in menCatarina D Campbell
Program in Genomics and Division of Endocrinology, Children s Hospital, Boston, Massachusetts 021115, USA
Diabetes 56:1460-7. 2007..73 x 10(-4), OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men...
- Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samplesCharleston W K Chiang
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 6:e1000866. 2010..e., AIMs) and that these AIMs are able to differentiate two closely related populations (HapMap JPT and CHB)...
- Transferability of tag SNPs in genetic association studies in multiple populationsPaul I W de Bakker
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
Nat Genet 38:1298-303. 2006..These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world...
- Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesityHelen N Lyon
Division of Genetics, Children s Hospital Boston, Enders 561, 300 Longwood Ave, Boston, MA 02115, USA
Diabetes 55:3180-4. 2006..6 [0.42-0.88], P = 0.007). However, these findings are not supported by other studies. We did not observe a reproducible association between these three ENPP1 variants and BMI or type 2 diabetes...
- Demonstrating stratification in a European American populationCatarina D Campbell
Program in Genomics and Division of Endocrinology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Genet 37:868-72. 2005..The failure of standard methods to detect this stratification indicates that new methods may be required...
- Genetics of common forms of obesity: a brief overviewHelen N Lyon
Children s Hospital Boston, Boston, MA 02115, USA
Am J Clin Nutr 82:215S-217S. 2005..New research tools and large studies will lead to an understanding of genes and their interaction to cause obesity, which may help guide successful interventions and treatments...
- On the replication of genetic associations: timing can be everything!Jessica Lasky-Su
SUNY Upstate Medical University, Syracuse, NY 13210, USA
Am J Hum Genet 82:849-58. 2008..If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed...
- Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008....
- Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsRicha Saxena
Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
Science 316:1331-6. 2007..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...