Helen N Lyon

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
  2. pmc The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA
    Charleston W K Chiang
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Hum Genet 130:607-21. 2011
  3. ncbi request reprint The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects
    Jarred B McAteer
    Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 57:1125-30. 2008
  4. ncbi request reprint Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, Boston, Massachusetts 021115, USA
    Diabetes 56:1460-7. 2007
  5. pmc Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples
    Charleston W K Chiang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000866. 2010
  6. ncbi request reprint Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
    Helen N Lyon
    Division of Genetics, Children s Hospital Boston, Enders 561, 300 Longwood Ave, Boston, MA 02115, USA
    Diabetes 55:3180-4. 2006
  7. ncbi request reprint Transferability of tag SNPs in genetic association studies in multiple populations
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
    Nat Genet 38:1298-303. 2006
  8. ncbi request reprint Demonstrating stratification in a European American population
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:868-72. 2005
  9. ncbi request reprint Genetics of common forms of obesity: a brief overview
    Helen N Lyon
    Children s Hospital Boston, Boston, MA 02115, USA
    Am J Clin Nutr 82:215S-217S. 2005
  10. pmc On the replication of genetic associations: timing can be everything!
    Jessica Lasky-Su
    SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Hum Genet 82:849-58. 2008

Detail Information

Publications12

  1. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  2. pmc The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA
    Charleston W K Chiang
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Hum Genet 130:607-21. 2011
    ..While our conclusions were based on the specific technology and study design we employed, the approach presented here will be useful for evaluating the utility of other or future genome-wide genotyping platforms in pooled DNA studies...
  3. ncbi request reprint The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects
    Jarred B McAteer
    Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 57:1125-30. 2008
    ..We therefore conducted a new meta-analysis that includes novel unpublished data from the ENPP1 Consortium and recent negative findings from large association studies to address the contribution of K121Q to type 2 diabetes...
  4. ncbi request reprint Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, Boston, Massachusetts 021115, USA
    Diabetes 56:1460-7. 2007
    ..73 x 10(-4), OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men...
  5. pmc Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples
    Charleston W K Chiang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000866. 2010
    ..e., AIMs) and that these AIMs are able to differentiate two closely related populations (HapMap JPT and CHB)...
  6. ncbi request reprint Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
    Helen N Lyon
    Division of Genetics, Children s Hospital Boston, Enders 561, 300 Longwood Ave, Boston, MA 02115, USA
    Diabetes 55:3180-4. 2006
    ..6 [0.42-0.88], P = 0.007). However, these findings are not supported by other studies. We did not observe a reproducible association between these three ENPP1 variants and BMI or type 2 diabetes...
  7. ncbi request reprint Transferability of tag SNPs in genetic association studies in multiple populations
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
    Nat Genet 38:1298-303. 2006
    ..These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world...
  8. ncbi request reprint Demonstrating stratification in a European American population
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:868-72. 2005
    ..The failure of standard methods to detect this stratification indicates that new methods may be required...
  9. ncbi request reprint Genetics of common forms of obesity: a brief overview
    Helen N Lyon
    Children s Hospital Boston, Boston, MA 02115, USA
    Am J Clin Nutr 82:215S-217S. 2005
    ..New research tools and large studies will lead to an understanding of genes and their interaction to cause obesity, which may help guide successful interventions and treatments...
  10. pmc On the replication of genetic associations: timing can be everything!
    Jessica Lasky-Su
    SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Hum Genet 82:849-58. 2008
    ..If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed...
  11. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  12. ncbi request reprint Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...