Affiliation: Harvard University
- Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine productionLydia Lynch
Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Immunity 37:574-87. 2012..This finding highlights the potential of iNKT cell-targeted therapies, previously proven to be safe in humans, in the management of obesity and its consequences...
- Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesityLydia Lynch
Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
Eur J Immunol 39:1893-901. 2009..004) compared with lean healthy subjects. These data suggest a novel role for the omentum in immune regulation and tumor immunity and identify it as a potential source of iNKT cells for therapeutic use...
- Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responsesAndrew E Hogan
Obesity Immunology Group, Education and Research Centre, St Vincents University Hospital, UCD, Dublin 4, Ireland
Clin Immunol 140:229-35. 2011..CSE inhibits the upregulation of CD107 but not CD69 or CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor responses, which may contribute to the role of smoking in the development of cancer...
- Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defectsMark A Exley
Department of Medicine, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Clin Immunol 140:184-95. 2011....
- Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smokeDonal O'Shea
Department of Endocrinology, St Vincent s University Hospital, Dublin, Ireland
PLoS ONE 5:e8660. 2010..Natural killer cells (NK) are critical mediators of anti-tumour immunity and are compromised in obese patients and smokers. We examined whether NK cell function was differentially affected by cigarette smoke in obese and lean subjects...
- The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesityJean O'Connell
Obesity Research Group, Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
PLoS ONE 5:e9997. 2010..It remains unclear what factors are responsible for this phenomenon. We proposed that adipocyte size might be a key factor in the protection of metabolically healthy obese (MHO) individuals from the adverse effects of obesity...
- The A2aR adenosine receptor controls cytokine production in iNKT cellsMichael Nowak
Department of Medicine, Divison of Hematology Oncology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
Eur J Immunol 40:682-7. 2010..While A2aR inhibits other lymphocyte populations, A2aR is required for the secretion of IL-4 and IL-10 by iNKT cells. These data suggest adenosine:A2aR-mediated mechanisms can control the cytokine secretion pattern of iNKT cells...
- Commitment of decidual haematopoietic progenitor cells in first trimester pregnancyLaszlo Szereday
Department of Medical Microbiology and Immunology, University of Pecs, Medical School, Hungary
Am J Reprod Immunol 67:9-16. 2012..Increased levels of NK progenitors in the decidua of women with early spontaneous abortion suggest a dysregulation of this pathway that may contribute to pregnancy failure...
- Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertilityEmma McGrath
Education and Research Centre, St Vincent s University Hospital Dublin, Dublin, Ireland
Am J Reprod Immunol 61:265-76. 2009..Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility...
- Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationshipsAoife O'Donovan
Department of Psychiatry and Mental Health Research, St Vincent s University Hospital, University College Dublin, Ireland
Brain Behav Immun 24:1074-7. 2010..Conversely, the groups had equivalent levels of CRP in all analyses. Results are indicative of anxiety-specific effects on inflammatory activity, and highlight a pathway by which anxiety may increase risk for inflammatory diseases...