Andrew D Luster

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc CCR4-dependent regulatory T cell function in inflammatory bowel disease
    Qian Yuan
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 204:1327-34. 2007
  2. pmc BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 202:97-110. 2005
  3. pmc A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis
    Nancy D Kim
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:829-35. 2006
  4. ncbi request reprint Immune cell migration in inflammation: present and future therapeutic targets
    Andrew D Luster
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 6:1182-90. 2005
  5. ncbi request reprint CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 176:7087-95. 2006
  6. pmc The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 107:444-53. 2006
  7. ncbi request reprint Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 4:982-90. 2003
  8. ncbi request reprint Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02120, USA
    J Immunol 172:767-75. 2004
  9. ncbi request reprint Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L170-8. 2006
  10. ncbi request reprint CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Immunol 176:7272-7. 2006

Detail Information

Publications109 found, 100 shown here

  1. pmc CCR4-dependent regulatory T cell function in inflammatory bowel disease
    Qian Yuan
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 204:1327-34. 2007
    ..Our study demonstrates that CCR4 plays an important role in T reg cell trafficking in LNs and that this is critical for T reg cell suppressive function in vivo...
  2. pmc BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 202:97-110. 2005
    ..This is the first report that describes a pathologic role for BLT1-mediated T lymphocyte recruitment in disease and identifies BLT1 as a potential therapeutic target after lung transplantation...
  3. pmc A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis
    Nancy D Kim
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:829-35. 2006
    ....
  4. ncbi request reprint Immune cell migration in inflammation: present and future therapeutic targets
    Andrew D Luster
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 6:1182-90. 2005
    ....
  5. ncbi request reprint CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 176:7087-95. 2006
    ....
  6. pmc The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 107:444-53. 2006
    ..Our studies provide novel insights into the LTB(4)-BLT1 lipid chemoattractant pathway in human T-cell responses, and how it may link innate and adaptive immunity...
  7. ncbi request reprint Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 4:982-90. 2003
    ..Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment...
  8. ncbi request reprint Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02120, USA
    J Immunol 172:767-75. 2004
    ..This study demonstrates the important role for CCR2 in early islet allograft rejection and highlights the tissue specificity of the chemokine/chemokine receptor system in vivo in regulating allograft rejection...
  9. ncbi request reprint Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L170-8. 2006
    ..We conclude that BLT1 mediates early recruitment of granulocytes into the airway in response to antigen-antibody interactions in a murine model of acute asthma...
  10. ncbi request reprint CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Immunol 176:7272-7. 2006
    ..Furthermore, the data clearly show that CARMA1 is essential for the development of allergic airway inflammation through its role in T lymphocytes, and may provide a novel means to inhibit NF-kappaB for therapy in asthma...
  11. ncbi request reprint Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function
    Richard A Colvin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Biol Chem 279:30219-27. 2004
    ..Our findings demonstrate that distinct domains of CXCR3 mediate its functions and suggest that the differential requirement of these domains contributes to the complexity of the chemokine system...
  12. ncbi request reprint Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    Joseph El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Med 13:432-8. 2007
    ..Thus, Ccr2-dependent microglial accumulation plays a protective role in the early stages of Alzheimer disease by promoting Abeta clearance...
  13. pmc CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation
    Joanna R Groom
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 37:1091-103. 2012
    ..Thus, different chemokines acting on the same receptor can function locally to facilitate DC-T cell interactions and globally to influence intranodal positioning, and both functions contribute to Th1 cell differentiation...
  14. ncbi request reprint STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells
    Zamaneh Mikhak
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:4959-67. 2006
    ....
  15. pmc Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria
    Gabriele S V Campanella
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:4814-9. 2008
    ....
  16. ncbi request reprint IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis
    Robyn S Klein
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital East, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Immunol 172:550-9. 2004
    ..Our data demonstrated that IP-10 was not required for the trafficking of pathogenic T cells into the CNS in EAE but played an unexpected role in determining the threshold of disease susceptibility in the periphery...
  17. ncbi request reprint Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity
    Gabriele S V Campanella
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 177:6991-8. 2006
    ..We therefore propose that oligomerization of IP-10 is required for presentation on endothelial cells and subsequent transendothelial migration, an essential step for lymphocyte recruitment in vivo...
  18. pmc Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction
    Diana M Brainard
    Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:8439-50. 2007
    ..These data suggest that both CXCR3(+) CD8 T cells and LN CXCR3 ligands decrease as HIV infection progresses, resulting in reduced homing of CTL into LNs and contributing to immune dysfunction...
  19. ncbi request reprint Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway
    Seddon Y Thomas
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 179:1901-12. 2007
    ..Our data therefore suggests a role for CCR6 and CXCR3, in conjunction with other chemoattractant receptors, in the recruitment of inflammatory T cells into the BAL during the allergic asthmatic response...
  20. pmc Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, CNY 8301, 149 13th Street, Charlestown, MA 02129, USA
    Am J Respir Cell Mol Biol 41:397-406. 2009
    ..These data provide a possible mechanism for the association between obesity and asthma, and suggest a potential novel link between obesity, inflammatory lung disease, and pulmonary hypertension...
  21. ncbi request reprint Inhibited aortic aneurysm formation in BLT1-deficient mice
    Neil Ahluwalia
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 179:691-7. 2007
    ..These findings extend the role of BLT1 to a critical complication of vascular disease and underscore its potential as a target for intervention in modulating multiple pathologies related to atherosclerosis...
  22. pmc CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 182:623-35. 2009
    ..These data reveal that CD11b(+) myeloid cells in the lung help orchestrate the adaptive immune response in asthma, in part, through the production of STAT6-inducible chemokines and the recruitment of Th2 lymphocytes into the airway...
  23. ncbi request reprint Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
    Shannon K Bromley
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 6:895-901. 2005
    ..Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues...
  24. ncbi request reprint Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling
    Anuja Mathew
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 169:651-5. 2002
    ..These studies conclusively demonstrate that trafficking of Th2 cells into the lung is an active process dependent on chemoattractant receptors...
  25. pmc Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation
    Roshi Afshar
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Allergy Clin Immunol 131:1644-52. 2013
    ..Understanding these aspects of Treg cell biology will be important for harnessing their power in the clinic...
  26. ncbi request reprint T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity
    Viviany R Taqueti
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:5890-901. 2006
    ..These findings highlight the potential therapeutic benefit of targeting T-bet-regulated gene expression and CXCR3-dependent migration in immune-mediated heart disease...
  27. pmc Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation
    Zamaneh Mikhak
    Division of Rheumatology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Immunol 182:7946-56. 2009
    ..This reciprocal interaction between LPS and Ag-activated Th1 cells represents a collaborative connection between the innate and adaptive arms of the immune system...
  28. ncbi request reprint Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
    Katayoon Goodarzi
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:965-73. 2003
    ..These results identify LTB4-BLT1 as a potent nonchemokine pathway for cytotoxic effector cell traffic...
  29. pmc Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation
    Zamaneh Mikhak
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 123:67-73.e3. 2009
    ....
  30. ncbi request reprint Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells
    Eric A Heller
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Circulation 113:2301-12. 2006
    ..Here, we tested the hypothesis that deletion of CXCL10 (IP-10), a chemokine specific for effector T cells that has been localized within atherosclerotic lesions, would significantly inhibit atherogenesis...
  31. ncbi request reprint CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells
    Seddon Y Thomas
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    J Immunol 171:2571-80. 2003
    ....
  32. ncbi request reprint IL-8 responsiveness defines a subset of CD8 T cells poised to kill
    Christoph Hess
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Blood 104:3463-71. 2004
    ..Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation...
  33. pmc Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis
    Richard C Chou
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 33:266-78. 2010
    ....
  34. pmc Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4
    Zamaneh Mikhak
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 210:1855-69. 2013
    ..Thus, lung DCs imprint T cell lung homing and promote lung immunity in part through CCR4. ..
  35. pmc Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling
    Christian D Sadik
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:E3177-85. 2012
    ....
  36. pmc CD36 mediates the innate host response to beta-amyloid
    Joseph B El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 197:1657-66. 2003
    ..Our data reveal that CD36, a major pattern recognition receptor, mediates microglial and macrophage response to beta-amyloid, and imply that CD36 plays a key role in the proinflammatory events associated with AD...
  37. ncbi request reprint Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells
    Qian Yuan
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Eur J Immunol 36:2700-14. 2006
    ..We thus provide evidence that cell surface-associated eotaxin-3 is the critical IL-4-dependent chemotactic signal mediating eosinophil transepithelial migration in the setting of allergic inflammation...
  38. ncbi request reprint IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 168:5278-86. 2002
    ..Our results demonstrate that IP-10, a Th1-type chemokine, is up-regulated in allergic pulmonary inflammation and that this contributes to the airway hyperreactivity and Th2-type inflammation seen in this model of asthma...
  39. pmc Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation
    Christian D Sadik
    Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Leukoc Biol 91:207-15. 2012
    ..These new discoveries establish a paradigm for leukocyte recruitment in inflammation--described as lipid-cytokine-chemokine cascades--as a driving force in the effector phase of immune responses...
  40. ncbi request reprint Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, MA 02129, USA
    Am J Respir Cell Mol Biol 31:395-404. 2004
    ..Our findings suggest that interruption of fibroblast recruitment may represent a novel therapeutic strategy for pulmonary fibrosis, which could have applicability to a wide range of fibrotic illnesses...
  41. pmc Development of a novel chemokine-mediated in vivo T cell recruitment assay
    Gabriele S V Campanella
    Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Immunol Methods 331:127-39. 2008
    ..This assay will therefore help elucidate a deeper understanding of the chemokine system in vivo...
  42. ncbi request reprint The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  43. ncbi request reprint The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:2489-95. 2002
    ..Targeting this chemokine receptor, therefore, may provide a clinically useful strategy to prevent islet allograft rejection...
  44. pmc Identification of human CCR8 as a CCL18 receptor
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114
    J Exp Med 210:1889-98. 2013
    ..Identifying CCR8 as a chemokine receptor for CCL18 will help clarify the biological role of this highly expressed chemokine in human disease. ..
  45. ncbi request reprint CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus
    Paul Robertson
    Center for Regenerative Medicine and Technology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Exp Hematol 34:308-19. 2006
    ....
  46. pmc Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis
    Mei Chen
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:5503-11. 2010
    ..Our results identify novel roles for FLSs and LTB(4) in joints, placing LTB(4) regulation of FLS biology at the center of a previously unrecognized amplification loop for synovial inflammation and tissue pathology...
  47. pmc CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality
    Shaza A Fadel
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Eur J Immunol 38:3376-87. 2008
    ..In conclusion, CXCR3-deficiency attenuated the lethal cellular immune response in CCR5(-/-) influenza-infected mice without hindering viral clearance or long-term immunity...
  48. ncbi request reprint The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
    Terry K Means
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 170:5165-75. 2003
    ..These results demonstrate that flagellin can directly stimulate human but not murine DC maturation, providing an additional mechanism by which motile bacteria can initiate an acquired immune response...
  49. pmc HIV-infected T cells are migratory vehicles for viral dissemination
    Thomas T Murooka
    the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 490:283-7. 2012
    ..Migration of T cells in lymph nodes therefore spreads infection locally, whereas their recirculation through tissues is important for efficient systemic viral spread, suggesting new molecular targets to antagonize HIV infection...
  50. ncbi request reprint Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs
    Marie T Rubio
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, MGH East, Building 149 5102, 13th Street, Boston 02129, USA
    Int Immunol 17:1561-72. 2005
    ..In conclusion, MoDCs matured in the presence of PGE2 display characteristics of more efficient antigen-presenting cells that might be optimal for use in cancer vaccine-based clinical trials...
  51. pmc The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity
    Zaida G Ramirez-Ortiz
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Immunol 14:917-26. 2013
    ..The discovery of such interactions of SCARF1 with C1q and apoptotic cells provides insight into the molecular mechanisms involved in the maintenance of tolerance and prevention of autoimmune disease. ..
  52. pmc Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice
    Diana M Brainard
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 83:7305-21. 2009
    ....
  53. pmc Proinflammatory functions of vascular endothelial growth factor in alloimmunity
    Marlies E J Reinders
    Division of Nephrology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:1655-65. 2003
    ..Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. Together, these observations provide mechanistic insight into the proinflammatory function of VEGF in immunity...
  54. pmc Synaptotagmin-mediated vesicle fusion regulates cell migration
    Richard A Colvin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Immunol 11:495-502. 2010
    ..Our data identify a molecular pathway required for chemotaxis that links chemoattractant-induced calcium flux to exocytosis and uropod release...
  55. pmc Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
    Junghee J Shin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Arthritis Res Ther 12:R168. 2010
    ..We hypothesized that B. burgdorferi stimulates chemokine secretion from monocytes/macrophages in multiple ways, thereby linking innate and adaptive immune responses...
  56. ncbi request reprint Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment
    Eric A Heller
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, East 8307, 149 13th St, Charlestown, MA 02129, USA
    Circulation 112:578-86. 2005
    ..LTB(4) signals primarily through its high-affinity G protein-coupled receptor BLT1, which is expressed on specific leukocyte subsets. BLT1 receptor expression and function on other atheroma-associated cell types is unknown...
  57. pmc Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:167-77. 2011
    ..In humans, CCR8 expression also defined an IL-5-enriched T(H)2 cell subset. The CCL8-CCR8 chemokine axis is therefore a crucial regulator of T(H)2 cell homing that drives IL-5-mediated chronic allergic inflammation...
  58. pmc CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis
    Richard A Colvin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 149 Thirteenth Street, Room 8031, Charlestown, MA 02129, USA
    Mol Cell Biol 26:5838-49. 2006
    ..This lower-affinity interaction is necessary to induce chemotaxis but not ligand-induced CXCR3 internalization, further suggesting that different domains of CXCR3 mediate distinct functions...
  59. ncbi request reprint Role of CXC chemokine receptor 3 pathway in renal ischemic injury
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:716-23. 2006
    ..It is concluded that CXCR3 plays an important role in orchestrating the recruitment of Th1 cells to the ischemic kidney and in mediating I/R injury and therefore may serve as a novel target for the therapy of I/R injury...
  60. ncbi request reprint BLT1 and BLT2: the leukotriene B(4) receptors
    Andrew M Tager
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, MA 02129, USA
    Prostaglandins Leukot Essent Fatty Acids 69:123-34. 2003
    ..Reduced disease severity in animal inflammatory models seen with LTB(4) receptor antagonists and in mice with targeted deletion of BLT1 have revealed important roles for LTB(4) and its receptors in regulating pathologic inflammation...
  61. pmc Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis
    Robyn S Klein
    Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 79:11457-66. 2005
    ....
  62. ncbi request reprint Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis
    Yoshihisa Okamoto
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 102:218-25. 2008
    ..This study establishes that low levels of adiponectin associated with obesity, the metabolic syndrome, and diabetes favor T-lymphocyte recruitment and contribute to adaptive immune response during atherogenesis...
  63. ncbi request reprint Chemokines in islet allograft rejection
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Diabetes Metab Res Rev 19:186-90. 2003
    ..Hence, each organ or tissue may require a unique set of chemokines to generate acute rejection. Targeting the appropriate chemokine receptors may provide a clinically useful strategy to prevent islet allograft rejection...
  64. pmc Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction
    Marcin Bujak
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
    Circ Res 105:973-83. 2009
    ..Interferon-gamma-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic chemokine with an important role in T-cell trafficking, is markedly induced in myocardial infarcts, and may regulate the reparative response...
  65. pmc Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4
    Dianhua Jiang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Invest 120:2049-57. 2010
    ..Thus, administration of CXCL10 protein defective in CXCR3 binding may represent a novel therapy for pulmonary fibrosis...
  66. doi request reprint T cell trafficking in allergic asthma: the ins and outs
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Annu Rev Immunol 26:205-32. 2008
    ....
  67. pmc LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation
    Norihiko Sakai
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    FASEB J 27:1830-46. 2013
    ....
  68. pmc Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern
    Shannon K Bromley
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 190:970-6. 2013
    ..Our results identify a novel subset of recirculating memory CD4(+) T cells equipped to deliver help to both distal lymphoid and cutaneous tissues...
  69. pmc T cell homing to epithelial barriers in allergic disease
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Nat Med 18:705-15. 2012
    ..Inflammation- and tissue-specific T lymphocyte trafficking pathways are currently being targeted as new treatments for non-allergic inflammatory diseases and may yield effective new therapeutics for allergic diseases...
  70. pmc Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation
    Michiko K Oyoshi
    Division of Immunology, Boston Children s Hospital, MA 02115, USA
    Immunity 37:747-58. 2012
    ..Our results demonstrate that a neutrophil-T cell axis reliant on LTB4-BLT1 interaction is required for allergic skin inflammation...
  71. pmc CXCL10 can inhibit endothelial cell proliferation independently of CXCR3
    Gabriele S V Campanella
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 5:e12700. 2010
    ..Thus, using a very defined system, we show that CXCL10 can inhibit endothelial cell proliferation through a CXCR3-independent mechanism...
  72. pmc In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment
    Dorothy A Sipkins
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, Massachusetts 02114, USA
    Nature 435:969-73. 2005
    ..Specialized vascular structures therefore appear to delineate a microenvironment with unique physiology that can be exploited by circulating malignant cells...
  73. doi request reprint Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications
    Joseph El Khoury
    Division of Rheumatology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Trends Pharmacol Sci 29:626-32. 2008
    ..Here, we review the role of microglia in AD and the mechanisms of their accumulation and discuss implications for AD therapy...
  74. pmc Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury
    Barry S Shea
    Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Am J Respir Cell Mol Biol 43:662-73. 2010
    ....
  75. pmc Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    Terry K Means
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 115:407-17. 2005
    ....
  76. pmc Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes
    Jung Hwan Sung
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 150:1249-63. 2012
    ....
  77. pmc Neutrophils cascading their way to inflammation
    Christian D Sadik
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Immunol 32:452-60. 2011
    ..Recent data, however, suggest that neutrophil chemoattractants have unique functions in the recruitment of neutrophils into inflammatory sites in vivo, dictated by their distinct patterns of temporal and spatial expression...
  78. ncbi request reprint Pathogenic T-cell recruitment into the airway in human disease
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Bldg 149 8301, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1062:220-41. 2005
    ..We then speculate on the potential role of these chemokine receptors in the pathogenesis of these disorders and potential novel therapeutic approaches suggested by these data...
  79. pmc Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:1209-16. 2006
    ..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
  80. pmc IL-17RA signaling amplifies antibody-induced arthritis
    Christian D Sadik
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e26342. 2011
    ..To investigate the role of IL-17RA signaling in the effector phase of inflammatory arthritis using the K/BxN serum-transfer model...
  81. pmc Differential requirement for CARMA1 in agonist-selected T-cell development
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02114, USA
    Eur J Immunol 39:78-84. 2009
    ..Overall, these data reveal an important but differential role for CARMA1-mediated TCR signaling in T-cell development...
  82. pmc Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection
    Edward Seung
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 186:6830-8. 2011
    ..These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8(+) Teff into the target organ and suggest a novel approach to achieve transplant tolerance...
  83. doi request reprint Orchestrating the orchestrators: chemokines in control of T cell traffic
    Shannon K Bromley
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:970-80. 2008
    ..Here we review such advances with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation...
  84. ncbi request reprint T-cell trafficking in asthma: lipid mediators grease the way
    Andrew D Luster
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Immunol 4:711-24. 2004
    ....
  85. ncbi request reprint Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and
    David Xiao Ming Zhao
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 169:1556-60. 2002
    ..This chemokine pathway may serve as a monitor and target for novel therapies to prevent CAV and rejection...
  86. ncbi request reprint The role of chemokines in linking innate and adaptive immunity
    Andrew D Luster
    Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Curr Opin Immunol 14:129-35. 2002
    ..The chemokine system has emerged as an essential regulator of this dendritic cell and lymphocyte trafficking, which is necessary to turn an innate immune response into an adaptive response...
  87. ncbi request reprint Targeting monocyte recruitment in CNS autoimmune disease
    Leonid Izikson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
    Clin Immunol 103:125-31. 2002
    ....
  88. pmc Thymocyte emigration is mediated by active movement away from stroma-derived factors
    Mark C Poznansky
    AIDS Research Center and Massachusetts General Hospital Cancer Center, Building 149 13th Street, Room 4005A, Boston, MA 02129, USA
    J Clin Invest 109:1101-10. 2002
    ..Thymic emigration is mediated, at least in part, by specific fugetaxis-inducing factors to which only mature cells respond...
  89. ncbi request reprint IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking
    Jennifer H Dufour
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 168:3195-204. 2002
    ..Taken together, our data suggest a role for IP-10 in both effector T cell generation and trafficking in vivo...
  90. pmc Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling
    Brian D Thompson
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 282:9547-55. 2007
    ..This interplay has heretofore been masked by the use of pertussis toxin, a broad inhibitor of the G alpha(i/o) protein family...
  91. pmc CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion
    Silke Gillessen
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:8874-9. 2003
    ..DCs from immunized CD1d-deficient mice showed compromised maturation and function. Together, these results delineate a role for CD1d-restricted T cell-DC cross talk in the shaping of antitumor immunity...
  92. pmc Chapter 18. A chemokine-mediated in vivo T-cell recruitment assay
    Gabriele S V Campanella
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Methods Enzymol 461:397-412. 2009
    ....
  93. ncbi request reprint T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction
    Hyeon Seok Eom
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital Harvard Medical School, Boston, 02129, USA
    Exp Hematol 33:1564-73. 2005
    ..We hypothesized that Fuc-TIV(-/-)/Fuc-TVII(-/-) donor T cells might have reduced capacity to roll on vessels of inflamed target tissues and mediate graft-vs-host disease (GVHD)...
  94. ncbi request reprint A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
    ....
  95. pmc The emergence of basophils as antigen-presenting cells in Th2 inflammatory responses
    Zamaneh Mikhak
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02482, USA
    J Mol Cell Biol 1:69-71. 2009
    ..Basophils gain prominence in Th2 inflammatory responses with the discovery that they function as antigen-presenting cells and are sufficient to drive Th2 cell differentiation...
  96. ncbi request reprint Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
    Harry Bjorkbacka
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 10:416-21. 2004
    ..These findings link elevated serum lipid levels to a proinflammatory signaling cascade that is also engaged by microbial pathogens...
  97. doi request reprint Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis
    Kathryn L Jones
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 46:85-92. 2008
    ..afzelii infection in Europe. However, reasons for these differences are not yet known...
  98. ncbi request reprint The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 176:3157-64. 2006
    ..Together, these data define the important role for mast cells and the LTB4-BLT1 pathway in the development of CD8+ T cell-mediated allergic responses in the lung...
  99. ncbi request reprint Donor T cell activation initiates small bowel allograft rejection through an IFN-gamma-inducible protein-10-dependent mechanism
    Zheng Zhang
    Department of Surgery, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 168:3205-12. 2002
    ..Blocking this pathway may be of therapeutic value in controlling SB allograft rejection...
  100. ncbi request reprint Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 171:6838-45. 2003
    ....
  101. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase...