Research Topics
| Scott LukasSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkersScott E Lukas
Behavioral Psychopharmacology Research Laboratory MIC, Mail Stop 319 McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 226:65-73. 2013..The present study was conducted in nontreatment-seeking heavy drinkers to assess the safety and efficacy of 4 weeks of kudzu extract in an outpatient setting...- Effects of perceived cocaine availability on subjective and objective responses to the drugRINAH T YAMAMOTO
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA, USA
Subst Abuse Treat Prev Policy 2:30. 2007..Several lines of evidence suggest that cocaine expectancy and craving are two related phenomena. The present study assessed this potential link by contrasting reactions to varying degrees of the drug's perceived availability... 
An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic settingScott E Lukas
Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
Alcohol Clin Exp Res 29:756-62. 2005..Extracts of kudzu containing a variety of isoflavones have been shown to reduce alcohol drinking in rats and hamsters...- Pretreatment with transdermal nicotine enhances some of ethanol's acute effects in menElena M Kouri
Behavioral Psychopharmacology Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 75:55-65. 2004..These findings suggest that nicotine enhances some of the positive subjective effects of acute ethanol and may help explain the high prevalence of the combined use of these two drugs... - A low-cost, MR-compatible olfactometerSteven B Lowen
McLean Hospital and Harvard Medical School, Belmont, Massachusetts, USA
Behav Res Methods 38:307-13. 2006..A validation study verified that the olfactometer reliably presents odors to test subjects. Errors and response latency times decreased with increased flow rate in an orderly manner, as expected... - Benztropine pretreatment does not affect responses to acute cocaine administration in human volunteersDavid M Penetar
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School MA 02478, USA
Hum Psychopharmacol 21:549-59. 2006..The exact therapeutic application of benztropine as a possible adjunct treatment for cocaine abuse in humans require further exploration... - An MR-compatible device for delivering smoked marijuana during functional imagingBlaise deB Frederick
McLean Hospital and Harvard Medical School, Belmont, MA, USA
Pharmacol Biochem Behav 87:81-9. 2007..The use of this device will help advance research studies on smoked drugs including marijuana, tobacco and crack cocaine... - Brain phosphorus magnetic resonance spectroscopy imaging of sleep homeostasis and restoration in drug dependenceGeorge H Trksak
Behavioral Pharmacology Research Laboratory, McLean Hospital, Belmont, MA, USA
ScientificWorldJournal 7:217-22. 2007..Additional sleep studies in drug abusing populations are needed, particularly those that examine potential differential effects of sleep deprivation... - Comparison among plasma, serum, and whole blood ethanol concentrations: impact of storage conditions and collection tubesDavid M Penetar
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
J Anal Toxicol 32:505-10. 2008..This study shows that blood samples containing ethanol at levels ranging from 60 to 90 mg/dL (0.06 to 0.09 mg%) are not significantly altered by the type of collection tube used or storage condition during a 10-day period... - A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot studyStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Eur J Pharmacol 598:64-7. 2008..Thus, a therapeutic dose of zolpidem may have limited potential for misuse among females who have no experience with drugs of abuse... - A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 TStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 203:819-29. 2009..A great deal is known about the behavioral effects of this drug in humans and laboratory animals, but little is known about zolpidem's specific effects on neurochemistry in vivo... - Nicotine pretreatment increases dysphoric effects of alcohol in luteal-phase female volunteersDavid M Penetar
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Int J Environ Res Public Health 6:526-46. 2009..Luteal-phase women reported peak positive (e.g. "stimulated") and peak negative effects (e.g. "clumsy", "dizzy") almost twice as great as low progesterone women... - Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging studyGeorge H Trksak
Behavioral Pharmacology Research Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02472, USA
Drug Alcohol Depend 106:79-91. 2010..Results suggest that differences in sleep and brain chemistry during RE in MM participants may be reflective of a disruption in homeostatic sleep function... 
Cerebellar lingula size and experiential risk factors associated with high levels of alcohol and drug use in young adultsCarl M Anderson
The NeuroImaging Center, McLean Hospital, Belmont, MA 02478, USA
Cerebellum 9:198-209. 2010..Lingula thickness may represent a novel, experientially sensitive, phenotypic risk factor for enhanced alcohol and drug use that perhaps modulates sensitivity to these agents...- Age-related changes in brain energetics and phospholipid metabolismBrent P Forester
Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
NMR Biomed 23:242-50. 2010..Unlike some previous studies of aging and brain chemistry, this study examined healthy, non-demented and psychiatrically stable older adults and specifically analyzed gray-white matter differences in brain metabolism... - Modest abuse-related subjective effects of zolpidem in drug-naive volunteersStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, Neuroimaging Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Behav Pharmacol 22:160-6. 2011.... - Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteersDavid M Penetar
Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Belmont, MA 02478, USA
J Altern Complement Med 12:543-8. 2006..This study was undertaken to assess the pharmacokinetic profile of puerarin, the major isoflavone found in a kudzu (Pueraria lobata) extract after acute and repeated administration... - Incidence and patterns of polydrug use and craving for ecstasy in regular ecstasy users: an ecological momentary assessment studyJames W Hopper
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
Drug Alcohol Depend 85:221-35. 2006..Previous studies employing retrospective assessments methods found that regular ecstasy users frequently use alcohol, marihuana and other drugs in combination with ecstasy... - Effects of oral contraceptives on acute cocaine response in female volunteersElena M Kouri
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Pharmacol Biochem Behav 74:173-80. 2002.... - Phosphorous31 magnetic resonance spectroscopy after total sleep deprivation in healthy adult menCynthia M Dorsey
Sleep Disorders Center, Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont 02478, USA
Sleep 26:573-7. 2003..To investigate chemical changes in the brains of healthy adults after sleep deprivation and recovery sleep, using phosphorous magnetic resonance spectroscopy... - Acute cortisol administration triggers craving in individuals with cocaine dependenceIgor Elman
Behavioral Psychopharmacology Research Laboratory, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
Psychopharmacol Bull 37:84-9. 2003..These pilot data suggest that cortisol can induce a state that is associated with drug abuse... - Oral methylphenidate challenge selectively decreases putaminal T2 in healthy subjectsMarisa M Silveri
Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Drug Alcohol Depend 76:173-80. 2004..These data suggest that T2 relaxometry can be used to study the time course of regional cerebral blood volume responses to MPH and perhaps to other stimulant drugs... - Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteersIgor Elman
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
Addict Behav 30:859-64. 2005..These different neuroendocrine response profiles point to important differences between dopaminergic effects of cortisol and cocaine... - Transdermal nicotine alters some of marihuana's effects in male and female volunteersDavid M Penetar
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 79:211-23. 2005..These effects have implications for the safety and efficacy of marihuana smokers who are self-medicating with the nicotine transdermal patch to manage their tobacco dependence... - Cerebellar vermis involvement in cocaine-related behaviorsCarl M Anderson
Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 31:1318-26. 2006.... - Impaired reproduction of three-dimensional objects by cocaine-dependent subjectsIgor Elman
Department of Psychiatry, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
J Neuropsychiatry Clin Neurosci 20:478-84. 2008..g., parietal lobe damage) and their role in the pathophysiology of cocaine dependence... - Long-term neuropsychiatric consequences of "ecstasy" (MDMA): a reviewAlonso G Montoya
Department of Neurology, McLean Hospital, Belmont, MA 02478, USA
Harv Rev Psychiatry 10:212-20. 2002..Additional research is necessary to determine whether the MDMA-induced destruction of serotonergic neurons can have long-term and possibly permanent neuropsychiatric consequences in humans... - Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and lossesJames W Hopper
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
J Psychiatr Res 42:802-7. 2008..Posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. The present study assessed for such dysfunction in both the expectancy and outcome phases of reward processing... - Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agentsIgor Elman
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 31:2091-120. 2006..These effects can further deteriorate eating patterns. Pathophysiological and therapeutic implications of these insights need further validation via prospective clinical trials and neuroimaging studies... - Determination of puerarin in human plasma by high performance liquid chromatographyZhongze Ma
Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
J Chromatogr B Analyt Technol Biomed Life Sci 823:108-14. 2005..The preliminary pharmacokinetic study after oral administration of the Kudzu capsules containing 400mg of puerarin to a healthy volunteer confirmed that the present method was suitable for determining puerarin in human plasma... - Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry studyRonald L Cowan
Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Drug Alcohol Depend 72:225-35. 2003.... - Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophreniaIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 176:369-75. 2004..Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function... - Probing reward function in post-traumatic stress disorder with beautiful facial imagesIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychiatry Res 135:179-83. 2005..There were no significant group differences in the attractiveness ratings. However, PTSD patients expended less effort to extend the viewing time of the beautiful female faces. These findings suggest a reward deficit in PTSD... - Negative cocaine effect expectancies are associated with subjective response to cocaine challenge in recreational cocaine usersLeslie H Lundahl
Department of Psychiatry Psychology, Harvard Medical School McLean Hospital, USA
Addict Behav 32:1262-71. 2007.... - Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependenceKatherine H Karlsgodt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Drug Alcohol Abuse 29:539-51. 2003.... - Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug usersRonald L Cowan
Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University Medical Center, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, USA
Psychiatry Res 155:179-88. 2007..These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results...
Research Grants
- ISOFLAVONE TREATMENT FOR ALCOHOL ABUSEScott E Lukas; Fiscal Year: 2010..5) We have collected preliminary data showing that kudzu increases the rate. ..
- MEDICATION DEVELOPMENT FOR COCAINE ABUSE--CDP CHOLINEScott Lukas; Fiscal Year: 2004....
- ISOFLAVONE TREATMENT FOR ALCOHOL ABUSEScott Lukas; Fiscal Year: 2003..Further, its anti-inebriating effects may make it useful in keeping "slips" from becoming full relapses. ..
- Cannabis Dependence: Imaging and Medication DevelopmentScott Lukas; Fiscal Year: 2005..abstract_text> ..
- PHARMACOLOGICAL AND BEHAVIORAL INDICES OF DRUG ABUSEScott Lukas; Fiscal Year: 2006..abstract_text> ..
- ISOFLAVONE TREATMENT FOR ALCOHOL ABUSEScott Lukas; Fiscal Year: 2007..5) We have collected preliminary data showing that kudzu increases the rate. ..
- Citicoline-Induced Modulation of Cannabis Effects: Imaging & Mechanism of ActionScott E Lukas; Fiscal Year: 2010..Using magnetic resonance brain imaging and EEG techniques, this application will explore the mechanism of action and develop new treatment strategies for marihuana dependence. ..
- PHARMACOLOGICAL AND BEHAVIORAL INDICES OF DRUG ABUSEScott Lukas; Fiscal Year: 2007..bythe time of award PHS 398 (Rev 05/01) Page 3 RCA Substitute Form Page 3 Number pages consecutively at the bottom throughout the application Do not use suffixes such as 3a 3b [] [] ..
- POLYDRUG ABUSE-IMAGING AND BEHAVIORScott Lukas; Fiscal Year: 2006..Results of these studies may also reveal why cue-induced craving has not been a good predictor of relapse as there may be significant cross generalization among the cues that can trigger relapse in successfully treated patients. ..
- Training in Drug Abuse and Brain ImagingScott Lukas; Fiscal Year: 2007....
- POLYDRUG ABUSE--EEG AND BEHAVIORScott Lukas; Fiscal Year: 2000....
- POLYDRUG ABUSE: EEG AND BEHAVIORScott Lukas; Fiscal Year: 1993..Results from the buprenorphine and methadone maintenance experiments will have direct applications in the management and treatment of individuals who are dully dependent on opiates and cocaine...
- POLYDRUG ABUSE: EEG AND BEHAVIORScott Lukas; Fiscal Year: 1991..Results from the drug self-administration and the detoxification experiments will have direct applications in the management and treatment of drug abuse...