Research Topics
| David LudwigSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Weight loss strategies for adolescents: a 14-year-old struggling to lose weightDavid S Ludwig
New Balance Foundation Obesity Prevention Center, Children s Hospital Boston, and Harvard Medical School, Boston, Massachusetts 02115, USA
JAMA 307:498-508. 2012..Ultimately, the obesity epidemic can be attributed to changes in the social environment that hinder healthful lifestyle habits, and prevention will require a comprehensive public health strategy...
Nutrition attitudes and knowledge in medical students after completion of an integrated nutrition curriculum compared to a dedicated nutrition curriculum: a quasi-experimental studyCarolyn O Walsh
Boston Combined Residency Program in Pediatrics, Children s Hospital Boston, Boston, MA 02115, USA
BMC Med Educ 11:58. 2011..The objective of the current study was to assess the effect of the curriculum change on medical student attitudes and knowledge about nutrition...- Training in childhood obesity management in the United States: a survey of pediatric, internal medicine-pediatrics and family medicine residency program directorsMargaret S Wolff
Division of Endocrinology, Children s Hospital Boston, Boston, MA, USA
BMC Med Educ 10:18. 2010..Information about the availability and effectiveness of childhood obesity training during residency is limited... 
Can the food industry play a constructive role in the obesity epidemic?David S Ludwig
Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
JAMA 300:1808-11. 2008- Programming obesity in childhoodDavid S Ludwig
Department of Medicine, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Lancet 364:226-7. 2004 - Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animalsDorota B Pawlak
Department of Medicine, Children s Hospital, Boston, MA, USA
Lancet 364:778-85. 2004..This study examined the independent effects of GI in animals... - The association between pregnancy weight gain and birthweight: a within-family comparisonDavid S Ludwig
Department of Medicine, Children s Hospital, Boston, MA 02115, USA
Lancet 376:984-90. 2010..We aimed to examine the association between maternal weight gain and birthweight using state-based birth registry data that allowed us to compare several pregnancies in the same mother... - Clinical update: the low-glycaemic-index dietDavid S Ludwig
Department of Medicine, Children's Hospital, Boston, MA 02115, USA
Lancet 369:890-2. 2007 
Relationship between funding source and conclusion among nutrition-related scientific articlesLenard I Lesser
Department of Medicine, Children s Hospital, Boston, Massachusetts, United States of America
PLoS Med 4:e5. 2007..The purpose of this study is to characterize financial sponsorship of scientific articles addressing the health effects of three commonly consumed beverages, and to determine how sponsorship affects published conclusions...- Mindfulness in medicineDavid S Ludwig
Department of Medicine, Children's Hospital, Boston, MA 02115, USA
JAMA 300:1350-2. 2008 - Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in miceKelly B Scribner
Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Am J Physiol Endocrinol Metab 295:E1126-31. 2008.... - Acute effects of dietary glycemic index on antioxidant capacity in a nutrient-controlled feeding studyDiego Botero
Department of Medicine, Children s Hospital Boston, Boston, Massachusetts, USA
Obesity (Silver Spring) 17:1664-70. 2009.... - Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrateKelly B Scribner
Children s Hospital Boston, Department of Medicine, 333 Longwood Avenue, Boston, MA 02115, USA
Obesity (Silver Spring) 15:2190-9. 2007..slowly absorbed carbohydrate (SAC), controlled for confounding dietary factors, causes NAFLD in mice with similar body weight. An animal model was chosen because of logistical and ethical challenges to conducting this study in humans... - A reduced-glycemic load diet in the treatment of adolescent obesityCara B Ebbeling
Division of Endocrinology, Department of Medicine, Children's Hospital Boston, MA 02115, USA
Arch Pediatr Adolesc Med 157:773-9. 2003..Large-scale randomized controlled trials are needed to further evaluate the effectiveness of reduced-GL and -glycemic index diets in the treatment of obesity and prevention of type 2 diabetes... - Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot studyCara B Ebbeling
Division of Endocrinology, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA
Pediatrics 117:673-80. 2006..The beneficial effect on body weight of reducing SSB consumption increased with increasing baseline body weight, offering additional support for American Academy of Pediatrics guidelines to limit SSB consumption... - Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight lossMark A Pereira
Department of Medicine, Children's Hospital, Boston, Mass 02115, USA
JAMA 292:2482-90. 2004..Reduction in glycemic load may aid in the prevention or treatment of obesity, cardiovascular disease, and diabetes mellitus... - Compensation for energy intake from fast food among overweight and lean adolescentsCara B Ebbeling
Division of Endocrinology, Department of Medicine, Children's Hospital, Boston, Mass 02115, USA
JAMA 291:2828-33. 2004..Moreover, overweight adolescents were less likely to compensate for the energy in fast food, by adjusting energy intake throughout the day, than their lean counterparts... - Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged womenMatthias B Schulze
Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
JAMA 292:927-34. 2004.... - Screening for type 2 diabetes mellitus in children and adolescents: attitudes, barriers, and practices among pediatric cliniciansErinn T Rhodes
Division of Endocrinology, Children s Hospital Boston, MA 02115, USA
Ambul Pediatr 6:110-4. 2006..The purpose of this study was to describe attitudes, barriers, and practices related to type 2 diabetes screening in children among pediatric clinicians... - The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular diseaseDavid S Ludwig
Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
JAMA 287:2414-23. 2002..The purpose of this review is to examine the physiological effects of the glycemic index and the relevance of these effects in preventing and treating obesity, diabetes, and cardiovascular disease... - Accuracy of administrative coding for type 2 diabetes in children, adolescents, and young adultsErinn T Rhodes
Division of Endocrinology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Diabetes Care 30:141-3. 2007 - Association of consumption of fried food away from home with body mass index and diet quality in older children and adolescentsElsie M Taveras
Department of Ambulatory Care and Prevention, Harvard Medical School, Harvard Pilgrim Health Care, Boston, MA, USA
Pediatrics 116:e518-24. 2005.... - The glycemic index at 20 yDavid S Ludwig
Department of Medicine, Children's Hospital, Boston, MA 02115, USA
Am J Clin Nutr 76:264S-5S. 2002 - Altering portion sizes and eating rate to attenuate gorging during a fast food meal: effects on energy intakeCara B Ebbeling
Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Pediatrics 119:869-75. 2007..Eating large amounts of food at a rapid rate, defined as gorging, may contribute to excess energy intake. We aimed to evaluate whether altering portion sizes and eating rate could decrease energy intake during an extra-large fast food meal... - Pediatric obesity management: variation by specialty and awareness of guidelinesErinn T Rhodes
Division of Endocrinology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Clin Pediatr (Phila) 46:491-504. 2007..Specialty differences in dietary recommendations, referrals, and barriers to treatment were identified. Pediatric overweight management guidelines should consider specialty differences and be accessible to all pediatric care providers... - A physiological basis for disparities in diabetes and heart disease risk among racial and ethnic groupsDavid S Ludwig
Department of Medicine, Children's Hospital, Boston, MA 02115, USA
J Nutr 132:2492-3. 2002 - Effects of an ad libitum low-glycemic load diet on cardiovascular disease risk factors in obese young adultsCara B Ebbeling
Division of Endocrinology, Department of Medicine, Children's Hospital, Boston, MA 02115, USA
Am J Clin Nutr 81:976-82. 2005..CONCLUSION: An ad libitum low-glycemic load diet may be more efficacious than a conventional, energy-restricted, low-fat diet in reducing cardiovascular disease risk... - Effects of a low-glycemic load diet in overweight and obese pregnant women: a pilot randomized controlled trialErinn T Rhodes
Division of Endocrinology, Children s Hospital Boston, Boston, MA, USA
Am J Clin Nutr 92:1306-15. 2010..The optimal diet for pregnancy that is complicated by excessive weight is unknown... - Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA StudyMark A Pereira
Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
JAMA 287:2081-9. 2002..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated... - A paradoxical signal intensity increase in fatty livers using opposed-phase gradient echo imaging with fat-suppression pulsesRobert V Mulkern
Department of Radiology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Pediatr Radiol 38:1099-104. 2008..The result is a paradoxical increase in signal from fatty liver that will depend on both fat content and the relative longitudinal relaxation times of fat methylene protons and water... - Dietary glycemic index and the regulation of body weightDavid S Ludwig
Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
Lipids 38:117-21. 2003.... - Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination SurveySarah D de Ferranti
Department of Cardiology, Children's Hospital, Boston, Mass 02115, USA
Circulation 110:2494-7. 2004..Because childhood MetS likely tracks into adulthood, early identification may help target interventions to improve future cardiovascular health... - Glycemic load comes of ageDavid S Ludwig
Department of Medicine, Children's Hospital, Boston, MA 02115, USA
J Nutr 133:2695-6. 2003 - When children eat what they watch: impact of television viewing on dietary intake in youthJean L Wiecha
Departments of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Arch Pediatr Adolesc Med 160:436-42. 2006.... - Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination SurveysSarah D de Ferranti
Department of Cardiology; Division of Endocrinology, Children's Hospital, Boston, MA 02115, USA
Clin Chem 52:1325-30. 2006..Adolescents with more metabolic abnormalities have higher CRP, which may be an indicator of greater metabolic derangement and future cardiovascular risk... - Best practice guidelines in pediatric/adolescent weight loss surgeryCaroline M Apovian
Department of Medicine, Surgery, and Pediatrics, and Section of Endocrinology, Diabetes and Nutrition, Boston University Medical Center, 88 East Newton Street, Robinson Building, Suite 4400, Boston, MA 02118, USA
Obes Res 13:274-82. 2005..To establish evidence-based guidelines for best practices in pediatric/adolescent weight loss surgery (WLS)... - Effects of a low-glycemic load vs low-fat diet in obese young adults: a randomized trialCara B Ebbeling
Department of Medicine, Children s Hospital Boston, Boston, Mass 02115, USA
JAMA 297:2092-102. 2007..The results of clinical trials involving diet in the treatment of obesity have been inconsistent, possibly due to inherent physiological differences among study participants... - Effect of low-dose insulin treatment on body weight and physical development in children and adolescents at risk for type 1 diabetesErinn T Rhodes
Division of Endocrinology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Diabetes Care 28:1948-53. 2005..53) or BMI (P = 0.95) over 2 years after adjustment for relevant covariates. CONCLUSIONS: Low-dose insulin treatment for 2 years did not affect the weight, BMI, or physical development of nondiabetic children and adolescents... - Childhood obesity: public-health crisis, common sense cureCara B Ebbeling
Division of Endocrinology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Lancet 360:473-82. 2002..In view of its rapid development in genetically stable populations, the childhood obesity epidemic can be primarily attributed to adverse environmental factors for which straightforward, if politically difficult, solutions exist... - Eating disorder pathology among overweight treatment-seeking youth: clinical correlates and cross-sectional risk modelingKamryn T Eddy
Center for Anxiety and Related Disorders, Boston University, 648 Beacon Street, 6th Floor, Boston, MA 02215, USA
Behav Res Ther 45:2360-71. 2007.... - Effects of replacing the habitual consumption of sugar-sweetened beverages with milk in Chilean childrenCecilia Albala
Institute of Nutrition and Food Technology Instituto de Nutrición y Tecnología de Alimentos, INTA, University of Chile, Santiago, Chile
Am J Clin Nutr 88:605-11. 2008..Obesity is now the primary nutritional problem in posttransitional Chile... - Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysisMark A Pereira
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Lancet 365:36-42. 2005..0083). INTERPRETATION: Fast-food consumption has strong positive associations with weight gain and insulin resistance, suggesting that fast food increases the risk of obesity and type 2 diabetes... - Surveillance of insulin resistance in childrenMark A Pereira
Clin Chem 49:540-1. 2003 - A novel interaction between dietary composition and insulin secretion: effects on weight gain in the Quebec Family StudyJean Philippe Chaput
Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Canada
Am J Clin Nutr 87:303-9. 2008..This variation has been attributed to psychological and behavioral factors, although biological differences may also play a role... - Childhood obesity--the shape of things to comeDavid S Ludwig
Optimal Weight for Life Program in the Division of Endocrinology, Children's Hospital Boston, USA
N Engl J Med 357:2325-7. 2007 - Hard facts about soft drinksDavid S Ludwig
Arch Pediatr Adolesc Med 158:290; author reply 290. 2004 - Effects of fast-food consumption on energy intake and diet quality among children in a national household surveyShanthy A Bowman
US Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA
Pediatrics 113:112-8. 2004..CONCLUSION: Consumption of fast food among children in the United States seems to have an adverse effect on dietary quality in ways that plausibly could increase risk for obesity... - Carbohydrates and the postprandial state: have our cake and eat it too?David S Ludwig
Am J Clin Nutr 80:797-8. 2004 - Putting your genes on a diet: the molecular effects of carbohydrateSandra L Salsberg
Am J Clin Nutr 85:1169-70. 2007 - Spirited critique of glycaemic index (GI) and its role in the treatment of obesityDorota B Pawlak
Obes Rev 4:73-4. 2003 - In search of a lifestyle prescription to control body weightMark A Pereira
Am J Clin Nutr 76:1140-1; author reply 1141-2. 2002 - Type 2 diabetes and the vegetarian dietDavid J A Jenkins
Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada
Am J Clin Nutr 78:610S-616S. 2003..It is anticipated that their combined use in vegetarian diets will produce very significant metabolic advantages for the prevention and treatment of diabetes and its complications... - Tracking pediatric obesity: an index of uncertainty?Cara B Ebbeling
JAMA 299:2442-3. 2008 - A potential decline in life expectancy in the United States in the 21st centuryS Jay Olshansky
University of Illinois at Chicago, Chicago 60612, USA
N Engl J Med 352:1138-45. 2005..From our analysis of the effect of obesity on longevity, we conclude that the steady rise in life expectancy during the past two centuries may soon come to an end... - Recommendations for treatment of child and adolescent overweight and obesityBonnie A Spear
Department of Pediatrics, University of Alabama at Birmingham, AL 35233, USA
Pediatrics 120:S254-88. 2007.... - Childhood obesity as a chronic disease: keeping the weight offErinn T Rhodes
JAMA 298:1695-6. 2007 - Misdirection on the road to Shangri-LaS Jay Olshansky
Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60612, USA
Sci Aging Knowledge Environ 2005:pe15. 2005..S. pattern of longevity will follow that of other longer lived nations and on the extrapolation of historical trends in life expectancy into the future... - The insulin-like growth factor axis: a potential link between glycemic index and cancerSudha B Biddinger
Am J Clin Nutr 82:277-8. 2005 - Influence of glycemic index/load on glycemic response, appetite, and food intake in healthy humansDavid S Ludwig
Diabetes Care 29:474; author reply 475-6. 2006 - Overweight children and adolescentsDavid S Ludwig
N Engl J Med 353:1070-1; author reply 1070-1. 2005 - Storm over statins--the controversy surrounding pharmacologic treatment of childrenSarah de Ferranti
Preventive Cardiology Clinic, Children's Hospital Boston, USA
N Engl J Med 359:1309-12. 2008
Research Grants
- Reducing Sugar-Sweetened Beverage Consumption in Overweight AdolescentsDavid Ludwig; Fiscal Year: 2007..These results should have immediate public health application, and aid in the design of future, comprehensive obesity prevention interventions. ..
- Popular Diets, Metabolism, and CVD RiskDavid Ludwig; Fiscal Year: 2007..This study should have major public health implications to the millions of Americans currently following diets to decrease body weight and risk for CVD. ..
- Glycemic Load and infant birth weight in pregnant/glucose intolerant womenDavid Ludwig; Fiscal Year: 2007..A successful outcome of this study will provide preliminary data upon which to design a multi- centered clinical trial. ..
- Reducing Sugar-Sweetened Beverage Consumption in Overweight AdolescentsDavid S Ludwig; Fiscal Year: 2010..These results should have immediat public health application, and aid in the design of future, comprehensive obesity prevention interventions. ..
- Reducing Sugar-Sweetened Beverage Consumption in Overweight AdolescentsDavid Ludwig; Fiscal Year: 2009..These results should have immediate public health application, and aid in the design of future, comprehensive obesity prevention interventions. ..
- Sugar-sweetened beverages and cardiovascular disease risk: an RCTDavid S Ludwig; Fiscal Year: 2010..The present study aims to fill this critical knowledge gap, by comparing the effects of ASB, not just to sugar-sweetened beverages, but also to unsweetened beverages in a large- scale randomized controlled trial. ..
- Glycemic Index, Obesity, Insulin Resistance and CVD RiskDavid Ludwig; Fiscal Year: 2005..The project's key personnel and consultants include individuals with a diversity of expertise and perspective, ensuring a rigorous and impartial evaluation of study hypotheses. ..
- Sugar-sweetened Beverages and Weight Gain in ChildrenDavid Ludwig; Fiscal Year: 2003..abstract_text> ..
- A Novel Diet-Phenotype Interaction Affecting Body WeightDavid S Ludwig; Fiscal Year: 2010....