D S Ludwig

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The glycemic index at 20 y
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 76:264S-5S. 2002
  2. ncbi request reprint A physiological basis for disparities in diabetes and heart disease risk among racial and ethnic groups
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    J Nutr 132:2492-3. 2002
  3. ncbi request reprint The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease
    David S Ludwig
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2414-23. 2002
  4. ncbi request reprint Glycemic load comes of age
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    J Nutr 133:2695-6. 2003
  5. ncbi request reprint Dietary glycemic index and the regulation of body weight
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Lipids 38:117-21. 2003
  6. ncbi request reprint Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis
    D S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Lancet 357:505-8. 2001
  7. pmc Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice
    Kelly B Scribner
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 295:E1126-31. 2008
  8. pmc Acute effects of dietary glycemic index on antioxidant capacity in a nutrient-controlled feeding study
    Diego Botero
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1664-70. 2009
  9. ncbi request reprint Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrate
    Kelly B Scribner
    Children s Hospital Boston, Department of Medicine, 333 Longwood Avenue, Boston, MA 02115, USA
    Obesity (Silver Spring) 15:2190-9. 2007
  10. ncbi request reprint Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatrics 117:673-80. 2006

Detail Information

Publications67

  1. ncbi request reprint The glycemic index at 20 y
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 76:264S-5S. 2002
  2. ncbi request reprint A physiological basis for disparities in diabetes and heart disease risk among racial and ethnic groups
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    J Nutr 132:2492-3. 2002
  3. ncbi request reprint The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease
    David S Ludwig
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2414-23. 2002
    ..The purpose of this review is to examine the physiological effects of the glycemic index and the relevance of these effects in preventing and treating obesity, diabetes, and cardiovascular disease...
  4. ncbi request reprint Glycemic load comes of age
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    J Nutr 133:2695-6. 2003
  5. ncbi request reprint Dietary glycemic index and the regulation of body weight
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Lipids 38:117-21. 2003
    ....
  6. ncbi request reprint Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis
    D S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Lancet 357:505-8. 2001
    ..The rising prevalence of obesity in children has been linked in part to the consumption of sugar-sweetened drinks. Our aim was to examine this relation...
  7. pmc Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice
    Kelly B Scribner
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 295:E1126-31. 2008
    ....
  8. pmc Acute effects of dietary glycemic index on antioxidant capacity in a nutrient-controlled feeding study
    Diego Botero
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1664-70. 2009
    ....
  9. ncbi request reprint Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrate
    Kelly B Scribner
    Children s Hospital Boston, Department of Medicine, 333 Longwood Avenue, Boston, MA 02115, USA
    Obesity (Silver Spring) 15:2190-9. 2007
    ..slowly absorbed carbohydrate (SAC), controlled for confounding dietary factors, causes NAFLD in mice with similar body weight. An animal model was chosen because of logistical and ethical challenges to conducting this study in humans...
  10. ncbi request reprint Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatrics 117:673-80. 2006
    ..We conducted a pilot study to examine the effect of decreasing SSB consumption on body weight...
  11. ncbi request reprint A reduced-glycemic load diet in the treatment of adolescent obesity
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 157:773-9. 2003
    ..The incidence of type 2 diabetes increases markedly for obese children after puberty. However, the effect of dietary composition on body weight and diabetes risk factors has not been studied in adolescents...
  12. ncbi request reprint Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss
    Mark A Pereira
    Department of Medicine, Children s Hospital, Boston, Mass 02115, USA
    JAMA 292:2482-90. 2004
    ..Weight loss elicits physiological adaptations relating to energy intake and expenditure that antagonize ongoing weight loss...
  13. ncbi request reprint Compensation for energy intake from fast food among overweight and lean adolescents
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital, Boston, Mass 02115, USA
    JAMA 291:2828-33. 2004
    ..However, if fast food and obesity are causally related, the question arises of why some children who frequently eat fast food do not become overweight...
  14. ncbi request reprint Treating obesity in youth: should dietary glycemic load be a consideration?
    C B Ebbeling
    Harvard Medical School, and Children s Hospital, Boston, Mass, USA
    Adv Pediatr 48:179-212. 2001
    ..This chapter provides an overview of the available evidence suggesting that dietary glycemic load, and its related factor, the glycemic index, should be taken into consideration in the design of weight loss interventions...
  15. ncbi request reprint Dietary fiber and body-weight regulation. Observations and mechanisms
    M A Pereira
    Division of Endocrinology, Departments of Pediatrics and Medicine, Harvard Medical School and Children s Hospital, Boston, Massachusetts, USA
    Pediatr Clin North Am 48:969-80. 2001
    ..Such diets may have additional benefits, independent of changes in adiposity, in the prevention of cardiovascular disease and type 2 diabetes...
  16. ncbi request reprint Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study
    Mark A Pereira
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2081-9. 2002
    ..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated...
  17. ncbi request reprint Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey
    Sarah D de Ferranti
    Department of Cardiology, Children s Hospital, Boston, Mass 02115, USA
    Circulation 110:2494-7. 2004
    ..Metabolic syndrome (MetS) is defined by the Third Report of the Adult Treatment Panel (ATP III) using criteria easily applied by clinicians and researchers. There is no standard pediatric definition...
  18. ncbi request reprint Altering portion sizes and eating rate to attenuate gorging during a fast food meal: effects on energy intake
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatrics 119:869-75. 2007
    ..Eating large amounts of food at a rapid rate, defined as gorging, may contribute to excess energy intake. We aimed to evaluate whether altering portion sizes and eating rate could decrease energy intake during an extra-large fast food meal...
  19. ncbi request reprint Effects of an ad libitum low-glycemic load diet on cardiovascular disease risk factors in obese young adults
    Cara B Ebbeling
    Division of Endocrinology, Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 81:976-82. 2005
    ..The optimal nutritional approach for the prevention of cardiovascular disease among obese persons remains a topic of intense controversy. Available approaches range from conventional low-fat to very-low-carbohydrate diets...
  20. ncbi request reprint Screening for type 2 diabetes mellitus in children and adolescents: attitudes, barriers, and practices among pediatric clinicians
    Erinn T Rhodes
    Division of Endocrinology, Children s Hospital Boston, MA 02115, USA
    Ambul Pediatr 6:110-4. 2006
    ..The purpose of this study was to describe attitudes, barriers, and practices related to type 2 diabetes screening in children among pediatric clinicians...
  21. ncbi request reprint Clinical update: the low-glycaemic-index diet
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Lancet 369:890-2. 2007
  22. pmc Relationship between funding source and conclusion among nutrition-related scientific articles
    Lenard I Lesser
    Department of Medicine, Children s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 4:e5. 2007
    ..The purpose of this study is to characterize financial sponsorship of scientific articles addressing the health effects of three commonly consumed beverages, and to determine how sponsorship affects published conclusions...
  23. ncbi request reprint Association of consumption of fried food away from home with body mass index and diet quality in older children and adolescents
    Elsie M Taveras
    Department of Ambulatory Care and Prevention, Harvard Medical School, Harvard Pilgrim Health Care, Boston, MA, USA
    Pediatrics 116:e518-24. 2005
    ....
  24. ncbi request reprint Accuracy of administrative coding for type 2 diabetes in children, adolescents, and young adults
    Erinn T Rhodes
    Division of Endocrinology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Diabetes Care 30:141-3. 2007
  25. ncbi request reprint Pediatric obesity management: variation by specialty and awareness of guidelines
    Erinn T Rhodes
    Division of Endocrinology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Clin Pediatr (Phila) 46:491-504. 2007
    ..Specialty differences in dietary recommendations, referrals, and barriers to treatment were identified. Pediatric overweight management guidelines should consider specialty differences and be accessible to all pediatric care providers...
  26. ncbi request reprint Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals
    Dorota B Pawlak
    Department of Medicine, Children s Hospital, Boston, MA, USA
    Lancet 364:778-85. 2004
    ..This study examined the independent effects of GI in animals...
  27. pmc Effects of a low-glycemic load diet in overweight and obese pregnant women: a pilot randomized controlled trial
    Erinn T Rhodes
    Division of Endocrinology, Children s Hospital Boston, Boston, MA, USA
    Am J Clin Nutr 92:1306-15. 2010
    ..The optimal diet for pregnancy that is complicated by excessive weight is unknown...
  28. pmc The association between pregnancy weight gain and birthweight: a within-family comparison
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Lancet 376:984-90. 2010
    ..We aimed to examine the association between maternal weight gain and birthweight using state-based birth registry data that allowed us to compare several pregnancies in the same mother...
  29. ncbi request reprint Can the food industry play a constructive role in the obesity epidemic?
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    JAMA 300:1808-11. 2008
  30. doi request reprint A paradoxical signal intensity increase in fatty livers using opposed-phase gradient echo imaging with fat-suppression pulses
    Robert V Mulkern
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatr Radiol 38:1099-104. 2008
    ..The result is a paradoxical increase in signal from fatty liver that will depend on both fat content and the relative longitudinal relaxation times of fat methylene protons and water...
  31. ncbi request reprint When children eat what they watch: impact of television viewing on dietary intake in youth
    Jean L Wiecha
    Departments of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 160:436-42. 2006
    ....
  32. doi request reprint Mindfulness in medicine
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    JAMA 300:1350-2. 2008
  33. ncbi request reprint Programming obesity in childhood
    David S Ludwig
    Department of Medicine, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:226-7. 2004
  34. ncbi request reprint Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    JAMA 292:927-34. 2004
    ....
  35. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
    ..Heterozygote C57BL/6J mice expressing the transgene showed increased body weight on a standard diet, confirming that MCH overexpression can lead to obesity...
  36. ncbi request reprint Should obese patients be counselled to follow a low-glycaemic index diet? Yes
    D B Pawlak
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Obes Rev 3:235-43. 2002
    ..This review examines the mechanisms underlying the potential benefits of a low GI diet, and whether such diets should be recommended in the clinical setting...
  37. ncbi request reprint Best practice guidelines in pediatric/adolescent weight loss surgery
    Caroline M Apovian
    Department of Medicine, Surgery, and Pediatrics, and Section of Endocrinology, Diabetes and Nutrition, Boston University Medical Center, 88 East Newton Street, Robinson Building, Suite 4400, Boston, MA 02118, USA
    Obes Res 13:274-82. 2005
    ..To establish evidence-based guidelines for best practices in pediatric/adolescent weight loss surgery (WLS)...
  38. ncbi request reprint Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys
    Sarah D de Ferranti
    Department of Cardiology Division of Endocrinology, Children s Hospital, Boston, MA 02115, USA
    Clin Chem 52:1325-30. 2006
    ..Understanding of C-reactive protein (CRP) in adult metabolic syndrome is increasing; however, this relationship in children is less clear...
  39. ncbi request reprint Adolescent obesity, a need for greater awareness and improved treatment
    M E Trent
    Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 11:297-302. 1999
    ..This review summarizes the epidemiology, evaluation, and management of adolescent obesity, focusing on promising treatment strategies for the future...
  40. ncbi request reprint Effects of a low-glycemic load vs low-fat diet in obese young adults: a randomized trial
    Cara B Ebbeling
    Department of Medicine, Children s Hospital Boston, Boston, Mass 02115, USA
    JAMA 297:2092-102. 2007
    ..The results of clinical trials involving diet in the treatment of obesity have been inconsistent, possibly due to inherent physiological differences among study participants...
  41. doi request reprint Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus
    E T Rhodes
    Division of Endocrinology, Children s Hospital Boston, Boston, MA 02115, USA
    Diabet Med 29:453-63. 2012
    ..To estimate remaining life expectancy (RLE), quality-adjusted life expectancy (QALE), causes of death and lifetime cumulative incidence of microvascular/macrovascular complications of diabetes for youths diagnosed with Type 2 diabetes...
  42. pmc Training in childhood obesity management in the United States: a survey of pediatric, internal medicine-pediatrics and family medicine residency program directors
    Margaret S Wolff
    Division of Endocrinology, Children s Hospital Boston, Boston, MA, USA
    BMC Med Educ 10:18. 2010
    ..Information about the availability and effectiveness of childhood obesity training during residency is limited...
  43. ncbi request reprint Effect of low-dose insulin treatment on body weight and physical development in children and adolescents at risk for type 1 diabetes
    Erinn T Rhodes
    Division of Endocrinology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Diabetes Care 28:1948-53. 2005
    ..Insulin's role in body weight regulation is controversial. We evaluated the effect of parenteral insulin on body weight and physical development in children and adolescents at risk for type 1 diabetes...
  44. ncbi request reprint A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
    ..These findings suggest that MCH participates in the hypothalamic regulation of body weight...
  45. ncbi request reprint Childhood obesity: public-health crisis, common sense cure
    Cara B Ebbeling
    Division of Endocrinology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Lancet 360:473-82. 2002
    ..In view of its rapid development in genetically stable populations, the childhood obesity epidemic can be primarily attributed to adverse environmental factors for which straightforward, if politically difficult, solutions exist...
  46. ncbi request reprint Eating disorder pathology among overweight treatment-seeking youth: clinical correlates and cross-sectional risk modeling
    Kamryn T Eddy
    Center for Anxiety and Related Disorders, Boston University, 648 Beacon Street, 6th Floor, Boston, MA 02215, USA
    Behav Res Ther 45:2360-71. 2007
    ....
  47. ncbi request reprint A novel interaction between dietary composition and insulin secretion: effects on weight gain in the Quebec Family Study
    Jean Philippe Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Canada
    Am J Clin Nutr 87:303-9. 2008
    ..This variation has been attributed to psychological and behavioral factors, although biological differences may also play a role...
  48. pmc Effects of replacing the habitual consumption of sugar-sweetened beverages with milk in Chilean children
    Cecilia Albala
    Institute of Nutrition and Food Technology Instituto de Nutrición y Tecnología de Alimentos, INTA, University of Chile, Santiago, Chile
    Am J Clin Nutr 88:605-11. 2008
    ..Obesity is now the primary nutritional problem in posttransitional Chile...
  49. ncbi request reprint Putting your genes on a diet: the molecular effects of carbohydrate
    Sandra L Salsberg
    Am J Clin Nutr 85:1169-70. 2007
  50. ncbi request reprint Surveillance of insulin resistance in children
    Mark A Pereira
    Clin Chem 49:540-1. 2003
  51. ncbi request reprint Spirited critique of glycaemic index (GI) and its role in the treatment of obesity
    Dorota B Pawlak
    Obes Rev 4:73-4. 2003
  52. ncbi request reprint Childhood obesity--the shape of things to come
    David S Ludwig
    Optimal Weight for Life Program in the Division of Endocrinology, Children s Hospital Boston, USA
    N Engl J Med 357:2325-7. 2007
  53. ncbi request reprint Effects of fast-food consumption on energy intake and diet quality among children in a national household survey
    Shanthy A Bowman
    US Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA
    Pediatrics 113:112-8. 2004
    ..The aim of this study was to test the hypothesis that fast-food consumption adversely affects dietary factors linked to obesity risk...
  54. ncbi request reprint Hard facts about soft drinks
    David S Ludwig
    Arch Pediatr Adolesc Med 158:290; author reply 290. 2004
  55. ncbi request reprint Carbohydrates and the postprandial state: have our cake and eat it too?
    David S Ludwig
    Am J Clin Nutr 80:797-8. 2004
  56. ncbi request reprint Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis
    Mark A Pereira
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Lancet 365:36-42. 2005
    ..We aimed to investigate the association between reported fast-food habits and changes in bodyweight and insulin resistance over a 15-year period in the USA...
  57. ncbi request reprint Childhood obesity as a chronic disease: keeping the weight off
    Erinn T Rhodes
    JAMA 298:1695-6. 2007
  58. ncbi request reprint Influence of glycemic index/load on glycemic response, appetite, and food intake in healthy humans
    David S Ludwig
    Diabetes Care 29:474; author reply 475-6. 2006
  59. ncbi request reprint Overweight children and adolescents
    David S Ludwig
    N Engl J Med 353:1070-1; author reply 1070-1. 2005
  60. ncbi request reprint The insulin-like growth factor axis: a potential link between glycemic index and cancer
    Sudha B Biddinger
    Am J Clin Nutr 82:277-8. 2005
  61. ncbi request reprint A potential decline in life expectancy in the United States in the 21st century
    S Jay Olshansky
    University of Illinois at Chicago, Chicago 60612, USA
    N Engl J Med 352:1138-45. 2005
    ..From our analysis of the effect of obesity on longevity, we conclude that the steady rise in life expectancy during the past two centuries may soon come to an end...
  62. doi request reprint Storm over statins--the controversy surrounding pharmacologic treatment of children
    Sarah de Ferranti
    Preventive Cardiology Clinic, Children s Hospital Boston, USA
    N Engl J Med 359:1309-12. 2008
  63. ncbi request reprint Misdirection on the road to Shangri-La
    S Jay Olshansky
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60612, USA
    Sci Aging Knowledge Environ 2005:pe15. 2005
    ..S. pattern of longevity will follow that of other longer lived nations and on the extrapolation of historical trends in life expectancy into the future...
  64. ncbi request reprint In search of a lifestyle prescription to control body weight
    Mark A Pereira
    Am J Clin Nutr 76:1140-1; author reply 1141-2. 2002
  65. ncbi request reprint Type 2 diabetes and the vegetarian diet
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 78:610S-616S. 2003
    ..It is anticipated that their combined use in vegetarian diets will produce very significant metabolic advantages for the prevention and treatment of diabetes and its complications...
  66. ncbi request reprint Tracking pediatric obesity: an index of uncertainty?
    Cara B Ebbeling
    JAMA 299:2442-3. 2008
  67. ncbi request reprint Recommendations for treatment of child and adolescent overweight and obesity
    Bonnie A Spear
    Department of Pediatrics, University of Alabama at Birmingham, AL 35233, USA
    Pediatrics 120:S254-88. 2007
    ....