Yan Lu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Lipid mediator informatics and proteomics in inflammation resolution
    Yan Lu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    ScientificWorldJournal 6:589-614. 2006
  2. ncbi request reprint Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms
    Yan Lu
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, and Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Rapid Commun Mass Spectrom 21:7-22. 2007
  3. pmc Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids
    Shuhua Xia
    Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:12499-504. 2006
  4. ncbi request reprint Resolvin E1 metabolome in local inactivation during inflammation-resolution
    Song Hong
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:3512-9. 2008
  5. ncbi request reprint Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 432:275-317. 2007
  6. pmc Lipid mediator informatics-lipidomics: novel pathways in mapping resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Thorn Building for Medical Research, 7th Floor, Brigham and Women s Hospital, Boston, MA 02115, USA
    AAPS J 8:E284-97. 2006
  7. ncbi request reprint Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:1848-59. 2006
  8. pmc Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms
    Song Hong
    Analytical Core, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Mass Spectrom 18:128-44. 2007
  9. ncbi request reprint Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis
    Song Hong
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 78:107-16. 2005
  10. ncbi request reprint Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators
    Yan Lu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Lipid Res 46:790-802. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Lipid mediator informatics and proteomics in inflammation resolution
    Yan Lu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    ScientificWorldJournal 6:589-614. 2006
    ....
  2. ncbi request reprint Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms
    Yan Lu
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, and Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Rapid Commun Mass Spectrom 21:7-22. 2007
    ..Negative ion electrospray low-collision-energy MS/MS spectra provide adequate data to elucidate and identify the structures of RvE1 and other EPA-derived lipid mediators at levels below a few picomoles in trout samples...
  3. pmc Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids
    Shuhua Xia
    Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:12499-504. 2006
    ..These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3)...
  4. ncbi request reprint Resolvin E1 metabolome in local inactivation during inflammation-resolution
    Song Hong
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:3512-9. 2008
    ..e., RvE1, to permit the coordinated return to homeostasis. Moreover, the RvE1 metabolome may serve as a biomarker of these processes...
  5. ncbi request reprint Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 432:275-317. 2007
    ....
  6. pmc Lipid mediator informatics-lipidomics: novel pathways in mapping resolution
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Thorn Building for Medical Research, 7th Floor, Brigham and Women s Hospital, Boston, MA 02115, USA
    AAPS J 8:E284-97. 2006
    ..Here, we review liquid chromatography tandem mass spectrometry-based lipidomic analyses to address bioactive lipid mediators in signaling pathways and the roles of lipid-derived mediators in resolution of inflammation...
  7. ncbi request reprint Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:1848-59. 2006
    ..PD1 also reduced PMN infiltration after initiation (2 h) of inflammation and was additive with resolvin E1. These results indicate that PD1 is a potent stereoselective anti-inflammatory molecule...
  8. pmc Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms
    Song Hong
    Analytical Core, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Mass Spectrom 18:128-44. 2007
    ..Based on the MS/MS spectra and fragmentation mechanisms, we identified RvD1, PD1, and mono-hydroxy-DHA products in human neutrophils and blood, trout head-kidney, and stroke-injury murine brain-tissue...
  9. ncbi request reprint Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis
    Song Hong
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 78:107-16. 2005
    ....
  10. ncbi request reprint Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators
    Yan Lu
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Lipid Res 46:790-802. 2005
    ..These results indicate that COCAD has many advantages for profiling and identification of LMs compared with the conventional dot-product algorithm...
  11. pmc Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
    Christian A Hudert
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11276-81. 2006
    ..They add insight into the molecular mechanisms of inflammation protection afforded by n-3 PUFA through formation of resolvins and protectins other than inhibition of n-6 PUFA-derived eicosanoid formation...
  12. ncbi request reprint Resolvin D series and protectin D1 mitigate acute kidney injury
    Jeremy S Duffield
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:5902-11. 2006
    ..These data may also have therapeutic implications for potentiation of recovery from acute kidney injury...
  13. pmc Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1
    Michael Costigan
    F M Kirby Neurobiology Centre, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Brain 133:2519-27. 2010
    ..Screening for this allele could help define those individuals prone to a transition to persistent pain, and thus requiring therapeutic strategies or lifestyle changes that minimize nerve injury...
  14. pmc In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response
    Zhigang Fan
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:718-22. 2010
    ..These results establish real-time cell tracking as a powerful means to probe the dynamic cellular interplay mediating immunologic rejection or transplant tolerance...
  15. ncbi request reprint Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis
    William Kim
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th St, P and S 17 501, New York, New York 10032, USA
    Ann N Y Acad Sci 1043:553-61. 2005
    ..Studies are in progress to test the premise that antagonism of this interaction is a logical strategy for the prevention and treatment of diabetes...
  16. ncbi request reprint Binding of human serum albumin to N-(p-ethoxy-phenyl)-N'-(1-naphthyl)thiourea and synchronous fluorescence determination of human serum albumin
    Fengling Cui
    School of Chemistry and Environmental Science, Key Laboratory for Environmental Pollution Control Technology of Henan Province, Henan Normal University, People s Repblic of China
    Anal Sci 23:719-25. 2007
    ..The effects of energy transfer and other ions on the binding constant were considered. In addition, synchronous fluorescence technology was successfully applied to the determination of HSA added into the EPNT solution...
  17. ncbi request reprint Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury
    Zhongmin Zhou
    Experimental Interventional Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:2238-43. 2003
    ..However, the role of RAGE/ligand interaction in neointimal hyperplasia after vascular injury remains unclear...
  18. ncbi request reprint Investigation of interaction between human serum albumin and N6-(2-hydroxyethyl)-adenosine by fluorescence spectroscopy and molecular modelling
    Fengling Cui
    School of Chemistry and Environmental Science, Key Laboratory for Environmental Pollution Control Technology of Henan Province, Henan Normal University, Xinxiang 453007, People s Republic of China
    Luminescence 22:546-53. 2007
    ..05 kJ/mol and 30.23 J/mol/K, respectively. The effects of common ions on the binding constant of the HEA-HSA complex at room temperature were also investigated...
  19. pmc Increased lymphangiogenesis in joints of mice with inflammatory arthritis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 9:R118. 2007
    ..The lymphatic system may play an important role in the pathogenesis of inflammatory arthritis...
  20. pmc Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice
    Evis Harja
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:183-94. 2008
    ..These data highlight unifying mechanisms whereby endothelial RAGE and its ligands mediate vascular and inflammatory stresses that culminate in atherosclerosis in the vulnerable vessel wall...
  21. ncbi request reprint Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection
    Xiaolei Xie
    The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, PR China
    Biochim Biophys Acta 1784:276-84. 2008
    ..Our study also provides novel insight into the mechanism of type 1 diabetes mellitus...
  22. pmc Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1
    Eric J Haas-Stapleton
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1316. 2007
    ..These results reveal an inter-species chemical signaling system that modulates host immune functions and may play a role in balancing host carriage of commensal and pathogenic C. albicans...
  23. ncbi request reprint Melanocytes are potential immunocompetent cells: evidence from recognition of immunological characteristics of cultured human melanocytes
    Yan Lu
    Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Pigment Cell Res 15:454-60. 2002
    ..As a result of CD 40 expression on the cell surface, melanocytes might contact and subsequently stimulate CD8+ cytotoxic T lymphocytes directly via CD 40-CD 40 L interaction in some cases...
  24. ncbi request reprint Molecular recognition through the exact placement of functional groups on non-covalent molecularly imprinted polymers
    Yan Lu
    State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, PR China
    J Chromatogr A 950:89-97. 2002
    ..The implication of these findings with respect of the mechanism of recognition was discussed...
  25. pmc A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
    Yan Lu
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Med 3:e467. 2006
    ..As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence...
  26. ncbi request reprint Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders
    Barry I Hudson
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Biochem Biophys 419:80-8. 2003
    ..Here, we will summarize the known consequences of RAGE activation in the tissues and highlight novel areas for therapeutic intervention in these disease states...
  27. ncbi request reprint A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:1956-63. 2006
    ..These experiments identified patterns of gene expressions that both offer clues for green tea's potential mechanisms of action and provide a molecular signature specific for green tea exposure...
  28. ncbi request reprint A critical role for enhanced TGF-alpha and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease
    Mario Cozzolino
    Renal Division, Dept of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Renal Physiol 289:F1096-102. 2005
    ....
  29. pmc Accurate haplotype inference for multiple linked single-nucleotide polymorphisms using sibship data
    Peng Yuan Liu
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Genetics 174:499-509. 2006
    ..The utility of our method was illustrated with an application to the analyses of haplotypes of three candidate genes for osteoporosis...
  30. ncbi request reprint Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis
    Wei Ji
    Rheumatism Immunity Department of The First Hospital Affiliated to Nanjing University of Traditional Chinese Medicine
    Chin J Integr Med 11:15-21. 2005
    ..To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therapeutic mechanism...
  31. ncbi request reprint A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes
    Yao Zhong Liu
    Osteoporosis Research Center, Creighton University Medical Center, Creighton University, Omaha, NE 68131, USA
    J Biol Chem 280:29011-6. 2005
    ..The results may contribute to identification of new genes and their functions for osteoporosis and suggest genetic markers to discern individuals at higher risk to osteoporosis with an aim for preventive intervention and treatment...
  32. ncbi request reprint Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
    ..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...
  33. ncbi request reprint Hotelling's T2 multivariate profiling for detecting differential expression in microarrays
    Yan Lu
    Osteoporosis Research Center, Creighton University 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    Bioinformatics 21:3105-13. 2005
    ..Extensive bioinformatics analyses and cross-validation of DEGs identified in the application datasets showed the significant advantages of our new algorithm...
  34. pmc Expression analysis of secreted and cell surface genes of five transformed human cell lines and derivative xenograft tumors
    Robert A Stull
    PPD Discovery, 1505 O Brien Street, Menlo Park, California 94025, USA
    BMC Genomics 6:55. 2005
    ..The origins of these human cell lines were lung (A549), breast (MDA MB-231), colon (HCT-116), ovarian (SK-OV-3) and prostate (PC3) carcinomas...
  35. ncbi request reprint Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice
    Shan Zeng
    Division of Liver Diseases and Transplantation, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Hepatology 39:422-32. 2004
    ..We propose that blockade of this pathway may represent a novel strategy to attenuate injury in hepatic I/R and to facilitate regeneration...
  36. ncbi request reprint Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: insights into the pathogenesis of macrovascular complications in diabetes
    Thoralf Wendt
    Division of Surgical Science, Department of Surgery, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P and S 17 401, New York, NY 10032, USA
    Curr Atheroscler Rep 4:228-37. 2002
    ..Insights into therapeutic strategies to prevent or interrupt these processes are presented...