Xin Lu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi Cell fusion hypothesis of the cancer stem cell
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
    Adv Exp Med Biol 714:129-40. 2011
  2. pmc VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
    Xin Lu
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cancer Cell 20:701-14. 2011
  3. pmc In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cancer Res 70:3905-14. 2010
  4. pmc Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 106:9385-90. 2009
  5. pmc Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:29087-96. 2009
  6. pmc Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, Washington Road, LTL 255, NJ 08544, USA
    Cell Res 20:1012-22. 2010
  7. pmc Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 285:9317-21. 2010
  8. pmc Hypoxia and hypoxia-inducible factors: master regulators of metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Clin Cancer Res 16:5928-35. 2010
  9. pmc Cell fusion as a hidden force in tumor progression
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cancer Res 69:8536-9. 2009
  10. doi Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Med 15:960-6. 2009

Detail Information

Publications13

  1. doi Cell fusion hypothesis of the cancer stem cell
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
    Adv Exp Med Biol 714:129-40. 2011
    ..The cell fusion hypothesis of CSCs adds an important functional underpinning to the potential multifaceted roles of cell fusion in the initiation and progression of cancer...
  2. pmc VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
    Xin Lu
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cancer Cell 20:701-14. 2011
    ..These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone...
  3. pmc In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cancer Res 70:3905-14. 2010
    ..Our study shows distinct functions of hypoxia in regulating angiogenesis and metastasis in different organ microenvironments and establishes HIF-1alpha as a promising target for controlling organotropic metastasis of breast cancer...
  4. pmc Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 106:9385-90. 2009
    ..Our study suggests cell fusion as an efficient means of phenotypic evolution during tumor progression and additionally demonstrates the compatibility of different metastasis organotropisms...
  5. pmc Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:29087-96. 2009
    ..Therefore, CCL2 and CCR2 are promising therapeutic targets for simultaneously inhibiting lung and bone metastasis of breast cancer...
  6. pmc Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, Washington Road, LTL 255, NJ 08544, USA
    Cell Res 20:1012-22. 2010
    ..Our results suggest a potential mechanistic link between ploidy duplication and enhancement of metastatic potentials, as was observed in previous clinical studies of breast cancer...
  7. pmc Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 285:9317-21. 2010
    ..These results suggest possible biomarkers of breast cancer progression as well as opportunities of interrupting tumor progression through the targeting of metabolic pathways...
  8. pmc Hypoxia and hypoxia-inducible factors: master regulators of metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Clin Cancer Res 16:5928-35. 2010
    ..Multiple approaches to targeting hypoxia and HIFs, including HIF inhibitors, hypoxia-activated bioreductive prodrugs, and gene therapies may become effective treatments to prevent or reduce metastasis...
  9. pmc Cell fusion as a hidden force in tumor progression
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cancer Res 69:8536-9. 2009
    ....
  10. doi Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    Nat Med 15:960-6. 2009
    ....
  11. ncbi Automated scoring of multiprobe FISH in human spermatozoa
    Melissa J Perry
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cytometry A 71:968-72. 2007
    ....
  12. pmc ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 23:1882-94. 2009
    ..This study established MMP1 and ADAMTS1 in tumor cells, as well as EGFR signaling in osteoblasts, as promising therapeutic targets for inhibiting bone metastasis of breast cancer...
  13. ncbi Organotropism of breast cancer metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    J Mammary Gland Biol Neoplasia 12:153-62. 2007
    ..A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field...