M L Lu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    M L Lu
    Division of Urologic Surgery, Department of Surgery, Renal Division, Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13442-51. 2001
  2. ncbi SRY interacts with and negatively regulates androgen receptor transcriptional activity
    X Yuan
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:46647-54. 2001
  3. ncbi SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells
    Hongyun Wang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Urology Research Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 67:528-36. 2007
  4. pmc Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells
    Xin Yuan
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Pathol 169:682-96. 2006
  5. ncbi Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    Michael R Freeman
    The Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, USA
    Trends Endocrinol Metab 16:273-9. 2005
  6. ncbi Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, MD 21201, USA
    Oncogene 21:5609-18. 2002
  7. ncbi Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
    David Masiello
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:26321-6. 2002
  8. ncbi Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells
    Liyan Zhuang
    The Urologic Laboratory, Department of Urology, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 62:2227-31. 2002
  9. ncbi AR and ER interaction with a p21-activated kinase (PAK6)
    Suzanne R Lee
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 16:85-99. 2002
  10. doi Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins
    Ramneet Kaur
    Department of Medicine, Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Prostate 68:1510-6. 2008

Collaborators

  • Keith R Solomon
  • X Yuan
  • X Zhang
  • Steven P Balk
  • M R Freeman
  • Hongyun Wang
  • David Masiello
  • Ramneet Kaur
  • Zongjian Jia
  • Yuexing Zhang
  • Liyan Zhuang
  • Suzanne R Lee
  • Soichiro Ibaragi
  • Irwin Leav
  • Michael Wegner
  • Guo fu Hu
  • Tao Zhang
  • Nicole C McKnight
  • Josette Noël
  • Ivan R Nabi
  • Julie Vadnais
  • Shinta Cheng
  • Andrew Ko
  • Anne W Hamburger
  • Joseph D Fondell
  • Kenneth D Swanson
  • Glenn J Bubley
  • Jianqing Lin
  • Qianben Wang
  • Sharon M Ramos
  • Aiwu Cheng
  • Xianmin Xia

Detail Information

Publications12

  1. ncbi Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    M L Lu
    Division of Urologic Surgery, Department of Surgery, Renal Division, Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13442-51. 2001
    ..Using a mammalian two-hybrid assay system, we determine that the NH(2) terminus region of caveolin-1 is responsible for the interaction with both the NH(2)-terminal domain and the ligand-binding domain of AR...
  2. ncbi SRY interacts with and negatively regulates androgen receptor transcriptional activity
    X Yuan
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:46647-54. 2001
    ....
  3. ncbi SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells
    Hongyun Wang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Urology Research Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 67:528-36. 2007
    ..These results indicate that SOX9 in prostate basal cells supports the development and maintenance of the luminal epithelium and that a subset of prostate cancer cells may escape basal cell requirements through SOX9 expression...
  4. pmc Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells
    Xin Yuan
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Pathol 169:682-96. 2006
    ..These results reveal a potentially critical function of AR in androgen-independent PCa that is distinct from its previously described transcriptional or nontranscriptional functions...
  5. ncbi Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    Michael R Freeman
    The Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, USA
    Trends Endocrinol Metab 16:273-9. 2005
    ..We discuss the hypothesis that the cholesterol-rich lipid-raft compartment(s) of cancer-cell membranes might provide privileged sites for nongenomic signals mediated by the AR...
  6. ncbi Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, MD 21201, USA
    Oncogene 21:5609-18. 2002
    ..These studies suggest that Ebp1 may play a role in the function of the AR and provide a link between ErbB receptors and the AR...
  7. ncbi Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
    David Masiello
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:26321-6. 2002
    ..These results demonstrate that bicalutamide stimulates the assembly of a transcriptionally inactive AR on DNA and support altered coactivator (or corepressor) expression as a mechanism of bicalutamide-resistant androgen-independent PCa...
  8. ncbi Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells
    Liyan Zhuang
    The Urologic Laboratory, Department of Urology, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 62:2227-31. 2002
    ..These results suggest that cholesterol present in membrane microdomains is a prominent mediator of survival in prostate cancer cells...
  9. ncbi AR and ER interaction with a p21-activated kinase (PAK6)
    Suzanne R Lee
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 16:85-99. 2002
    ..PAK6 interaction provides a mechanism for cross-talk between steroid hormone receptors and Cdc42-mediated signal transduction pathways and could contribute to the effects of tamoxifen in breast cancer and in other tissues...
  10. doi Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins
    Ramneet Kaur
    Department of Medicine, Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Prostate 68:1510-6. 2008
    ....
  11. ncbi Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation
    Zongjian Jia
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Biol Cell 98:337-51. 2006
    ....
  12. doi SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion
    Hongyun Wang
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 68:1625-30. 2008
    ..These results support important functions of SOX9 in both the development and maintenance of normal prostate, and indicate that these functions contribute to PCa tumor growth and invasion...