Kun P Lu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The prolyl isomerase Pin1 in breast development and cancer
    Gerburg Wulf
    Cancer Biology Program, Division of Hematology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Breast Cancer Res 5:76-82. 2003
  2. ncbi request reprint Pinning down proline-directed phosphorylation signaling
    Kun Ping Lu
    Cancer Biology Program, Division of Hematology Oncology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    Trends Cell Biol 12:164-72. 2002
  3. ncbi request reprint Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease
    Kun Ping Lu
    Cancer Biology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Bioessays 25:174-81. 2003
  4. ncbi request reprint Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
    Masafumi Nakamura
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    FEBS Lett 514:193-8. 2002
  5. pmc Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation
    Adam R Cole
    Neurosciences Institute, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Biol Chem 283:18227-37. 2008
  6. ncbi request reprint Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis
    Rukhsana Sultana
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Neurobiol Aging 27:918-25. 2006
  7. ncbi request reprint Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 11:7523-31. 2005
  8. ncbi request reprint The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
    Tae Ho Lee
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Biol Chem 281:759-68. 2006
  9. pmc Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction
    Shao Yong Chen
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell Biol 26:929-39. 2006
  10. pmc Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis
    Futoshi Suizu
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:1463-79. 2006

Collaborators

Detail Information

Publications45

  1. pmc The prolyl isomerase Pin1 in breast development and cancer
    Gerburg Wulf
    Cancer Biology Program, Division of Hematology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Breast Cancer Res 5:76-82. 2003
    ..In addition, Pin1 knockout in mice prevents massive proliferation of breast epithelial cells during pregnancy. Pin1 plays a pivotal role in breast development and may be a promising new anticancer target...
  2. ncbi request reprint Pinning down proline-directed phosphorylation signaling
    Kun Ping Lu
    Cancer Biology Program, Division of Hematology Oncology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    Trends Cell Biol 12:164-72. 2002
    ..Furthermore, this post-phosphorylation mechanism might play an important role in cell growth control and diseases such as cancer and Alzheimer's...
  3. ncbi request reprint Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease
    Kun Ping Lu
    Cancer Biology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Bioessays 25:174-81. 2003
    ....
  4. ncbi request reprint Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
    Masafumi Nakamura
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    FEBS Lett 514:193-8. 2002
    ....
  5. pmc Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation
    Adam R Cole
    Neurosciences Institute, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Biol Chem 283:18227-37. 2008
    ..We propose that relative resistance to phosphatases might be a common feature of Cdk5 substrates and could contribute to the hyperphosphorylation of CRMP2 and Tau observed in Alzheimer disease...
  6. ncbi request reprint Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis
    Rukhsana Sultana
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Neurobiol Aging 27:918-25. 2006
    ..Taken together, these results provide evidence supporting a direct link between oxidative damage to neuronal Pin1 and the pathobiology of AD...
  7. ncbi request reprint Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 11:7523-31. 2005
    ..In the present study, we sought to determine the potential of Pin1-targeted gene silencing in inhibiting cellular growth and tumorigenicity in prostate cancer...
  8. ncbi request reprint The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
    Tae Ho Lee
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Biol Chem 281:759-68. 2006
    ..Thus, Fbx4 may play a critical role in telomere maintenance...
  9. pmc Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction
    Shao Yong Chen
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell Biol 26:929-39. 2006
    ....
  10. pmc Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis
    Futoshi Suizu
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:1463-79. 2006
    ..These results demonstrate for the first time that the phosphorylation-specific isomerase Pin1 regulates centrosome duplication and its deregulation can induce centrosome amplification, chromosome instability, and oncogenesis...
  11. ncbi request reprint The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
    Lucia Pastorino
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 440:528-34. 2006
    ..These findings provide new insight into the pathogenesis and treatment of Alzheimer's disease...
  12. ncbi request reprint Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1
    Liang Yu
    Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, SE 4186 Stockholm, Sweden
    J Biol Chem 281:18201-7. 2006
    ..Our results indicate that the peptidylprolyl isomerase Pin1 interacts with Btk in a cell cycle-dependent manner, regulating the Btk expression level...
  13. ncbi request reprint Targeting carcinogenesis: a role for the prolyl isomerase Pin1?
    Kun Ping Lu
    Department of Medicine, Cancer Biology Program, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:397-402. 2006
    ..These results suggest that Pin1-mediated postphosphorylation regulation may provide a unique opportunity for disrupting oncogenic pathways, and thereby represent an appealing target for novel anticancer therapies...
  14. ncbi request reprint Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1
    Tatsuya Saitoh
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nat Immunol 7:598-605. 2006
    ..These results elucidate a previously unknown mechanism for controlling innate antiviral responses by negatively regulating IRF3 activity via Pin1...
  15. ncbi request reprint Pathogenic mechanisms in Alzheimer's disease
    Lucia Pastorino
    Cancer Biology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Eur J Pharmacol 545:29-38. 2006
    ..This review discusses recent literature on beta- and gamma-secretase, and on those cellular factors, like cholesterol and phosphorylation of APP, that are involved in aging and may affect the function of both beta- and gamma-secretase...
  16. pmc Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration
    Martin Balastik
    Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany
    Proc Natl Acad Sci U S A 105:12016-21. 2008
    ..Our results demonstrate that TRIM2 is an ubiquitin ligase and point to a mechanism regulating NF-L metabolism through an ubiquitination pathway that, if deregulated, triggers neurodegeneration...
  17. pmc Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?
    Martin Balastik
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Biochim Biophys Acta 1772:422-9. 2007
    ..Moreover, in the human AD brain Pin1 is downregulated or inhibited by oxidative modifications and/or genetic changes. These results suggest that Pin1 deregulation may provide a link between formation of tangles and plaques in AD...
  18. ncbi request reprint Phosphorylation-specific prolyl isomerase Pin1 as a new diagnostic and therapeutic target for cancer
    Greg Finn
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 1030, Boston, MA 02115, USA
    Curr Cancer Drug Targets 8:223-9. 2008
    ....
  19. ncbi request reprint Prolyl cis-trans Isomerization as a molecular timer in Crk signaling
    Linda K Nicholson
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Mol Cell 25:483-5. 2007
    ....
  20. ncbi request reprint Prolyl cis-trans isomerization as a molecular timer
    Kun Ping Lu
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 1030, Boston, Massachusetts 02215, USA
    Nat Chem Biol 3:619-29. 2007
    ....
  21. ncbi request reprint The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
    Kun Ping Lu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, NRB1030, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 8:904-16. 2007
    ..In line with the diverse physiological roles of PIN1, it has also been linked to several diseases that include cancer, Alzheimer's disease and asthma, and thus it might represent a novel therapeutic target...
  22. pmc Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
    Jormay Lim
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1877-89. 2008
    ..Thus, Pin1 has opposite effects on the tauopathy phenotype depending on whether the tau is WT or a P301L mutant, indicating the need for disease-specific therapies for tauopathies...
  23. ncbi request reprint Phosphorylation-specific prolyl isomerization: is there an underlying theme?
    Gerburg Wulf
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 1030, Boston, MA 02115, USA
    Nat Cell Biol 7:435-41. 2005
    ..Here, we provide an overview of the plethora of regulatory events that involve this unique enzyme, with a particular focus on oncogenic signalling and neurodegeneration...
  24. ncbi request reprint Regulation of Raf-1 by direct feedback phosphorylation
    Michele K Dougherty
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Mol Cell 17:215-24. 2005
    ..These findings elucidate a critical Raf-1 regulatory mechanism that contributes to the sensitive, temporal modulation of Ras signaling...
  25. ncbi request reprint Pinning down phosphorylated tau and tauopathies
    Jormay Lim
    Cancer Biology Program Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, NRB 1030K, Boston, MA 02215, USA
    Biochim Biophys Acta 1739:311-22. 2005
    ..Thus, Pin1 is pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration. This could represent a promising interventive target to prevent neurodegenerative diseases...
  26. pmc Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:1335-40. 2002
    ..Our results provide genetic evidence for an essential role of Pin1 in maintaining cell proliferation and regulating cyclin D1 function...
  27. ncbi request reprint Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1
    Oliver Kops
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, HIM 1047, 330 Brookline Avenue, Boston, MA 02215, USA
    FEBS Lett 513:305-11. 2002
    ..Together, our results indicate a new role for Pin1 in the regulation of CTD phosphorylation and present a further example for prolyl isomerization-dependent protein dephosphorylation...
  28. ncbi request reprint Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function
    Pei Jung Lu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:2381-4. 2002
    ..Thus, phosphorylation is a new mechanism critical for regulating WW domain phosphoserine binding activity and Pin1 function...
  29. pmc PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells
    Akihide Ryo
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell Biol 22:5281-95. 2002
    ..Thus, Pin1 is an E2F target gene that is essential for the Neu/Ras-induced transformation of mammary epithelial cells through activation of cyclin D1...
  30. ncbi request reprint Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage
    Gerburg M Wulf
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:47976-9. 2002
    ..Moreover, Pin1 null cells displayed significant defects in cell cycle checkpoints induced by DNA damage. These results demonstrate a new role of Pin1 in regulating p53 function during DNA damage...
  31. ncbi request reprint The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
    Hongwu Zheng
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 419:849-53. 2002
    ..Together, these data suggest a mechanism for p53 regulation in cellular response to genotoxic stress...
  32. ncbi request reprint Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer
    Akihide Ryo
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 116:773-83. 2003
    ..Pin1 is also a critical regulator of the tumor suppressor p53 during DNA damage response. Given its role in cell growth control and oncogenesis, Pin1 could represent a new anti-cancer target...
  33. ncbi request reprint Role of Pin2/TRF1 in telomere maintenance and cell cycle control
    Xiao Zhen Zhou
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    J Cell Biochem 89:19-37. 2003
    ..These results have led us to propose that Pin2/TRF1 functions as a key molecule in connecting telomere maintenance and cell cycle control...
  34. ncbi request reprint Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 424:556-61. 2003
    ..Thus, Pin1 is pivotal in protecting against age-dependent neurodegeneration, providing insight into the pathogenesis and treatment of Alzheimer's disease and other tauopathies...
  35. ncbi request reprint Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics
    Kun Ping Lu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 4:175-80. 2003
  36. pmc Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis
    Gerburg Wulf
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    EMBO J 23:3397-407. 2004
    ..Thus, Pin1 is essential for tumorigenesis and is an attractive anticancer target. Our ex vivo assay can be used to study early events of breast cancer development in genetically predisposed mice...
  37. ncbi request reprint Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint
    Kyung Tae Kim
    Cancer Biology Program, Hematology and Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:38597-602. 2004
    ..Moreover, these cells underwent microtubule inhibitor-induced reduplication, leading to a polyploidy state. Our findings imply that Rit42 plays a role in the regulation of microtubule dynamics and the maintenance of euploidy...
  38. pmc Prevalent overexpression of prolyl isomerase Pin1 in human cancers
    Lere Bao
    Pintex Pharmaceuticals Incorporated, Watertown, Massachusetts 02472, USA
    Am J Pathol 164:1727-37. 2004
    ....
  39. ncbi request reprint Pinning down cell signaling, cancer and Alzheimer's disease
    Kun Ping Lu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, NRB 1030K, Boston, MA 02215, USA
    Trends Biochem Sci 29:200-9. 2004
    ..Thus, Pin1 plays a key role in linking signal transduction to the pathogenesis of cancer and Alzheimer's disease - two major age-related diseases...
  40. ncbi request reprint Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA
    Akihide Ryo
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
    Mol Cell 12:1413-26. 2003
    ..These findings uncover two important mechanisms of regulating NF-kappaB signaling and offer new insight into the pathogenesis and treatment of some human diseases such as cancers...
  41. pmc Pin1 modulates the structure and function of human RNA polymerase II
    Yu Xin Xu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genes Dev 17:2765-76. 2003
    ..Pin1 thus plays a significant role in regulating RNAP II CTD structure and function...
  42. ncbi request reprint A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells
    Shuji Kishi
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Biol Chem 277:7420-9. 2002
    ....
  43. ncbi request reprint An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors
    Dirk Wildemann
    Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
    Biol Chem 388:1103-11. 2007
    ..laevis...
  44. pmc Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury
    Qi Ming Li
    Center for Molecular Neurobiology and Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 27:8395-404. 2007
    ..This report thus unveils a mechanism by which cytochrome c release is under the opposite control of JNK3 and Pin1, regulators for which the activities are intricately coupled...
  45. ncbi request reprint The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer
    Gustavo Ayala
    Baylor College of Medicine, One Baylor Plaza M929, Houston, TX 77030, USA
    Cancer Res 63:6244-51. 2003
    ..Thus, this study suggests a role for Pin1 expression as a potentially excellent prognostic marker in PCa and suggests that Pin1 may also serve as a novel therapeutic target for PCa...