Jun Lu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
  2. ncbi request reprint Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 26:193-202. 2006
  3. doi request reprint Role of endogenous sleep-wake and analgesic systems in anesthesia
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:648-62. 2008
  4. pmc Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment
    Heinrich S Gompf
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 30:14543-51. 2010
  5. ncbi request reprint Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    Thomas C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10691-702. 2003
  6. pmc Reassessment of the structural basis of the ascending arousal system
    Patrick M Fuller
    Division of Sleep Medicine, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 519:933-56. 2011
  7. ncbi request reprint Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:4568-76. 2002
  8. pmc Identification and characterization of a sleep-active cell group in the rostral medullary brainstem
    Christelle Anaclet
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 32:17970-6. 2012
  9. doi request reprint Basal ganglia control of sleep-wake behavior and cortical activation
    Mei Hong Qiu
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Eur J Neurosci 31:499-507. 2010
  10. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010

Research Grants

  1. Mechanism of Dopaminergic Arousal
    Jun Lu; Fiscal Year: 2007
  2. Mechanism of Dopaminergic Arousal
    Jun Lu; Fiscal Year: 2009
  3. Pontine circuitry regulating REM sleep and atonia
    Jun Lu; Fiscal Year: 2009
  4. Pontine motor circuits
    Jun Lu; Fiscal Year: 2010
  5. Pontine circuitry regulating REM sleep and atonia
    Jun Lu; Fiscal Year: 2010

Detail Information

Publications80

  1. ncbi request reprint A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
    ..The mutually inhibitory interactions of the REM-on and REM-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to sudden, unwanted transitions-for example, in narcolepsy...
  2. ncbi request reprint Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 26:193-202. 2006
    ....
  3. doi request reprint Role of endogenous sleep-wake and analgesic systems in anesthesia
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:648-62. 2008
    ....
  4. pmc Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment
    Heinrich S Gompf
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 30:14543-51. 2010
    ..Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention...
  5. ncbi request reprint Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    Thomas C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10691-702. 2003
    ..Through these pathways, the DMH may influence a wide range of behavioral circadian rhythms...
  6. pmc Reassessment of the structural basis of the ascending arousal system
    Patrick M Fuller
    Division of Sleep Medicine, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 519:933-56. 2011
    ....
  7. ncbi request reprint Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:4568-76. 2002
    ..The connections and physiological activity of the extended VLPO suggest a specialized role in the regulation of REM sleep...
  8. pmc Identification and characterization of a sleep-active cell group in the rostral medullary brainstem
    Christelle Anaclet
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 32:17970-6. 2012
    ..These results together reveal the location and neurochemical identity of a delimited node of sleep-active neurons within the rostral medullary brainstem...
  9. doi request reprint Basal ganglia control of sleep-wake behavior and cortical activation
    Mei Hong Qiu
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Eur J Neurosci 31:499-507. 2010
    ..Collectively, our results suggest that the BG, via a cortico-striato-pallidal loop, are important neural circuitry regulating sleep-wake behaviors and cortical activation...
  10. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    ..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy...
  11. pmc Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus
    Elda Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Eur J Neurosci 30:2112-20. 2009
    ..LTP in VLPO-lesioned animals was partially restored by adenosine antagonists, suggesting that adenosine accumulation in VLPO-lesioned animals could account for some of the observed synaptic plasticity deficits...
  12. ncbi request reprint Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
  13. pmc Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia
    Martina Krenzer
    Division of Sleep Medicine, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24998. 2011
    ..Previous work has suggested, but not demonstrated directly, a critical role for both glutamatergic and GABAergic neurons of the pontine tegmentum in the regulation of rapid eye movement (REM) sleep...
  14. pmc Differential rescue of light- and food-entrainable circadian rhythms
    Patrick M Fuller
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 320:1074-7. 2008
    ..These results demonstrate that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms...
  15. pmc Lineage-specific transcriptional regulation of DICER by MITF in melanocytes
    Carmit Levy
    Department of Dermatology, Cutaneous Biology Research Center, Mass General Hospital, Harvard Medical School, MA 02115, USA
    Cell 141:994-1005. 2010
    ..These observations highlight a central mechanism underlying lineage-specific miRNA regulation which could exist for other cell types during development...
  16. pmc Medullary circuitry regulating rapid eye movement sleep and motor atonia
    Ramalingam Vetrivelan
    Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 29:9361-9. 2009
    ..These findings, together, demonstrate that SOM glutamatergic neurons comprise key elements of the medullary circuitry mediating REM atonia...
  17. ncbi request reprint A broad role for melanopsin in nonvisual photoreception
    Joshua J Gooley
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:7093-106. 2003
    ....
  18. pmc Brainstem circuitry regulating phasic activation of trigeminal motoneurons during REM sleep
    Christelle Anaclet
    Division of Sleep Medicine, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8788. 2010
    ..We hypothesized that the PCRt-PMnR, but not the SLD, regulates masseter phasic activity during REMS...
  19. pmc Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:1949-54. 2008
    ..Our results demonstrate the critical role of the Dicer-dependent pathway in the regulation of chondrocyte proliferation and differentiation during skeletal development...
  20. pmc Metabolic effects of chronic sleep restriction in rats
    Ramalingam Vetrivelan
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 35:1511-20. 2012
    ..We used rats with lesions in the ventrolateral preoptic area (VLPO), which spontaneously sleep about 30% less than intact rats, as an animal model to study the consequences of chronic partial sleep loss on energy metabolism...
  21. ncbi request reprint Sleep circuitry and the hypnotic mechanism of GABAA drugs
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    J Clin Sleep Med 2:S19-26. 2006
    ..The integration of these data into the flip-flop switch model can be used to better understand sleep-wake control and augment existing therapeutic treatments for sleep disorders...
  22. ncbi request reprint Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats
    Xi Bin Liang
    Department of Neurology, Johns Hopkins University, School of Medicine, USA
    Neuroreport 14:1177-81. 2003
    ....
  23. ncbi request reprint The hypothalamic integrator for circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 28:152-7. 2005
    ....
  24. pmc Standards of evidence in chronobiology: A response
    Patrick M Fuller
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
    J Circadian Rhythms 7:9. 2009
    ....
  25. ncbi request reprint Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  26. pmc The pontine REM switch: past and present
    Patrick M Fuller
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Physiol 584:735-41. 2007
    ..Our findings demonstrating independent pathways mediating atonia and the EEG components of REM provide a basis for their occasional dissociation in pathological states, e.g. REM sleep behaviour disorder...
  27. ncbi request reprint Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
    ..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
  28. pmc Role of Basal Ganglia in sleep-wake regulation: neural circuitry and clinical significance
    Ramalingam Vetrivelan
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA, USA
    Front Neuroanat 4:145. 2010
    ..Furthermore, the arousal effects of psychostimulants (methamphetamine, cocaine, and modafinil) may be linked to the ventral periaquductal gray (vPAG) dopaminergic circuitry targeting the extra-BG sleep-wake network...
  29. pmc Perspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorder
    Vetrivelan Ramaligam
    Department of Neurology and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Sleep Med 14:707-13. 2013
    ..Animal research has lead to the hypothesis that complex behaviors in RBD are due to SLD pathology, while simple behaviors of RBD may be due to less severe SLD pathology or dysfunction of the VMM, ventral pons, or spinal cord. ..
  30. pmc An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice
    Mai T Dang
    Department of Neurology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 226:465-72. 2012
    ....
  31. pmc MicroRNA miR-125a controls hematopoietic stem cell number
    Shangqin Guo
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:14229-34. 2010
    ..These data demonstrate cell-state-specific regulation by microRNA and identify a unique microRNA functioning to regulate the stem cell pool size...
  32. pmc Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18266. 2011
    ....
  33. pmc microRNA expression during trophectoderm specification
    Srinivas R Viswanathan
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA
    PLoS ONE 4:e6143. 2009
    ..We have compared miRNA expression in embryonic stem cell (ESC)-derived trophectoderm and in staged murine embryos to identify a set of candidate miRNAs likely to be involved in trophectoderm specification...
  34. ncbi request reprint Altered microRNA expression in human heart disease
    Sadakatsu Ikeda
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Physiol Genomics 31:367-73. 2007
    ..These data will guide further studies of the contribution of microRNAs to heart disease pathogenesis...
  35. pmc Lin28 promotes transformation and is associated with advanced human malignancies
    Srinivas R Viswanathan
    Children s Hospital Boston, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA
    Nat Genet 41:843-8. 2009
    ..Our work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis...
  36. pmc MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes
    Sadakatsu Ikeda
    Department of Cardiology, Children s Hospital Boston, Department of Genetics, Harvard Medical School, Boston, Massachusetts 021151, USA
    Mol Cell Biol 29:2193-204. 2009
    ..Our data indicate that miR-1 regulates cardiomyocyte growth responses by negatively regulating the calcium signaling components calmodulin, Mef2a, and Gata4...
  37. pmc The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells
    Yu Fen Chou
    Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, CPZN 4256, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 135:449-61. 2008
    ..We demonstrate that the culture growth factor environment and cell-cell interaction play a critical role in defining several unique and stable stem cell ground states...
  38. ncbi request reprint A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation
    Yulia Kaluzhny
    Department of Biochemistry, K225, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    FEBS Lett 527:279-83. 2002
    ..Our study is the first to suggest that Mpl ligand-induced lineage specification is also determined by message stabilization...
  39. ncbi request reprint Roads to polyploidy: the megakaryocyte example
    Katya Ravid
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Cell Physiol 190:7-20. 2002
    ..Future studies will aim to further explore these two groups of genes...
  40. ncbi request reprint Trace amounts of copper induce neurotoxicity in the cholesterol-fed mice through apoptosis
    Jun Lu
    Institute of Molecular Medicine and Genetics Research Center, School of Basic Medical Science, Southeast University, Nanjing 210009, PR China
    FEBS Lett 580:6730-40. 2006
    ..These findings suggest that trace amounts of copper induce neurotoxicity in cholesterol-fed mice through apoptosis caused by oxidative stress...
  41. ncbi request reprint The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects
    Laura E Nelson
    Department of Anaesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Anesthesiology 98:428-36. 2003
    ..The authors investigated whether the sedative, or hypnotic, action of the general anesthetic dexmedetomidine (a selective alpha -adrenoceptor agonist) activates endogenous nonrapid eye movement (NREM) sleep-promoting pathways...
  42. ncbi request reprint Impaired microRNA processing enhances cellular transformation and tumorigenesis
    Madhu S Kumar
    MIT Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 39:673-7. 2007
    ..Furthermore, conditional deletion of Dicer1 enhanced tumor development in a K-Ras-induced mouse model of lung cancer. Overall, these studies indicate that abrogation of global miRNA processing promotes tumorigenesis...
  43. ncbi request reprint The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast
    Fen Li
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, PR China
    Mol Genet Genomics 273:264-72. 2005
    ..The data presented in this report suggest that the Elp3 subunits of human and yeast are highly conserved in their structure and functions...
  44. ncbi request reprint MicroRNA expression profiles classify human cancers
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 435:834-8. 2005
    ..These findings highlight the potential of miRNA profiling in cancer diagnosis...
  45. pmc Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    Xiaohui Xie
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 434:338-45. 2005
    ..The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available...
  46. ncbi request reprint Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors
    Yanmei Zhao
    The Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, PR China
    J Exp Biol 208:697-705. 2005
    ..These data suggested a close correlation among histone acetylation, hsp gene expression and longevity in D. melanogaster...
  47. ncbi request reprint Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats
    Jun Lu
    Departmrent of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Japan
    J Thorac Cardiovasc Surg 128:850-9. 2004
    ..We postulated that inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates inflammation and the development of pulmonary hypertension in monocrotaline-treated rats...
  48. pmc Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome
    Elaine M Sloand
    Hematology Branch, National Heart, Lung, and Blood Institute, Bldg 10, Rm 7C108, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 106:841-51. 2005
    ..An increased number of T cells with apparent specificity for trisomy 8 cells is consistent with an autoimmune pathophysiology in trisomy 8 MDS...
  49. ncbi request reprint Mutational analysis of TraM correlates oligomerization and DNA binding with autoregulation and conjugative DNA transfer
    Jun Lu
    Department of Biological Sciences, CW405 Biological Sciences Building, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    J Biol Chem 279:55324-33. 2004
    ..These findings support the hypothesis that TraM functions as a "signaling" factor that triggers DNA transport during F conjugation...
  50. ncbi request reprint Enhancing immunogenicity of a CTL epitope from carcinoembryonic antigen by selective amino acid replacements
    Eduardo Huarte
    Department of Internal Medicine, University of Navarra, 31008 Pamplona, Spain
    Clin Cancer Res 8:2336-44. 2002
    ..We have applied this strategy to enhance the immunogenicity of the HLA-A2-restricted CTL epitope CEA691 (IMIGVLVGV) from carcinoembryonic antigen (CEA), which is expressed by a wide variety of tumors...
  51. ncbi request reprint Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy
    Xi Bin Liang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res Mol Brain Res 108:51-9. 2002
    ..Activation of endogenous neurotrophins by EA may be involved in the regeneration of the injured dopaminergic neurons, which may underlie the effectiveness of EA in the treatment of PD...
  52. ncbi request reprint Multiepitope Trojan antigen peptide vaccines for the induction of antitumor CTL and Th immune responses
    Jun Lu
    Department of Immunology and Cancer Center, Mayo College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 172:4575-82. 2004
    ....
  53. ncbi request reprint Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1
    Chunyan Liu
    Institute of Genetics and Cytology, Northeast Normal University, Jilin, 130024, China
    Cytokine 27:93-100. 2004
    ..This report provided evidence, for the first time, that CBP/p300 was involved in IL-5 gene expression and the HAT activity was important in regulation of IL-5 expression...
  54. ncbi request reprint Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression
    Dan Tao
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Acta Biochim Biophys Sin (Shanghai) 36:618-22. 2004
    ..Present data implicate that TSA may affect the lifespan of Drosophila through changing the level of histone acetylation and influencing the expression of hsp22 gene that is related to aging...
  55. ncbi request reprint A comparison of gene expression profiles produced by SAGE, long SAGE, and oligonucleotide chips
    Jun Lu
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA
    Genomics 84:631-6. 2004
    ..However, 4-7% of the 10-bp tags were redundancies that could have been resolved by long SAGE and 10-20% of the short SAGE tags had no obvious match to currently annotated human transcript sequences...
  56. ncbi request reprint Motif CXCC in nitrile hydratase activator is critical for NHase biogenesis in vivo
    Jun Lu
    The Institute of Physical and Chemical Research, Wako Shi, 351 0198 Saitama, Japan
    FEBS Lett 553:391-6. 2003
    ..These findings suggest NHase activator mainly participates in iron trafficking in NHase biogenesis as an iron type metallochaperone...
  57. ncbi request reprint Histone acetyltransferase activity of p300 enhances the activation of IL-18 promoter
    Haijing Sun
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, P R China
    J Cell Biochem 94:566-72. 2005
    ..Data presented in this paper implicate important roles of p300 in the transcriptional regulation of IL-18...
  58. doi request reprint Protein tyrosine phosphatase receptor-type O (PTPRO) is co-regulated by E2F1 and miR-17-92
    Xin Xu
    Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    FEBS Lett 582:2850-6. 2008
    ..This study provides evidence that the PTPRO gene is co-regulated by both E2F1 and miR-17-92...
  59. pmc MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Dev Cell 14:843-53. 2008
    ..These experiments show that miR-150 regulates MEP fate, and thus establish a role for miRNAs in lineage specification of mammalian multipotent cells...
  60. ncbi request reprint hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells
    Qiuju Han
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Acta Biochim Biophys Sin (Shanghai) 39:453-61. 2007
    ..Data presented in this report provide further insight and direct evidence of the functions of hELP3 in HSP70-2 gene transcriptional elongation in human cells...
  61. pmc Pathway level analysis of gene expression using singular value decomposition
    John Tomfohr
    Department of Biostatistics and Bioinformatics, Center for Bioinformatics and Computational Biology, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    BMC Bioinformatics 6:225. 2005
    ..The activity levels, which are derived from singular value decompositions, form the basis for statistical comparisons and other applications...
  62. ncbi request reprint Inhibition of angiogenesis by the antifungal drug itraconazole
    Curtis R Chong
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    ACS Chem Biol 2:263-70. 2007
    ..Together, these findings suggest that itraconazole has the potential to serve as an antiangiogenic drug and that lanosterol 14DM is a promising new target for discovering new angiogenesis inhibitors...
  63. ncbi request reprint A minimal domain responsible for Munc13 activity
    Jayeeta Basu
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Struct Mol Biol 12:1017-8. 2005
    ..Here we identify a large alpha-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s...
  64. pmc Transcript-based redefinition of grouped oligonucleotide probe sets using AceView: high-resolution annotation for microarrays
    Jun Lu
    Genomics Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA
    BMC Bioinformatics 8:108. 2007
    ..Shortfalls in the original Affymetrix probe annotation have been described; however, few studies have provided rigorous solutions for routine data analysis...
  65. pmc Kainic acid induces early and transient autophagic stress in mouse hippocampus
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, SC 961, 1530 3rd Ave S, Birmingham, AL 35294 0017, USA
    Neurosci Lett 414:57-60. 2007
    ..Together these data indicate the transient induction of autophagic stress by KA which may serve to regulate excitotoxic death in mouse hippocampus...
  66. ncbi request reprint Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats
    Deming Gong
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Pharmacol 70:2045-51. 2006
    ..These findings are relevant to the restoration toward normal by TETA treatment of cardiac and arterial structure and function in diabetes...
  67. ncbi request reprint Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo
    Jun Lu
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Med Chem 49:5645-8. 2006
    ..It is also active in a mouse model of angiogenesis in vivo. Unlike TNP-470, fumarranol does not covalently bind to MetAP2. Fumarranol may serve as a lead for a new class of angiogenesis inhibitors...
  68. ncbi request reprint Establishment of a nude mice model of human monocytic leukemia with CNS and multiorgan extramedullary infiltration
    Zhenjiang Li
    Leukemia Research Unit, Jiangsu Institute of Hematology, Suzhou, China
    Eur J Haematol 77:128-33. 2006
    ..To establish a human monocytic leukemia model with central nervous system infiltration in BALB/c nude mice...
  69. pmc A detailed transcript-level probe annotation reveals alternative splicing based microarray platform differences
    Joseph C Lee
    Genomics Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 8:284. 2007
    ..Alternative splicing has been cited as a possible cause of differences in expression measurements across platforms, though no study to this point has been conducted to show its influence in cross-platform differences...
  70. pmc Mutations in the C-terminal region of TraM provide evidence for in vivo TraM-TraD interactions during F-plasmid conjugation
    Jun Lu
    Department of Biological Sciences, University of Alberta, Canada
    J Bacteriol 187:4767-73. 2005
    ..This arrangement of functional domains could in part allow TraM to receive the mating signal generated by donor-recipient contact and transfer it to the relaxosome, thereby triggering DNA transfer...
  71. ncbi request reprint Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression
    Lina Pan
    Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin Province, China
    Cancer 109:1676-88. 2007
    ..The aim of this work was to investigate whether changes in PTEN expression are involved in TSA/doxorubicin-induced apoptosis...
  72. pmc Identifying differential expression in multiple SAGE libraries: an overdispersed log-linear model approach
    Jun Lu
    Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina 27708, USA
    BMC Bioinformatics 6:165. 2005
    ..The merits of these tests, however, have not been fully evaluated. Questions still remain on whether further improvements can be made...
  73. ncbi request reprint [Effect of p38 MAPK on elemene-induced cell cycle arrest in C6 glioblastoma cells]
    Yi Qun Yao
    Department of Neurosurgery, 1st Affiliated Hospital of Dalian Medical University, Dalian 116011, China
    Zhonghua Yi Xue Za Zhi 88:56-8. 2008
    ..To observe the effect of elemene on cell cycle of rat C6 glioblastoma cells...
  74. doi request reprint Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity
    Cristina M L Carvalho
    I Med, Faculty of Pharmacy, University of Lisbon, Av Prof Gama Pinto, 1649 003 Lisbon, Portugal
    J Biol Chem 283:11913-23. 2008
    ..In particular, the remarkable potency of the mercury compounds to bind to the selenol-thiol in the active site of TrxR should be a major molecular mechanism of mercury toxicity...
  75. doi request reprint Purple sweet potato color repairs d-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins
    Dong Mei Wu
    Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, No 101 Shanghai Road, Xuzhou 221116, Jiangsu Province, PR China
    Neurobiol Learn Mem 90:19-27. 2008
    ..The results of this study suggested that memory impairment and synaptic protein loss in d-gal-treated mice may be improved by treatment with PSPC...
  76. doi request reprint A genetic epidemiologic study of social support in a Chinese sample
    Wen yan Ji
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
    Twin Res Hum Genet 11:55-62. 2008
    ..Except for objective support, genetic factors probably influence variation in subjective support and utilization of support. Shared environmental factors may influence all dimensions of social support...
  77. doi request reprint Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity
    Eng Hui Chew
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 17177 Stockholm, Sweden
    FASEB J 22:2072-83. 2008
    ..From the results obtained, we propose that TrxR inhibition is a critical cellular event that contributes to the proapoptotic effects of quinols...
  78. pmc MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
    Shuangli Mi
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:19971-6. 2007
    ....
  79. pmc Rapid assembly of multiple-exon cDNA directly from genomic DNA
    Xiaoping An
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 2:e1179. 2007
    ....
  80. ncbi request reprint [Expression and implication of cyclooxygenase-2 mRNA in prostate cancer]
    Ming shan Yang
    Department of Urology, the First Hospital of Shanghai Jiaotong University, Shanghai 200080, China
    Zhonghua Nan Ke Xue 12:159-61. 2006
    ..To investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa)...

Research Grants9

  1. Mechanism of Dopaminergic Arousal
    Jun Lu; Fiscal Year: 2007
    ....
  2. Mechanism of Dopaminergic Arousal
    Jun Lu; Fiscal Year: 2009
    ....
  3. Pontine circuitry regulating REM sleep and atonia
    Jun Lu; Fiscal Year: 2009
    ..Results from our studies will provide the foundation for the development of diagnostic and therapeutic strategies for treating RBD. ..
  4. Pontine motor circuits
    Jun Lu; Fiscal Year: 2010
    ..Results from our studies will provide data important for the development of therapeutic and diagnostic strategies for treating Parkinsonism and possibly other movement disorders such as cataplexy. ..
  5. Pontine circuitry regulating REM sleep and atonia
    Jun Lu; Fiscal Year: 2010
    ..Findings from the present proposal will provide a context for understanding the pathophysiologic mechanisms and etiological bases for a variety of sleep disorders, including REM sleep behavior disorder. ..