Bradford B Lowell
Affiliation: Harvard University
Shah B, Vong L, Olson D, Koda S, Krashes M, Ye C, et al
. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc Natl Acad Sci U S A. 2014;111:13193-8 pubmed publisher
..This suggests a basis for the feeding-regulating effects of MC4Rs. ..
Li M, Madara J, Steger J, Krashes M, Balthasar N, Campbell J, et al
. The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Neuron. 2019;: pubmed publisher
..This expands the CNS satiety circuitry to include two non-overlapping PVH to hindbrain circuits. ..
Kong D, Dagon Y, Campbell J, Guo Y, Yang Z, Yi X, et al
. A Postsynaptic AMPKâ†’p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016;91:25-33 pubmed publisher
..This provides a signaling and neurobiological basis for both AMPK regulation of energy balance and AgRP neuron state-dependent plasticity. ..
Andermann M, Lowell B. Toward a Wiring Diagram Understanding of Appetite Control. Neuron. 2017;95:757-778 pubmed publisher
..The aim of this review is to cover the major underpinnings of appetite regulation, describe recent advances resulting from new technologies, and synthesize these findings into an updated view of appetite regulation. ..
Mandelblat Cerf Y, Kim A, Burgess C, SUBRAMANIAN S, Tannous B, Lowell B, et al
. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons. Neuron. 2017;93:57-65 pubmed publisher
..These rapid and distinct changes in activity during drinking and feeding suggest diverse neural mechanisms underlying anticipatory regulation of VPpp neurons. ..
Resch J, Fenselau H, Madara J, Wu C, Campbell J, Lyubetskaya A, et al
. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017;96:190-206.e7 pubmed publisher
..The interaction between angiotensin signaling and NTSHSD2 neurons provides a neuronal context for the long-standing "synergy hypothesis" of sodium appetite regulation. ..