Research Topics
| RICHARD MARC LOSICKSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Tracing the domestication of a biofilm-forming bacteriumAnna L McLoon
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
J Bacteriol 193:2027-34. 2011..Thus, domestication of B. subtilis involved the accumulation of four mutations and the loss of a plasmid-borne gene...- The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilisPatrick Eichenberger
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
PLoS Biol 2:e328. 2004..The logic of the program is that of a linked series of feed-forward loops, which generate successive pulses of gene transcription. Similar regulatory circuits could be a common feature of other systems of cellular differentiation... - A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formationYunrong Chai
Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
J Bacteriol 191:2423-30. 2009.... - Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanismsArnaud Chastanet
Molecular and Cellular Biology Department, Harvard University, 16 Divinity Ave, Cambridge, MA 02138 1903, USA
J Bacteriol 193:6366-74. 2011.... - Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm developmentAllon I Hochbaum
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 1903, USA
J Bacteriol 193:5616-22. 2011..subtilis and S. aureus. Finally, to investigate the potential utility of D-amino acids in preventing device-related infections, we have shown that surfaces impregnated with D-amino acids were effective in preventing biofilm growth... - Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilisAllison V Banse
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Bacteriol 193:3949-55. 2011..We propose that Med directly or indirectly interacts with KinD in the cytoplasmic membrane and that this interaction is required for KinD-dependent phosphorylation of Spo0A... - The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acidsLilah Rahn-Lee
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, Massachusetts 02138, USA
J Bacteriol 193:1302-7. 2011..DnaA mutants containing amino acid substitutions of the 3 residues are functional in replication initiation but are immune to inhibition by SirA... - Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilisAnna L McLoon
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
J Bacteriol 193:679-85. 2011..Our findings suggest that multiple signals from the older and younger regions of the colony are integrated by the kinases to determine the overall architecture of the biofilm community... - A small protein required for the switch from {sigma}F to {sigma}G during sporulation in Bacillus subtilisAmy H Camp
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Bacteriol 193:116-24. 2011..Based in part on the similarity of Fin to the anti-σ(G) factor CsfB (also called Gin), we speculate that Fin is an anti-σ(F) factor which, by disabling σ(F), promotes the switch to late developmental gene expression in the forespore... - The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinCMoshe Shemesh
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Bacteriol 192:6352-6. 2010..Importantly, strains unable to make a matrix were hypersensitive to ClO(2), indicating that biofilm formation is a defensive response that helps protect cells from the toxic effects of the biocide...
Research Grants
- Role of RNA Polymerase in Bacterial DifferentionRICHARD MARC LOSICK; Fiscal Year: 2010..whose answers are, thus far, only partially known: (I) how do regulatory circuits and morphogenetic events result in the conversion of a cell into a spore? (II) How does sporulation occur in the context of a multicellular community? ..
- RNA POLYMERASE AND BACTERIAL DIFFERENTIATIONRichard Losick; Fiscal Year: 2003..These objectives address basic questions of differentiation and morphogenesis that are common to developing systems of many kinds, including complex systems of normal and abnormal development in higher organisms. ..
- ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATIONRichard Losick; Fiscal Year: 2007..These goals address basic questions of differentiation and gene control that are common to developing systems of many kinds, including complex systems of normal and abnormal development in higher organisms. ..
- ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATIONRichard Losick; Fiscal Year: 1980..In pilot experiments we have identified a modifed form of core RNA polymerase that selectively and asymmetrically copies a gene that is activated at an early stage of spore development...