RICHARD MARC LOSICK

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Tracing the domestication of a biofilm-forming bacterium
    Anna L McLoon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Bacteriol 193:2027-34. 2011
  2. pmc The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis
    Patrick Eichenberger
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 2:e328. 2004
  3. pmc A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation
    Yunrong Chai
    Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    J Bacteriol 191:2423-30. 2009
  4. pmc Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms
    Arnaud Chastanet
    Molecular and Cellular Biology Department, Harvard University, 16 Divinity Ave, Cambridge, MA 02138 1903, USA
    J Bacteriol 193:6366-74. 2011
  5. pmc Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development
    Allon I Hochbaum
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 1903, USA
    J Bacteriol 193:5616-22. 2011
  6. pmc Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis
    Allison V Banse
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Bacteriol 193:3949-55. 2011
  7. pmc The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acids
    Lilah Rahn-Lee
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, Massachusetts 02138, USA
    J Bacteriol 193:1302-7. 2011
  8. pmc Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilis
    Anna L McLoon
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    J Bacteriol 193:679-85. 2011
  9. pmc A small protein required for the switch from {sigma}F to {sigma}G during sporulation in Bacillus subtilis
    Amy H Camp
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Bacteriol 193:116-24. 2011
  10. pmc The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC
    Moshe Shemesh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Bacteriol 192:6352-6. 2010

Research Grants

  1. Role of RNA Polymerase in Bacterial Differention
    RICHARD MARC LOSICK; Fiscal Year: 2010
  2. RNA POLYMERASE AND BACTERIAL DIFFERENTIATION
    Richard Losick; Fiscal Year: 2003
  3. ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATION
    Richard Losick; Fiscal Year: 2007
  4. ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATION
    Richard Losick; Fiscal Year: 1980

Collaborators

Detail Information

Publications10

  1. pmc Tracing the domestication of a biofilm-forming bacterium
    Anna L McLoon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Bacteriol 193:2027-34. 2011
    ..Thus, domestication of B. subtilis involved the accumulation of four mutations and the loss of a plasmid-borne gene...
  2. pmc The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis
    Patrick Eichenberger
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 2:e328. 2004
    ..The logic of the program is that of a linked series of feed-forward loops, which generate successive pulses of gene transcription. Similar regulatory circuits could be a common feature of other systems of cellular differentiation...
  3. pmc A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation
    Yunrong Chai
    Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    J Bacteriol 191:2423-30. 2009
    ....
  4. pmc Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms
    Arnaud Chastanet
    Molecular and Cellular Biology Department, Harvard University, 16 Divinity Ave, Cambridge, MA 02138 1903, USA
    J Bacteriol 193:6366-74. 2011
    ....
  5. pmc Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development
    Allon I Hochbaum
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 1903, USA
    J Bacteriol 193:5616-22. 2011
    ..subtilis and S. aureus. Finally, to investigate the potential utility of D-amino acids in preventing device-related infections, we have shown that surfaces impregnated with D-amino acids were effective in preventing biofilm growth...
  6. pmc Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis
    Allison V Banse
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Bacteriol 193:3949-55. 2011
    ..We propose that Med directly or indirectly interacts with KinD in the cytoplasmic membrane and that this interaction is required for KinD-dependent phosphorylation of Spo0A...
  7. pmc The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acids
    Lilah Rahn-Lee
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, Massachusetts 02138, USA
    J Bacteriol 193:1302-7. 2011
    ..DnaA mutants containing amino acid substitutions of the 3 residues are functional in replication initiation but are immune to inhibition by SirA...
  8. pmc Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilis
    Anna L McLoon
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    J Bacteriol 193:679-85. 2011
    ..Our findings suggest that multiple signals from the older and younger regions of the colony are integrated by the kinases to determine the overall architecture of the biofilm community...
  9. pmc A small protein required for the switch from {sigma}F to {sigma}G during sporulation in Bacillus subtilis
    Amy H Camp
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Bacteriol 193:116-24. 2011
    ..Based in part on the similarity of Fin to the anti-σ(G) factor CsfB (also called Gin), we speculate that Fin is an anti-σ(F) factor which, by disabling σ(F), promotes the switch to late developmental gene expression in the forespore...
  10. pmc The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC
    Moshe Shemesh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Bacteriol 192:6352-6. 2010
    ..Importantly, strains unable to make a matrix were hypersensitive to ClO(2), indicating that biofilm formation is a defensive response that helps protect cells from the toxic effects of the biocide...

Research Grants25

  1. Role of RNA Polymerase in Bacterial Differention
    RICHARD MARC LOSICK; Fiscal Year: 2010
    ..whose answers are, thus far, only partially known: (I) how do regulatory circuits and morphogenetic events result in the conversion of a cell into a spore? (II) How does sporulation occur in the context of a multicellular community? ..
  2. RNA POLYMERASE AND BACTERIAL DIFFERENTIATION
    Richard Losick; Fiscal Year: 2003
    ..These objectives address basic questions of differentiation and morphogenesis that are common to developing systems of many kinds, including complex systems of normal and abnormal development in higher organisms. ..
  3. ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATION
    Richard Losick; Fiscal Year: 2007
    ..These goals address basic questions of differentiation and gene control that are common to developing systems of many kinds, including complex systems of normal and abnormal development in higher organisms. ..
  4. ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATION
    Richard Losick; Fiscal Year: 1980
    ..In pilot experiments we have identified a modifed form of core RNA polymerase that selectively and asymmetrically copies a gene that is activated at an early stage of spore development...