Stephen H Loring

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Expiratory abdominal rounding in acute dyspnea suggests congestive heart failure
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Lung 184:324-9. 2006
  2. pmc Pulmonary characteristics in COPD and mechanisms of increased work of breathing
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 107:309-14. 2009
  3. pmc Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?
    Stephen H Loring
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:515-22. 2010
  4. ncbi request reprint Sources of graft restriction after single lung transplantation for emphysema
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    J Thorac Cardiovasc Surg 134:204-9. 2007
  5. ncbi request reprint Central airway mechanics and flow limitation in acquired tracheobronchomalacia
    Stephen H Loring
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, DA 717, Boston, MA 02215, USA
    Chest 131:1118-24. 2007
  6. doi request reprint Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats
    Stephen H Loring
    Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, and Servizio di Coagulazione, IRCCS Ospedale San Raffaele, Milan, Italy
    Crit Care Med 38:2358-64. 2010
  7. ncbi request reprint Transpulmonary pressures and lung mechanics with glossopharyngeal insufflation and exsufflation beyond normal lung volumes in competitive breath-hold divers
    Stephen H Loring
    Dept of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Appl Physiol (1985) 102:841-6. 2007
  8. ncbi request reprint Lubrication regimes in mesothelial sliding
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, DA 717, 330 Brookline Avenue, Boston, MA 02215 5491, USA
    J Biomech 38:2390-6. 2005
  9. doi request reprint Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
  10. pmc Esophageal and transpulmonary pressures in acute respiratory failure
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Crit Care Med 34:1389-94. 2006

Detail Information

Publications52

  1. ncbi request reprint Expiratory abdominal rounding in acute dyspnea suggests congestive heart failure
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Lung 184:324-9. 2006
    ..The clinical utility of this diagnostic sign remains to be determined in a prospective study...
  2. pmc Pulmonary characteristics in COPD and mechanisms of increased work of breathing
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 107:309-14. 2009
    ..Extrinsic restriction, in which the chest wall fails to achieve and maintain abnormally high lung volumes in COPD, can limit ventilatory function and contribute to disability...
  3. pmc Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?
    Stephen H Loring
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:515-22. 2010
    ..We suggest that Pes can be used to estimate transpulmonary pressures that are consistent with known physiology and can provide meaningful information, otherwise unavailable, in critically ill patients...
  4. ncbi request reprint Sources of graft restriction after single lung transplantation for emphysema
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    J Thorac Cardiovasc Surg 134:204-9. 2007
    ..We sought to determine the contributions of donor-recipient size matching, postoperative native lung hyperinflation, and postoperative chest wall volume reduction to graft restriction after transplantation...
  5. ncbi request reprint Central airway mechanics and flow limitation in acquired tracheobronchomalacia
    Stephen H Loring
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, DA 717, Boston, MA 02215, USA
    Chest 131:1118-24. 2007
    ..It is usually not known whether central airway malacia contributes to airflow obstruction. This study was undertaken to quantify central airway collapsibility and relate it to expiratory flow limitation in patients with TBM...
  6. doi request reprint Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats
    Stephen H Loring
    Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, and Servizio di Coagulazione, IRCCS Ospedale San Raffaele, Milan, Italy
    Crit Care Med 38:2358-64. 2010
    ....
  7. ncbi request reprint Transpulmonary pressures and lung mechanics with glossopharyngeal insufflation and exsufflation beyond normal lung volumes in competitive breath-hold divers
    Stephen H Loring
    Dept of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Appl Physiol (1985) 102:841-6. 2007
    ..We conclude that the lungs of some healthy individuals are able to withstand repeated inflation to transpulmonary pressures far greater than those to which they would normally be exposed...
  8. ncbi request reprint Lubrication regimes in mesothelial sliding
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, DA 717, 330 Brookline Avenue, Boston, MA 02215 5491, USA
    J Biomech 38:2390-6. 2005
    ..We conclude that mesothelial surfaces, sliding under physiological conditions, are protected from excessive shear by hydrodynamic pressures that increase separation of surfaces...
  9. doi request reprint Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
    ....
  10. pmc Esophageal and transpulmonary pressures in acute respiratory failure
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Crit Care Med 34:1389-94. 2006
    ..By measuring esophageal pressure (Pes), we sought to characterize influence of the chest wall on Ppl and transpulmonary pressure (PL) in patients with acute respiratory failure...
  11. pmc Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD
    Alejandro A Diaz
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 141:736-44. 2012
    ..Additionally, we compared clinical and CT scan features of subjects with (airway constrictors) and without a decrease in airway caliber...
  12. pmc Comparison of plethysmographic and helium dilution lung volumes: which is best for COPD?
    Carl R O'Donnell
    ScD, Beth Israel Deaconess Medical Center, Dana 717, 330 Brookline Ave, Boston, MA 02215, USA
    Chest 137:1108-15. 2010
    ..We sought to compare plethysmography (Pleth)-, helium dilution (He)- and CT scan-derived lung volume measurements in a sample containing many patients with severe airflow obstruction...
  13. pmc Physiological and computed tomographic predictors of outcome from lung volume reduction surgery
    George R Washko
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:494-500. 2010
    ..We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial...
  14. doi request reprint Esophageal pressure as an estimate of average pleural pressure with lung or chest distortion in rats
    Matteo Pecchiari
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita di Milano, Milan, Italy
    Respir Physiol Neurobiol 186:229-35. 2013
    ..With chest wall distortion and dependent deformation of the normal lung, changes of Ples-V curves are qualitatively consistent with greater work of inflation...
  15. pmc Cytokine release following recruitment maneuvers
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, CC 470, Boston MA 02215, USA
    Chest 132:1434-9. 2007
    ..There are reports of rigors and/or clinical deterioration following recruitment maneuvers (RMs), leading us to question whether the use of sustained high-pressure inflation could lead to release of inflammatory mediators...
  16. ncbi request reprint Elastohydrodynamic separation of pleural surfaces during breathing
    Andrew Gouldstone
    Physiology Program, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Respir Physiol Neurobiol 137:97-106. 2003
    ..These results suggest that in the pleural space during normal breathing, separation of pleural surfaces is promoted by the reciprocating sliding of lung and chest wall...
  17. ncbi request reprint Physiological characterization of variability in response to lung volume reduction surgery
    Edward P Ingenito
    Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 94:20-30. 2003
    ..Among nonresponders, recoil pressure increased out of proportion to reduced volume, such that no increase in vital capacity or improvement in FEV(1) occurred...
  18. ncbi request reprint Volume-related and volume-independent effects of posture on esophageal and transpulmonary pressures in healthy subjects
    George R Washko
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol 100:753-8. 2006
    ..We conclude that postural differences in estimated transpulmonary pressure at a given lung volume are small compared with the substantial range of PLrel in patients with acute lung injury...
  19. pmc "Ventilatory alternans": a left-right alternation of inspiratory airflow in humans
    Yanping Sun
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Respir Physiol Neurobiol 185:468-71. 2013
    ..We speculate that cardiogenic pendelluft, possibly from ballistic lateral motion of the beating heart, could cause alternating variations of inspiratory flow to the lungs...
  20. pmc Inhalation heterogeneity from subresidual volumes in elite divers
    Iga Muradyan
    Department of Radiology, Brigham and Women s Hospital, LMRC, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 109:1969-73. 2010
    ..Our results demonstrate the concept of frank airway closure below RV in young healthy adults with an intact chest wall...
  21. pmc Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond
    Yanping Sun
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Respir Physiol Neurobiol 169:44-9. 2009
    ....
  22. doi request reprint Bronchial collapsibility at forced expiration in healthy volunteers: assessment with multidetector CT
    Diana Litmanovich
    Center for Airway Imaging and Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Radiology 257:560-7. 2010
    ..To assess forced-expiratory bronchial collapsibility in healthy volunteers by using multidetector computed tomography (CT) and to compare the results with the current diagnostic criterion for bronchomalacia...
  23. doi request reprint Dynamic expiratory tracheal collapse in morbidly obese COPD patients
    Phillip M Boiselle
    1From the Center for Airway Imaging and the Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    COPD 10:604-10. 2013
    ....
  24. pmc Determinants of friction in soft elastohydrodynamic lubrication
    Taraneh Moghani
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Biomech 42:1069-74. 2009
    ..The results confirm that the shear-induced deformation of an initially symmetrical shape, including generalizations to other symmetrical geometries such as quadratic or piecewise linear bumps, leads to load-supporting behavior...
  25. pmc Tracheal collapsibility in healthy volunteers during forced expiration: assessment with multidetector CT
    Phillip M Boiselle
    Center for Airway Imaging, Departments of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Radiology 252:255-62. 2009
    ..To assess forced expiratory tracheal collapsibility in healthy volunteers by using multidetector computed tomography and to compare the results with the current diagnostic criterion for tracheomalacia...
  26. ncbi request reprint Tracheobronchomalacia: comparison between end-expiratory and dynamic expiratory CT for evaluation of central airway collapse
    Ronaldo H Baroni
    Departments of Radiology, Pulmonary Medicine, and Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Radiology 235:635-41. 2005
    ..To compare dynamic expiratory and end-expiratory computed tomography (CT) for depicting central airway collapse in patients with acquired tracheobronchomalacia (TBM)...
  27. ncbi request reprint Stiffness of the pleural surface of the chest wall is similar to that of the lung
    Andrew Gouldstone
    Physiology Program, Harvard School of Public Health, Department of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol 95:2345-9. 2003
    ....
  28. doi request reprint Diaphragm training in amyotrophic lateral sclerosis
    Rachel Nardin
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Neuromuscul Dis 10:56-60. 2008
    ..A larger study of this technique is warranted; however, in determining the sample size for a larger study, the difficulty for patients in mastering the technique must be taken into consideration...
  29. ncbi request reprint Airway stabilization with silicone stents for treating adult tracheobronchomalacia: a prospective observational study
    Armin Ernst
    Chief, Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Chest 132:609-16. 2007
    ..Rationale: It is postulated that in patients with severe tracheobronchomalacia (TBM), airway stabilization with stents may relieve symptoms...
  30. pmc Dynamic expiratory tracheal collapse in COPD: correlation with clinical and physiologic parameters
    Phillip M Boiselle
    Center for Airway Imaging and Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Chest 142:1539-44. 2012
    ....
  31. pmc Age and sex dependence of forced expiratory central airway collapse in healthy volunteers
    Carl R O'Donnell
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Chest 142:168-74. 2012
    ..Given differences in subject characteristics between the two samples, we hypothesized that these discrepant findings may reflect a heretofore unrecognized association between forced expiratory tracheal collapse and age or sex...
  32. pmc Reproducibility of forced expiratory tracheal collapse: assessment with MDCT in healthy volunteers
    Phillip M Boiselle
    Center for Airway Imaging and the Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Acad Radiol 17:1186-9. 2010
    ..To assess the reproducibility of multidetector-row computed tomography (MDCT)-measured forced expiratory tracheal collapse in healthy volunteers...
  33. pmc Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity
    Negin Behazin
    Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:212-8. 2010
    ..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes...
  34. ncbi request reprint Airflow synchronous with oscillatory acceleration reflects involuntary respiratory muscle activity
    Richard E Brown
    Harvard School of Public Health, Boston, MA, USA
    Respir Physiol Neurobiol 140:265-82. 2004
    ..We conclude that periodic muscle activity, probably a reflex response to body wall deformation during OAA, strongly influences the involuntary airflow synchronous with OAA...
  35. doi request reprint Pleural pressure and optimal positive end-expiratory pressure based on esophageal pressure versus chest wall elastance: incompatible results*
    Gaurav Gulati
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 41:1951-7. 2013
    ....
  36. pmc Sitting and supine esophageal pressures in overweight and obese subjects
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2354-60. 2012
    ..These data indicate that mediastinal weight and postural effects on P(Es) are within a clinically acceptable range, and suggest that esophageal manometry can be used to inform clinical decision making across wide range of body types...
  37. pmc Evidence for adult lung growth in humans
    James P Butler
    Division of Sleep Disorders, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 367:244-7. 2012
    ..This study provides evidence that new lung growth can occur in an adult human...
  38. pmc Hydrodynamic thickening of lubricating fluid layer beneath sliding mesothelial tissues
    Judy L Lin
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Biomech 41:1197-205. 2008
    ..A similar phenomenon could maintain fluid continuity in the pleural space, reducing frictional force and shear stress during breathing...
  39. ncbi request reprint Friction and lubrication of pleural tissues
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Universita degli Studi di Milano, Via Mangiagalli 32, 20133 Milan, Italy
    Respir Physiol Neurobiol 142:55-68. 2004
    ....
  40. pmc Probing softness of the parietal pleural surface at the micron scale
    Jae Hun Kim
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Dana 715, Boston, MA 02215, USA
    J Biomech 44:2558-64. 2011
    ..The observed softness of the pleura supports the hypothesis that unevenness of the pleural surface on this scale is smoothed by local hydrodynamic pressure...
  41. ncbi request reprint Mediastinal and chest wall limitations to asymmetry of lung inflation
    Ken C Lin
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 5491, USA
    J Appl Physiol 96:999-1004. 2004
    ..Simulations with a previously published model showed that changes in E(Asym) in the range of values observed could substantially affect lung ventilation after single-lung transplantation for emphysema...
  42. pmc Influence of the softness of the parietal pleura on respiratory sliding mechanisms
    Jae Hun Kim
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Respir Physiol Neurobiol 177:114-9. 2011
    ..These results suggest that during sliding motion, unevenness of the pleural surface is smoothed by local hydrodynamic pressure, preventing any significant contribution of solid-solid contacts...
  43. ncbi request reprint Quantitative analysis of the velocity and synchronicity of diaphragmatic motion: dynamic MRI in different postures
    Shigeru Kiryu
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Magn Reson Imaging 24:1325-32. 2006
    ..In addition, diaphragmatic motion differed between expiratory and inspiratory phases. This study suggests the further potential of dynamic MR imaging for the evaluation of pulmonary functions or deficiencies...
  44. doi request reprint Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies
    Lauren A Henderson
    Division of Immunology, Boston Children s Hospital, Boston, MA 02115, USA
    J Rheumatol 40:273-81. 2013
    ..The pathophysiology of shrinking lung syndrome (SLS) is poorly understood. We sought to define the structural basis for this condition through the study of pulmonary mechanics in affected patients...
  45. doi request reprint Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis
    Jeremy R Beitler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, BLI 036, Boston, MA, 02115, USA
    Intensive Care Med 40:332-41. 2014
    ..This meta-analysis was performed to integrate these findings with existing literature and test whether differences in tidal volume explain conflicting results among randomized trials...
  46. ncbi request reprint Relative motion of lung and chest wall promotes uniform pleural space thickness
    Jean Lai
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Respir Physiol Neurobiol 131:233-43. 2002
    ..Results also suggest a possible mechanism for pleural fluid redistribution during breathing, whereby irreversible fluid motion is associated with the deformability of the membrane...
  47. ncbi request reprint The male predisposition to pharyngeal collapse: importance of airway length
    Atul Malhotra
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1388-95. 2002
    ..This study suggests that the male predisposition to pharyngeal collapse is anatomically based, primarily as the result of an increased length of vulnerable airway as well as increased soft palate size...
  48. pmc Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?
    Stephen H Loring
    Chest 131:646-8. 2007
  49. ncbi request reprint Plateau pressures in the ARDSnet protocol: cause of injury or indication of disease?
    Stephen H Loring
    Am J Respir Crit Care Med 176:99-100; author reply 100-1. 2007
  50. ncbi request reprint Whole-body "negative-pressure" ventilation: is it really different?
    Stephen H Loring
    Am J Respir Crit Care Med 178:542; author reply 542-3. 2008
  51. ncbi request reprint Heavy breathing
    Robert B Banzett
    J Appl Physiol 102:2090-1. 2007
  52. ncbi request reprint Mechanical ventilation and disuse atrophy of the diaphragm
    Stephen H Loring
    N Engl J Med 359:89-90; author reply 91-2. 2008