Research Topics
| Stephen H LoringSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Expiratory abdominal rounding in acute dyspnea suggests congestive heart failureStephen H Loring
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Lung 184:324-9. 2006..The clinical utility of this diagnostic sign remains to be determined in a prospective study...- Sources of graft restriction after single lung transplantation for emphysemaStephen H Loring
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
J Thorac Cardiovasc Surg 134:204-9. 2007..We sought to determine the contributions of donor-recipient size matching, postoperative native lung hyperinflation, and postoperative chest wall volume reduction to graft restriction after transplantation... - Central airway mechanics and flow limitation in acquired tracheobronchomalaciaStephen H Loring
Beth Israel Deaconess Medical Center, 330 Brookline Ave, DA 717, Boston, MA 02215, USA
Chest 131:1118-24. 2007..It is usually not known whether central airway malacia contributes to airflow obstruction. This study was undertaken to quantify central airway collapsibility and relate it to expiratory flow limitation in patients with TBM... 
Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?Stephen H Loring
Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol 108:515-22. 2010..We suggest that Pes can be used to estimate transpulmonary pressures that are consistent with known physiology and can provide meaningful information, otherwise unavailable, in critically ill patients...- Pulmonary characteristics in COPD and mechanisms of increased work of breathingStephen H Loring
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol 107:309-14. 2009..Extrinsic restriction, in which the chest wall fails to achieve and maintain abnormally high lung volumes in COPD, can limit ventilatory function and contribute to disability... - Transpulmonary pressures and lung mechanics with glossopharyngeal insufflation and exsufflation beyond normal lung volumes in competitive breath-hold diversStephen H Loring
Dept of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Appl Physiol 102:841-6. 2007..We conclude that the lungs of some healthy individuals are able to withstand repeated inflation to transpulmonary pressures far greater than those to which they would normally be exposed... - Lubrication regimes in mesothelial slidingStephen H Loring
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, DA 717, 330 Brookline Avenue, Boston, MA 02215 5491, USA
J Biomech 38:2390-6. 2005..We conclude that mesothelial surfaces, sliding under physiological conditions, are protected from excessive shear by hydrodynamic pressures that increase separation of surfaces... 
Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted ratsStephen H Loring
Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, and Servizio di Coagulazione, IRCCS Ospedale San Raffaele, Milan, Italy
Crit Care Med 38:2358-64. 2010....- Mechanical ventilation guided by esophageal pressure in acute lung injuryDaniel Talmor
Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
N Engl J Med 359:2095-104. 2008.... - Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPDAlejandro A Diaz
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Chest 141:736-44. 2012..Additionally, we compared clinical and CT scan features of subjects with (airway constrictors) and without a decrease in airway caliber... - Comparison of plethysmographic and helium dilution lung volumes: which is best for COPD?Carl R O'Donnell
ScD, Beth Israel Deaconess Medical Center, Dana 717, 330 Brookline Ave, Boston, MA 02215, USA
Chest 137:1108-15. 2010..We sought to compare plethysmography (Pleth)-, helium dilution (He)- and CT scan-derived lung volume measurements in a sample containing many patients with severe airflow obstruction... - Physiological and computed tomographic predictors of outcome from lung volume reduction surgeryGeorge R Washko
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 181:494-500. 2010..We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial... - Esophageal and transpulmonary pressures in acute respiratory failureDaniel Talmor
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA
Crit Care Med 34:1389-94. 2006..Systematic use of esophageal manometry has the potential to improve ventilator management in acute respiratory failure by providing more direct assessment of lung distending pressure... - Physiological characterization of variability in response to lung volume reduction surgeryEdward P Ingenito
Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Appl Physiol 94:20-30. 2003..Among nonresponders, recoil pressure increased out of proportion to reduced volume, such that no increase in vital capacity or improvement in FEV(1) occurred... - Cytokine release following recruitment maneuversDaniel Talmor
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, CC 470, Boston MA 02215, USA
Chest 132:1434-9. 2007..There are reports of rigors and/or clinical deterioration following recruitment maneuvers (RMs), leading us to question whether the use of sustained high-pressure inflation could lead to release of inflammatory mediators... - Elastohydrodynamic separation of pleural surfaces during breathingAndrew Gouldstone
Physiology Program, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Respir Physiol Neurobiol 137:97-106. 2003..These results suggest that in the pleural space during normal breathing, separation of pleural surfaces is promoted by the reciprocating sliding of lung and chest wall... - Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyondYanping Sun
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
Respir Physiol Neurobiol 169:44-9. 2009.... - Inhalation heterogeneity from subresidual volumes in elite diversIga Muradyan
Department of Radiology, Brigham and Women s Hospital, LMRC, 221 Longwood Ave, Boston, MA 02115, USA
J Appl Physiol 109:1969-73. 2010..Our results demonstrate the concept of frank airway closure below RV in young healthy adults with an intact chest wall... - Bronchial collapsibility at forced expiration in healthy volunteers: assessment with multidetector CTDiana Litmanovich
Center for Airway Imaging and Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Radiology 257:560-7. 2010..To assess forced-expiratory bronchial collapsibility in healthy volunteers by using multidetector computed tomography (CT) and to compare the results with the current diagnostic criterion for bronchomalacia... - Stiffness of the pleural surface of the chest wall is similar to that of the lungAndrew Gouldstone
Physiology Program, Harvard School of Public Health, Department of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol 95:2345-9. 2003.... - Determinants of friction in soft elastohydrodynamic lubricationTaraneh Moghani
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Biomech 42:1069-74. 2009..The results confirm that the shear-induced deformation of an initially symmetrical shape, including generalizations to other symmetrical geometries such as quadratic or piecewise linear bumps, leads to load-supporting behavior... - Airway stabilization with silicone stents for treating adult tracheobronchomalacia: a prospective observational studyArmin Ernst
Chief, Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Chest 132:609-16. 2007..Rationale: It is postulated that in patients with severe tracheobronchomalacia (TBM), airway stabilization with stents may relieve symptoms... - Volume-related and volume-independent effects of posture on esophageal and transpulmonary pressures in healthy subjectsGeorge R Washko
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol 100:753-8. 2006..We conclude that postural differences in estimated transpulmonary pressure at a given lung volume are small compared with the substantial range of PLrel in patients with acute lung injury... - Diaphragm training in amyotrophic lateral sclerosisRachel Nardin
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Clin Neuromuscul Dis 10:56-60. 2008..A larger study of this technique is warranted; however, in determining the sample size for a larger study, the difficulty for patients in mastering the technique must be taken into consideration... - Tracheal collapsibility in healthy volunteers during forced expiration: assessment with multidetector CTPhillip M Boiselle
Center for Airway Imaging, Departments of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Radiology 252:255-62. 2009..To assess forced expiratory tracheal collapsibility in healthy volunteers by using multidetector computed tomography and to compare the results with the current diagnostic criterion for tracheomalacia... - Tracheobronchomalacia: comparison between end-expiratory and dynamic expiratory CT for evaluation of central airway collapseRonaldo H Baroni
Departments of Radiology, Pulmonary Medicine, and Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Radiology 235:635-41. 2005..5% with dynamic expiration versus 28.6% with end expiration (P = .0022). CONCLUSION: Dynamic expiratory CT elicits a significantly greater degree of airway collapse than standard end-expiratory CT in patients with TBM... - Dynamic expiratory tracheal collapse in COPD: correlation with clinical and physiologic parametersPhillip M Boiselle
Center for Airway Imaging and Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Chest 142:1539-44. 2012.... - Age and sex dependence of forced expiratory central airway collapse in healthy volunteersCarl R O'Donnell
Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Chest 142:168-74. 2012..Given differences in subject characteristics between the two samples, we hypothesized that these discrepant findings may reflect a heretofore unrecognized association between forced expiratory tracheal collapse and age or sex... - Respiratory restriction and elevated pleural and esophageal pressures in morbid obesityNegin Behazin
Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol 108:212-8. 2010..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes... - Reproducibility of forced expiratory tracheal collapse: assessment with MDCT in healthy volunteersPhillip M Boiselle
Center for Airway Imaging and the Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Acad Radiol 17:1186-9. 2010..To assess the reproducibility of multidetector-row computed tomography (MDCT)-measured forced expiratory tracheal collapse in healthy volunteers... - Airflow synchronous with oscillatory acceleration reflects involuntary respiratory muscle activityRichard E Brown
Harvard School of Public Health, Boston, MA, USA
Respir Physiol Neurobiol 140:265-82. 2004..We conclude that periodic muscle activity, probably a reflex response to body wall deformation during OAA, strongly influences the involuntary airflow synchronous with OAA... - Evidence for adult lung growth in humansJames P Butler
Division of Sleep Disorders, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 367:244-7. 2012..This study provides evidence that new lung growth can occur in an adult human... - Hydrodynamic thickening of lubricating fluid layer beneath sliding mesothelial tissuesJudy L Lin
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Biomech 41:1197-205. 2008..A similar phenomenon could maintain fluid continuity in the pleural space, reducing frictional force and shear stress during breathing... - Friction and lubrication of pleural tissuesEdgardo D'Angelo
Istituto di Fisiologia Umana I, Universita degli Studi di Milano, Via Mangiagalli 32, 20133 Milan, Italy
Respir Physiol Neurobiol 142:55-68. 2004.... - "Ventilatory alternans": a left-right alternation of inspiratory airflow in humansYanping Sun
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
Respir Physiol Neurobiol 185:468-71. 2013..We speculate that cardiogenic pendelluft, possibly from ballistic lateral motion of the beating heart, could cause alternating variations of inspiratory flow to the lungs... - Probing softness of the parietal pleural surface at the micron scaleJae Hun Kim
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Dana 715, Boston, MA 02215, USA
J Biomech 44:2558-64. 2011..The observed softness of the pleura supports the hypothesis that unevenness of the pleural surface on this scale is smoothed by local hydrodynamic pressure... - Influence of the softness of the parietal pleura on respiratory sliding mechanismsJae Hun Kim
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Respir Physiol Neurobiol 177:114-9. 2011..These results suggest that during sliding motion, unevenness of the pleural surface is smoothed by local hydrodynamic pressure, preventing any significant contribution of solid-solid contacts... - Quantitative analysis of the velocity and synchronicity of diaphragmatic motion: dynamic MRI in different posturesShigeru Kiryu
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Magn Reson Imaging 24:1325-32. 2006..In addition, diaphragmatic motion differed between expiratory and inspiratory phases. This study suggests the further potential of dynamic MR imaging for the evaluation of pulmonary functions or deficiencies... - Mediastinal and chest wall limitations to asymmetry of lung inflationKen C Lin
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215-5491, USA
J Appl Physiol 96:999-1004. 2004..Simulations with a previously published model showed that changes in E(Asym) in the range of values observed could substantially affect lung ventilation after single-lung transplantation for emphysema... - Esophageal pressure as an estimate of average pleural pressure with lung or chest distortion in ratsMatteo Pecchiari
Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita di Milano, Milan, Italy
Respir Physiol Neurobiol 186:229-35. 2013..With chest wall distortion and dependent deformation of the normal lung, changes of Ples-V curves are qualitatively consistent with greater work of inflation... - Relative motion of lung and chest wall promotes uniform pleural space thicknessJean Lai
Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
Respir Physiol Neurobiol 131:233-43. 2002..Results also suggest a possible mechanism for pleural fluid redistribution during breathing, whereby irreversible fluid motion is associated with the deformability of the membrane... - The male predisposition to pharyngeal collapse: importance of airway lengthAtul Malhotra
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 166:1388-95. 2002..This study suggests that the male predisposition to pharyngeal collapse is anatomically based, primarily as the result of an increased length of vulnerable airway as well as increased soft palate size... - Sitting and supine esophageal pressures in overweight and obese subjectsRobert L Owens
Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Obesity (Silver Spring) 20:2354-60. 2012..These data indicate that mediastinal weight and postural effects on P(Es) are within a clinically acceptable range, and suggest that esophageal manometry can be used to inform clinical decision making across wide range of body types... - Plateau pressures in the ARDSnet protocol: cause of injury or indication of disease?Stephen H Loring
Am J Respir Crit Care Med 176:99-100; author reply 100-1. 2007 - Whole-body "negative-pressure" ventilation: is it really different?Stephen H Loring
Am J Respir Crit Care Med 178:542; author reply 542-3. 2008 - Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?Stephen H Loring
Chest 131:646-8. 2007 - Heavy breathingRobert B Banzett
J Appl Physiol 102:2090-1. 2007 - Mechanical ventilation and disuse atrophy of the diaphragmStephen H Loring
N Engl J Med 359:89-90; author reply 91-2. 2008